Research Specialists +886-2-27855696,8011
Room 801 SCF, IBC, AS


Manager of synthesis core facility (SCF), supporting users as follows:

  • Various synthesized biomolecules as research stuffs, for example:
    Functional peptides;
    Enzyme/lectin inhibitors;
    Oligonucleotides and their bioconjugates;
    Glycan related to viral/bacterial infections;
    Tumor-associated carbohydrate antigens (TACAs);
    Probes of metabolites in natural products biosynthesis;
    Tools to study targets of interest in chemistry and biology;
    Other tailor-made synthesized molecules.
  • High-end and well-maintained instruments including:
    HPLC (Waters e2695, on-line reservation);
    HPLC (Schimadzu Prominence-I LC-2030C 3D Plus, on-line reservation);
    Polarimeter (JASCO P-2000, Na light source (589 nm) with temperature-controlled chip module, on-line reservation).

Organic synthesis:

Synthesis of natural product or bacterial metabolites; strategy development to label intermediate of interest; design and synthesis of wash-free fluorescent probe; synthesis and purification of oligonucleotide-peptide conjugates (OPC) with varied linkers.

Carbohydrate chemistry:

Synthesis and characterization of well-patterned sulfated sugars; Immobilization and NMR characterization of well-defined sulfated glycans on polyacrylic acid (PAA); Structure-guided synthesis of galectin inhibitors; Incorporation of BODIPY to thiodigalactoside as the fluorescent polarization (FP) probe for galectin binding assay: a better probe with bio-compatible, lifetime, stability and could be applied for cell-based experiments.

Laboratory design:

This is more like personal interest and I have managed labs for two PIs and involved in design and renovation of three labs.

Degrees and Positions Held

  • 2002 – 2006   Ph.D., Department of Chemistry, National Taiwan Normal University
  • 1997 – 2001   B.S., Department of Chemistry, National Taiwan
  • 2020 – present Assistant Research Specialist, Synthesis Core Facility, Institute of Biological Chemistry, Academia Sinica
  • 2016 – 2020   Project Manager, Institute of Biological Chemistry, Academia Sinica
  • 2016 – 2016   Visiting Postdoctoral Fellow, Centennial Centre of Interdisciplinary Science (CCIS) in University of Alberta, Canada
  • 2007 – 2016   Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica

Selected Publications

Selection of Galectin-3 Ligands Derived from Genetically Encorded Glycopeptide Libraries. 
Vinals, D. F.; Kitov, P. I.; Tu, Z. ; Zou, C.; Cairo, C. W.; Lin, C.-H. and Derda, R.* 
Peptide Sci. (2019)

Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions. 
Chan, Y.-C. ; Lin, H.-Y. ; Tu, Z. ; Kuo, Y.-H.; Hsu, Danny S.-T. and Lin, C.-H.* 
( Authors contributed equally to this work) 
Int. J. Mol. Sci. (2018)

Dual Thio-digalactoside-binding Modes of Human Galectins as the Structural Basis for the Design of Potent and Selective Inhibitors. 
Lin, H.-Y.; Hsieh, T.-Y.; Tu, Z.; Chien, C.-T.; Huang, B.-S.; Wu, S.-C. and Lin, C.-H.* 
Scientific Reports (2016)

Expeditious Synthesis of Orthogonally Protected Saccharides through Consecutive Protection/Glycosylation Steps. 
Tu, Z.; Liu, P.-K.; Wu, M.-C. and Lin, C.-H.* 
Israel J. Chem. (2015)

Development of Fucosyltransferase and Fucosidase Inhibitors. 
Tu, Z.; Lin, Y.-N. and Lin, C.-H.* 
Chem. Soc. Rev. (2013)

Synthesis and Characterization of Sulfated Galβ-1,3/4-GlcNAc Disaccharides via Consecutive Protection/Glycosylation Steps. 
Tu, Z.; Hsieh, H.-W.; Tsai, C.-M.; Hsu, C.-W.; Wang, S.-G.; Wu, K.-J.; Lin, K.-I* and Lin, C.-H.* 
Chem. Asian J. (2013)

Rapid Synthesis of Oligomannosides with Orthogonally Protected Monosaccharides. 
Chang, S.-M.; Tu, Z.; Jan, H.-M.; Pan, C.-F. and Lin, C.-H.* 
Chem. Commum. (2013)

Straightforward and Highly Efficient Catalyst-Free Regioselective Reaction of Thiol to β-Nitrostyrene: A Concise Synthesis of Vinyl Sulfide and Nitro Sulfide. 
Chu, C.-M. ; Tu, Z.; Wu, P.; Wang, C.-C.; Liu, J.-T.; Kuo, C.-W.; Shin, Y.-H. and Yao, C.-F.* 
( Authors contributed equally to this work) 
Tetrahedron (2009)

An Efficient Method for the Synthesis of α-Arylated Nitroalkanes and α-Arylated Hydroximoyl Chlorides Mediated by AlCl3. 
Tu, Z.; Raju, B. R.; Liou, T.-R.; Kavala, V.; Kuo, C.-W.; Jang, Y.; Shih, Y.-H.; Wang, C.-C. and Yao, C.-F.* 
Tetrahedron (2009)

An Investigation of the Reaction of 2-Aminobenzaldehyde Derivatives with Conjugated Nitro-olefins: An Easy and Efficient Synthesis of 3-Nitro-1,2-dihydroquinolines and 3-Nitroquinolines. 
Yan, M.-C.; Tu, Z.; Lin, C.; Ko, S.; Hsu, J. and Yao, C.-F.* 
J. Org. Chem. (2004)

Publication List