實驗室的研究著重於蛋白的結構、功能與生物物理性質的瞭解。所探討的成果 可以應用在癌症治療的抑制劑設計或工業酵素的設計。本實驗室之研究常用到蛋白晶體學、光譜學及酵素學等相關技術,並且經常性與其他實驗室進行合作。
目前實驗室主要研究方向有三:(1) 稻米抗淹水蛋白的調控機制 (2)與癌症有關的蛋白間交互作用 (3)工業用酵素的設計。
Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin.
Chiu YC, Yeh MC, Wang CH, Chen YA, Chang H, Lin HY, Ho MC, Lin SM
Nature Communications (2023)
Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.
Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, Chen RP*
Nature Communications (2023)
A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination.
Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC*
Nature Communications (2023)
SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice.
Lin CC, Lee WJ, Zheng CY, Chou MY, Lin TJ, Lin CS, Ho MC*, Shih MC*
PNAS Nexus (2023)
Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC*, Chen CJ*
Nature Communications (2023)
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
Nature Communications (2021)
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary SK, Zheng YG, Ho MC*
Cellular and Molecular Life Sciences (2019)
Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence.
Lin CC, Chao YT, Chen WC, Ho HY, Chou MY, Li YR, Wu YL, Yang HA, Hsieh H, Lin CS, Wu FH, Chou SJ, Jen HC, Huang YH, Irene D, Wu WJ, Wu JL, Gibbs DJ, Ho MC*, Shih MC*
Proceedings of the National Academy of Sciences of the United States of America (2019)
Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity. (cover article)
Lee WC, Lin WL, Matsui T, Chen ES, Wei TY, Lin WH, Hu H, Zheng YG, Tsai MD, Ho MC*
Biochemistry (2015)
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity.
Ho MC*, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D*
PLoS ONE (2013)