中央研究院 生物化學研究所
中央研究院 生物化學研究所
中央研究院 生物化學研究所
huangkf@gate.sinica.edu.tw
+886-2-27855696,4010
專長
研究
Structural and biological insights into Klebsiella pneumonia surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
Tu IF, Lin TL, Yang FL, Lee IM, Tu WL, Liao JH, Ko TP, Wu WJ, Jan JT, Ho MR, Chou CY, Wang AH, Wu CY, Wang JT, Huang KF, Wu SH
Journal of Biomedical Science (2022)
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability.
Chen ST, Liao JH, Huang KF, Lee IM, Wong WT, Wu SH, Hua KF
Chemical Communications (2021)
A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.
Huang KF, Huang JS, Wu ML, Hsieh WL, Hsu KC, Hsu HL, Ko TP, Wang AH
Journal of Molecular Biology (2021)
Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein.
Lee IM, Tu IF, Yang FL, Ko TP, Liao JH, Lin NT, Wu CY, Ren CT, Wang AH, Chang CM, Huang KF, Wu SH
Scientific Reports (2017)
A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3.
Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, Wu SH
Journal of the American Chemical Society (2016)
Linked Production of Pyroglutamate-Modified Proteins via Self-Cleavage of Fusion Tags with TEV Protease and Autonomous N-Terminal Cyclization with Glutaminyl Cyclase In Vivo.
Shih YP, Chou CC, Chen YL, Huang KF, Wang AH
PLoS One (2014)
Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding.
Huang KF, Hsu HL, Karim S, Wang AH
Acta Crystallographica Section D : Biological Crystallography (2014)
Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding.
Huang KF, Liaw SS, Huang WL, Chia CY, Lo YC, Chen YL, Wang AH
Journal of Biological Chemistry (2011)
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Huang KF, Wang YR, Chang EC, Chou TL, Wang AH
The Biochemical journal (2008)
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.
Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH
Proceedings of the National Academy of Sciences of the United States of America (2005)
