Institute of Biological Chemistry, Academia Sinica

Research

Please visit the website (http://idv.sinica.edu.tw/chunhung) for the details. Research in Lin’s lab involves multi-disciplinary areas including glycobiology, enzymology, synthetic chemistry and biophysics. Special emphasis is stressed to develop bioorganic and biochemical approaches for investigating the carbohydrate-related enzymes at molecular level, particularly in association with infectious diseases and cancers. Development of enzyme inhibitors has been carried out to study how small molecules interact with proteins and in turns, understand how potent enzyme inhibitors intervene in pathogenesis. Great success has been made to establish practical activity assays with high sensitivity and throughput, paving the way for discovery of the most potent glycosidase inhibitor to date (Ki = 0.46 pM).

Degrees and Positions Held

• 2007 – present   Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 2017 – 2020   Director, Department of Academic Affairs and Instrument Service, Academia Sinica
• 2014   Outstanding Research Award, Ministry of Science and Technology
• 2014 – 2017   Deputy Director, Institute of Biological Chemistry, Academia Sinica
• 2011   Investigator Award of Academia Sinica, Academia Sinica
• 2010   Young Investigator Award, Academia Sinica
• 2010   Young Scholar Award, Tien-De Li Biomedical Foundation
• 2008   The Top Ten Rising Stars in Taiwan, Selected by the Central NEws Agency of Taiwan
• 2006   Excellent Young Scholar Award, The Chemical Society Located at Taipei
• 2005   Mentor Recognition Award, University of California, San Diego
• 2002 – 2004   Secretary-General, Taiwan Biophysics Society
• 2002 – 2007   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1998   Heritage Prize and Fellowship, Li’s Foundation
• 1998 – 2002   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1993 – 1994   Glaxo Fellowship, Scripps Research Institute

• 1995 – 1997   Research Fellow, Harvard Medical School
• 1990 – 1995   Ph.D., Chemistry, Scripps Research Institute.
• 1986 – 1990   B.S., Chemistry, National Taiwan University.

Selected Publications

Tunable Strategy for the Asymmetric Synthesis of Sulfoglycolipids from Mycobacterium tuberculosis To Elucidate the Structure and Immunomodulatory Property Relationships. 
Mondal S, Tseng CJ, Tan JJ, Lin DY, Lin HY, Weng JH, Lin CH*, Mong KT* 
Angew Chem Int Ed. (2023)

Metabolic Isolation, Stereochemical Determination, and Total Synthesis of Predominant Native Cholesteryl Phosphatidyl-α-glucoside from Carcinogenic Helicobacter pylori. 
Chang CC, Jan HM, Tseng CJ, Mondal S, Abera AB, Hsieh MY, Yang TC, Muthusamy S, Huang SC, Lin CH*, Mong KT* 
Org Lett. (2022)

Enhanced enzymatic production of cholesteryl 6ʹ-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori. 
Muthusamy S, Jan HM, Hsieh MY, Mondal S, Liu WC, Ko YA, Yang WY, Mong KT, Chen GC, Lin CH* 
J Biomed Sci. (2021)

A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii. 
Chen SP, Chen EH, Yang SY, Kuo PS, Jan HM, Yang TC, Hsieh MY, Lee KT, Lin CH, Chen RP 
Front Microbiol. (2021)

Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. 
Lin HY, Chen CY, Lin TC, Yeh LF, Hsieh WC, Gao S, Burnouf PA, Chen BM, Hsieh TJ, Dashnyam P, Kuo YH, Tu Z, Roffler SR*, Lin CH* 
Commun Biol. (2021)

Threshold of Thioglycoside Reactivity Difference Is Critical for Efficient Synthesis of Type I Oligosaccharides by Chemoselective Glycosylation. 
Verma N, Tu Z, Lu MS, Liu SH, Renata S, Phang R, Liu PK, Ghosh B, Lin CH* 
J Org Chem. (2021)

Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium. 
Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KT*, Lin CH* 
Commun Biol. (2020)

Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. 
Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, Lin CH* 
J Med Chem. (2020)

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease. 
Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, Lin CH, Liu FT, Chern Y 
Nat Commun.(2019)

Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence. 
Jan HM, Chen YC, Shih YY, Huang YC, Tu Z, Ingle AB, Liu SW, Wu MS, Gervay-Hague J, Mong KT, Chen YR, Lin CH 
Chemical Science (2016)

Publication List