中央研究院 生物化學研究所
中央研究院 生物化學研究所
中央研究院 生物化學研究所
huangkf@as.edu.tw
+886-2-27855696,4010
Site-specific histidine Aza-Michael addition in proteins enabled by a ferritin-based metalloenzyme.
Tsou JC, Tsou CJ, Wang CH, Ko AA, Wang YH, Liang HH, Sun JC, Huang KF, Ko TP, Lin SY, Wang YS
Journal of the American Chemical Society (2024)
Mechanistic insights into dibasic iminosugars as pH-selective pharmacological chaperones to stabilize human α-galactosidase.
Li HY, Lin HY, Chang SK, Chiu YT, Hou CC, Ko TP, Huang KF, Niu DM, Cheng WC
JACS Au (2024)
Klebsiella pneumonia K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation.
Ye TJ, Fung KM, Lee IM, Ko TP, Lin CY, Wong CL, Tu IF, Huang TY, Yang FL, Chang YP, Wang JT, Lin TL, Huang KF*, Wu SH*
mBio (2024)
Structure, dynamics, and stability of the smallest and most complex 71 protein knot.
Hsu MF, Sriramoju MK, Lai CH, Chen YR, Huang JS, Ko TP, Huang KF, Hsu SD
Journal of Biological Chemistry (2024)
Visualizing the DNA repair process by a photolyase at atomic resolution.
Maestre-Reyna M, Wang PH, Nango E, Hosokawa Y, Saft M, Furrer A, Yang CH, Gusti Ngurah Putu EP, Wu WJ, Emmerich HJ, Caramello N, Franz-Badur S, Yang C, Engilberge S, Wranik M, Glover HL, Weinert T, Wu HY, Lee CC, Huang WC, Huang KF, Chang YK, Liao JH, Weng JH, Gad W, Chang CW, Pang AH, Yang KC, Lin WT, Chang YC, Gashi D, Beale E, Ozerov D, Nass K, Knopp G, Johnson PJM, Cirelli C, Milne C, Bacellar C, Sugahara M, Owada S, Joti Y, Yamashita A, Tanaka R, Tanaka T, Luo F, Tono K, Zarzycka W, Müller P, Alahmad MA, Bezold F, Fuchs V, Gnau P, Kiontke S, Korf L, Reithofer V, Rosner CJ, Seiler EM, Watad M, Werel L, Spadaccini R, Yamamoto J, Iwata S, Zhong D, Standfuss J, Royant A, Bessho Y, Essen LO, Tsai MD
Science (2023)
Structural and biological insights into Klebsiella pneumonia surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
Tu IF, Lin TL, Yang FL, Lee IM, Tu WL, Liao JH, Ko TP, Wu WJ, Jan JT, Ho MR, Chou CY, Wang AH, Wu CY, Wang JT, Huang KF*, Wu SH*
Journal of Biomedical Science (2022)
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Lin CC, Hoo SY, Ma LT, Lin C, Huang KF, Ho YN, Sun CH, Lee HJ, Chen PY, Shu LJ, Wang BW, Hsu WC, Ko TP, Yang YL
Communications Biology (2022)
Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase.
Ye TJ, Huang KF, Ko TP, Wu SH
Acta Crystallographica Section D-Structural Biology (2022)
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability.
Chen ST, Liao JH, Huang KF, Lee IM, Wong WT, Wu SH, Hua KF
Chemical Communications (2021)
A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.
Huang KF*, Huang JS, Wu ML, Hsieh WL, Hsu KC, Hsu HL, Ko TP, Wang AH*
Journal of Molecular Biology (2021)
