中央研究院 生物化學研究所

研究領域與專長

1. 維護本所生物物理公用儀器室(BIL)各項設施並提供使用者相關儀器的操作課程及技術支援。
2. 量測生物分子間結合力與動力結合速率以及利用熱動力學方式研究交互作用力。
3. 應用生物物理學技術探討蛋白質折疊、穩定性、構型、聚集與聚合等特性。

學經歷

• 2003 – 2008   博士, 生物資訊與結構生物學研究所, 國立清華大學

• 2021 – 迄今   研究副技師, 中央研究院生物化學研究所
• 2016 – 2021   研究助技師, 中央研究院生物化學研究所
• 2012 – 2016   生物物理公用儀器室經理, 中央研究院生物化學研究所
• 2011 – 2012   博士後研究員, 美國德州大學達拉斯西南醫學中心
• 2008 – 2011   博士後研究員, 中央研究院生物醫學研究所

主要著作

Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G. 
Ho MR, Wu YM, Lu YC, Ko TP, Wu KP 
Journal of Structural Biology (2023)

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function. 
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu SD 
Nature Structural & Molecular Biology (2021)

Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism. 
Wu AY, Sung YC, Chen YJ, Chou ST, Guo V, Chien JC, Ko JJ, Yang AL, Huang HC, Chuang JC, Wu S, Ho MR, Ericsson M, Lin WW, Cheung CHY, Juan HF, Ueda K, Chen Y, Lai CP 
Advanced Science (2020)

RIM C₂B Domains Target Presynaptic Active Zone Functions to PIP₂-Containing Membranes. 
de Jong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS 
Neuron (2018)

Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. 
Su MY, Som N, Wu CY, Su SC, Kuo YT, Ke LC, Ho MR, Tzeng SR, Teng CH, Mengin-Lecreulx D, Reddy M, Chang CI 
Nature Communications (2017)

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3. 
Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, Wu SH 
Journal of the American Chemical Society (2016)

Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation. 
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH 
Science Signaling (2014)

Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein. 
Chang TH, Chang SJ, Hsieh FL, Ko TP, Lin CT, Ho MR, Wang I, Hsu ST, Guo RT, Chang W, Wang AH 
PLoS Pathogens (2013)

Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. 
Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C 
Journal of Molecular Biology (2010)

Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation. 
Ho MR, Lou YC, Lin WC, Lyu PC, Huang WN, Chen C 
The Journal of Biological Chemistry (2006)

著作列表