Institute of Biological Chemistry, Academia Sinica

Proteins on the surface of cells and viruses are often cloaked in a dense sugar coating, a key factor in their host recognition

Metabolic reprogramming is a hallmark of cancer. Cancer cells alter various cellular metabolism pathways to meet the high demand

In the escalating fight against drug-resistant Gram-negative bacteria, polymyxins are a last resort. Alarming is the rise of pol

Unlocking the potential of protein activation has historically posed challenges, necessitating extensive screening and biochemic

Human use of fossil fuels results in ~36 billion tons of carbon dioxide being released annually, severely impacting the carbon b

Immune checkpoint blockades targeting PD-1/PD-L1 or CTLA4 have revolutionized the current cancer therapy paradigm based on their

Porcine epidemic diarrhea virus (PEDV) belongs to the alphacoronavirus family. PEDV is highly contagious and particularly lethal

BRCA1-associated protein 1 (BAP1) is an important tumor suppressor that belongs to the ubiquitin C-terminal hydrolase (UCH) fami

Biological CO₂ fixation is so far the most effective means for CO₂ reduction at scale and accounts for most of the CO₂ fixed on

The Alpha variant of SARS-CoV-2, also known as the B.1.1.7 strain, was first identified in the UK in late 2020. It soon spread a

Fatty liver is a prevalent liver disease in Taiwan and worldwide and is associated with obesity, diabetes and cardiovascular dis

Cerebral cortex is responsible for sensory, motor, emotional processing and higher cognitive functions. The development of cereb

Genetic diversity is a key driving force of evolution. During homologous recombination, chromosomes from father and mother will

Synaptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransmitter release. Intense s

Degradation and collapse of stalled replication forks are main sources of genomic instability, yet the molecular mechanisms for

Pseudaminic acid (Pse), a unique carbohydrate in surface-associated glycans of pathogenic bacteria, has pivotal roles in virulen

The formation of the autophagosome is a dynamic and tightly regulated process. SNARE-mediated membrane fusion plays a pivotal ro

Amidst the raging COVID-19 pandemic, the world remains under the unceasing threat of climate change. Academia Sinica President J

Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with primary autosomal recessive microcephaly. In resp

Delineating multiple N- and O-glycosylation sites on single glycopeptides and deriving more glycan structure information to disc

A collaborative research between two teams led by Dr. Hsiao-Ching Lin, an assistant research fellow at the Institute of Biologic

Infecting more than half of the world’s population, Helicobacter pylori not only represents the most common etiological agent of

The recent outbreaks of severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the severe pi

A research team led by Dr. Hsiao-Ching Lin, an assistant research fellow at the Institute of Biological Chemistry, has elucidate

A research team led by Dr. Ruey-Hwa Chen, Distinguished Research Fellow at the Institute of Biological Chemistry, has discovered

Increased oxidative stress is considered to be one of the key factors leading to aging and neurodegenerative diseases, but it is

A team led by Academician Ming-Daw Tsai, a Distinguished Research Fellow, and Dr. Wen-Jin (Winston) Wu, an Associate Research Sp

Dr. Ming-Daw Tsai, Director of Academia Sinica Cryo-EM Center (ASCEM) and Distinguished Research Fellow of Institute of Biologic

Rice can be drowned! Although rice is a semi-aquatic plant, the seedlings will die if they are submerged completely under water

Academician Andrew H.-J. Wang and his team at the Institute of Biological Chemistry have recently found that the C-terminal D/E-

Infection by antibiotic resistant bacterial pathogens poses a serious global health threat. Therefore, a new therapy is urgently

Traditional medicines provide a fertile ground to explore potent “lead” compounds with desired effects; yet, their transformatio

By Cindy Lee

Academician Ming-Daw Tsai, a Distinguished Research Fellow, and Dr. Wen-Jin Wu, an Associate Research Specialist at the Institut

In nature, living organisms use primary metabolites containing simple building blocks as their starting materials. An important

Recent advances in cancer biology have evolved to consider cancers as complex “rough” organs in which transformed cells along wi

Dr. Rita P.-Y. Chen, an Associate Research Fellow at the Institute of Biological Chemistry along with Dr. Pang-hsien Tu, a forme

Dr. Rita P.-Y. Chen and her research team at the Institute of Biological Chemistry has recently discovered that polyhydroxycurcu

Though geographically compact, Taiwan is a hot spring of resources. In fact, researching “extreme” organisms from hot springs ma

A team led by Dr. Ruey-Hwa Chen, a Distinguished Research Fellow at the Institute of Biological Chemistry recently discovered th

In this report, the in vitro relative capabilities of curcumin (CCM) and didemethylated curcumin (DCCM) in preventing the seleni

Epidermal growth factor receptor (EGFR) pathway substrate 15 (Eps15) is a newly identified substrate for protein tyrosine phosph

Ras signaling cascade has long been considered as an attractive therapeutic target for colorectal cancer (CRC) where PTPN3 is hi

Replication of DNA occurs in all living organisms and forms the basis of biological inheritance. Replication of DNA famously occ

Research team led by Dr. Guang-Chao Chen used fruit fly (Drosophila) adult midgut and mammalian cells to investigate the role of

Research team led by Dr. Po-Huang Liang has identified a small-molecule inhibitor I-Lys, which can activate Caspase-7 to selecti

Research teams led by Dr. Andrew H.-J. Wang (IBC) and Dr. Wen Chang (IMB) have joined the effort to solve the crystal structure

L-Fucose-containing glycoconjugates play an indispensible role in a myriad of physiological and pathological activities, such as

A research team led by Associate Research Fellow Dr. Chung-I Chang and Distinguished Research Fellow Dr. Shih-Hsiung Wu from the

Staphylococci cause a wide range of diseases in human and animals such as skin infections, pneumonia, food poisoning and bl

Metastasis is the major cause of poor prognosis in colorectal cancer (CRC), and increasing evidence supports the contribution of

NkBgl, a β-glucosidase from Neotermes koshunensis, is a β-retaining glycosyl hydrolase family 1 enzyme that cleaves β-glucosidic

Glutathionylspermidine synthetase (GspS) was introduced into human cells to label endogenous glutathione (GSH) with biotinyl spe

Forced entry: NMR spectroscopy and isothermal titration calorimetry show that calcium ions are chelated by the hydroxylated THF

Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia signaling mechanism is not fully und

Autophagy is a membrane-mediated degradation process of macromolecule recycling. Although the formation of double-membrane degra

"Head-to-head" terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of t

Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAP

Terpenes (isoprenoids), derived from isoprenyl pyrophosphates, are versatile natural compounds that act as metabolism mediators,

Two loops were found to move inward toward the α-fucosidase active site to produce a closed conformation of complexes with inhib

Encapsulated Klebsiella pneumoniae is the predominant causative agent of pyogenic liver abscess, an emerging infectious disease

Infecting about one-half of the global human population, Helicobacter pylori is well established as the primary cause of gastrit

Sperm motility and maturation are known to be affected by a host of factors encountered en route in both male and female genital