20201002 Lowary TL paper photo

Synthesis of a Highly Branched Nonasaccharide Chlorella Virus N-Glycan Using a “Counterclockwise” Assembly Approach

Synthesis of a Highly Branched Nonasaccharide Chlorella Virus N-Glycan Using a

Org Lett. 2020 Oct 2; 22(19):7645-7649. Epub 2020 Sep 17.
doi: 10.1021/acs.orglett.0c02839

閱讀文章

摘要

Chloroviruses produce a capsid protein containing N-linked glycans differing in structure from those found in all other organisms. These species feature a core "hyper-branched" fucose residue in which every hydroxyl group is glycosylated. We describe the synthesis of a nonasaccharide from Paramecium bursaria chlorella virus 1, one of most complex chlorovirus N-glycans reported, using a "counterclockwise" strategy involving the sequential addition of trisaccharide, disaccharide, and monosaccharide motifs to a trisaccharide containing the core fucose residue.