Manager of synthesis core facility (SCF), supporting users as follows:
- Various synthesized biomolecules as research stuffs, for example:
Oligonucleotides and their bioconjugates;
Glycan related to viral/bacterial infections;
Tumor-associated carbohydrate antigens (TACAs);
Probes of metabolites in natural products biosynthesis;
Tools to study targets of interest in chemistry and biology;
Other tailor-made synthesized molecules.
- High-end and well-maintained instruments including:
HPLC (Waters e2695, on-line reservation);
HPLC (Schimadzu Prominence-I LC-2030C 3D Plus, on-line reservation);
Polarimeter (JASCO P-2000, Na light source (589 nm) with temperature-controlled chip module, on-line reservation).
Synthesis of natural product or bacterial metabolites; strategy development to label intermediate of interest; design and synthesis of wash-free fluorescent probe; synthesis and purification of oligonucleotide-peptide conjugates (OPC) with varied linkers.
Synthesis and characterization of well-patterned sulfated sugars; Immobilization and NMR characterization of well-defined sulfated glycans on polyacrylic acid (PAA); Structure-guided synthesis of galectin inhibitors; Incorporation of BODIPY to thiodigalactoside as the fluorescent polarization (FP) probe for galectin binding assay: a better probe with bio-compatible, lifetime, stability and could be applied for cell-based experiments.
This is more like personal interest and I have managed labs for two PIs and involved in design and renovation of three labs.