中央研究院 生物化學研究所
中央研究院 生物化學研究所
中央研究院 生物化學研究所
liaoj@gate.sinica.edu.tw
+886-2-27855696
廖俊智教授的研究領域為代謝及合成生物學, 特別在以微生物合成燃料的領域，及基礎代謝路徑的改造。此外，他更發展出網路構成要素分析法(Network Component Analysis) 及Ensemble Modeling，用以分析複雜的轉錄組調控，及設計人工基因轉錄調控迴路。
學歷
經歷
獎項
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria.
Lu KJ, Chang CW, Wang CH, Chen FY, Huang IY, Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD, Liao JC
Nature Metabolism (2023)
SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron.
Wu JL, Kuan II, Guo JY, Hsu WC, Tang WC, Chan HJ, Chen YJ, Chen BC, Wu HC, Liao JC
iScience (2023)
Climate change challenges, plant science solutions.
Eckardt NA, Ainsworth EA, Bahuguna RN, Broadley MR, Busch W, Carpita NC, Castrillo G, Chory J, DeHaan LR, Duarte CM, Henry A, Jagadish SVK, Langdale JA, Leakey ADB, Liao JC, Lu KJ, McCann MC, McKay JK, Odeny DA, Jorge de Oliveira E, Platten JD, Rabbi I, Rim EY, Ronald PC, Salt DE, Shigenaga AM, Wang E, Wolfe M, Zhang X.
The Plant Cell (2023)
Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics based on 10 million genomes.
Yang HC, Wang JH, Yang CT, Lin YC, Hsieh HN, Chen PW, Liao HC, Chen CH, Liao JC
PNAS Nexus (2022)
Metabolomics-Driven Identification of the Rate-Limiting Steps in 1-Propanol Production.
Ohtake T, Kawase N, Pontrelli S, Nitta K, Laviña WA, Shen CR, Putri SP, Liao JC, Fukusaki E
Frontiers in Microbiology (2022)
A cell-free self-replenishing CO2-fixing system.
Luo S, Lin PP, Nieh LY, Liao GB, Tang PW, Chen C, Liao JC
Nature Catalysis (2022)
Identification of COVID-19 B-cell epitopes with phage-displayed peptide library.
Guo JY, Liu IJ, Lin HT, Wang MJ, Chang YL, Lin SC, Liao MY, Hsu WC, Lin YL, Liao JC, Wu HC
Journal of Biomedical Science (2021)
Role of cyanobacterial phosphoketolase in energy regulation and glucose secretion under dark anaerobic and osmotic stress conditions.
Chuang DS, Liao JC
Metabolic Engineering (2021)
Novel allosteric inhibition of phosphoribulokinase identified by ensemble kinetic modeling of Synechocystis sp. PCC 6803 metabolism.
Nishiguchi H, Liao JC, Shimizu H, Matsuda F
Metabolic Engineering Communications (2020)
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
Yang HC, Chen CH, Wang JH, Liao HC, Yang CT, Chen CW, Lin YC, Kao CH, Lu MJ, Liao JC
Proc Natl Acad Sci USA (2020)
Converting Escherichia coli to a Synthetic Methylotroph Growing Solely on Methanol.
Chen FY, Jung HW, Tsuei CY, Liao JC
Cell (2020)
Metabolome analysis revealed the knockout of glyoxylate shunt as an effective strategy for improvement of 1-butanol production in transgenic Escherichia coli.
Nitta K, Laviña WA, Pontrelli S, Liao JC, Putri SP, Fukusaki E
Journal of Bioscience and Bioengineering (2019)
Synthetic methanol auxotrophy of Escherichia coli for methanol-dependent growth and production.
Chen CT, Chen FY, Bogorad IW, Wu TY, Zhang R, Lee AS, Liao JC
Metabolic Engineering (2018)
Escherichia coli as a host for metabolic engineering.
Pontrelli S, Chiu TY, Lan EI, Chen FY, Chang P, Liao JC
Metabolic Engineering (2018)
Metabolic repair through emergence of new pathways in Escherichia coli.
Pontrelli S, Fricke RCB, Teoh ST, Laviña WA, Putri SP, Fitz-Gibbon S, Chung M, Pellegrini M, Fukusaki E, Liao JC
Nature Chemical Biology (2018)
A modified serine cycle in Escherichia coli coverts methanol and CO2 to two-carbon compounds.
Yu H, Liao JC
Nature Communications (2018)
Directed strain evolution restructures metabolism for 1-butanol production in minimal media.
Pontrelli S, Fricke RCB, Sakurai SSM, Putri SP, Fitz-Gibbon S, Chung M, Wu HY, Chen YJ, Pellegrini M, Fukusaki E, Liao JC
Metabolic Engineering (2018)
Augmenting the Calvin-Benson-Bassham cycle by a synthetic malyl-CoA-glycerate carbon fixation pathway.
Yu H, Li X, Duchoud F, Chuang DS, Liao JC
Nature Communications (2018)
Construction and evolution of an Escherichia coli strain relying on nonoxidative glycolysis for sugar catabolism.
Lin PP, Jaeger AJ, Wu TY, Xu SC, Lee AS, Gao F, Chen PW, Liao JC
Proc Natl Acad Sci USA (2018)
Rearrangement of Coenzyme A-Acylated Carbon Chain Enables Synthesis of Isobutanol via a Novel Pathway in Ralstonia eutropha.
Black WB, Zhang L, Kamoku C, Liao JC, Li H
ACS Synthetic Biology (2018)
Orthogonal partial least squares/projections to latent structures regression-based metabolomics approach for identification of gene targets for improvement of 1-butanol production in Escherichia coli.
Nitta K, Laviña WA, Pontrelli S, Liao JC, Putri SP, Fukusaki E
Journal of Bioscience and Bioengineering (2017)
Metabolomics-driven approach to solving a CoA imbalance for improved 1-butanol production in Escherichia coli.
Ohtake T, Pontrelli S, Laviña WA, Liao JC, Putri SP, Fukusaki E
Metabolic Engineering (2017)
Kinetically accessible yield (KAY) for redirection of metabolism to produce exo-metabolites.
Lafontaine Rivera JG, Theisen MK, Chen PW, Liao JC
Metabolic Engineering (2017)
Metabolic systems modeling for cell factories improvement.
Chen PW, Theisen MK, Liao JC
Current Opinion in Biotechnology (2017)
Rational engineering of diol dehydratase enables 1,4-butanediol biosynthesis from xylose.
Wang J, Jain R, Shen X, Sun X, Cheng M, Liao JC, Yuan Q, Yan Y
Metabolic Engineering (2017)
Engineering a Thermostable Keto Acid Decarboxylase Using Directed Evolution and Computationally Directed Protein Design.
Soh LMJ, Mak WS, Lin PP, Mi L, Chen FY, Damoiseaux R, Siegel JB, Liao JC
ACS Synthetic Biology (2017)
