Institute of Biological Chemistry, Academia Sinica

Research

The study on relationship of structure and function of biomolecules is the main theme of our research. The basic techniques used in our studies include NMR, GC-Mass and MS, BIAcore, CD, organic synthesis, cloning, site-directed mutagenesis and other physical methods and chromatographies. At present, our works focus on several topics described as follows:

• Carbohydrate Chemistry and Glycobiology
• Drug Discovery and Development from the Secondary metabolites of microorganisms
• Studies on the structure-functional relationship of proteins and peptides by NMR and X-ray diffraction
• Proteomic studies

Degrees and Positions Held

• 1987   Ph.D., Pharmacy, University of Wisconsin, Madison.
• 1977   M.S., Biochemistry, National Taiwan University
• 1975   B.S., Botany, National Taiwan University

• 2023 – present   Adjunct Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1991 – present   Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
• 2008 – 2023   Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 2006 – 2012   Deputy Director, Institute of Biological Chemistry, Academia Sinica
• 1998 – 1999   General Secretary, Taiwan Society of Biochemistry and Molecular Biology
• 1997 – 1999   Deputy Director, Institute of Biological Chemistry, Academia Sinica
• 1994 – 1995   Visiting Scholar, The Scripps Research Institute
• 1991 – 2008   Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1988 – 1991   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1979 – 1988   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1978 – 1979   Group Leader, Panlabs Taiwan Ltd

Selected Publications

A hexasaccharide from capsular polysaccharide of carbapenem-resistant Klebsiella pneumonia KN2 is a ligand of Toll-like receptor 4. 
Lee IM, Huang TY, Yang FL, Johansson V, Hsu CR, Hsieh PF, Chen ST, Yang YJ, Konradsson P, Sheu JH, Wang JT, Wu SH 
Carbohydrate Polymers (2022)

Structural and biological insights into Klebsiella pneumonia surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use. 
Tu IF, Lin TL, Yang FL, Lee IM, Tu WL, Liao JH, Ko TP, Wu WJ, Jan JT, Ho MR, Chou CY, Wang AH, Wu CY, Wang JT, Huang KF, Wu SH 
Journal of Biomedical Science (2022)

Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase. 
Ye TJ, Huang KF, Ko TP, Wu SH 
Acta Crystallographica Section D: Structural Biology (2022)

Bacteriophage Tail-Spike Proteins Enable Detection of Pseudaminic-Acid-Coated Pathogenic Bacteria and Guide the Development of Antiglycan Antibodies with Cross-Species Antibacterial Activity.  
Lee IM, Tu IF, Yang FL, Wu SH 
Journal of the American Chemical Society (2020)

Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae. 
Perera N , Yang FL , Chern J , Chiu HW , Hsieh CY , Li LH , Zhang YL , Hua KF , Wu SH 
Chemical Communications (2018)

Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity. 
Lee IM, Yang FL, Chen TL, Liao KS, Ren CT, Lin NT, Chang YP, Wu CY, Wu SH 
Journal of the American Chemical Society (2018)

Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade. 
Chern J, Lu CP, Fang Z, Chang CM, Hua KF, Chen YT, Ng CY, Chen YS, Lam Y, Wu SH 
Angewandte Chemie International Edition (2018)

Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages. 
Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, Wu SH 
Organic Letters (2017)

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3. 
Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, Wu SH 
Journal of the American Chemical Society (2016)

Avenaciolides: Potential MurA-Targeted Inhibitors Against Peptidoglycan Biosynthesis in Methicillin-Resistant Staphylococcus aureus (MRSA). 
Chang CM, Chern J, Chen MY, Huang KF, Chen CH, Yang YL, Wu SH 
Journal of the American Chemical Society (2015)

Publication List