Our research interests are mainly focused on the structure, function, and biophysical properties of proteins. The information we discovered can further guide the inhibitor design to aid in cancer therapy or enzyme engineering for industrial uses. We conduct our studies primarily using X-ray crystallography, spectroscopy and enzymology and routinely collaborates with other laboratories worldwide.
Our current studies involves three areas: (1) reconstruct the rice survival strategy under submergence (2) protein-protein interaction related to cancer (3) enzyme engineering for industrial use.
Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin.
Chiu YC, Yeh MC, Wang CH, Chen YA, Chang H, Lin HY, Ho MC, Lin SM
Nature Communications (2023)
Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.
Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, Chen RP*
Nature Communications (2023)
A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination.
Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC*
Nature Communications (2023)
SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice.
Lin CC, Lee WJ, Zheng CY, Chou MY, Lin TJ, Lin CS, Ho MC*, Shih MC*
PNAS Nexus (2023)
Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions.
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC*, Chen CJ*
Nature Communications (2023)
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
Nature Communications (2021)
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary SK, Zheng YG, Ho MC*
Cellular and Molecular Life Sciences (2019)
Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence.
Lin CC, Chao YT, Chen WC, Ho HY, Chou MY, Li YR, Wu YL, Yang HA, Hsieh H, Lin CS, Wu FH, Chou SJ, Jen HC, Huang YH, Irene D, Wu WJ, Wu JL, Gibbs DJ, Ho MC*, Shih MC*
Proceedings of the National Academy of Sciences of the United States of America (2019)
Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity. (cover article)
Lee WC, Lin WL, Matsui T, Chen ES, Wei TY, Lin WH, Hu H, Zheng YG, Tsai MD, Ho MC*
Biochemistry (2015)
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity.
Ho MC*, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D*
PLoS ONE (2013)