20210606 Lowary TL Epub

Structure-activity relationship of avocadyne

Structure-activity relationship of avocadyne

Food Funct. 2021 Jul 21; 12(14):6323-6333. Epub 2021 Jun 6.
doi: 10.1039/d1fo00693b


Vockley J, O'Doherty GA, Lowary TL, Spagnuolo PA


Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.