In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.
Huang CY, Draczkowski P, Wang YS, Chang CY, Chien YC, Cheng YH, Wu YM, Wang CH, Chang YC, Chang YC, Yang TJ, Tsai YX, Khoo KH, Chang HW, Hsu STD*
Nature Communications (2022)
Tumor suppressor BAP1 nuclear import is governed by transportin-1.
Yang TJ, Li TN, Huang RS, Pan MY, Lin SY, Lin S, Wu KP, Wang LH, Hsu STD*
Journal of Cell Biology (2022)
Impacts of cancer-associated mutations on the structure-activity relationship of BAP1.
Puri S, Chen SN, Chiu YH, Draczkowski P, Ko KT, Yang TJ, Wang YS, Uchiyama S, Hsu STD*
Journal of Molecular Biology (2022)
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation.
Yang TJ, Yu PY, Chang YC, Hsu STD*
Journal of Biological Chemistry (2021)
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*
Nature Structural & Molecular Biology (2021)
Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans.
Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
Proceedings of the National Academy of Sciences of the United States of America (2020)
Untying a knotted SPOUT RNA methyltransferase by circular permutation results in a domain-swapped dimer.
Ko KT, Hu IC, Huang KF, Lyu PC, Hsu STD*
Untying a protein knot by circular permutation.
Chuang YC, Hu IC, Lyu PC, Hsu STD*
Journal of Molecular Biology (2019)
Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease.
Sriramoju MS, Chen Y, Lee YC, Hsu STD*
Scientific Reports (2018)
A natively monomeric deubiquitinase UCH-L1 forms highly dynamic but defined metastable oligomeric folding intermediates.
Lee YTC, Hsu STD*
The Journal of Physical Chemistry Letters (2018)