Our laboratory has been focusing on (i) mechanistic and structural studies of prenyltransferases catalyzing chain elongation, such as undecaprenyl diphosphate synthase, octaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase; (ii) antivirus and anti-cancer drug discovery targeting 3C protease from Enterovirus 71, 3C-like proteases from SARS-CoV and MERS-CoV, neuraminidase from avian flu virus, and protein-protein interactions; (iii) multi-functional cellulose/hemicellulose degrading enzymes for biofuel production.
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLpro inhibitors.
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH
Antiviral research (2017)
Fluorescent farnesyl diphosphate analogue: A probe to validate trans-prenyltransferase inhibitors.
Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH
BIOCHEMISTRY (2016)
Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.
Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH
The Journal of biological chemistry (2015)
Identification, synthesis and evaluation of new neuraminidase inhibitors.
Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng, YS, Liang PH
Organic Letters (2014)
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction.
Chang CK, Teng KH, Lin SW, Chang TH, Liang PH
Biochemistry (2013)
Targeting the XIAP/caspase-7 complex selectively kills caspase-3 deficient malignancies.
Lin, Y. F. Lai, T. C., Chang, C. K., Chen, C.L., Huang, M.S., Yang, C.J., Liu, H. G., Dong, J. J., Chou, Y.A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M., and Liang, P. H.
J. Clinical Investigation (2013)
Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.
Lin YF, Lee YF, Liang PH
Cell Death & Disease (2012)
Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability.
Lee HL, Chang CK, Teng KH, Liang PH
BIORESOURCE TECHNOLOGY (2011)
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Chia-Hsiang Lo, Ying-Hsuan Chang, Jon D. Wright, Shih-Hsun Chen, Daphne Kan, Carmay Lim, and Po-Huang Liang
Journal of the American Chemical Society (2009)
Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.
Yuan-Feng Lin, Wen-Ping Tsai, Hon-Ge Liu, and Po-Huang Liang
Cancer Research (2009)