2020-01-15 10:00 ~ 2020-01-15 11:00
地點: 生醫所地下室B1B演講廳
主講人: Dr. Michael Thomas Dill
主講人背景: 德國海德堡大學附屬醫院內科臨床研究員
演講主持人: 賴時磊助研究員
演講摘要:
The liver is a quiescent organ with a remarkable capacity to regenerate, both acutely and under chronic conditions. The significant cellular plasticity of liver epithelial cells in chronic liver regeneration and the underlying signaling pathways have become the focus of recent research efforts, trying to understand how this physiological response can be utilized to improve the biological fate of chronic liver disease, and how these chronic signaling inputs affect liver carcinogenesis. Among the pathways involved, Hippo-YAP signaling is a well-conserved pathway important for organ size and cell fate determination, as well as cancer formation. This seminar will cover how our single cell RNA-sequencing study of the liver epithelium led to the identification of YAP activity as the main determinant of biliary heterogeneity, why YAP is essential in both the quiescent and regenerative liver, and how we used novel murine liver cancer models to dissect the role of YAP, once tumors have formed. -Dr. Michael Thomas Dill
洽詢人員: 劉小姐
洽詢電話: 02-27855696#2061
洽詢信箱: liukchun@gate.sinica.edu.tw
中央研究院 生物化學研究所
