專任研究人員
pyc@gate.sinica.edu.tw +886-2-2785-5696,5040
陳佩燁 研究員
中研院生化所 504室

研究領域與專長

My research interest is regarding protein folding and misfolding behaviors in order to answer how proteins can fold into its native structure and how certain proteins can misfold and cause disease. Studies about protein folding are mainly the development of new methodologies to explore the folding process in order to unravel the intrinsic folding properties. Studies about protein misfolding are focus on two diseases: prion disease and Alzheimer’s disease. We are interested in studying the mechanism of amyloid fibril formation, factors influencing molecular assembly, designing inhibitor for amyloid formation, and species barrier in prion disease.

學經歷

  • 1993 – 1998   博士, 生化系, 英國劍橋大學
  • 1989 – 1991   碩士, 生化科學所, 國立臺灣大學
  • 1985 – 1989   學士, 農業化學系, 國立臺灣大學
  • 2017 – 迄今   研究員, 中央研究院生化所
  • 2019 – 2022   副所長, 中央研究院生物化學研究所
  • 2010 – 2017   副研究員, 中央研究院生化所
  • 2003 – 2010   助研究員, 中央研究院生化所
  • 1999 – 2003   博士後研究員, 中央研究院化學所
  • 1992 – 1993   研究助理, 中央研究院生物化學所

主要著作

Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein. 
Wang DT, Tang TYC, Kuo CT, Yu YT, Chen EHL, Lee MT, Tsai RF, Chen HY, Chiang YW*, Chen RPY
PNAS Nexus (2023)

2.2 Å Cryo-EM Tetra-Protofilament Structure of the Hamster Prion 108–144 Fibril Reveals an Ordered Water Channel in the Center. 
Chen EH, Kao HW, Lee CH, Huang JYC, Wu KP*, Chen RP
Journal of the American Chemical Society (2022)

Biodistribution analysis of an intranasal-delivered peptide by the nanoSPECT/CT imaging. 
Lo WL, Wang YH, Chen EH, Wang SM, Chen LC, Chen RP
Journal of Drug Delivery Science and Technology (2022)

Location of the cross‐β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy. 
Chu BK, Tsai RF, Hung CL, Kuo YH, Chen EH, Chiang YW*, Chan SI*, Chen RP
Protein Science (2022)

An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice. 
Cheng YS, Chen ZT, Liao TY, Lin C, Shen HC, Wang YH, Chang CW, Liu RS, Chen RP*, Tu PH* 
EMBO molecular medicine (2017)

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