| Affiliation | Name | Appointment period |
| Director | Todd L. Lowary | July 01, 2019- Present |
| Acting Director | Kay-Hooi Khoo | Aug. 15, 2017 – June 30, 2019 |
| Director | Ching-Shih Chen | Aug. 15, 2014 – Aug. 14, 2017 |
| Director | Ming-Daw Tsai | Aug. 15, 2008 – Aug. 14, 2014 |
| Acting Director | Ming-Daw Tsai | Oct. 19, 2006 – Aug. 14, 2008 |
| Director | Andrew H.-J. Wang | July 1, 2000 – Oct. 18, 2006 |
| Acting Director | Yee-Hsiung Chen | June 1, 1999 – June 30, 2000 |
| Director | Darrell T. Liu | Sept. 1, 1995 – May31, 1999 |
| Acting Director | Jong-Chin Su | July 1, 1992 – Aug. 31, 1995 |
| Director | Wen-Chang Chang | July 1, 1989 – June 30, 1992 |
| Acting Director | Wen-Chang Chang | July 1, 1986 – June 30, 1989 |
| Director | Kung-Tsung Wang | July 1, 1980 – June 30, 1986 |
| Director | Tung-Bin Lo | July 1, 1977 – June 30, 1980 |
| Director (Preparatory Office) | Tung-Bin Lo | May. 1, 1972 – June 30, 1977 |
| Director (Preparatory Office) | Jong-Chin Su | Feb. 1, 1970 – Apr. 30, 1972 |
Institute of Biological Chemistry, Academia Sinica