IBC - 梁博煌

Research

Our laboratory has been focusing on (i) mechanistic and structural studies of prenyltransferases catalyzing chain elongation, such as undecaprenyl diphosphate synthase, octaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase; (ii) antivirus and anti-cancer drug discovery targeting 3C protease from Enterovirus 71, 3C-like proteases from SARS-CoV and MERS-CoV, neuraminidase from avian flu virus, and protein-protein interactions; (iii) multi-functional cellulose/hemicellulose degrading enzymes for biofuel production.

Degrees and Positions Held

1989 – 1994 Ph.D., Biochemistry, University of Maryland.
1982 – 1986 B. S., Chemistry, National Taiwan University.

2009 – present Council Member, The Taiwan society for Biochemistry and Molecular Biology
2007 – present Joint Professor, Insti. of Biochemical Sciences, National Taiwan University
2007 – present Editorial Board, Bioorganic Chemistry (Elsevier) and JCCS
2006 – present Research fellow, Institute of Biological Chemistry, Academia Sinica
2017 – 2019 Acting Deputy Director, Institute of Biological Chemistry, Academia Sinica
2017 – 2017 Deputy Director, Institute of Biological Chemistry, Academia Sinica
2010 – 2015 Council Member, Asia Pacific Protein Association (APPA)
2007 – 2016 Council Member, Biophysics society of ROC
2006 – 2011 Deputy Director, Institute of Biological Chemistry, Academia Sinica
2005 – 2008 PI, Core Facility of Recombinant Protein Production
2004 – 2011 Chem Biology & Mol Biophys Coordinator, TIGP
2002 – 2006 Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
1999 – 2002 Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica.
1996 – 1999 Investigator, SmithKline Beecham Pharmaceuticals.
1995 – 1996 Associate Research Scientist, Yale Medical School.
1994 – 1995 Postdoc. Pharmacology, Yale Medical School.

Selected Publications

Complexation and evolution of cis-prenyltransferase homologues in Cinnamomum kanehirae deduced from kinetic and functional characterizations.
Liu JJ, Liang PH
Protein Science (2023)

Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors.
Palla SR, Li CW, Chao TL, Lo HV, Jia-Jin L, Pan MY, Chiu YT, Lin WC, Hu CW, Yang CM, Chen YY, Fang JT, Lin SW, Lin YT, Lin HC, Kuo CJ, Wang LH, Chang SY, Liang PH
Antiviral Research (2023)

SARS-CoV-2 3CL^pro displays faster self-maturation in vitro than SARS-CoV 3CL^pro due to faster C-terminal cleavage.
Kuo CJ, Liang PH
FEBS Letters (2022)

Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2.
Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LH, Hsieh MC, Chang SY, Liang PH
Antimicrobial Agents and Chemotherapy (2021)

Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.
Liu YJ, Chang YJ, Kuo YT, Liang PH
Carcinogenesis (2020)

A flexible loop for mannan recognition and activity enhancement in a bifunctional glycoside hydrolase family 5.
Liang PH, Lin WL, Hsieh HY, Lin TY, Chen CH, Tewary SK, Lee HL, Yuan SF, Yang B, Yao JY, Ho MC
Biochimica et Biophysica Acta (BBA) - General Subjects (2018)

Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation.
Liu YJ, Kumar V, Lin YF, Liang PH
Cell Death & Disease (2017)

Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL^pro inhibitors.
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH
Antiviral Research (2017)

Fluorescent farnesyl diphosphate analogue: A probe to validate trans-prenyltransferase inhibitors.
Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH
Biochemistry (2016)

Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.
Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH
Journal of Biological Chemistry (2015)

Research

Degrees and Positions Held

Selected Publications

Publication List