中央研究院 生物化學研究所

研究領域與專長

嘌呤體是由嘌呤從頭合成途徑中所有六種酵素組成的生物分子縮合物。在多種細胞壓力條件下，細胞對嘌呤的需求增加，嘌呤體形成以促進嘌呤從頭合成途徑的通量，使細胞適應壓力。本實驗室與嘌呤體相關的主要研究方向如下：

1. 嘌呤體的組裝和解聚機制

2. 嘌呤體在調控細胞代謝和細胞器功能中的作用

3. 嘌呤體在調控癌細胞存活、腫瘤微環境及治療抗性中的作用

4. 嘌呤體在調控代謝性疾病和老化中的作用

學經歷

• 1987 – 1991   博士, 密西根州立大學
• 1983 – 1985   碩士, 生化科學研究所, 臺灣大學
• 1979 – 1983   學士, 農化系, 臺灣大學

• 2012 – 迄今   特聘研究員, 中研院生化所
• 2011 – 2014   副所長, 中研院生化所
• 2006 – 2012   研究員, 中研院生化所
• 2003 – 2006   教授, 臺大醫學院分子醫學研究所
• 1996 – 2003   副教授, 臺大醫學院分子醫學研究所
• 1995 – 1996   助研究員, 加州大學舊金山分校
• 1992 – 1995   博士後研究員, 加州大學舊金山分校

主要著作

Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies.  
Yeat NY, Liu LH, Chang YH, Lai CP, Chen RH  
Developmental Cell (2025)

PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.  
Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Huang Jr, Chen RH  
Molecular Cell (2023)

TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.     
Chen YH, Chen HH, Wang WJ, Chen HY, Huang WS, Kao CH, Lee SR, Yeat NY, Yan RL, Chan SJ, Wu KP, Chen RH     
Nature Communications (2023)

VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.     
Chen YH, Huang TY, Lin YT, Lin SY, Li WH, Hsiao HJ, Yan RL, Tang HW, Shen ZQ, Chen GC, Wu KP, Tsai TF, Chen RH     
Nature Communications (2021)

Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization.     
Chiang SY, Wu HC, Lin SY, Chen HY, Wang CF, Yeh NH, Shih JH, Huang YS, Kuo HC, Chou SJ, Chen RH     
Science Advances (2021)

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment. (Selected as a highlight in JCI This Month)     
Wang YT, Chen J, Chang CW, Jen J, Huang TY, Chen CM, Shen R, Liang SY, Cheng IC, Yang SC, Lai WW, Cheng KH, Hsieh TS, Lai MZ, Cheng HC, Wang YC, Chen RH     
J Clin Invest (2017)

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. (Highlighted in Editor’s Corner and Selected for a ‘Punctum’ contribution in Autophagy)     
Liu CC, Lin YC, Chen YH, Chen CM, Pang LY, Chen HA, Wu PR, Lin MY, Jiang ST, Tai TF, Chen RH     
Mol Cell (2016)

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. (selected as a Mol Cell Preview and a Research Highlight in Nature Rev Mol Cell Biol)     
Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, Hung CC, Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH     
Mol Cell (2014)

USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.     
Wu HC, Lin YC, Liu CH, Chung HC, Wang YT, Lin YW, Ma HI, Tu PH, Lawler SE, Chen RH     
Nature Commun (2014)

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression. (recommended by Faculty of 1000 Biology as F1000 factor 9.0 “MUST READ” grade)     
Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH     
Cancer cell (2011)

著作列表