中央研究院 生物化學研究所

The nucleosome is a hub of genetic processes and is thus the target of gene regulatory enzymes and factors. My laboratory is interested in understanding how chromatin enzymes and factors interact with their nucleosome substrates to achieve the appropriate biological outcome. I will discuss principles for how the nucleosome is recognized by chromatin enzymes and factors gleaned from the collective structural and biochemical studies from my and other laboratories. I will also present our latest studies of how the BRD4 chromatin reader interacts with the nucleosome.