wu201901

Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

Tetrahedron Letters Volume 60, Issue 3, 17 January 2019, Pages 288-291
doi: 10.1016/j.tetlet.2018.12.031

閱讀文章

Susanto W, Kong KH, Hua KF, Wu SH, Lam Y

摘要

The incidences of primary, pyrogenic liver abscess complicated by meningitis and septic endophthalmitis caused by Klebsiella pneumoniae has increased globally. Earlier studies have shown that the capsular polysaccharide (CPS) of Klebsiella pneumoniae plays an important role in the resistance to phagocytosis and related pathogenicity. The first chemical synthesis of the trisaccharide repeating unit of this CPS has been achieved via stereoselective glycosylation with orthogonal and appropriate protecting groups. A new method for the pyruvylation of trans diol was developed.