Experience in qualitative and quantitative proteomics (iTRAQ, SILAC, label-free) workflows by NanoLC-MS/MS analyses, in conjunction with utilizing a variety of database search engine and data handling programs for high-throughput expression profiling and quantification.
Comprehensive proteome-wide analysis of post-translational modifications, such as phosphorylation, and targeted analysis of protein sumoylation, neddylation and cysteine modifications etc.
Targeted analysis or manual examination of MS and MS/MS data to determine a true protein ID hit from false positive, to rescue false negative from the data, to confirm predicted sequence or modifications, and to determine site-specific PTM.
Ko YC, Tsai WH, Wang PW, Wu IL, Lin SY, Chen YL, Chen JY, Lin SF
Journal of biomedical science (2012)
Tsai WH, Wang PW, Lin SY, Wu IL, Ko YC, Chen YL, Li M, Lin SF
Frontiers in microbiology (2012)
Chang CC, Naik MT, Huang YS, Jeng JC, Liao PH, Kuo HY, Ho CC, Hsieh YL, Lin CH, Huang NJ, Naik NM, Kung CC, Lin SY, Chen RH, Chang KS, Huang TH, Shih HM
Molecular cell (2011)
Huang KY, Chen GD, Cheng CH, Liao KY, Hung CC, Chang GD, Hwang PP, Lin SY, Tsai MC, Khoo KH, Lee MT, Huang CJ
PloS one (2011)
Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC
EMBO JOURNAL (2011)
Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, Chen HC, Yeh SD, Wu CW
Cancer research (2010)
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH
MOLECULAR & CELLULAR PROTEOMICS (2009)
Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC
Journal of proteome research (2008)
Lin SY, Chen YY, Fan YY, Lin CW, Chen ST, Wang AH, Khoo KH
Journal of proteome research (2008)
Hsiao HH, Hsieh HY, Chou CC, Lin SY, Wang AH, Khoo KH
Journal of proteome research (2007)