Seminars & Symposia
Intrinsically disordered regions of proteins mediate their liquid-liquid phase separation
2020-07-09 11:00 ~ 2020-07-09 12:00
Venue: IBC R209
Speaker: Dr. Jie-Rong Huang
Current Position: Associate Professor, Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taiwan
Host: Dr. Shang-Te Danny Hsu
Abstract:
Tons of biomolecules react in a cell simultaneously, but how does one biomolecule “know” where and when to react? The prevailing intrinsically disordered proteins (IDPs; >30% in eukaryotic cells) or proteins with intrinsically disordered regions (IDRs; >50% in eukaryotic cells), which do not adopt a defined three-dimension structure, may play a role in the spatiotemporal control of biochemical reactions. Recent studies have demonstrated that some IDPs undergo liquid-liquid phase separation (LLPS) to respond to environmental changes (e.g. temperature, pH) to determine the timing of a reaction (“when”). The increased local concentration within phase-separated droplets also controls the location (“where”) to react. The physicochemical properties of these ID regions probably govern the location and timing for a molecule to react. In this talk, I will use TDP-43 (2018 BBA 1866:214; 2018 JBC 293(16):6090) and Galectin-3 (2017 JBC 292(43) 17845; 2020 Nat Comm 11:1229) as examples to demonstrate how the physicochemical properties of IDRs can relate to their cellular functions and diseases. -Dr. Jie-Rong Huang
Contact person: Ms. Nancy Liu
Tel: 02-27855696#2061
Email: liukchun@gate.sinica.edu.tw