中央研究院 生物化學研究所

研究領域與專長

Molecular Mechanisms of Genome Stability

Our research aims to understand the molecular mechanisms that maintain genome stability during DNA replication and repair. We are particularly interested in how cells respond to replication-associated DNA damage, how DNA repair and recombination pathways are regulated and coordinated, and how these mechanisms preserve chromosome integrity.

We combine structural biology, biochemistry, single-molecule approaches, molecular and cell biology, proteomics and functional genomics to uncover these mechanisms from the molecular to the cellular level. Ultimately, we aim to understand how defects in genome maintenance contribute to human disease and whether these pathways can reveal new therapeutic opportunities.

We combine structural biology, biochemistry, single-molecule approaches, molecular and cell biology, proteomics and functional genomics to uncover these mechanisms from the molecular to the cellular level. Ultimately, we aim to understand how defects in genome maintenance contribute to human disease and whether these pathways can reveal new therapeutic opportunities.

學經歷

• 2016   DPhil in Biochemistry, University of Oxford, UK
• 2012   MSc in Biochemistry, University of Oxford, UK
• 2008   BSc in Life Science, National Taiwan University, Taiwan

• 2026 – 迄今   助研究員，中央研究院生物化學研究所
• 2025 – 2026   Research Associate, Imperial College London, UK
• 2017 – 2025   Postdoctoral Fellow, The Francis Crick Institute, London, UK
• 2016 – 2017   Postdoctoral Research Associate, University of Oxford, UK

主要著作

Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.
Greenhough LA, Galanti L, Liang CC, Boulton SJ, West SC
Science (2026)

Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC*, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC*
Nature (2024)

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
Greenhough LA^#, Liang CC^#, Belan O^#, Kunzelmann S, Maslen S, Rodrigo-Brenni MC, Anand R, Skehel M, Boulton SJ, West SC
Nature (2023) ^#Equal contribution

Purification of DNA repair protein complexes from mammalian cells.
Liang CC, Cohn MA
STAR Protocols(2021)

The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2.
Liang CC, Li Z, Lopez-Martinez D, Nicholson WV, Vénien-Bryan C, Cohn MA
Nature Communications (2016)

UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.
Liang CC^#, Zhan B^#, Yoshikawa Y^#, Haas W, Gygi SP, Cohn MA
Cell Reports (2015) ^#Equal contribution

著作列表