專任研究人員
angata@gate.sinica.edu.tw +886-2-27855696,6140,6141
安形高志 副研究員
中研院生化所 614室

研究領域與專長

唾液酸隸屬於酸性糖中的一個家族,大量而廣泛的表現在所有脊索動物和部份的細菌。我們實驗室的主要研究目標分為兩方面:

  1. 了解唾液酸和其結合蛋白的交互作用如何調控哺乳動物的生理機能。
  2. 利用糖類生物功能的知識,致力於人體健康的提升。

目前我們的研究聚焦在唾液酸結合蛋白家族(Siglecs) ,這類蛋白大多表現在免疫系統。最近我們發現部份Siglecs 的DNA序列多樣性,會影響人類疾病與臨床病徵。現在我們正設法更進一步探究 Siglecs的分子與生理功能,並找出其基因序列多樣性和人類疾病的關聯性。遠程目標是希望應用我們的研究成果。轉而發展出唾液酸相關的疾病診斷與臨床治療方法。

學經歷

  • 1998   博士, 生物物理與生物化學系, 科學研究所, 東京大學
  • 1995   碩士, 生物物理與生物化學系, 科學研究所, 東京大學
  • 1993   學士, 生物物理與生物化學系, 科學學院, 東京大學
  • 2013 – 迄今   副研究員, 中研院生化所
  • 2011 – 2013   Team Leader, RIKEN (Japan)
  • 2009 – 2011   Specially Appointed Associate Professor, Osaka University (Japan)
  • 2003 – 2009   Research Scientist, National Institute of Advanced Industrial Science and Technology (Japan)
  • 1998 – 2003   Post-doctoral fellow, University of California at San Diego (USA)

主要著作

Roles of Siglecs in neurodegenerative diseases. 
Siew JJ, Chern Y, Khoo KH, Angata T 
Molecular Aspects of Medicine (2023)

Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia. 
Wu JL, Wu HY, Wu SJ, Tsai HY, Weng SH, Lin KT, Lin LI, Yao CY, Zamanova M, Lee YY, Angata T, Tien HF, Chen YJ, Lin KI 
Molecular Cancer Research (2022)

Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells. 
Chang LY, Liang SY, Lu SC, Tseng HC, Tsai HY, Tang CJ, Sugata M, Chen YJ, Chen YJ, Wu SJ, Lin KI, Khoo KH, Angata T 
Frontiers in Immunology (2022)

Sugar nucleotide regeneration system for the synthesis of Bi- and triantennary N-glycans and exploring their activities against siglecs. 
Anwar MT, Kawade SK, Huo YR, Adak AK, Sridharan D, Kuo YT, Fan CY, Wu HR, Lee YS, Angata T, Lin CC 
European Journal of Medicinal Chemistry (2022)

Recent Progress in the Methodologies to Identify Physiological Ligands of Siglecs. 
Jiang HS, Zhuang SC, Lam CH, Chang LY, Angata T 
Frontiers in Immunology (2021)

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. 
Angata T 
Journal of Biomedical Science (2020)

Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding. 
Wu HR, Anwar MT, Fan CY, Low PY, Angata T, Lin CC 
European Journal of Medicinal Chemistry (2019)

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. 
Huang PJ, Low PY, Wang I, Hsu SD, Angata T 
The Journal of Biological Chemistry (2018)

Identification of Siglec ligands using a proximity labeling method. 
Chang L, Chen YJ, Fan CY, Tang CJ, Chen YH, Low PY, Ventura A, Lin CC, Chen YJ, Angata T 
Journal of Proteome Research (2017)

Associations of genetic polymorphisms of Siglecs with human diseases. 
Angata T 
Glycobiology (2014)

著作列表