2020-01-15 10:00 ~ 2020-01-15 11:00
Venue: B1B Lecture Room, IBMS
Speaker: Dr. Michael Thomas Dill
Current Position: Clinical Fellow, Gastroenterology, Internal Medicine Department, University Clinics Heidelberg, Germany
Host: Dr. Shih-Lei (Ben) Lai
Abstract:
The liver is a quiescent organ with a remarkable capacity to regenerate, both acutely and under chronic conditions. The significant cellular plasticity of liver epithelial cells in chronic liver regeneration and the underlying signaling pathways have become the focus of recent research efforts, trying to understand how this physiological response can be utilized to improve the biological fate of chronic liver disease, and how these chronic signaling inputs affect liver carcinogenesis. Among the pathways involved, Hippo-YAP signaling is a well-conserved pathway important for organ size and cell fate determination, as well as cancer formation. This seminar will cover how our single cell RNA-sequencing study of the liver epithelium led to the identification of YAP activity as the main determinant of biliary heterogeneity, why YAP is essential in both the quiescent and regenerative liver, and how we used novel murine liver cancer models to dissect the role of YAP, once tumors have formed. -Dr. Michael Thomas Dill
Contact person: Ms. Nancy Liu
Tel: 02-27855696#2061
Email: liukchun@gate.sinica.edu.tw
Institute of Biological Chemistry, Academia Sinica
