Institute of Biological Chemistry, Academia Sinica

Research

1. Maintain IBC Biophysical Instrumentation Laboratory (BIL) and provide training courses and technical supports to BIL users.
2. Quantitative measurement of binding kinetic rate constants, affinities and thermodynamic basis of biomolecular interactions.
3. Using biophysical technologies to characterize protein folding, stability, conformation, protein aggregation and oligomeric state of the native protein.

Degrees and Positions Held

• 2003 – 2008   Ph.D., Institute of Bioinformatics and Structural Biology, National Tsing Hua University

• 2021 – present   Associate Research Specialist, Institute of Biological Chemistry, Academia Sinica
• 2016 – 2021   Assistant Research Specialist, Institute of Biological Chemistry, Academia Sinica
• 2012 – 2016   Manager, Biophysical Instrumentation Laboratory of Institute of Biological Chemistry, Academia Sinica
• 2011 – 2012   Postdoctoral Fellow, University of Texas Southwestern Medical Center at Dallas, USA
• 2008 – 2011   Postdoctoral Fellow, Institute of Biomedical Science, Academia Sinica

Selected Publications

Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G. 
Ho MR, Wu YM, Lu YC, Ko TP, Wu KP 
Journal of Structural Biology (2023)

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function. 
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu SD 
Nature Structural & Molecular Biology (2021)

Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism. 
Wu AY, Sung YC, Chen YJ, Chou ST, Guo V, Chien JC, Ko JJ, Yang AL, Huang HC, Chuang JC, Wu S, Ho MR, Ericsson M, Lin WW, Cheung CHY, Juan HF, Ueda K, Chen Y, Lai CP 
Advanced Science (2020)

RIM C₂B Domains Target Presynaptic Active Zone Functions to PIP₂-Containing Membranes. 
de Jong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS 
Neuron (2018)

Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. 
Su MY, Som N, Wu CY, Su SC, Kuo YT, Ke LC, Ho MR, Tzeng SR, Teng CH, Mengin-Lecreulx D, Reddy M, Chang CI 
Nature Communications (2017)

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3. 
Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, Wu SH 
Journal of the American Chemical Society (2016)

Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation. 
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH 
Science Signaling (2014)

Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein. 
Chang TH, Chang SJ, Hsieh FL, Ko TP, Lin CT, Ho MR, Wang I, Hsu ST, Guo RT, Chang W, Wang AH 
PLoS Pathogens (2013)

Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. 
Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C 
Journal of Molecular Biology (2010)

Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation. 
Ho MR, Lou YC, Lin WC, Lyu PC, Huang WN, Chen C 
The Journal of Biological Chemistry (2006)

Publication List