Institute of Biological Chemistry, Academia Sinica

Research

1. Clinical Oncology,
2. Cancer drug development,
3. Translational medicine

Degrees and Positions Held

• 1985 – 1988   Ph.D., Pathology and Cell Biology, Thomas Jefferson University
• 1975 – 1982   MD, School of Medicine, Taipei Medical College

• 2014 – present   Joint Appointment Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 2011 – present   The Ph.D. program for Cancer Biology and Drug Discovery ,Professor, Taipei Medical University
• 2011 – 2017   President, Taipei Medical University
• 2003 – 2011   City of Hope, National Medical Center, Professor

Selected Publications

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials. 
Liu JW, Chen C, Loh EW, Chu CC, Wang MY, Ouyang HJ, Chang YT, Zhuang WZ, Chou CW, Huang DJ, Lee CH, Yen Y, Tam KW. 
Curr Med Res Opin. (2018)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer. 
Luu T, Kim KP, Blanchard S, Anyang B, Hurria A, Yang L, Beumer JH, Somlo G, Yen Y. 
Breast Cancer Res Treat. (2018)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors. 
Hsieh TH, Liu YR, Chang TY, Liang ML, Chen HH, Wang HW, Yen Y, Wong TT. 
Neuro Oncol. (2018)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma. 
Liu YM, HuangFu WC, Huang HL, Wu WC, Chen YL, Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL, Liou JP. 
Eur J Med Chem. (2017)

Benzodiazepines use and breast cancer risk: A population-based study and gene expression profiling evidence. 
Iqbal U, Chang TH, Nguyen PA, Syed-Abdul S, Yang HC, Huang CW, Atique S, Yang WC, Moldovan M, Jian WS, Hsu MH, Yen Y, Jack Li YC. 
J Biomed Inform. (2017)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers. 
Ding J, Kuo ML, Su L, Xue L, Luh F, Zhang H, Wang J, Lin TG, Zhang K, Chu P, Zheng S, Liu X, Yen Y. 
Carcinogenesis. (2017)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1a co-activator driving oral cancer progression. 
Jing-Wen Shih, Wei-Fan Chiang, Alexander T.H. Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yen Y & Hsing-Jien Kung. 
Nature Communications. (2017)

Mechanism and Clinical Properties of StemBios Cell Therapy: Induction of Early Osseointegration in Novel Dental Implants. 
Weng CC, Ou KL, Wu CY, Huang YH, Wang J, Yen Y, Cheng HY, Lin YH. 
Int J Oral Maxillofac Implants. (2017)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways. 
Huang YJ, Yang CK, Wei PL, Huynh TT, Whang-Peng J, Meng TC, Hsiao M, Tzeng YM, Wu AT, Yen Y. 
J Hematol Oncol. (2017)

Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis. 
Guosong Shen, Pingya He, Yingying Mao, Peipei Li, Frank Luh, Guohui Ding, Xiyong Liu, Yun Yen. 
Breast Cancer (2017)

Publication List