2023-06-09 14:00 ~ 2023-06-09 15:00
地點: 生化所209研討室
主講人: Zhihao Zhuang博士
主講人背景: 美國University of Delaware化學暨生化研究所教授
演講主持人: 陳瑞華特聘研究員
演講摘要:
Posttranslational modification of proteins by ubiquitin (Ub) is a crucial regulatory mechanism in various cellular processes. Ubiquitin-mediated pathways are being rapidly discovered in different aspects of cell biology. Human deubiquitinases (DUBs) are an emerging class of therapeutic targets for drug discovery against cancer and neurodegenerative diseases. Activity-based DUB probes are powerful tools for identifying new DUB functions, understanding DUB catalysis and specificity, and developing DUB inhibitors. My lab has developed protein- and polyubiquitin-based DUB probes that helped identify DUBs targeting specific proteins, and elucidate the mode of ubiquitin chain recognition and cleavage by human ubiquitin-specific protease (USP). We have also worked on cell-permeable DUB probes that enable DUB profiling in live cells and inhibitor discovery. These chemical biology approaches offer insights into various cellular processes that involve protein ubiquitination and deubiquitination, laying the groundwork for future development of therapeutics that modulate DUBs.-Dr. Zhihao Zhuang
洽詢人員: 劉小姐
洽詢電話: 27855696#2061
洽詢信箱: liukchun@gate.sinica.edu.tw
中央研究院 生物化學研究所
