研究領域與專長

中研院學儀處, 冷凍電顯中心經理

  1. 冷凍電顯
  2. 原子力顯微鏡
  3. 超高真空電顯
  4. 奈米探針
學經歷
經歷
  • 2021 – 迄今   研究副技師, 中研院生物化學研究所 / 學儀處
  • 2017 – 2020 研究副技師, 中研院細胞與個體生物學研究所 / 學儀處
  • 2011 – 2017 研究助技師, 中研院細胞與個體生物學研究所 / 學儀處
  • 2004 – 2010 博士後研究員, 中研院奈米科學實驗室@物理所
  • 1999 – 2003 研究助理, 中研院奈米科學實驗室@物理所
學歷
  • 1999 – 2004   博士, 工程科技研究所, 國立雲林科技大學
  • 1997 – 1999   碩士, 機械工程研究所, 國立雲林科技大學
主要著作
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*
Nature Structural & Molecular Biology (2021)
Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu SD.
Proceedings of the National Academy of Sciences of the United States of America (2020)
Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD.
Journal of the American Chemical Society (2019)
Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD.
Journal of the American Chemical Society (2019)
Tsai CY, Chang YC, Lobato I, Van Dyck D, Chen FR.
Scientific Reports (2016)
Chen YS, Chang YC, Wang SC, Chen LY, Lien DH, Chen LJ, Chang CS.
Small (2012)
Chang YC, Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT.
Small (2008)
Chin SC, Chang YC, Chang CS, Woon WY, Lin LT, Tao HJ.
Applied Physics Letters (2008)
Chen YK, Leng CH, Olivares H, Lee MH, Chang YC, Kung WM, Ti SC, Lo YH, Wang AH, Chang CS, Bishop DK, Hsueh YP, Wang TF.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Chang YC, Wang DC, Chang CS, Tsong TT.
Applied Physics Letters (2003)
著作列表
  1. Yang TJ, Yu PY, (Chang YC), Hsu STD*  (2021-10)  Journal of biological chemistry  297(4), 101238  "D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation"
  2. Su SC, Yang TJ, Yu PY, Liang KH, Chen WY, Yang CW, Lin HT, Wang MJ, Lu RM, Tso HC, Chung MJ, Hsieh TY, Chang YL, Lin SC, Hsu FY, Ke FY, Wu YH, Hwang YC, Liu IJ, Liang JJ, Liao CC, Ko HY, Sun CP, Wu PY, Jan JT, (Chang YC), Lin YL*, Tao MH*, Hsu STD*, Wu HC*  (2021-10)  PLOS PATHOGENS  17(10), e1009704  "Structure-guided antibody cocktail for prevention and treatment of COVID-19"
  3. Yang TJ, Yu PY, (Chang YC), Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*  (2021-09)  NATURE STRUCTURAL & MOLECULAR BIOLOGY  28(9), 731-739  "Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function"
  4. Tzu-Jing Yang, Pei-Yu Yu, (Yuan-Chih Chang), Ning-En Chang, Yu-Xi Tsai, Kang-Hao Liang, Piotr Draczkowski, Bertina Lin, Yong-Sheng Wang, Yu-Chun Chien, Kay-Hooi Khoo, Han-Chung Wu, and Shang-Te Danny Hsu  (2021-09)  bioRxiv  459978, 1-32  "Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants"
  5. (Chang YC), Chen CY, Tsai MD*  (2021-07)  Jove-Journal of Visualized Experiments  173, e62772  "Preparation of High Temperature Sample Grids for Cryo-EM"
  6. Even Chen, Bing-Mae Chen, Yu-Cheng Su, (Yuan-Chih Chang), Tian-Lu Cheng, Yechezekel Barenholz, and Steve Roffler  (2020-07)  ACS NANO  14(7),7808-7822  "Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex"
  7. Tzu-Jing Yang, Yen-Chen Chang, Tzu-Ping Ko, Piotr Draczkowski, Yu-Chun Chien, (Yuan-Chih Chang), Kuen-Phon Wu, Kay-Hooi Khoo, Hui-Wen Chang and Shang-Te Danny Hsu  (2020-01)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  117(3), 1438-1446  "Cryo-EM Analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans"
  8. Chin-Yu Chen, (Yuan-Chih CHANG), Bo-Lin Lin, Chun-Hsiang Huang and Ming-Daw Tsai  (2019-12)  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  141(51), 19983-19987  "Temperature-resolved Cryo-EM Uncovers Structural Bases of Temperature-dependent Enzyme Functions"
  9. Leon Chien-Wei Lin, Chen-Yu Huang, Bing-Yu Yao, Jung-Chen Lin, Anurodh Agrawal, Abdullah Algaissi, Bi-Hung Peng, Yu-Han Liu, Ping-Han Huang, Rong-Huay Juang, (Yuan-Chih Chang), Chien-Te Tseng, Hui-Wen Chen, and Che-Ming Jack Hu  (2019-07)  ADVANCED FUNCTIONAL MATERIALS  29(28), 1807616  "Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus"
  10. Ming-Shou Hsieh, (Yuan-Chih Chang), Jie-Long He, and Rong-Huay Juang  (2019-05)  VIRUS RESEARCH  265, 132-137  "Positive charge of Arg-201 on hemagglutinin is required for the binding of H6N1 avian influenza virus to its target through a two-step process"
  11. Chin-Yu Chen, (Yuan-Chih Chang) , Bo-Lin Lin, Kuan-Fu Lin , Chun-Hsiang Huang, Dong-Lin Hsieh, Tzu-Ping Ko , and Ming-Daw Tsai  (2019-04)  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  141(15), 6136-6140  "Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase"
  12. Yu-Han Liu, Shu-Chen Kuo, Bing-Yu Yao, Zih-Syun Fang, Yi-Tzu Lee, (Yuan-Chih Chang), Te-Li Chen, and Che-Ming Jack Hu  (2018-12)  ACTA BIOMATERIALIA  82, 133-142  "Colistin nanoparticle assembly by coacervate complexation with polyanionic peptides for treating drug-resistant gram-negative bacteria"
  13. Qiaofeng Jin, Chih-Yu Lin, (Yuan-Chih Chang) and Chih-Kuang Yeh  (2018-01)  Langmuir  34(4), 1256-1265  "Roles of Textural and Surface Properties of Nanoparticles in Ultrasound-Responsive Systems"
  14. Hui-Wen Chen, Zih-Syun Fang, You-Ting Chen, Yuan-I Chen, Bing-Yu Yao, Ju-Yun Cheng, Chen-Ying Chien, (Yuan-Chih Chang), and Che-Ming J. Hu  (2017-11)  ACS APPLIED MATERIALS & INTERFACES  9(46), 39953-39961  "Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection"
  15. En-Ling Chang, Chien-Yu Ting, Po-Hong Hsu, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, (Yuan-Chih Chang), Hong-Lin Chan,Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan, and Chih-Kuang Yeh  (2017-06)  Journal of Controlled Release  256, 1  "Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors"
  16. Qiaofeng Jin, Chih-Yu Lin, Shih-Tsung Kang, (Yuan-Chih Chang), Hairong Zheng, Chia-Min Yang, Chih-Kuang Yeh  (2017-05)  Ultrasonics Sonochemistry  36, 262-269  "Superhydrophobic Silica Nanoparticles as Ultrasound Contrast Agents"
  17. Bo-Lin Lin, Chin-Yu Chen, Chun-Hsiang Huang, Tzu-Ping Ko, Cheng-Hung Chiang, Kuan-Fu Lin, (Yuan-Chih Chang), Po-Yen Lin, Hui-Hsu Gavin Tsai, and Andrew H.-J. Wang  (2017-01)  PLOS ONE  12(1), e0169627  "The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA"
  18. Ching-Hsiang Fan, En-Ling Chang, Chien-Yu Ting, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, (Yuan-Chih Chang), Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh  (2016-11)  Biomaterials  106, 46-57  "Folate-Conjugated Gene-Carrying Microbubbles with Focused Ultrasound for Concurrent Blood-Brain Barrier Opening and Local Gene Delivery"
  19. Bill Cheng, Elsie K. W. Toh, Kun-Hung Chen, (Yuan-Chih Chang), Che-Ming J. Hu, Han-Chung Wu, Lee-Young Chau, Peilin Chen, and Patrick C. H. Hsieh  (2016-10)  Advanced Healthcare Materials  5(20), 2686-2697  "Biomimicking Platelet–Monocyte Interactions as a Novel Targeting Strategy for Heart Healing"
  20. Qiaofeng Jin, Shih-Tsung Kang, (Yuan-Chih Chang), Hairong Zheng, Chih-Kuang Yeh  (2016-09)  ULTRASONICS SONOCHEMISTRY  32, 1-7  "Inertial cavitation initiated by polytetrafluoroethylene nanoparticles under pulsed ultrasound stimulation"
  21. Kuan-Yin Shen, Hsin-Yu Liu, Hui-Ju Li, Chiao-Chieh Wu, Gunn-Guang Liou, (Yuan-Chih Chang), Chih-Hsiang Leng, Shih-Jen Liu   (2016-07)  JOURNAL OF CONTROLLED RELEASE  233, 57-63  "A novel liposomal recombinant lipoimmunogen enhances anti-tumor immunity"
  22. Chun-Ying Tsai, (Yuan-Chih Chang), Ivan Lobato, Dirk Van Dyck and Fu-Rong Chen  (2016-06)  Scientific Reports  6, 27701  "Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins"
  23. Yi Ju Ho, (Yuan-Chih Chang), and Chih-Kuang Yeh  (2016-03)  Theranostics  6(3), 392-403  "Improving Nanoparticles Penetration in Solid Tumors by Vascular Disruption with Acoustic Droplet Vaporization"
  24. Shih-Chieh Su, Chien-Chu Lin, Hui-Chung Tai, Mu-yueh Chang, Meng-Ru Ho, Satheesan Babu, Jiahn-Haur Liao, Shih-Hsiung Wu, (Yuan-Chih Chang), Carmay Lim, and Chung-I Chang  (2016-03)  STRUCTURE  24, 676-686  "Structural basis for the magnesium-dependent activation and hexamerization of the Lon AAA+ protease"
  25. C. H. Fan, C. Y. Ting, C. Y. Lin, H. L. Chan, (Y. C. Chang), Y. Y. Chen, H. L. Liu and C. K. Yeh  (2016-01)  Scientific Reports  6, 19579  "Noninvasive, Targeted, and Non-viral Ultrasound-Mediated Gene Delivery for Parkinson's Disease Treatment"
  26. Ya-Ling Chiang, (Yuan-Chih Chang), I-Chen Chiang, Huey-Ming Mak, Ing-Shouh Hwang, Yu-Ling Shih  (2015-11)  PLoS One  10(11), e0142506  "Atomic force microscopy characterization of protein fibrils formed by the amyloidogenic region of the bacterial protein MinE on mica and a supported lipid bilayer"
  27. Ming-Yuan Su, Wen-Hsin Peng, Meng-Ru Ho, Shih-Chieh Su, (Yuan-Chih Chang), Guang-Chao Chen, and Chung-I Chang  (2015-09)  Autophagy  11(9), 1580-1593  "Structure of yeast Ape1 and its role in autophagic vesicle formation"
  28. Shih-Tsung Kang, Jian-Liang Lin, Chung-Hsin Wang, (Yuan-Chih Chang) and Chih-Kuang Yeh  (2015-07)  JOURNAL OF MATERIALS CHEMISTRY  3, 5938-5941  "Internal Polymer Scaffolding in Lipid-Coated Microbubbles for Control of Inertial Cavitation in Ultrasound Theranostics"
  29. Yu-Wen Huang, (Yuan-Chih Chang), Ruben Diaz-Avalos and Chih-Yen King  (2015-06)  Prion  9, 207-227  "W8, a New Sup35 Prion Strain, Transmits Distinctive Information with a Conserved Assembly Scheme"
  30. Yann-Wen Lan, Wen-Hao Chang, (Yuan-Chih Chang), Chia-Seng Chang and Chii-Dong Chen  (2015-02)  Nanotechnology  26, 055705  "Effect of focused ion beam deposition induced contamination on the transport properties of nano devices"
  31. Ching-Hsiang Fan, Chien-Yu Ting, (Yuan-Chih Chang), Kuo-Chen Wei, Hao-Li Liu, and Chih-Kuang Yeh  (2015-01)  Acta Biomaterialia  15, 89-101  "Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery"
  32. Yann-Wen Lan, Wen-Hao Chang, Yuan-Yao Li, (Yuan-Chih Chang), Chia-Seng Chang, and Chii-Dong Chen  (2014-09)  Applied Physics Letters  105(10), 1035505  "Stacking fault induced tunnel barrier in platelet graphite nanofiber"
  33. Chun-Han Ho, Hao-Ching Wang, Tzu-Ping Ko, (Yuan-Chih Chang), and Andrew H.-J. Wang  (2014-09)  Journal of Biological Chemistry  289, 27046-27054  "The T4 Phage DNA Mimic Protein Arn Inhibits the DNA-binding Activity of the Bacterial Histone-like Protein H-NS"
  34. Ming-Hsing Lin, (Yuan-Chih Chang), Chwan-Deng Hsiao, Shih-Hsun Huang, Min-Shi Wang, Yi-Ching Ko, Chih-Wei Yang, and Yuh-Ju Sun  (2013-12)  PLoS ONE  8(12), e83246  "LipL41, a Hemin Binding Protein from Leptospira santarosai serovar Shermani"
  35. Cheng Hui-Wen, (Chang Yuan-Chih), Tang Song-Nien, Yuan Chi-Tsu, Tang Jau, Tseng Fan-Gang  (2013-11)  Nanoscale Research Letters  8, 482  "Characterization of single 1.8-nm Au nanoparticle attachments on AFM tips for single sub-4-nm object pickup"
  36. Hui-Wen Cheng, (Yuan-Chih Chang), Chi-Tsu Yuan, Song-Nien Tang, Chia-Seng Chang, Jau Tang, Fu-Rong Chen, Rong-Long Pan, and Fan-Gang Tseng*   (2013-06)  The Journal of Physical Chemistry C  117(25), 13239-13246  "Simple and fast method to fabricate single-nanoparticle-terminated atomic force microscope tips"
  37. Ing-Shouh Hwang, Che-Cheng Chang, Chien-Hung Lu, Shih-Chin Liu, (Yuan-Chih Chang), Ting-Kuo Lee, Horng-Tay Jeng, Hong-Shi Kuo, Chun-Yueh Lin, Chia-Seng Chang and Tien T Tsong  (2013-04)  NEW JOURNAL OF PHYSICS  15, 043015  "Investigation of single-walled carbon nanotubes with a low-energy electron point projection microscope"
  38. Yu-Ming Chang, Cammy K. -M. Chen, (Yuan-Chih Chang), Wen-Yih Jeng, Ming-Hon Hou, and Andrew H. -J. Wang*  (2012-09)  PLoS ONE  7(9), e45665  "Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis"
  39. Yen-Song Chen, (Yuan-Chih Chang), Shau-Chieh Wang, Li-Ying Chen, Der-Hsien Lien, Lih-Juann Chen, and Chia-Seng Chang*  (2012)  SMALL  8, 2158-2162  "Critical Capillary Absorption of Current-Melted Silver Nanodroplets into Multiwalled Carbon Nanotubes"
  40. Yann-Wen Lan, Wen-Hao Chang, Shui-Jin Lai, (Yuan-Chih Chang), Cen-Shawn Wu, Chieh-Hsiung Kuan, Chia-Seng Chang, Chii-Dong Chen*  (2012)  CARBON  50, 4619-4627  "Effects of oxygen bonding on defective semiconducting and metallic single-walled carbon nanotube bundles "
  41. Lai WC, Chin SC, (Chang YC), Chen LY, Chang CS  (2010)  Nanotechnology  21(5), 055702  "Lattice-resolved frictional pattern probed by tailored carbon nanotubes."
  42. Shau-Chieh Wang, (Yuan-Chih Chang), Der-Hsien Lien, Tung Hsu, Chia-Seng Chang*  (2010)  Applied Physics Letters  97, 133105  "Resonance frequency shift of a carbon nanotube with a silver nanoparticle adsorbed at various positions"
  43. Wen YC, Hsieh CL, Lin KH, Chen HP, Chin SC, Hsiao CL, Lin YT, Chang CS, (Chang YC), Tu LW, Sun CK  (2009)  Physical review letters  103(26), 264301  "Specular scattering probability of acoustic phonons in atomically flat interfaces."
  44. Chin SC, (Chang YC), Chang CS  (2009)  Nanotechnology  20(28), 285307  "The fabrication of carbon nanotube probes utilizing ultra-high vacuum transmission electron microscopy."
  45. Yu-Wei Chang, Tzu-Ping Ko, Chien-Der Lee, (Yuan-Chih Chang), Kuai-Ann Lin, Chia-Seng Chang, Andrew H.-J. Wang, Ting-Fang Wang  (2009)  PLoS ONE  4, e4890  "Three new structures of left-handed RadA helical filaments: structural flexibility of N-terminal domain is critical for RadA’s recombinase activity"
  46. Shu-Cheng Chin, (Yuan-Chih Chang), Chen-Chih Hsu, Wei-Hsiang Lin, Chih-I Wu, Chia-Seng Chang, Tien-T Tsong, Wei-Yen Woon, Li-Te Lin and Hun-Jan-Tao  (2008-08)  NANOTECHNOLOGY  19(32), 325703  "Two-dimensional dopant profiling by electrostatic force microscopy using carbon nanotube modified cantilevers"
  47. (Chang YC), Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT  (2008)  SMALL  4(12), 2195-2198  "In situ tailoring and manipulation of carbon nanotubes."
  48. Shu-Cheng Chin, (Yuan-Chih Chang), Chia-Seng Chang, Wei-Yen Woon, Li-Te Lin, Hung-Jan Tao  (2008)  Applied Physics Letters  93, 253102  "Nanoscale doping fluctuation resolved by electrostatic force microscopy via the effect of surface band bending"
  49. Li-Tzu Chen, Tzu-Ping Ko, (Yuan-Chih Chang), Kuei-An Lin, Chia-Seng Chang, Andrew H.-J. Wang, Ting-Fang Wang  (2007)  Nucleic Acids Research  35, 1787-1801  "Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins"
  50. Ming-Hui Lee, (Yuan-Chih Chang), Eurie-L Hong, Jennifer Grubb, Chia-Seng Chang, Douglas-K Bishop and Ting-Fang Wang  (2006-01)  JOURNAL OF BIOLOGICAL CHEMISTRY  280(49), 40980  "Calcium Ion Promotes Yeast Dmc1 Activity via Formation of Long and Fine Helical Filaments with Single-stranded DNA"
  51. (Chang YC), Lo YH, Lee MH, Leng CH, Hu SM, Chang CS, Wang TF  (2005)  Biochemistry  44(16), 6052-6058  "Molecular visualization of the yeast Dmc1 protein ring and Dmc1-ssDNA nucleoprotein complex."
  52. Cheng-Che Chu, Gan-Lin Hwang, Jau-Wern Chiou, Way-Faung Pong, Cheng-Lan Lin, Chien-Ying Tsai, Hsiu-Mei Lin, (Yuan-Chih Chang), Chia-Seng Chang, Allen H. Hsu, Wu-Liang Huang, Jinghua Guo, Ping-Hei Chen, Tien-Yau Luh  (2005)  Advanced Materials  17(22), 2707-2710  "Polymerization of a confined π‐system: chemical synthesis of tetrahedral amorphous carbon nanoballs from graphitic carbon nanocapsules"
  53. Yi-Kai Chen, Chih-Hsing Leng, Heidi Olivares, Ming-Hui Lee, (Yuan-Chih Chang), Wen-Mei Kung, Shih-Chieh Ti, Yu-Hui Lo, Andrew H.-J. Wang, Chia-Seng Chang, Douglas K. Bishop, Yi-Ping Hsueh, Ting-Fang Wang  (2004)  Proceedings of the National Academy of Sciences of the United States of America  101, 10572-10577  "Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homologous juxtaposition and strand-assimilation"
  54. (Yuan-Chih Chang), Chia-Seng Chang, Dau Chung Wang, Ming-Hui Lee, Ting-Fang Wang, Mei-Yueh Wu, Tsu-Yi Fu and Tien T Tsong  (2004)  Japanese Journal of Applied Physics  43(7), 4517-4520  "Nanoscale Imaging of Biomolecules by Controlled Carbon Nanotube Probes"
  55. Ming-Hui Lee, Chih-Hsiang Leng, (Yuan-Chih Chang), Chia-Cheng Chou, Yi-Kai Chen, Fu-Fei Hsu, Chia-Seng Chang, Andrew H-J Wnag and Ting-Fang Wang  (2004)  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  323(3), 845-851  "Self-polymerization of archaeal RadA protein into long and fine helical filaments"
  56. (Yuan-Chih Chang), Dau-Chung Wang, Chia-Seng Chang and Tien T Tsong  (2003)  APPLIED PHYSICS LETTERS  82(20), 3541-3543  "Easy method to adjust the angle of the carbon nanotube probe of an atomic force microscope"

中研院學儀處, 冷凍電顯中心經理

  1. 冷凍電顯
  2. 原子力顯微鏡
  3. 超高真空電顯
  4. 奈米探針
經歷
  • 2021 – 迄今   研究副技師, 中研院生物化學研究所 / 學儀處
  • 2017 – 2020 研究副技師, 中研院細胞與個體生物學研究所 / 學儀處
  • 2011 – 2017 研究助技師, 中研院細胞與個體生物學研究所 / 學儀處
  • 2004 – 2010 博士後研究員, 中研院奈米科學實驗室@物理所
  • 1999 – 2003 研究助理, 中研院奈米科學實驗室@物理所
學歷
  • 1999 – 2004   博士, 工程科技研究所, 國立雲林科技大學
  • 1997 – 1999   碩士, 機械工程研究所, 國立雲林科技大學
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*
Nature Structural & Molecular Biology (2021)
Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu SD.
Proceedings of the National Academy of Sciences of the United States of America (2020)
Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD.
Journal of the American Chemical Society (2019)
Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD.
Journal of the American Chemical Society (2019)
Tsai CY, Chang YC, Lobato I, Van Dyck D, Chen FR.
Scientific Reports (2016)
Chen YS, Chang YC, Wang SC, Chen LY, Lien DH, Chen LJ, Chang CS.
Small (2012)
Chang YC, Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT.
Small (2008)
Chin SC, Chang YC, Chang CS, Woon WY, Lin LT, Tao HJ.
Applied Physics Letters (2008)
Chen YK, Leng CH, Olivares H, Lee MH, Chang YC, Kung WM, Ti SC, Lo YH, Wang AH, Chang CS, Bishop DK, Hsueh YP, Wang TF.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Chang YC, Wang DC, Chang CS, Tsong TT.
Applied Physics Letters (2003)
  1. Yang TJ, Yu PY, (Chang YC), Hsu STD*  (2021-10)  Journal of biological chemistry  297(4), 101238  "D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation"
  2. Su SC, Yang TJ, Yu PY, Liang KH, Chen WY, Yang CW, Lin HT, Wang MJ, Lu RM, Tso HC, Chung MJ, Hsieh TY, Chang YL, Lin SC, Hsu FY, Ke FY, Wu YH, Hwang YC, Liu IJ, Liang JJ, Liao CC, Ko HY, Sun CP, Wu PY, Jan JT, (Chang YC), Lin YL*, Tao MH*, Hsu STD*, Wu HC*  (2021-10)  PLOS PATHOGENS  17(10), e1009704  "Structure-guided antibody cocktail for prevention and treatment of COVID-19"
  3. Yang TJ, Yu PY, (Chang YC), Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*  (2021-09)  NATURE STRUCTURAL & MOLECULAR BIOLOGY  28(9), 731-739  "Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function"
  4. Tzu-Jing Yang, Pei-Yu Yu, (Yuan-Chih Chang), Ning-En Chang, Yu-Xi Tsai, Kang-Hao Liang, Piotr Draczkowski, Bertina Lin, Yong-Sheng Wang, Yu-Chun Chien, Kay-Hooi Khoo, Han-Chung Wu, and Shang-Te Danny Hsu  (2021-09)  bioRxiv  459978, 1-32  "Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants"
  5. (Chang YC), Chen CY, Tsai MD*  (2021-07)  Jove-Journal of Visualized Experiments  173, e62772  "Preparation of High Temperature Sample Grids for Cryo-EM"
  6. Even Chen, Bing-Mae Chen, Yu-Cheng Su, (Yuan-Chih Chang), Tian-Lu Cheng, Yechezekel Barenholz, and Steve Roffler  (2020-07)  ACS NANO  14(7),7808-7822  "Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex"
  7. Tzu-Jing Yang, Yen-Chen Chang, Tzu-Ping Ko, Piotr Draczkowski, Yu-Chun Chien, (Yuan-Chih Chang), Kuen-Phon Wu, Kay-Hooi Khoo, Hui-Wen Chang and Shang-Te Danny Hsu  (2020-01)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  117(3), 1438-1446  "Cryo-EM Analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans"
  8. Chin-Yu Chen, (Yuan-Chih CHANG), Bo-Lin Lin, Chun-Hsiang Huang and Ming-Daw Tsai  (2019-12)  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  141(51), 19983-19987  "Temperature-resolved Cryo-EM Uncovers Structural Bases of Temperature-dependent Enzyme Functions"
  9. Leon Chien-Wei Lin, Chen-Yu Huang, Bing-Yu Yao, Jung-Chen Lin, Anurodh Agrawal, Abdullah Algaissi, Bi-Hung Peng, Yu-Han Liu, Ping-Han Huang, Rong-Huay Juang, (Yuan-Chih Chang), Chien-Te Tseng, Hui-Wen Chen, and Che-Ming Jack Hu  (2019-07)  ADVANCED FUNCTIONAL MATERIALS  29(28), 1807616  "Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus"
  10. Ming-Shou Hsieh, (Yuan-Chih Chang), Jie-Long He, and Rong-Huay Juang  (2019-05)  VIRUS RESEARCH  265, 132-137  "Positive charge of Arg-201 on hemagglutinin is required for the binding of H6N1 avian influenza virus to its target through a two-step process"
  11. Chin-Yu Chen, (Yuan-Chih Chang) , Bo-Lin Lin, Kuan-Fu Lin , Chun-Hsiang Huang, Dong-Lin Hsieh, Tzu-Ping Ko , and Ming-Daw Tsai  (2019-04)  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  141(15), 6136-6140  "Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase"
  12. Yu-Han Liu, Shu-Chen Kuo, Bing-Yu Yao, Zih-Syun Fang, Yi-Tzu Lee, (Yuan-Chih Chang), Te-Li Chen, and Che-Ming Jack Hu  (2018-12)  ACTA BIOMATERIALIA  82, 133-142  "Colistin nanoparticle assembly by coacervate complexation with polyanionic peptides for treating drug-resistant gram-negative bacteria"
  13. Qiaofeng Jin, Chih-Yu Lin, (Yuan-Chih Chang) and Chih-Kuang Yeh  (2018-01)  Langmuir  34(4), 1256-1265  "Roles of Textural and Surface Properties of Nanoparticles in Ultrasound-Responsive Systems"
  14. Hui-Wen Chen, Zih-Syun Fang, You-Ting Chen, Yuan-I Chen, Bing-Yu Yao, Ju-Yun Cheng, Chen-Ying Chien, (Yuan-Chih Chang), and Che-Ming J. Hu  (2017-11)  ACS APPLIED MATERIALS & INTERFACES  9(46), 39953-39961  "Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection"
  15. En-Ling Chang, Chien-Yu Ting, Po-Hong Hsu, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, (Yuan-Chih Chang), Hong-Lin Chan,Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan, and Chih-Kuang Yeh  (2017-06)  Journal of Controlled Release  256, 1  "Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors"
  16. Qiaofeng Jin, Chih-Yu Lin, Shih-Tsung Kang, (Yuan-Chih Chang), Hairong Zheng, Chia-Min Yang, Chih-Kuang Yeh  (2017-05)  Ultrasonics Sonochemistry  36, 262-269  "Superhydrophobic Silica Nanoparticles as Ultrasound Contrast Agents"
  17. Bo-Lin Lin, Chin-Yu Chen, Chun-Hsiang Huang, Tzu-Ping Ko, Cheng-Hung Chiang, Kuan-Fu Lin, (Yuan-Chih Chang), Po-Yen Lin, Hui-Hsu Gavin Tsai, and Andrew H.-J. Wang  (2017-01)  PLOS ONE  12(1), e0169627  "The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA"
  18. Ching-Hsiang Fan, En-Ling Chang, Chien-Yu Ting, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, (Yuan-Chih Chang), Hong-Lin Chan, Kuo-Chen Wei, and Chih-Kuang Yeh  (2016-11)  Biomaterials  106, 46-57  "Folate-Conjugated Gene-Carrying Microbubbles with Focused Ultrasound for Concurrent Blood-Brain Barrier Opening and Local Gene Delivery"
  19. Bill Cheng, Elsie K. W. Toh, Kun-Hung Chen, (Yuan-Chih Chang), Che-Ming J. Hu, Han-Chung Wu, Lee-Young Chau, Peilin Chen, and Patrick C. H. Hsieh  (2016-10)  Advanced Healthcare Materials  5(20), 2686-2697  "Biomimicking Platelet–Monocyte Interactions as a Novel Targeting Strategy for Heart Healing"
  20. Qiaofeng Jin, Shih-Tsung Kang, (Yuan-Chih Chang), Hairong Zheng, Chih-Kuang Yeh  (2016-09)  ULTRASONICS SONOCHEMISTRY  32, 1-7  "Inertial cavitation initiated by polytetrafluoroethylene nanoparticles under pulsed ultrasound stimulation"
  21. Kuan-Yin Shen, Hsin-Yu Liu, Hui-Ju Li, Chiao-Chieh Wu, Gunn-Guang Liou, (Yuan-Chih Chang), Chih-Hsiang Leng, Shih-Jen Liu   (2016-07)  JOURNAL OF CONTROLLED RELEASE  233, 57-63  "A novel liposomal recombinant lipoimmunogen enhances anti-tumor immunity"
  22. Chun-Ying Tsai, (Yuan-Chih Chang), Ivan Lobato, Dirk Van Dyck and Fu-Rong Chen  (2016-06)  Scientific Reports  6, 27701  "Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins"
  23. Yi Ju Ho, (Yuan-Chih Chang), and Chih-Kuang Yeh  (2016-03)  Theranostics  6(3), 392-403  "Improving Nanoparticles Penetration in Solid Tumors by Vascular Disruption with Acoustic Droplet Vaporization"
  24. Shih-Chieh Su, Chien-Chu Lin, Hui-Chung Tai, Mu-yueh Chang, Meng-Ru Ho, Satheesan Babu, Jiahn-Haur Liao, Shih-Hsiung Wu, (Yuan-Chih Chang), Carmay Lim, and Chung-I Chang  (2016-03)  STRUCTURE  24, 676-686  "Structural basis for the magnesium-dependent activation and hexamerization of the Lon AAA+ protease"
  25. C. H. Fan, C. Y. Ting, C. Y. Lin, H. L. Chan, (Y. C. Chang), Y. Y. Chen, H. L. Liu and C. K. Yeh  (2016-01)  Scientific Reports  6, 19579  "Noninvasive, Targeted, and Non-viral Ultrasound-Mediated Gene Delivery for Parkinson's Disease Treatment"
  26. Ya-Ling Chiang, (Yuan-Chih Chang), I-Chen Chiang, Huey-Ming Mak, Ing-Shouh Hwang, Yu-Ling Shih  (2015-11)  PLoS One  10(11), e0142506  "Atomic force microscopy characterization of protein fibrils formed by the amyloidogenic region of the bacterial protein MinE on mica and a supported lipid bilayer"
  27. Ming-Yuan Su, Wen-Hsin Peng, Meng-Ru Ho, Shih-Chieh Su, (Yuan-Chih Chang), Guang-Chao Chen, and Chung-I Chang  (2015-09)  Autophagy  11(9), 1580-1593  "Structure of yeast Ape1 and its role in autophagic vesicle formation"
  28. Shih-Tsung Kang, Jian-Liang Lin, Chung-Hsin Wang, (Yuan-Chih Chang) and Chih-Kuang Yeh  (2015-07)  JOURNAL OF MATERIALS CHEMISTRY  3, 5938-5941  "Internal Polymer Scaffolding in Lipid-Coated Microbubbles for Control of Inertial Cavitation in Ultrasound Theranostics"
  29. Yu-Wen Huang, (Yuan-Chih Chang), Ruben Diaz-Avalos and Chih-Yen King  (2015-06)  Prion  9, 207-227  "W8, a New Sup35 Prion Strain, Transmits Distinctive Information with a Conserved Assembly Scheme"
  30. Yann-Wen Lan, Wen-Hao Chang, (Yuan-Chih Chang), Chia-Seng Chang and Chii-Dong Chen  (2015-02)  Nanotechnology  26, 055705  "Effect of focused ion beam deposition induced contamination on the transport properties of nano devices"
  31. Ching-Hsiang Fan, Chien-Yu Ting, (Yuan-Chih Chang), Kuo-Chen Wei, Hao-Li Liu, and Chih-Kuang Yeh  (2015-01)  Acta Biomaterialia  15, 89-101  "Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery"
  32. Yann-Wen Lan, Wen-Hao Chang, Yuan-Yao Li, (Yuan-Chih Chang), Chia-Seng Chang, and Chii-Dong Chen  (2014-09)  Applied Physics Letters  105(10), 1035505  "Stacking fault induced tunnel barrier in platelet graphite nanofiber"
  33. Chun-Han Ho, Hao-Ching Wang, Tzu-Ping Ko, (Yuan-Chih Chang), and Andrew H.-J. Wang  (2014-09)  Journal of Biological Chemistry  289, 27046-27054  "The T4 Phage DNA Mimic Protein Arn Inhibits the DNA-binding Activity of the Bacterial Histone-like Protein H-NS"
  34. Ming-Hsing Lin, (Yuan-Chih Chang), Chwan-Deng Hsiao, Shih-Hsun Huang, Min-Shi Wang, Yi-Ching Ko, Chih-Wei Yang, and Yuh-Ju Sun  (2013-12)  PLoS ONE  8(12), e83246  "LipL41, a Hemin Binding Protein from Leptospira santarosai serovar Shermani"
  35. Cheng Hui-Wen, (Chang Yuan-Chih), Tang Song-Nien, Yuan Chi-Tsu, Tang Jau, Tseng Fan-Gang  (2013-11)  Nanoscale Research Letters  8, 482  "Characterization of single 1.8-nm Au nanoparticle attachments on AFM tips for single sub-4-nm object pickup"
  36. Hui-Wen Cheng, (Yuan-Chih Chang), Chi-Tsu Yuan, Song-Nien Tang, Chia-Seng Chang, Jau Tang, Fu-Rong Chen, Rong-Long Pan, and Fan-Gang Tseng*   (2013-06)  The Journal of Physical Chemistry C  117(25), 13239-13246  "Simple and fast method to fabricate single-nanoparticle-terminated atomic force microscope tips"
  37. Ing-Shouh Hwang, Che-Cheng Chang, Chien-Hung Lu, Shih-Chin Liu, (Yuan-Chih Chang), Ting-Kuo Lee, Horng-Tay Jeng, Hong-Shi Kuo, Chun-Yueh Lin, Chia-Seng Chang and Tien T Tsong  (2013-04)  NEW JOURNAL OF PHYSICS  15, 043015  "Investigation of single-walled carbon nanotubes with a low-energy electron point projection microscope"
  38. Yu-Ming Chang, Cammy K. -M. Chen, (Yuan-Chih Chang), Wen-Yih Jeng, Ming-Hon Hou, and Andrew H. -J. Wang*  (2012-09)  PLoS ONE  7(9), e45665  "Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis"
  39. Yen-Song Chen, (Yuan-Chih Chang), Shau-Chieh Wang, Li-Ying Chen, Der-Hsien Lien, Lih-Juann Chen, and Chia-Seng Chang*  (2012)  SMALL  8, 2158-2162  "Critical Capillary Absorption of Current-Melted Silver Nanodroplets into Multiwalled Carbon Nanotubes"
  40. Yann-Wen Lan, Wen-Hao Chang, Shui-Jin Lai, (Yuan-Chih Chang), Cen-Shawn Wu, Chieh-Hsiung Kuan, Chia-Seng Chang, Chii-Dong Chen*  (2012)  CARBON  50, 4619-4627  "Effects of oxygen bonding on defective semiconducting and metallic single-walled carbon nanotube bundles "
  41. Lai WC, Chin SC, (Chang YC), Chen LY, Chang CS  (2010)  Nanotechnology  21(5), 055702  "Lattice-resolved frictional pattern probed by tailored carbon nanotubes."
  42. Shau-Chieh Wang, (Yuan-Chih Chang), Der-Hsien Lien, Tung Hsu, Chia-Seng Chang*  (2010)  Applied Physics Letters  97, 133105  "Resonance frequency shift of a carbon nanotube with a silver nanoparticle adsorbed at various positions"
  43. Wen YC, Hsieh CL, Lin KH, Chen HP, Chin SC, Hsiao CL, Lin YT, Chang CS, (Chang YC), Tu LW, Sun CK  (2009)  Physical review letters  103(26), 264301  "Specular scattering probability of acoustic phonons in atomically flat interfaces."
  44. Chin SC, (Chang YC), Chang CS  (2009)  Nanotechnology  20(28), 285307  "The fabrication of carbon nanotube probes utilizing ultra-high vacuum transmission electron microscopy."
  45. Yu-Wei Chang, Tzu-Ping Ko, Chien-Der Lee, (Yuan-Chih Chang), Kuai-Ann Lin, Chia-Seng Chang, Andrew H.-J. Wang, Ting-Fang Wang  (2009)  PLoS ONE  4, e4890  "Three new structures of left-handed RadA helical filaments: structural flexibility of N-terminal domain is critical for RadA’s recombinase activity"
  46. Shu-Cheng Chin, (Yuan-Chih Chang), Chen-Chih Hsu, Wei-Hsiang Lin, Chih-I Wu, Chia-Seng Chang, Tien-T Tsong, Wei-Yen Woon, Li-Te Lin and Hun-Jan-Tao  (2008-08)  NANOTECHNOLOGY  19(32), 325703  "Two-dimensional dopant profiling by electrostatic force microscopy using carbon nanotube modified cantilevers"
  47. (Chang YC), Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT  (2008)  SMALL  4(12), 2195-2198  "In situ tailoring and manipulation of carbon nanotubes."
  48. Shu-Cheng Chin, (Yuan-Chih Chang), Chia-Seng Chang, Wei-Yen Woon, Li-Te Lin, Hung-Jan Tao  (2008)  Applied Physics Letters  93, 253102  "Nanoscale doping fluctuation resolved by electrostatic force microscopy via the effect of surface band bending"
  49. Li-Tzu Chen, Tzu-Ping Ko, (Yuan-Chih Chang), Kuei-An Lin, Chia-Seng Chang, Andrew H.-J. Wang, Ting-Fang Wang  (2007)  Nucleic Acids Research  35, 1787-1801  "Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins"
  50. Ming-Hui Lee, (Yuan-Chih Chang), Eurie-L Hong, Jennifer Grubb, Chia-Seng Chang, Douglas-K Bishop and Ting-Fang Wang  (2006-01)  JOURNAL OF BIOLOGICAL CHEMISTRY  280(49), 40980  "Calcium Ion Promotes Yeast Dmc1 Activity via Formation of Long and Fine Helical Filaments with Single-stranded DNA"
  51. (Chang YC), Lo YH, Lee MH, Leng CH, Hu SM, Chang CS, Wang TF  (2005)  Biochemistry  44(16), 6052-6058  "Molecular visualization of the yeast Dmc1 protein ring and Dmc1-ssDNA nucleoprotein complex."
  52. Cheng-Che Chu, Gan-Lin Hwang, Jau-Wern Chiou, Way-Faung Pong, Cheng-Lan Lin, Chien-Ying Tsai, Hsiu-Mei Lin, (Yuan-Chih Chang), Chia-Seng Chang, Allen H. Hsu, Wu-Liang Huang, Jinghua Guo, Ping-Hei Chen, Tien-Yau Luh  (2005)  Advanced Materials  17(22), 2707-2710  "Polymerization of a confined π‐system: chemical synthesis of tetrahedral amorphous carbon nanoballs from graphitic carbon nanocapsules"
  53. Yi-Kai Chen, Chih-Hsing Leng, Heidi Olivares, Ming-Hui Lee, (Yuan-Chih Chang), Wen-Mei Kung, Shih-Chieh Ti, Yu-Hui Lo, Andrew H.-J. Wang, Chia-Seng Chang, Douglas K. Bishop, Yi-Ping Hsueh, Ting-Fang Wang  (2004)  Proceedings of the National Academy of Sciences of the United States of America  101, 10572-10577  "Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homologous juxtaposition and strand-assimilation"
  54. (Yuan-Chih Chang), Chia-Seng Chang, Dau Chung Wang, Ming-Hui Lee, Ting-Fang Wang, Mei-Yueh Wu, Tsu-Yi Fu and Tien T Tsong  (2004)  Japanese Journal of Applied Physics  43(7), 4517-4520  "Nanoscale Imaging of Biomolecules by Controlled Carbon Nanotube Probes"
  55. Ming-Hui Lee, Chih-Hsiang Leng, (Yuan-Chih Chang), Chia-Cheng Chou, Yi-Kai Chen, Fu-Fei Hsu, Chia-Seng Chang, Andrew H-J Wnag and Ting-Fang Wang  (2004)  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  323(3), 845-851  "Self-polymerization of archaeal RadA protein into long and fine helical filaments"
  56. (Yuan-Chih Chang), Dau-Chung Wang, Chia-Seng Chang and Tien T Tsong  (2003)  APPLIED PHYSICS LETTERS  82(20), 3541-3543  "Easy method to adjust the angle of the carbon nanotube probe of an atomic force microscope"