#host–microbe-interactions

Host – Microbe Interactions

Interactions between microbes and host organisms, such as microbiota in the human gut, are essential to health but can also lead to diseases with profound societal impacts (e.g., COVID-19). IBC researchers probe interactions among proteins and between glycans and proteins that are fundamental to host–microbe interactions. Our researchers also study important enzymes or proteins of microorganisms and identify new compounds, both from nature and through chemical synthesis, that have therapeutic potential or that can be biological probes. In other focus areas, we work toward developing new vaccines and diagnostics.

Host – Microbe Interactions researchers at IBC:

    Todd L. Lowary
    Synthetic Chemistry, Carbohydrate Chemistry

    Rita Pei-Yeh Chen
    Protein Folding and Misfolding, Drug Discovery for Neurodegenerative Diseases and Drug-resistant Pathogens

    Takashi Angata
    The Regulation of Physiological Processes by Sialic Acids

    Yu-Ling Shih
    Bacterial Physiology Underlying Cell Growth, Division, and Morphogenesis

    Chun-Hung Lin
    Glycobiology, Enzymology, Synthetic Chemistry, Biophysics

    Danny Shang-Te Hsu
    Structural Biology, Biophysical Chemistry

    Po-Huang Liang
    Mechanistic and Structural Studies of Prenyltransferases, Microorganism-Derived Proteases, Biofuel Production

    Hsin-Yung (Jason) Yen

    Hsiao-Ching Lin
    Bioactive Natural Products

    Meng-Chiao Ho
    Structure, Function, and Biophysical Properties of Proteins

    Shih-Hsiung Wu
    Carbohydrate Chemistry, Glycobiology, Proteomics

    Tzu-Ching Meng
    Fundamental Principle that Governs Redox Regulation of Cysteine Enzymes

#intracellular–extracellular-communication

Intracellular – Extracellular Communication

Communication across cell membranes is critical to a wide array of biological phenomena and diseases. IBC researchers study intracellular and extracellular signaling and membrane dynamics at the molecular level. Their findings will apply to treating neurodegenerative diseases, preventing infection, treating cancer and using stem cells in disease therapies.

Intracellular – Extracellular Communication researchers at IBC:

    Ruey-Hwa Chen
    The Roles of Cullin-RING Family Ubiquitin Ligases in Human Cancers, The Roles of Ubiquitination in Autophagy Regulation

    Chi-Kuang Yao
    Molecular Control of Synaptic Vesicle Cycle in Neurotransmission, Pathogenic Role of Dysregulated Neurotransmission in Human Diseases

    Takashi Angata
    The Regulation of Physiological Processes by Sialic Acids

    Wei-Yuan Yang
    Autophagy, Organelle Damage Responses, Cell Imaging, Optogenetics

    Yu-Ling Shih
    Bacterial Physiology Underlying Cell Growth, Division, and Morphogenesis

    Guang-Chao Chen
    Functional Analysis of PTPs in Development and Human Diseases, Molecular Signaling and PTM of Autophagy

    Chun-Hung Lin
    Glycobiology, Enzymology, Synthetic Chemistry, Biophysics

    Ching-Jin Chang
    Gene Expression, mRNA Decay

    Jui-Hsia Weng

    Po-Huang Liang
    Mechanistic and Structural Studies of Prenyltransferases, Microorganism-Derived Proteases, Biofuel Production

    Hsin-Yung (Jason) Yen

    Hungwen Chen
    Molecular Mechanism Underlying the Stemness and Differentiation of Adult Stem Cells

    Kay-Hooi Khoo
    MS-based Protein Modification Analysis, Proteomics, Glycomics, Glycoproteomics

    Tzu-Ching Meng
    Fundamental Principle that Governs Redox Regulation of Cysteine Enzymes

#cell-homeostasis

Cell Homeostasis

Cell homeostasis is the ability of a cell to maintain an internal steady state. Imbalances in that state can lead to disease. IBC researchers investigate the mechanisms of homeostasis processes including autophagy, protein folding, protein quality control, redox regulation, and ubiquitination. They are developing foundational knowledge that will lead to therapies for cancer, infectious diseases and neurodegenerative diseases including Alzheimer’s disease.

Cell Homeostasis researchers at IBC:

    Rita Pei-Yeh Chen
    Protein Folding and Misfolding, Drug Discovery for Neurodegenerative Diseases and Drug-resistant Pathogens

    Ruey-Hwa Chen
    The Roles of Cullin-RING Family Ubiquitin Ligases in Human Cancers, The Roles of Ubiquitination in Autophagy Regulation

    Chi-Kuang Yao
    Molecular Control of Synaptic Vesicle Cycle in Neurotransmission, Pathogenic Role of Dysregulated Neurotransmission in Human Diseases

    Yane-Shih Wang
    Protein Post-Translational Modifications (PTMs) and Their Networks

    Chung-I Chang
    Intracellular Protein Degradation

    Kuen-Phon Wu
    Protein Ubiquitination, Amyloidosis

    Wei-Yuan Yang
    Autophagy, Organelle Damage Responses, Cell Imaging, Optogenetics

    Guang-Chao Chen
    Functional Analysis of PTPs in Development and Human Diseases, Molecular Signaling and PTM of Autophagy

    Danny Shang-Te Hsu
    Structural Biology, Biophysical Chemistry

    Meng-Chiao Ho
    Structure, Function, and Biophysical Properties of Proteins

    Kay-Hooi Khoo
    MS-based Protein Modification Analysis, Proteomics, Glycomics, Glycoproteomics

    Tzu-Ching Meng
    Fundamental Principle that Governs Redox Regulation of Cysteine Enzymes

#synthetic-biology

Synthetic Biology

Synthetic biology seeks to create or redesign biological materials for new purposes. IBC researchers working in synthetic biology are experts in gene editing, cell and protein engineering and design, biocatalyst optimization and natural product biosynthesis. Their findings can be applied to solving important sustainability problems (e.g., fuels from microbial synthesis), developing new cells for immunotherapy and synthesizing new chemical entities or novel proteins as potential therapeutics.

Synthetic Biology researchers at IBC:

    Steven Lin
    Developing CRISPR/Cas9 Methods to Enable Robust, Precise and Safe Genome Manipulations in Human Genome

    Yane-Shih Wang
    Protein Post-Translational Modifications (PTMs) and Their Networks

    Po-Huang Liang
    Mechanistic and Structural Studies of Prenyltransferases, Microorganism-Derived Proteases, Biofuel Production

    Hsiao-Ching Lin
    Bioactive Natural Products

    James C. Liao
    Metabolic Engineering, Synthetic Biology, Bioenergy, Bioengineering