#mechanism-based-drug-discovery

Mechanism-based Drug Discovery

Protein chemistry and chemical biology are a long-standing tradition of IBC. Institute PIs harness their expertise to resolve novel protein structures of relevance to disease and also identify new compounds, both from nature and obtained by chemical synthesis, with therapeutic potential or which can serve as biological probes. Vaccine and diagnostic development is another focus. Unmet medical needs in areas such as infectious disease, cancer, and other chronic afflictions including Alzheimer’s disease are of particular interest.

Mechanism-Based Drug Discovery researchers at IBC:

    Chung-I Chang
    Intracellular Protein Degradation

    Rita Pei-Yeh Chen
    Protein Folding and Misfolding, Drug Discovery for Neurodegenerative Diseases and Drug-resistant Pathogens

    Meng-Chiao Ho
    Structure, Function, and Biophysical Properties of Proteins

    Danny Shang-Te Hsu
    Structural Biology, Biophysical Chemistry

    Po-Huang Liang
    Mechanistic and Structural Studies of Prenyltransferases, Microorganism-Derived Proteases, Biofuel Production

    Chun-Hung Lin
    Glycobiology, Enzymology, Synthetic Chemistry, Biophysics

    Hsiao-Ching Lin
    Bioactive Natural Products

    Todd L. Lowary
    Synthetic Chemistry, Carbohydrate Chemistry

    Kuen-Phon Wu
    Protein Ubiquitination, Amyloidosis

    Shih-Hsiung Wu
    Carbohydrate Chemistry, Glycobiology, Proteomics

#glycosciences

Glycosciences

Glycans are carbohydrates that are essential for the development, functioning, and survival for all living organisms. Institute PIs with expertise in immunology, chemistry, biochemistry, proteomics, glycomics, and glycoproteomics use technologies such as mass spectrometry, cell biology and synthetic carbohydrate chemistry to study the molecular and physiological functions of glycans. In addition to gaining new understanding of the roles of glycans in biology, their work aims to discover innovative compounds and technologies with therapeutic potential for infectious disease and cancer.

Glycosciences researchers at IBC:

    Takashi Angata
    The Regulation of Physiological Processes by Sialic Acids

    Kay-Hooi Khoo
    MS-based Protein Modification Analysis, Proteomics, Glycomics, Glycoproteomics

    Chun-Hung Lin
    Glycobiology, Enzymology, Synthetic Chemistry, Biophysics

    Todd L. Lowary
    Synthetic Chemistry, Carbohydrate Chemistry

    Shih-Hsiung Wu
    Carbohydrate Chemistry, Glycobiology, Proteomics

#post-translational-modifications-in-physiology-and-diseases

Post-Translational Modifications in Physiology and Diseases

The location and identity of post-translational modifications (PTMs) on proteins is associated with their physiological functions and their role in disease. Institute PIs are particularly interested in the sequence and functional analysis of PTMs and their association with infectious disease, neurodegenerative disease, cardiovascular disease, metabolic disorder, and cancer. Among the PTMs of interest are ubiquitination and phosphorylation and the studies ongoing may also provide key knowledge in novel protein drug design.

PTM researchers at IBC:

    Ching-Jin Chang
    Gene Expression, mRNA Decay

    Guang-Chao Chen
    Functional Analysis of PTPs in Development and Human Diseases, Molecular Signaling and PTM of Autophagy

    Hungwen Chen
    Molecular Mechanism Underlying the Stemness and Differentiation of Adult Stem Cells

    Ruey-Hwa Chen
    The Roles of Cullin-RING Family Ubiquitin Ligases in Human Cancers, The Roles of Ubiquitination in Autophagy Regulation

    Kay-Hooi Khoo
    MS-based Protein Modification Analysis, Proteomics, Glycomics, Glycoproteomics

    Steven Lin
    Developing CRISPR/Cas9 Methods to Enable Robust, Precise and Safe Genome Manipulations in Human Genome

    Tzu-Ching Meng
    Fundamental Principle that Governs Redox Regulation of Cysteine Enzymes

    Yane-Shih Wang
    Protein Post-Translational Modifications (PTMs) and Their Networks

    Kuen-Phon Wu
    Protein Ubiquitination, Amyloidosis

#membrane-dynamics

Membrane Dynamics

Cell membranes are dynamic structures, which are essential to numerous fundamental cellular functions such as membrane trafficking, the release of vesicles, endocytosis, and interactions between cells. Institute PIs are focusing on membrane architecture associated with physiological functions including autophagy, host–pathogen interactions, metabolic regulation, neurotransmission, and organelle damage responses.

Membrane Dynamics researchers at IBC:

    Guang-Chao Chen
    Functional Analysis of PTPs in Development and Human Diseases, Molecular Signaling and PTM of Autophagy

    Ruey-Hwa Chen
    The Roles of Cullin-RING Family Ubiquitin Ligases in Human Cancers, The Roles of Ubiquitination in Autophagy Regulation

    Yu-Ling Shih
    Bacterial Physiology Underlying Cell Growth, Division, and Morphogenesis

    Wei-Yuan Yang
    Autophagy, Organelle Damage Responses, Cell Imaging, Optogenetics

    Chi-Kuang Yao
    Molecular Control of Synaptic Vesicle Cycle in Neurotransmission, Pathogenic Role of Dysregulated Neurotransmission in Human Diseases