中央研究院 生物化學研究所

研究領域與專長

Lactate, Biosensors, Fluorescent proteins, Protein engineering

學經歷

• 2009 - 2015   Ph.D. , Department of Chemistry, School of Science, The University of Tokyo
• 2005 - 2009   B.S. , Department of Chemistry, School of Science, The University of Tokyo

• 2024 – 迄今   助研究員，中央研究院生物化學研究所
• 2022 – 迄今   PRESTO, Japan Science and Technology Agency
• 2018 – 2024   Assistant Professor, Department of Chemistry, School of Science, The University of Tokyo
• 2015 – 2017   Researcher, Ukima Research Laboratories, Chugai Pharmaceutical Co., Ltd. (Roche Group)

主要著作

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice.  
Fernández-Moncada I*, Lavanco G, Fundazuri UB, Bollmohr N, Mountadem S, Dalla Tor T, Hachaguer P, Julio-Kalajzic F, Gisquet D, Serrat R, Bellocchio L, Cannich A, Fortunato-Marsol B, Nasu Y, Campbell RE, Drago F, Cannizzaro C, Ferreira G, Bouzier-Sore AK, Pellerin L, Bolaños JP, Bonvento G, Barros LF, Oliet SHR, Panatier A, Marsicano G*.  
Nature Communications (2024)

High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate.  
Hario S, Le GNT, Sugimoto H, Takahashi-Yamashiro K, Nishinami S, Toda H, Li S, Marvin JS, Kuroda S, Drobizhev M, Terai T, Nasu Y*, Campbell RE*.  
ACS Central Science (2024)

Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging.  
Nasu Y*, Aggarwal A, Le GNT, Vo CT, Kambe Y, Wang X, Beinlich FRM, Lee AB, Ram TR, Wang F, Gorzo KA, Kamijo Y, Boisvert M, Nishinami S, Kawamura G, Ozawa T, Toda H, Gordon GR, Ge S, Hirase H, Nedergaard M, Paquet ME, Drobizhev M, Podgorski K, Campbell RE*.  
Nature Communications (2023)

A genetically encoded far‐red fluorescent calcium ion biosensor derived from a biliverdin‐binding protein.  
Hashizume R, Fujii H, Mehta S, Ota K, Qian Y, Zhu W, Drobizhev M, Nasu Y*, Zhang J, Bito H, Campbell RE*.  
Protein Science (2022)

A genetically encoded fluorescent biosensor for extracellular L-lactate.  
Nasu Y, Murphy-Royal C, Wen Y, Haidey JN, Molina RS, Aggarwal A, Zhang S, Kamijo Y, Paquet ME, Podgorski K, Drobizhev M, Bains JS, Lemieux MJ, Gordon GR, Campbell RE*.  
Nature Communications (2021)

Structure- and mechanism-guided design of single fluorescent protein-based biosensors.  
Nasu Y, Shen Y, Kramer L, Campbell RE*.  
Nature Chemical Biology (2021)

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy.  
Nasu Y, Benke A, Arakawa S, Yoshida GJ, Kawamura G, Manley S, Shimizu S, Ozawa T*.  
Scientific reports (2016)

Genetically Encoded Fluorescent Probe for Imaging Apoptosis in Vivo with Spontaneous GFP Complementation.  
Nasu Y, Asaoka Y, Namae M, Nishina H, Yoshimura H, Ozawa T*.  
Analytical chemistry (2016)

著作列表