中央研究院 生物化學研究所

研究領域與專長

Our laboratory has been focusing on (i) mechanistic and structural studies of prenyltransferases catalyzing chain elongation, such as undecaprenyl diphosphate synthase, octaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase; (ii) antivirus and anti-cancer drug discovery targeting 3C protease from Enterovirus 71, 3C-like proteases from SARS-CoV and MERS-CoV, neuraminidase from avian flu virus, and protein-protein interactions; (iii) multi-functional cellulose/hemicellulose degrading enzymes for biofuel production.

學經歷

• 1989 – 1994   博士, 化學暨生化系, 美國馬里蘭大學
• 1982 – 1986   學士, 化學系, 臺灣大學。

• 2007 – 迄今   合聘教授, 臺大生命科學院生化所
• 2007 – 迄今   編輯委員, Bioorganic Chemistry (Elsevier) and JCCS
• 2006 – 迄今   研究員, 中研院生化所
• 2017 – 2019   代理副所長, 中央研究院生物化學研究所
• 2017 – 2017   副所長, 中央研究院生物化學研究所
• 2010 – 2015   理事, 亞太蛋白質學會
• 2009 – 2024   理事, 臺灣生物化學及分子生物學學會
• 2007 – 2016   理事, 中華民國生物物理學會
• 2006 – 2011   副所長, 中研院生化所
• 2005 – 2008   主持人, 重組蛋白生產核心設施
• 2004 – 2011   Chem Biology & Mol Biophys 召集人, 中研院國際研究生學程
• 2002 – 2006   副研究員, 中研院生化所
• 1999 – 2002   助研究員, 中研院生化所
• 1996 – 1999   研究員, 史克美占藥廠巨分子科學及蛋白質化學系
• 1995 – 1996   助理研究員, 美國耶魯大學醫學院藥學系
• 1994 – 1995   博士後研究員, 美國耶魯大學醫學院藥學系

主要著作

Complexation and evolution of cis-prenyltransferase homologues in Cinnamomum kanehirae deduced from kinetic and functional characterizations. 
Liu JJ, Liang PH 
Protein Science (2023)

Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors. 
Palla SR, Li CW, Chao TL, Lo HV, Jia-Jin L, Pan MY, Chiu YT, Lin WC, Hu CW, Yang CM, Chen YY, Fang JT, Lin SW, Lin YT, Lin HC, Kuo CJ, Wang LH, Chang SY, Liang PH 
Antiviral Research (2023)

SARS-CoV-2 3CL^pro displays faster self-maturation in vitro than SARS-CoV 3CL^pro due to faster C-terminal cleavage. 
Kuo CJ, Liang PH 
FEBS Letters (2022)

Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2. 
Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LH, Hsieh MC, Chang SY, Liang PH 
Antimicrobial Agents and Chemotherapy (2021)

Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. 
Liu YJ, Chang YJ, Kuo YT, Liang PH 
Carcinogenesis (2020)

A flexible loop for mannan recognition and activity enhancement in a bifunctional glycoside hydrolase family 5. 
Liang PH, Lin WL, Hsieh HY, Lin TY, Chen CH, Tewary SK, Lee HL, Yuan SF, Yang B, Yao JY, Ho MC 
Biochimica et Biophysica Acta (BBA) - General Subjects (2018)

Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation. 
Liu YJ, Kumar V, Lin YF, Liang PH 
Cell Death & Disease (2017)

Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL^pro inhibitors. 
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH 
Antiviral Research (2017)

Fluorescent farnesyl diphosphate analogue: A probe to validate trans-prenyltransferase inhibitors. 
Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH 
Biochemistry (2016)

Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum. 
Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH 
Journal of Biological Chemistry (2015)

著作列表