中央研究院 生物化學研究所

研究領域與專長

我的實驗室專注核糖體的逆向工程，並探索核酸分子在生物所扮演的功能與角色。

我們專注於各類核酸分子的研究，及核酸分子與金屬之間的關係。另外，我們使用類病毒粒子包裝各種不同大小的核酸分子，作為癌症免疫療法的應用。

學經歷

• 2008   博士, 生物化學暨化學系, 美國喬治亞理工學院

• 2021 – 迄今   合聘副研究員, 中央研究院生物化學所
• 2019 – 迄今   副教授, 台灣大學生化科學研究所
• 2015 – 2021   合聘助研究員, 中央研究院生物化學所
• 2014 – 2019   助理教授, 台灣大學生化科學研究所
• 2008 – 2014   博士後研究, 生物化學暨化學系，美國喬治亞理工學院

主要著作

Evolution of the ribosome at atomic resolution. 
A. S. Petrov, C. R. Bernier, C. Hsiao, A. M. Norris, N. A. Kovacs, C. C. Waterbury, V. G. Stepanov, S. C. Harvey, G. E. Fox, R. M. Wartell, N. V. Hud and L. D. Williams 
Proc Natl Acad Sci U S A (2014)

RiboVision suite for visualization and analysis of ribosomes. 
C. R. Bernier, A. S. Petrov, C. C. Waterbury, J. Jett, F. Li, L. E. Freil, X. Xiong, L. Wang, B. L. Migliozzi, E. Hershkovits, Y. Xue, C. Hsiao, C., Bowman, S. C. Harvey, M. A. Grover, Z. J. Wartell and L. D. Williams 
Faraday Discuss (2014)

Secondary Structures of rRNAs from All Three Domains of Life. 
A. S. Petrov, C. R. Bernier, B. Gulen, C. C. Waterbury, E. Hershkovits, C. Hsiao, S. C. Harvey, N. V. Hud, G. E. Fox, R. M. Wartell and L. D. Williams. 
PLoS One (2014)

Molecular paleontology: a biochemical model of the ancestral ribosome. 
Hsiao, C., Lenz, T.K., Peters, J.K., Fang, P.Y., Schneider, D.M., Anderson, E.J., Preeprem, T., Bowman, J.C., O'Neill, E.B., Lie, L., Athavale, S. S., Gossett, J.J., Trippe, C., Murray, J., Petrov, A.S., Wartell, R.M., Harvey, S.C., Hud, N.V., Williams, L.D. 
Nucleic Acids Res. (2013)

RNA with iron(II) as a cofactor catalyses electron transfer. 
Hsiao, C., Chou, I.C., Okafor, C.D., Bowman, J.C., O'Neill, E.B., Athavale, S.S., Petrov, A.S., Hud, N.V., Wartell, R.M., Harvey, S.C., Williams, L.D. 
Nature Chemistry (2013)

Secondary structure and domain architecture of the 23S and 5S rRNAs. 
Petrov, A.S., Bernier, C.R., Hershkovits, E., Xue, Y., Waterbury, C.C., Hsiao, C., Stepanov, V.G., Gaucher, E.A., Grover, M.A., Harvey, S.C., Hud, N.V., Wartell, R.M., Fox, G.E., Williams, L.D. 
Nucleic Acids Res. (2013)

B-DNA structure is intrinsically polymorphic: even at the level of base pair positions. 
Maehigashi T., Hsiao, C., Woods, K.K., Moulaei, T., and Williams, L.D. 
Nucleic Acids Res. (2012)

Domain III of the T. thermophilus 23S rRNA Folds Independently to a near-Native State. 
Athavale, S.S., Gossett, J.J., Hsiao, C., Bowman, J.C., O'Neill, E., Hershkovitz, E., Preeprem, T., Hud, N.V., Wartell, R.M., Harvey, S.C., and Williams, L.D. 
RNA (2012)

RNA Folding and Catalysis Mediated by Iron (II). 
Athavale, S.S., Petrov, A.S., Hsiao, C., Watkins, D., Prickett, C.D., Gossett, J.J., Lie, L., Bowman, J.C., O'Neill, E., Bernier, C.R., Hud, N.V., Wartell, R., Harvey, S.C., and Williams, L.D. 
PLoS ONE (2012)

RNA-Magnesium-Protein Interactions in Large Ribosomal Subunit. 
Petrov, A.S., Bernier, C., Hsiao, C.; Okafor, C.D., Tannenbaum, E, Stern, J., Gaucher, E., Schneider, D., Hud, N.V, Harvey, S.C.; Williams, L.D. 
J. Phys. Chem. B (2012)

著作列表