Institute of Biological Chemistry, Academia Sinica

Research

Research Background:

Molecular Cell Biology, Biochemistry, Genetics, System Biology.

Manager of Bio-Imaging Core Facility (BICF) Supporting users as follows:

• Advanced imaging systems
  Fluorescence microscope; Laser-scanning confocal microscopes; High-content screening station; Flow cytometers; Bioluminescence and Chemiluminescence Imager.
• Efficient technical consultation
  Design of imaging experiments, choice of training on suitable imaging systems. and subsequent image processing, visualization and analysis.
• Training courses and technician-assisted operation of instruments.

Degrees and Positions Held

• 2012-2018   Ph.D., Genome and Systems Biology Program, College of Life Science, National Taiwan University
• 2011-2012   M.S., Department of Applied Chemistry, National Chi-Nan University
• 2008-2011   B.S., Department of Applied Chemistry, National Chi-Nan University

• 2022 – present   Assistant Research Specialist, Bio-Imaging Core Facility, Institute of Biological Chemistry, Academia Sinica
• 2021 – 2022   Postdoctoral fellow, Institute of Biological Chemistry, Academia Sinica
• 2019 – 2021   Postdoctoral fellow (R&D alternative service), Institute of Biological Chemistry, Academia Sinica

Selected Publications

WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour. 
Chen SL, Liu BT, Lee WP, Liao SB, Deng YB, Wu CL, Ho SM, Shen BX, Khoo GH, Shiu WC, Chang CH, Shih HW, Wen JK, Lan TH, Lin CC, Tsai YC, Tzeng HF & Fu TF 
Nat Commun. (2022)

Drosophila as a model to study autophagy in neurodegenerative diseases and digestive tract. 
Tzou FY, Wen JK, Yeh JY, Huang SY, Chen GC, Chan CC 
IUBMB Life. (2022)

PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. 
Chou HY, Lee YT, Lin YH, Wen JK, a , Peng WH, Hsieh PL, Lin SY, Hung CC, and Chen GC 
Autophagy. (2021)

Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila. 
Wen JK, Wang YT, Chan CC, Hsieh CW, Liao HM, Hung CC, Chen GC 
Elife. (2017)

PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine. 
Kuo SY, Wu CL, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Yang CY, Guan HY, Wang PY, Lan TH, Fu TF 
Nat Commun. (2015)

Publication List