實驗室的研究著重於蛋白的結構、功能與生物物理性質的瞭解。所探討的成果 可以應用在癌症治療的抑制劑設計或工業酵素的設計。本實驗室之研究常用到蛋白晶體學、光譜學及酵素學等相關技術,並且經常性與其他實驗室進行合作。你可在http://ho.ibc.sinica.edu.tw/ 找到更多本實驗室的相關資訊。
目前實驗室主要研究方向有三:(1) 稻米抗淹水蛋白的調控機制 (2)與癌症有關的蛋白間交互作用 (3)工業用酵素的設計。
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan L, Yan C, Qian K, Su H, Kofsky-Wofford SA, Lee WC, Zhao X, Ho MC, Ivanov I, Zheng YG
Journal of medicinal chemistry (2014)
Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL
Chemistry & biology (2013)
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity.
Meng-Chiao Ho, Carola Wilczek, Jeffrey B. Bonanno, Li Xing, Janina Seznec, Tsutomu Matsui, Lester G. Carter, Takashi Onikubo, P. Rajesh Kumar, Man K. Chan, Michael Brenowitz, R. Holland Cheng, Ulf Reimer, Steven C. Almo, David Shechter
PLoS ONE (2013)
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
Hemeon I, Gutierrez J.A., Ho MC., Schramm V.L.
Anal Chem. (2011)
Entropy-driven binding of picomolar transition state analogue inhibitors to human 5’-methylthioadenosine phosphorylase.
Guan R, Ho MC, Brenowitz M, Tyler PC, Evans GB, Almo SC, Schramm VL
Biochemistry (2011)
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
Guan R, Ho MC, Almo SC, Schramm VL
Biochemistry (2011)
Four generations of transition-state analogues for human purine nucleoside phosphorylase.
Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, Almo SC, Schramm VL
Proceedings of the National Academy of Sciences of the United States of America (2010)
A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT.
Burgos ES, Ho MC, Almo SC, Schramm VL
Proceedings of the National Academy of Sciences of the United States of America (2009)
The origin of the electrostatic perturbation in acetoacetate decarboxylase.
Ho MC, Menetret JF, Tsuruta H, Allen KN
Nature (2009)
Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.
Ho MC, Sturm MB, Almo SC, Schramm VL
Proceedings of the National Academy of Sciences of the United States of America (2009)