2019-05-02 11:00 ~ 2019-05-02 12:00
地點: 生化所209室
主講人: Dr. Corwin A. Miller
主講人背景: 美國萊斯大學生物科學研究所研究科學員
演講主持人: 王彥士助研究員
演講摘要:
Synthetic biologists have steadily increased their capacity to incorporate non-standard amino acids into proteins, thereby expanding the genetic code of the cell. In the first part of my talk, I will discuss efforts to engineer pyrrolysyl-tRNA synthetase (PylRS) for improved incorporation of the synthetic amino acid Boc-lysine using Phage Assisted Non-Continuous Evolution (PANCE). In the second portion of my talk, I will discuss engineered coordination of iron-sulfur clusters by the 21st naturally occurring amino acid selenocysteine (Sec). Here we show that Sec can replace cysteine residues coordinating [2Fe-2S] or [4Fe-4S] clusters in two separate proteins without loss of enzymatic activity.-Dr. Corwin A. Miller
洽詢人員: 劉小姐
洽詢電話: 02-27855696#2061
洽詢信箱: liukchun@gate.sinica.edu.tw
中央研究院 生物化學研究所
