研究領域與專長
  1. Protein Chemistry: Cell culture, Molecular cloning, Site-directed mutagenesis, Protein expression, Protein purification, Enzyme kinetic analysis.
  2. Biophysical Instrument: Circular dichroism, Fluorescence spectroscopy, Analytic ultracentrifugation, Isothermal titration calorimetry, Surface plasmon resonance.
學經歷
經歷
  • 2019 – 迄今   研究副技師, 中央研究院生物化學研究所
  • 2010 – 2019   研究助技師, 中央研究院生物化學研究所
  • 2007 – 2009   博士後研究員, 中央研究院基因體研究中心
  • 2007 – 2007   博士後研究員, 中央研究院生物化學研究所
  • 2000 – 2005   研究助理, 中央研究院生物化學研究所
學歷
  • 2002 – 2007   博士, 生化科學研究所, 國立臺灣大學
  • 1997 – 1999   碩士, 生物科技研究所, 國立交通大學
主要著作
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*
Nucleic acids research (2012)
Lin YN, Stein DB, Lin SW, Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*
ADVANCED SYNTHESIS & CATALYSIS (2012)
Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH
The Journal of biological chemistry (2007)
Lin SW, Yuan TM, Li JR, Lin CH
Biochemistry (2006)
著作列表
  1. Chen YW, Satange R, Wu PC, Jhan CR, Chang CK, Chung KR, Waring MJ, (Lin SW), Hsieh LC, Hou MH  (2018-09)  International journal of molecular sciences  19(9), 2796  "Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex."
  2. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, (Lin SW), Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  3. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, (Lin SW), Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  4. Yeh HY, (Lin SW), Wu YC, Chan NL, Chi P  (2017-05)  Scientific reports  7(1), 2370  "Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans."
  5. Teng KH, Hsu ET, Chang YH, (Lin SW), Liang PH  (2016)  Biochemistry  55(31), 4366-74  "Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors."
  6. Kumar V, Tan KP, Wang YM, (Lin SW), Liang PH  (2016)  Bioorganic & medicinal chemistry  24(13), 3035-3042  "Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors."
  7. Su GC, Yeh HY, (Lin SW), Chung CI, Huang YS, Liu YC, Lyu PC, Chi P  (2016)  Nucleic acids research  44(13), 6242-51  "Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination."
  8. Chang HY, Liao CY, Su GC, (Lin SW), Wang HW, Chi P  (2015-08)  The Journal of biological chemistry  290(32), 19863-19873  "Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1."
  9. Lin TW, Chang HT, Chen CH, Chen CH, (Lin SW), Hsu TL, Wong CH  (2015-08)  Journal of the American Chemical Society  137(30), 9685-9693  "Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis."
  10. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang AH, Yu CM, Chen IC, Tung CP, Chen TH, Ping Chiu K, Ma C, Yuan Wu C, (Lin SW), Yang AS  (2015-07)  Scientific reports  5, 12411  "Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens."
  11. Chen PC, Chuang PK, Chen CH, Chan YT, Chen JR, (Lin SW), Ma C, Hsu TL, Wong CH  (2014-07)  ACS chemical biology  9(7), 1437-1443  "Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors."
  12. Su GC, Chung CI, Liao CY, (Lin SW), Tsai CT, Huang T, Li HW, Chi P  (2014-01)  Nucleic acids research  42(1), 349-358  "Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex."
  13. Chang CK, Teng KH, (Lin SW), Chang TH, Liang PH  (2013)  Biochemistry  52(16), 2783-2792  "Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction."
  14. Busygina V, Gaines WA, Xu Y, Kwon Y, Williams GJ, (Lin SW), Chang HY, Chi P, Wang HW, Sung P  (2013)  DNA repair  12(9), 707-712  "Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1."
  15. Chen SH, (Lin SW), Lin SR, Liang PH, Yang JM  (2013)  Journal of chemical information and modeling  53(9), 2299-2311  "Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase."
  16. Lin YN, Stein DB, (Lin SW), Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*  (2012)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  17. Tsai SP, Su GC, (Lin SW), Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*  (2012)  Nucleic acids research  40(14), 6558-6569  "Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex."
  18. Sun HY, (Lin SW), Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH  (2007)  The Journal of biological chemistry  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design."
  19. (Lin SW), Yuan TM, Li JR, Lin CH  (2006)  BIOCHEMISTRY  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."
  1. Protein Chemistry: Cell culture, Molecular cloning, Site-directed mutagenesis, Protein expression, Protein purification, Enzyme kinetic analysis.
  2. Biophysical Instrument: Circular dichroism, Fluorescence spectroscopy, Analytic ultracentrifugation, Isothermal titration calorimetry, Surface plasmon resonance.
經歷
  • 2019 – 迄今   研究副技師, 中央研究院生物化學研究所
  • 2010 – 2019   研究助技師, 中央研究院生物化學研究所
  • 2007 – 2009   博士後研究員, 中央研究院基因體研究中心
  • 2007 – 2007   博士後研究員, 中央研究院生物化學研究所
  • 2000 – 2005   研究助理, 中央研究院生物化學研究所
學歷
  • 2002 – 2007   博士, 生化科學研究所, 國立臺灣大學
  • 1997 – 1999   碩士, 生物科技研究所, 國立交通大學
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*
Nucleic acids research (2012)
Lin YN, Stein DB, Lin SW, Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*
ADVANCED SYNTHESIS & CATALYSIS (2012)
Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH
The Journal of biological chemistry (2007)
Lin SW, Yuan TM, Li JR, Lin CH
Biochemistry (2006)
  1. Chen YW, Satange R, Wu PC, Jhan CR, Chang CK, Chung KR, Waring MJ, (Lin SW), Hsieh LC, Hou MH  (2018-09)  International journal of molecular sciences  19(9), 2796  "Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex."
  2. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, (Lin SW), Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  3. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, (Lin SW), Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  4. Yeh HY, (Lin SW), Wu YC, Chan NL, Chi P  (2017-05)  Scientific reports  7(1), 2370  "Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans."
  5. Teng KH, Hsu ET, Chang YH, (Lin SW), Liang PH  (2016)  Biochemistry  55(31), 4366-74  "Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors."
  6. Kumar V, Tan KP, Wang YM, (Lin SW), Liang PH  (2016)  Bioorganic & medicinal chemistry  24(13), 3035-3042  "Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors."
  7. Su GC, Yeh HY, (Lin SW), Chung CI, Huang YS, Liu YC, Lyu PC, Chi P  (2016)  Nucleic acids research  44(13), 6242-51  "Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination."
  8. Chang HY, Liao CY, Su GC, (Lin SW), Wang HW, Chi P  (2015-08)  The Journal of biological chemistry  290(32), 19863-19873  "Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1."
  9. Lin TW, Chang HT, Chen CH, Chen CH, (Lin SW), Hsu TL, Wong CH  (2015-08)  Journal of the American Chemical Society  137(30), 9685-9693  "Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis."
  10. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang AH, Yu CM, Chen IC, Tung CP, Chen TH, Ping Chiu K, Ma C, Yuan Wu C, (Lin SW), Yang AS  (2015-07)  Scientific reports  5, 12411  "Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens."
  11. Chen PC, Chuang PK, Chen CH, Chan YT, Chen JR, (Lin SW), Ma C, Hsu TL, Wong CH  (2014-07)  ACS chemical biology  9(7), 1437-1443  "Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors."
  12. Su GC, Chung CI, Liao CY, (Lin SW), Tsai CT, Huang T, Li HW, Chi P  (2014-01)  Nucleic acids research  42(1), 349-358  "Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex."
  13. Chang CK, Teng KH, (Lin SW), Chang TH, Liang PH  (2013)  Biochemistry  52(16), 2783-2792  "Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction."
  14. Busygina V, Gaines WA, Xu Y, Kwon Y, Williams GJ, (Lin SW), Chang HY, Chi P, Wang HW, Sung P  (2013)  DNA repair  12(9), 707-712  "Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1."
  15. Chen SH, (Lin SW), Lin SR, Liang PH, Yang JM  (2013)  Journal of chemical information and modeling  53(9), 2299-2311  "Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase."
  16. Lin YN, Stein DB, (Lin SW), Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*  (2012)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  17. Tsai SP, Su GC, (Lin SW), Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*  (2012)  Nucleic acids research  40(14), 6558-6569  "Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex."
  18. Sun HY, (Lin SW), Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH  (2007)  The Journal of biological chemistry  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design."
  19. (Lin SW), Yuan TM, Li JR, Lin CH  (2006)  BIOCHEMISTRY  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."