中央研究院 生物化學研究所

研究領域與專長

中研院學儀處, 冷凍電顯中心經理

1. 冷凍電顯
2. 原子力顯微鏡
3. 超高真空電顯
4. 奈米探針

學經歷

• 1999 – 2004   博士, 工程科技研究所, 國立雲林科技大學
• 1997 – 1999   碩士, 機械工程研究所, 國立雲林科技大學

• 2025 – 迄今   研究技師, 中研院生物化學研究所 / 學儀處
• 2021 – 2025 研究副技師, 中研院生物化學研究所 / 學儀處
• 2017 – 2020 研究副技師, 中研院細胞與個體生物學研究所 / 學儀處
• 2011 – 2017 研究助技師, 中研院細胞與個體生物學研究所 / 學儀處
• 2004 – 2010 博士後研究員, 中研院奈米科學實驗室@物理所
• 1999 – 2003 研究助理, 中研院奈米科學實驗室@物理所

主要著作

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function. 
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD* 
Nature Structural & Molecular Biology (2021)

Cryo-EM Analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans. 
Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu SD. 
Proceedings of the National Academy of Sciences of the United States of America (2020)

Temperature-resolved Cryo-EM Uncovers Structural Bases of Temperature-dependent Enzyme Functions. 
Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD. 
Journal of the American Chemical Society (2019)

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase. 
Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD. 
Journal of the American Chemical Society (2019)

Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins. 
Tsai CY, Chang YC, Lobato I, Van Dyck D, Chen FR. 
Scientific Reports (2016)

Critical Capillary Absorption of Current-Melted Silver Nanodroplets into Multiwalled Carbon Nanotubes. 
Chen YS, Chang YC, Wang SC, Chen LY, Lien DH, Chen LJ, Chang CS. 
Small (2012)

In situ tailoring and manipulation of carbon nanotubes. 
Chang YC, Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT. 
Small (2008)

Nanoscale doping fluctuation resolved by electrostatic force microscopy via the effect of surface band bending. 
Chin SC, Chang YC, Chang CS, Woon WY, Lin LT, Tao HJ. 
Applied Physics Letters (2008)

Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homologous juxtaposition and strand-assimilation. 
Chen YK, Leng CH, Olivares H, Lee MH, Chang YC, Kung WM, Ti SC, Lo YH, Wang AH, Chang CS, Bishop DK, Hsueh YP, Wang TF. 
Proceedings of the National Academy of Sciences of the United States of America (2004)

Easy method to adjust the angle of the carbon nanotube probe of an atomic force microscope. 
Chang YC, Wang DC, Chang CS, Tsong TT. 
Applied Physics Letters (2003)

著作列表