研發各式串聯式質譜分析技術之應用於蛋白體、蛋白後修飾及醣質體的結構分析、定序與表現差異圖譜的鑑定,致力於提升技術平台的高效率、靈敏度與精確度,以期能更有效的切入探討其功能性。特別針對硫酸化醣質體、蛋白質醣化修飾及其他後修飾的有效鑑定及其於癌細胞與免疫細胞所影嚮的辨識作用、訊息傳遞與調控機制。
研究領域與專長
研發各式串聯式質譜分析技術之應用於蛋白體、蛋白後修飾及醣質體的結構分析、定序與表現差異圖譜的鑑定,致力於提升技術平台的高效率、靈敏度與精確度,以期能更有效的切入探討其功能性。特別針對硫酸化醣質體、蛋白質醣化修飾及其他後修飾的有效鑑定及其於癌細胞與免疫細胞所影嚮的辨識作用、訊息傳遞與調控機制。
學經歷
經歷
- 2012 – 迄今 特聘研究員, 中研院生化所
- 2017 – 2019 代理所長, 中研院生化所
- 2012 – 2017 副所長, 中研院生化所
- 2008 – 2012 研究員, 中研院生化所
- 1996 – 2008 副研究員, 中央研究院生物化學研究所
- 1994 – 1996 博士後研究員, 美國科羅拉多州立大學
- 1992 – 1994 博士後研究員, 英國倫敦大學帝國理工醫學院
學歷
- 1989 – 1992 博士, 帝國理工醫學院, 英國倫敦大學
- 1986 – 1989 學士, 帝國理工學院, 英國倫敦大學
主要著作
Glycobiology (2018)
Anal Chem (2017)
Mol Cell Proteomics (2017)
Mol Cell Proteomics (2016)
Anal Chem (2015)
J Biol Chem (2015)
Adv Neurobiol (2014)
Antioxid Redox Signal (2014)
Anal Chem (2014)
著作列表
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Kuo CW, Yang TJ, Chien YC, Yu PY, Hsu STD*, (Khoo KH)* (2022-01) Glycobiology 32(1), 60-72 "Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants."
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Tseng HC, Hsiao CT, Yamakawa N, Guerardel Y, (Khoo KH)* (2021-12) Frontiers in molecular biosciences 8, 771447 "Discovery Sulfoglycomics and Identification of the Characteristic Fragment Ions for High-Sensitivity Precise Mapping of Adult Zebrafish Brain-Specific Glycotopes."
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(Khoo KH) (2021-12) Nature Methods 18(12), 1457-1458 "Glycoproteomic software solutions spotlight glycans"
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Chen YJ, Yen TC, Lin YH, Chen YL, (Khoo KH), Chen YJ (2021-12) Analytical chemistry 93(48), 15931-15940 "ZIC-cHILIC-Based StageTip for Simultaneous Glycopeptide Enrichment and Fractionation toward Large-Scale N-Sialoglycoproteomics."
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Jung J, Enterina JR, Bui DT, Mozaneh F, Lin PH, Nitin, Kuo CW, Rodrigues E, Bhattacherjee A, Raeisimakiani P, Daskhan GC, St Laurent CD, (Khoo KH), Mahal LK, Zandberg WF, Huang X, Klassen JS, Macauley MS (2021-11) ACS chemical biology 16(11), 2673-2689 "Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands."
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Yamasaki F, Umezawa F, Sensui T, Anzo M, Abo H, Kuo CW, (Khoo KH), Kato K, Yagi H, Kawashima H (2021-11) Biochemical and biophysical research communications 579, 8-14 "Establishment of a novel monoclonal antibody against truncated glycoforms of alpha-dystroglycan lacking matriglycans."
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Li J, Wang D, Chang SC, Liang PH, Srivastava V, Guu SY, Shie JJ, (Khoo KH), Bulone V, Hsieh YSY (2021-03) Journal of Agricultural and Food Chemistry 69(11), 3371-3379 "Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli."
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(Khoo KH) (2021-02) Biochemical Society Transactions 49(1), 55-69 "A mass spectrometry-based glycotope-centric cellular glycomics is the more fruitful way forward to see the forest for the trees."
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Lin WD, Fan TC, Hung JT, Yeo HL, Wang SH, Kuo CW, (Khoo KH), Pai LM, Yu J, Yu AL (2021-01) Cancer Immunol Res. 9(1), 113-122 "Sialylation of CD55 by ST3GAL1 facilitates immune evasion in cancer."
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Delannoy C, Huang C, Coddeville B, Chen JY, Mouajjah D, Groux-Degroote S, Harduin-Lepers A, (Khoo KH), Guerardel Y, Elass-Rochard E (2020-08) Molecular omics 16(4), 345-354 "Mycobacterium bovis BCG infection alters the macrophage N-glycome."
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Lu HH, Lin SY, Weng RR, Juan YH, Chen YW, Hou HH, Hung ZC, Oswita GA, Huang YJ, Guu SY, (Khoo KH), Shih JY, Yu CJ, Tsai HC (2020-07) EBioMedicine 57, 102846 "Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma."
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Kuo CW, (Khoo KH) (2020-06) Analytical chemistry 92(11), 7612-7620 "Strategic applications of negative mode LC-MS/MS analyses to expedite confident mass spectrometry-based identification of multiple glycosylated peptides."
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Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, (Khoo KH), Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS, Hung MC (2020-06) Cancer research 80(11), 2298-2310 "Targeting glycosylated PD-1 induces potent anti-tumor immunity."
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Yu SY, Cheng CW, (Khoo KH) (2020-05) Bio-Protocol 10(10), e3618 "Negative Ion Mode nanoLC-ESI-MS/MS Analyses of Permethylated Sulfated Glycans."
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Yu SY, Snovida S, (Khoo KH) (2020-05) Bio-Protocol 10(10), e3617 "Permethylation and Microfractionation of Sulfated Glycans for MS Analysis."
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, (Khoo KH), Chang HW, Hsu STD (2020-01) Proceedings of the National Academy of Sciences of the United States of America 117(3), 1438-1446 "Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans."
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Wong KKL, Liu TW, Parker JM, Sinclair DAR, Chen YY, (Khoo KH), Vocadlo DJ, Verheyen EM (2020-01) Proceedings of the National Academy of Sciences of the United States of America 117(4), 2004-2013 "The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila."
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Lin CY, Lai HL, Chen HM, Siew JJ, Hsiao CT, Chang HC, Liao KS, Tsai SC, Wu CY, Kitajima K, Sato C, (Khoo KH), Chern Y (2019-08) Translational psychiatry 9(1), 209 "Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors."
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Khoo KH (2019-06) Current opinion in structural biology 56, 146-154 "Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity."
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Chang LY, Teppa E, Noel M, Gilormini PA, Decloquement M, Lion C, Biot C, Mir AM, Cogez V, Delannoy P, (Khoo KH), Petit D, Guerardel Y, Harduin-Lepers A (2019-02) International journal of molecular sciences 20(3), 622 "Novel Zebrafish Mono-alpha2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of alpha2,8-Sialylation."
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Yamakawa N, Vanbeselaere J, Chang LY, Yu SY, Ducrocq L, Harduin-Lepers A, Kurata J, Aoki-Kinoshita KF, Sato C, (Khoo KH), Kitajima K, Guerardel Y (2018-11) Nature communications 9(1), 4647 "Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns."
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Yu SY, Hsiao CT, Izawa M, Yusa A, Ishida H, Nakamura S, Yagi H, Kannagi R, (Khoo KH) (2018-09) The Journal of biological chemistry 293(39), 15163-15177 "Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis."
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Huang YL, Jhou BY, Chen SF, (Khoo KH) (2018-09) Analytical sciences 34(9), 1049-1054 "Identifying Specific and Differentially Linked Glycosyl Residues in Mammalian Glycans by Targeted LC-MS Analysis."
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Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, (Khoo KH), Hung MC (2018-08) Molecular cell 71(4), 606-620.e7 "Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1."
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Kuo CW, Guu SY, (Khoo KH) (2018-06) Journal of the American Society for Mass Spectrometry 29(6), 1166-1178 "Distinctive and Complementary MS(2) Fragmentation Characteristics for Identification of Sulfated Sialylated N-Glycopeptides by nanoLC-MS/MS Workflow."
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Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, (Khoo KH), Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC (2018-05) Nature communications 9(1), 1908 "STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion."
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Yu CH, Chou CC, Tu HF, Huang WC, Ho YY, (Khoo KH), Lee MS, Chang GD (2018-04) Oncotarget 9(30), 21512-21529 "Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase."
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Yu CH, Chou CC, Lee DY, (Khoo KH), Chang GD (2018-04) Bioscience reports 38(2), BSR20171717 "Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives."
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Moginger U, Grunewald S, Hennig R, Kuo CW, Schirmeister F, Voth H, Rapp E, (Khoo KH), Seeberger PH, Simon JC, Kolarich D (2018-03) Frontiers in oncology 8, 70 "Alterations of the Human Skin N- and O-Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma."
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Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, (Khoo KH), Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC (2018-02) Cancer cell 33(2), 187-201.e10 "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1."
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Chen JY, Huang HH, Yu SY, Wu SJ, Kannagi R and (Khoo KH)* (2018-01) Glycobiology 28(1), 9-20 "Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes."
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Hsiao CT, Wang PW, Chang HC, Chen YY, Wang SH, Chern Y and (Khoo KH)* (2017-12) Molecular Cellular Proteomics 16(12), 2268-2280 "Advancing a high throughput glycotope-centric glycomics workflow based on nanoLC-MS2-product dependent-MS3 analysis of permethylated glycans."
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Hsiao CT, Cheng HW, Huang CM, Li HR, Ou MH, Huang JR, (Khoo KH), Yu HW, Chen YQ, Wang YK, Chiou A, Kuo JC (2017-09) Oncotarget 8(41), 70653-70668 "Fibronectin in cell adhesion and migration via N-glycosylation."
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Pan KT, Chen CC, Urlaub H, (Khoo KH)* (2017-04) Analytical chemistry 89(8), 4532-4539 "Adapting data-independent acquisition for mass spectrometry-based protein site-specific N-glycosylation analysis."
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Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, (Khoo KH), Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DF (2017-04) Glycobiology 27(4), 280-284 "The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data."
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Yagi H, Kuo CW, Obayashi T, Ninagawa S, (Khoo KH)*, Kato K* (2016-11) MOLECULAR & CELLULAR PROTEOMICS 15(11), 3424-3434 "Direct mapping of additional modifications on phosphorylated O-glycans of alpha-dystroglycan by mass spectrometry analysis in conjunction with knocking out of causative genes for dystroglycanopathy."
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Hsu MF, Pan KT, Chang FY, (Khoo KH), Urlaub H, Cheng CF, Chang GD, Haj FG and Meng TC (2016-10) Free Radical Biology and Medicine 99, 199-213 "S-Nitrosylation of Endogenous Protein Tyrosine Phosphatases in Endothelial Insulin Signaling"
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Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, (Khoo KH), Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C (2016-09) Glycobiology 26(9), 907-910 "The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets."
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Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, (Khoo KH), Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC (2016-08) Nature communications 7, 12632 "Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity."
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Wu JL, Wu HY, Tsai DY, Chiang MF, Chen YJ, Gao S, Lin CC, Lin CH, (Khoo KH), Chen YJ, Lin KI (2016-08) Nature communications 7, 12526 "Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells."
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Yeh SC, Wang PY, Lou YW, (Khoo KH), Hsiao M, Hsu TL, Wong CH (2016-05) Proceedings of the National Academy of Sciences of the United States of America 113(20), 5592-5597 "Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity."
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Mabashi-Asazuma H, Sohn BH, Kim YS, Kuo CW, (Khoo KH), Kucharski CA, Fraser MJ Jr, Jarvis DL (2015-7) Insect biochemistry and molecular biology 65, 20-27 "Targeted glycoengineering extends the protein N-glycosylation pathway in the silkworm silk gland."
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Hsieh YC, Chen YM, Li CY, Chang YH, Liang SY, Lin SY, Lin CY, Chang SH, Wang YJ, (Khoo KH), Aoki T, Wang HC (2015-6) Developmental and comparative immunology 53(1), 85-95 "To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1alpha pathway."
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Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kannagi R, (Khoo KH), Paulson JC* (2015-12) The Journal of Biological Chemistry 290(50), 30066-30077 "Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man."
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Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL (2015-10) ACS chemical biology 10(10), 2199-2208 "Modifying an Insect Cell N-Glycan Processing Pathway Using CRISPR-Cas Technology."
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Lin HC, Ho SC, Chen YY, (Khoo KH), Hsu PH, Yen HC (2015-07) Science 349(6243), 91-95 "CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding."
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Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, (Khoo KH), Chang GD, Wu CW, Meng TC, Chen GC (2015-07) Oncogene 34(29), 3791-3803 "Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation."
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Cheng CW, Chou CC, Hsieh HW, Tu Z, Lin CH, Nycholat CM, Fukuda M, (Khoo KH)* (2015-06) Analytical chemistry 87(12), 6380-6388 "Efficient mapping of sulfated glycotopes by negative ion mode nanoLC-MS/MS-based sulfoglycomic analysis of permethylated glycans."
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Yu CH, Chou CC, Lee YJ, (Khoo KH), Chang GD (2015-03) Amino acids 47(3), 469-481 "Uncovering protein polyamination by the spermine-specific antiserum and mass spectrometric analysis."
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Chou CC, Chiang BY, Lin JC, Pan KT, Lin CH, (Khoo KH)* (2015-01) Journal of the American Society for Mass Spectrometry 26(1), 120-132 "Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein s-glutathionylation."
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Geisler C, Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL (2015-01) Journal of biotechnology 193, 52-65 "Engineering beta1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells."
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Lo HJ, Chu WL, Liou CH, Huang SH, (Khoo KH), Yang YL (2015-01) International journal of medical microbiology : IJMM 305(1), 170-173 "Ndt80p is involved in l-sorbose utilization through regulating SOU1 in Candida albicans."
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Chen YJ, Ching WC, Chen JS, Lee TY, Lu CT, Chou HC, Lin PY, (Khoo KH), Chen JH, Chen YJ (2014-11) Journal of proteome research 13(11), 4942-4958 "Decoding the S-nitrosoproteomic Atlas in Individualized Human Colorectal Cancer Tissues Using a Label-free Quantitation Strategy."
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Kaur D, Angala SK, Wu SW, (Khoo KH), Chatterjee D, Brennan PJ, Jackson M, McNeil MR (2014-10) The Journal of biological chemistry 289(44), 30249-30256 "A Single Arabinan Chain Is Attached to the Phosphatidylinositol Mannosyl Core of the Major Immunomodulatory Mycobacterial Cell Envelope Glycoconjugate, Lipoarabinomannan."
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Huang IH, Hsiao CT, Wu JC, Shen RF, Liu CY, Wang YK, Chen YC, Huang CM, Del Alamo JC, Chang ZF, Tang MJ, (Khoo KH), Kuo JC (2014-10) Journal of cell science 127(19), 4186-4200 "GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment."
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Lin JC, Chou CC, Tu Z, Yeh LF, Wu SC, (Khoo KH), Lin CH (2014-08) Journal of proteome research 13(8), 3523-3529 "Characterization of Protein Serotonylation via Bioorthogonal Labeling and Enrichment."
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Toth AM, Kuo CW, (Khoo KH), Jarvis DL (2014-07) Journal of biotechnology 182-183, 19-29 "A new insect cell glycoengineering approach provides baculovirus-inducible glycogene expression and increases human-type glycosylation efficiency."
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Liang SY, Wu SW, Pu TH, Chang FY, (Khoo KH) (2014-07) Bioinformatics 30(13), 1908-1916 "An Adaptive Workflow Coupled with Random Forest Algorithm to Identify Intact N-glycopeptides Detected from Mass Spectrometry."
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Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, (Khoo KH), Chang GD, Lo CF, Wang HC (2014-07) PLoS pathogens 10(6), e1004196 "An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway."
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Wang YM, Tsai IH, Chen JM, Cheng AC, (Khoo KH) (2014-06) PloS one 9(6), e100354 "Correlation between the Glycan Variations and Defibrinogenating Activities of Acutobin and Its Recombinant Glycoforms."
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Wu SW, Pu TH, Viner R, (Khoo KH) (2014-06) Analytical Chemistry 86(11), 5478-5486 "Novel LC-MS(2) Product Dependent Parallel Data Acquisition Function and Data Analysis Workflow for Sequencing and Identification of Intact Glycopeptides."
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York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, (Khoo KH), Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C (2014-05) Glycobiology 24(5), 402-406 "MIRAGE: The minimum information required for a glycomics experiment."
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Tsai CM, Wu HY, Su TH, Kuo CW, Huang HW, Chung CH, Chen CS, (Khoo KH), Chen YJ, Lin KI (2014-05) Journal of proteomics 103C, 241-253 "Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling."
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Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL (2014-03) Glycobiology 24(3), 325-340 "A novel baculovirus vector for the production of nonfucosylated recombinant glycoproteins in insect cells."
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Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, Meng TC, (Khoo KH) (2014-03) Antioxidants & redox signaling 20(9), 1365-1381 "Mass Spectrometry-Based Quantitative Proteomics for Dissecting Multiplexed Redox Cysteine Modifications in Nitric Oxide-Protected Cardiomyocyte Under Hypoxia."
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Lou YW, Wang PY, Yeh SC, Chuang PK, Li ST, Wu CY, (Khoo KH), Hsiao M, Hsu TL, Wong CH (2014-02) Proceedings of the National Academy of Sciences of the United States of America 111(7), 2482-2487 "Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers."
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Lin CH, Kuo CW, Jarvis DL, (Khoo KH) (2014-01) Proteomics 14(1), 87-92 "Facile removal of high mannose structures prior to extracting complex type N-glycans from de-N-glycosylated peptides retained by C18 solid phase to allow more efficient glycomic mapping."
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(Khoo KH) (2014) Advances in neurobiology 9, 129-164 "From mass spectrometry-based glycosylation analysis to glycomics and glycoproteomics."
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Aoki-Kinoshita KF, Sawaki H, An HJ, Campbell M, Cao Q, Cummings R, Hsu DK, Kato M, Kawasaki T, (Khoo KH), Kim J, Kolarich D, Li X, Liu M, Matsubara M, Okuda S, Packer NH, Ranzinger R, Shen H, Shikanai T, Shinmachi D, Toukach P, Yamada I, Yamaguchi Y, Yang P, Ying W, Yoo JS, Zhang Y, Zhang Y, Narimatsu H (2013-12) Glycobiology 23(12), 1422-1424 "The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository."
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Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, (Khoo KH), Oka S, Kato K (2013-11) Scientific Reports 3, 3288 "AGO61-dependent GlcNAc modification primes the formation of functional glycans on alpha-dystroglycan."
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Sugihara K, Shibata TK, Takata K, Kimura T, Kanayama N, Williams R, Hatakeyama S, Akama TO, Kuo CW, (Khoo KH), Fukuda MN (2013-10) FEBS letters 587(19), 3195-3201 "Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans."
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Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, (Khoo KH), Wu SH (2013-10) Molecular & cellular proteomics : MCP 12(10), 2701-2713 "Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27."
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Loo CS, Chen CW, Wang PJ, Chen PY, Lin SY, (Khoo KH), Fenton RA, Knepper MA, Yu MJ (2013-10) Proceedings of the National Academy of Sciences of the United States of America 110(42), 17119-17124 "Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells."
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Lu YW, Chien CW, Lin PC, Huang LD, Chen CY, Wu SW, Han CL, (Khoo KH), Lin CC, Chen YJ (2013-09) Analytical chemistry 85(17), 8268-8276 "BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichment of Glycoproteins."
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Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, (Khoo KH), Rosen SD (2013-09) The Journal of biological chemistry 288(37), 26533-26545 "Galactose-6-O-Sulfotransferases Are Not Required for the Generation of Siglec-F Ligands in Leukocytes or Lung Tissue."
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Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, (Khoo KH), Lin CH, Hsu HY, Wu CY, Wong CH (2013-08) Proceedings of the National Academy of Sciences of the United States of America 110(34), 13809-13814 "Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes."
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Cheng PF, Snovida S, Ho MY, Cheng CW, Wu AM, (Khoo KH) (2013-08) Analytical and bioanalytical chemistry 405(21), 6683-6695 "Increasing the depth of mass spectrometry-based glycomic coverage by additional dimensions of sulfoglycomics and target analysis of permethylated glycans."
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Wang SH, Tsai CM, Lin KI, (Khoo KH) (2013-06) Glycobiology 23(6), 677-689 "Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins."
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Wu SW, Liang SY, Pu TH, Chang FY, (Khoo KH) (2013-06) Journal of proteomics 84, 1-16 "Sweet-Heart - an integrated suite of enabling computational tools for automated MS2/MS3 sequencing and identification of glycopeptides."
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Lin JC, Chou CC, Gao S, Wu SC, (Khoo KH), Lin CH (2013-05) Chembiochem : a European journal of chemical biology 14(7), 813-817 "An in vivo tagging method reveals that Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation."
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Chang YC, Tang HW, Liang SY, Pu TH, Meng TC, (Khoo KH), Chen GC (2013-05) Journal of proteome research 12(5), 2138-2150 "Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation."
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Suzuki N, Nawa D, Su TH, Lin CW, (Khoo KH), Yamamoto K (2013-03) PloS one 8(3), e59291 "Distribution of the Galbeta1-4Gal Epitope among Birds: Species-Specific Loss of the Glycan Structure in Chicken and Its Relatives."
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Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjo L, Sakuma K, Uchimura K, (Khoo KH), Kannagi R, Rosen SD (2013-03) Glycobiology 23(3), 381-394 "KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing."
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Mabashi-Asazuma H, Shi X, Geisler C, Kuo CW, (Khoo KH), Jarvis DL (2013-02) Glycobiology 23(2), 199-210 "Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells."
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Suzuki-Anekoji M, Suzuki A, Wu SW, Angata K, Murai KK, Sugihara K, Akama TO, (Khoo KH), Nakayama J, Fukuda MN, Fukuda M (2013-02) The Journal of biological chemistry 288(7), 5007-5016 "In vivo regulation of steroid hormones by the chst10 sulfotransferase in mouse."
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Aoki-Kinoshita KF, Sawaki H, An HJ, Cho JW, Hsu D, Kato M, Kawano S, Kawasaki T, (Khoo KH), Kim J, Kim JD, Li X, Lutteke T, Okuda S, Packer NH, Paulson JC, Raman R, Ranzinger R, Shen H, Shikanai T, Yamada I, Yang P, Yamaguchi Y, Ying W, Yoo JS, Zhang Y, Narimatsu H (2013-02) Glycobiology 23(2), 144-146 "The Third ACGG-DB Meeting Report: Towards an international collaborative infrastructure for glycobioinformatics."
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Yu SY, Chang LY, Cheng CW, Chou CC, Fukuda MN, (Khoo KH) (2013-01) Glycoconjugate journal 30(2), 183-194 "Priming mass spectrometry-based sulfoglycomic mapping for identification of terminal sulfated lacdiNAc glycotope."
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Gupta V, Bhinge KN, Hosain SB, Xiong K, Gu X, Shi R, Ho MY, (Khoo KH), Li SC, Li YT, Ambudkar SV, Jazwinski SM, Liu YY (2012-10) The Journal of biological chemistry 287(44), 37195-37205 "Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells."
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Tsai IH, Chang HC, Chen JM, Cheng AC, (Khoo KH) (2012-08) The FEBS journal 279(15), 2672-2682 "Glycan structures and intrageneric variations of venom acidic phospholipases A(2) from Tropidolaemus pitvipers."
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Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, (Khoo KH), Lin CH (2012-06) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51(24), 5871-5875 "In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method."
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Shibata TK, Matsumura F, Wang P, Yu S, Chou CC, (Khoo KH), Kitayama K, Akama TO, Sugihara K, Kanayama N, Kojima-Aikawa K, Seeberger PH, Fukuda M, Suzuki A, Aoki D, Fukuda MN (2012) The Journal of biological chemistry 287(9), 6592-6602 "Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer."
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Coddeville B, Wu SW, Fabre E, Brassart C, Rombouts Y, Burguiere A, Kremer L, (Khoo KH), Elass-Rochard E, Guerardel Y (2012) Journal of proteomics 75(18), 5695-5705 "Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue."
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Vanbeselaere J, Chang LY, Harduin-Lepers A, Fabre E, Yamakawa N, Slomianny C, Biot C, (Khoo KH), Guerardel Y (2012) Journal of proteome research 11(4), 2164-2177 "Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies."
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Kuo-Yuan Hwa, Boopathi Subramani and (Kay-Hooi Khoo) (2012) SOFT COMPUTING 16(3), 381-391 "Putative xylosyltransferase genes in Trichomonas vaginalis"
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Kuo CW, Wu IL, Hsiao HH, (Khoo KH) (2012) Analytical and bioanalytical chemistry 402(9), 2765-2776 "Rapid glycopeptide enrichment and N-glycosylation site mapping strategies based on amine-functionalized magnetic nanoparticles."
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Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, (Khoo KH), Shen CN, Yu J (2011-12) Stem Cells 29(12), 1995-2004 "Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages."
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Lai YC, Pan KT, Chang GF, Hsu CH, (Khoo KH), Hung CH, Jiang YJ, Ho FM, Meng TC (2011-12) Circulation research 109(12), 1375-1386 "Nitrite-Mediated S-Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction."
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Wang CL, Pi CC, Kuo CW, Zhuang YJ, (Khoo KH), Liu WH, Chen CJ (2011-11) Biotechnology letters 33(11), 2271-2278 "Polysaccharides purified from the submerged culture of Ganoderma formosanum stimulate macrophage activation and protect mice against Listeria monocytogenes infection."
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Poh-Choo Pang*, Philip C. N. Chiu*, Cheuk-Lun Lee, Lan-Yi Chang, Maria Panico, Howard R. Morris, Stuart M. Haslam, (Kay-Hooi Khoo), Gary F. Clark, William S. B. Yeung, Anne Dell (2011-09) Science 333(6050), 1761-1764 "Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida"
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Li YT, Li SC, Buck WR, Haskins ME, Wu SW, (Khoo KH), Sidransky E, Bunnell BA (2011-09) Neurochemical research 36(9), 1612-1622 "Selective Extraction and Effective Separation of Galactosylsphingosine (Psychosine) and Glucosylsphingosine from Other Glycosphingolipids in Pathological Tissue Samples."
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Wang SH, Wu SW, (Khoo KH) (2011-07) Proteomics 11(14), 2812-2829 "MS-based glycomic strategies for probing the structural details of polylactosaminoglycan chain on N-glycans and glycoproteomic identification of its protein carriers."
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Liu YC, Yen HY, Chen CY, Chen CH, Cheng PF, Juan YH, Chen CH, (Khoo KH), Yu CJ, Yang PC, Hsu TL, Wong CH (2011-07) Proceedings of the National Academy of Sciences of the United States of America 108(28), 11332-11337 "Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells."
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Yeh YY, Shah KH, Chou CC, Hsiao HH, Wrasman KM, Stephan JS, Stamatakos D, (Khoo KH), Herman PK (2011-07) Autophagy 7(7), 716-726 "The identification and analysis of phosphorylation sites on the Atg1 protein kinase."
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Tsai HY, Boonyapranai K, Sriyam S, Yu CJ, Wu SW, (Khoo KH), Phutrakul S, Chen ST (2011-06) Proteomics 11(11), 2162-2170 "Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer."
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Kobayashi M, Mitoma J, Hoshino H, Yu SY, Shimojo Y, Suzawa K, (Khoo KH), Fukuda M, Nakayama J (2011-05) JOURNAL OF PATHOLOGY 224(1), 67-77 "Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma."
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Lin CW, Chen JM, Wang YM, Wu SW, Tsai IH, (Khoo KH) (2011-04) Glycobiology 21(4), 530-542 "Terminal disialylated multiantennary complex-type N-glycans carried on acutobin define the glycosylation characteristics of the Deinagkistrodon acutus venom."
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Huang KY, Chen GD, Cheng CH, Liao KY, Hung CC, Chang GD, Hwang PP, Lin SY, Tsai MC, (Khoo KH), Lee MT, Huang CJ (2011) PloS one 6(10), e26461 "Phosphorylation of the Zebrafish M6Ab at Serine 263 Contributes to Filopodium Formation in PC12 Cells and Neurite Outgrowth in Zebrafish Embryos."
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Chen YJ, Ku WC, Lin PY, Chou HC, (Khoo KH), Chen YJ (2010-12) Journal of proteome research 9(12), 6417-6439 "S-alkylating labeling strategy for site-specific identification of the s-nitrosoproteome."
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Liang YJ, Kuo HH, Lin CH, Chen YY, Yang BC, Cheng YY, Yu AL, (Khoo KH), Yu J (2010-12) Proceedings of the National Academy of Sciences of the United States of America 107(52), 22564-22569 "Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation."
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Lee SH, Yu SY, Nakayama J, (Khoo KH), Stone EL, Fukuda MN, Marth JD, Fukuda M (2010-11) JOURNAL OF BIOLOGICAL CHEMISTRY 285(48), 37683-37692 "Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation."
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Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Backstrom M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, (Khoo KH), Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N (2010-04) MOLECULAR & CELLULAR PROTEOMICS 9(4), 719-727 "Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1."
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Yagi H, Yamamoto M, Yu SY, Takahashi N, (Khoo KH), Lee YC, Kato K (2010-02) Carbohydrate research 345(3), 442-448 "N-Glycosylation profiling of turtle egg yolk: expression of galabiose structure."
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(Khoo KH), Yu SY (2010) Methods in enzymology 478, 3-26 "Mass spectrometric analysis of sulfated N- and O-glycans."
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Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH. (2009-12) MOLECULAR & CELLULAR PROTEOMICS 8(12), 2613-2623 "Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence."
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Lee SH, Hatakeyama S, Yu SY, Bao X, Ohyama C, Khoo KH, Fukuda MN, Fukuda M (2009) The Journal of biological chemistry 284(25), 17157-17169 "Core3 O-Glycan Synthase Suppresses Tumor Formation and Metastasis of Prostate Carcinoma PC3 and LNCaP Cells through Down-regulation of {alpha}2{beta}1 Integrin Complex."
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Hsiao ES, Chen JC, Tsai HY, Khoo KH, Chen ST, Tzen JT (2009) Journal of agricultural and food chemistry 57(15), 6757-6763 "Determination of N-Glycosylation Site and Glycan Structures of Pectin Methylesterase in Jelly Fig (Ficus awkeotsang) Achenes."
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Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guerardel Y (2009) Glycoconjugate journal 26(3), 247-261 "Developmental regulation of oligosialylation in zebrafish."
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Yu SY, Wu SW, Hsiao HH, Khoo KH (2009) Glycobiology 19(10), 1136-1149 "Enabling techniques and strategic workflow for sulfoglycomics based on mass spectrometry mapping and sequencing of permethylated sulfated glycans."
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Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, Yu LC, Khoo KH (2009) Glycobiology 19(4), 418-427 "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
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Wang CC, Chen JR, Tseng YC, Hsu CH, Hung YF, Chen SW, Chen CM, Khoo KH, Cheng TJ, Cheng YS, Jan JT, Wu CY, Ma C, Wong CH (2009) Proceedings of the National Academy of Sciences of the United States of America 106(43), 18137-18142 "Glycans on influenza hemagglutinin affect receptor binding and immune response."
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C. W. Kuo, C. M. Chen, Y. C. Lee, S. T. Chu and K. H. Khoo (2009) Mol Cell Proteomics 8(2), 325-42 "Glycomic and proteomic analyses of mouse uterine luminal fluid revealed a predominance of Lewis Y and X epitopes on specific protein carriers"
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Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T (2009) Glycobiology 19(4), 437-450 "Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26 (DPPVI) isolated from a human colorectal carcinoma cell line, SW1116."
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Yu SY, Yang Z, Khoo KH, Wu AM (2009) Proteomics 9(13), 3445-3462 "Identification of blood group A/A-Leb/y and B/B-Leb/y active glycotopes co-expressed on the O-glycans isolated from two distinct human ovarian cyst fluids."
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Suzuki N, Su TH, Wu SW, Yamamoto K, Khoo KH, Lee YC (2009) Glycobiology 19(7), 693-706 "Structural analysis of N-glycans from gull egg white glycoproteins and egg yolk IgG."
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Garenaux E, Yu SY, Florea D, Strecker G, Khoo KH, Guerardel Y (2008) Glycoconjugate journal 25(9), 903-915 "A single step method for purification of sulfated oligosaccharides."
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Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC (2008) The Journal of biological chemistry 283(50), 35265-72 "Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation."
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Yu SY, Khoo KH, Yang Z, Herp A, Wu AM (2008) Glycoconjugate journal 25(3), 199-212 "Glycomic mapping of O- and N-linked glycans from major rat sublingual mucin."
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Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo (2008) J Biol Chem 283(24), 16455-16468 "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
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Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ (2008) Journal of proteome research 7(9), 4058-4069 "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics."
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Chen HS, Chen JM, Lin CW, Khoo KH, Tsai IH (2008) The FEBS journal 275(15), 3944-58 "New insights into the functions and N-glycan structures of factor X activator from Russell's viper venom."
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Lin SY, Chen YY, Fan YY, Lin CW, Chen ST, Wang AH, Khoo KH (2008) Journal of proteome research 7(8), 3293-303 "Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics."
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C. H. Lin, C. W. Lin and K. H. Khoo (2008) Proteomics 8(3), 475-483 "Proteomic identification of specific glycosyltransferases functionally implicated for the biosynthesis of a targeted glyco-epitope"
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Y. W. Lou, Y. Y. Chen, S. F. Hsu, R. K. Chen, C. L. Lee, K. H. Khoo, N. K. Tonks and T. C. Meng (2008) FEBS J 275(1), 69-88 "Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells"
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Chen VC, Chou CC, Hsieh HY, Perreault H, Khoo KH (2008) JOURNAL OF MASS SPECTROMETRY 43(12), 1649-1658 "Targeted identification of phosphorylated peptides by off-line HPLC-MALDI-MS/MS using LC retention time prediction."
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Yagi H, Yasukawa N, Yu SY, Guo CT, Takahashi N, Takahashi T, Bukawa W, Suzuki T, Khoo KH, Suzuki Y and Kato K. (2008) CARBOHYDRATE RESEARCH 343(8), 1373-1377 "The expression of sialylated high-antennary N-glycans in edible bird's nest."
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Bhamidi S, Scherman MS, Rithner CD, Prenni JE, Chatterjee D, Khoo KH, McNeil MR (2008) The Journal of biological chemistry 283(19), 12992-3000 "The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan."
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Shi L, Zhou R, Liu Z, Lowary TL, Seeberger PH, Stocker BL, Crick DC, Khoo KH, Chatterjee D (2008) Journal of bacteriology 190(15), 5248-55 "Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability."
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Ying-Che Chang, Shu-Yu Lin, Suh-Yuen Liang, Kuan-Ting Pan, Chi-Chi Chou, Chien-Hung Chen, Chung-Ling Liao, Kay-Hooi Khoo and Tzu-Ching Meng (2008) J Proteome Res 7(3), 1055-1066 "Tyrosine Phosphoproteomics and Identification of Substrates of Protein Tyrosine Phosphatase dPTP61F in Drosophila S2 Cells by Mass Spectrometry-Based Substrate Trapping Strategy"
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M. Sutton-Smith, N. K. Wong, K. H. Khoo, S. W. Wu, S. Y. Yu, M. S. Patankar, R. Easton, F. A. Lattanzio, H. R. Morris, A. Dell and G. F. Clark (2007) Glycobiology 17(6), 553-567 "Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system"
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J. Zhang, K. H. Khoo, S. W. Wu and D. Chatterjee (2007) J Am Chem Soc 129(31), 9650-9662 "Characterization of a Distinct Arabinofuranosyltransferase in Mycobacterium smegmatis"
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Y. Wada, P. Azadi, C. E. Costello, A. Dell, R. A. Dwek, H. Geyer, R. Geyer, K. Kakehi, N. G. Karlsson, K. Kato, N. Kawasaki and K. H. Khoo et. al. (2007) Glycobiology 17(4), 411-422 "Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study."
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H. H. Hsiao, H. Y. Hsieh, C. C. Chou, S. Y. Lin, A. H. Wang and K. H. Khoo (2007) J Proteome Res 6(4), 1313-1324 "Concerted Experimental Approach for Sequential Mapping of Peptides and Phosphopeptides Using C18-Functionalized Magnetic Nanoparticles"
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Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, Fukuda M (2007) Nature immunology 8(4), 409-418 "Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment."
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Wu AM, Khoo KH, Yu SY, Yang Z, Kannagi R, Watkins WM (2007) Proteomics 7(20), 3699-3717 "Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins: identification of Lewis and sialyl Lewis glycotopes."
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Y. Y. Chen, Y. F. Huang, K. H. Khoo and T. C. Meng (2007) Methods 42(3), 243-249 "Mass spectrometry-based analyses for identifying and characterizing S-nitrosylation of protein tyrosine phosphatases"
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D. Kaur, M. R. McNeil, K. H. Khoo, D. Chatterjee, D. C. Crick, M. Jackson and P. J. Brennan (2007) J Biol Chem 282(37), 27133-27140 "New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene"
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Yu SY, Wu SW, Khoo KH (2006) Glycoconjugate journal 23(5-6), 355-369 "Distinctive characteristics of MALDI-Q/TOF and TOF/TOF tandem mass spectrometry for sequencing of permethylated complex type N-glycans."
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Guerardel Y, Chang LY, Maes E, Huang CJ, Khoo KH (2006) Glycobiology 16(3), 244-257 "Glycomic survey mapping of zebrafish identifies unique sialylation pattern."
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K. Kitajima, K. H. Khoo and S. I. Hakomori (2006) GLYCOCONJUGATE JOURNAL 23(5-6), 273-276 "Introduction. Professor Yasuo Inoue: 1934-2005"
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Wang HL, Yeh KW, Chen PR, Chang CH, Chen JM, Khoo KH (2006) Bioscience Biotechnology and Biochemistry 70(2), 551-553 "Isolation and characterization of a pure mannan from Oncidium (cv. Gower Ramsey) current pseudobulb during initial inflorescence development."
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A. Lee, S. W. Wu, M. S. Scherman, J. B. Torrelles, D. Chatterjee, M. R. McNeil and K. H. Khoo (2006) Biochemistry 45(51), 15817-15828 "Sequencing of Oligoarabinosyl Units Released from Mycobacterial Arabinogalactan by Endogenous Arabinanase: Identification of Distinctive and Novel Structural Motifs"
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L. Shi, S. Berg, A. Lee, J. S. Spencer, J. Zhang, V. Vissa, M. R. McNeil, K. H. Khoo and D. Chatterjee (2006) J Biol Chem 281(28), 19512-19526 "The carboxy terminus of EmbC from Mycobacterium smegmatis mediates chain length extension of the Arabinan in lipoarabinomannan"
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Terada M, Khoo KH, Inoue R, Chen CI, Yamada K, Sakaguchi H, Kadowaki N, Ma BY, Oka S, Kawasaki T, Kawasaki N (2005) The Journal of biological chemistry 280(12), 10897-10913 "Characterization of oligosaccharide ligands expressed on SW1116 cells recognized by mannan-binding protein. A highly fucosylated polylactosamine type N-glycan."
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Chow LP, Chiu LL, Khoo KH, Peng HJ, Yang SY, Huang SW, Su SN (2005) The FEBS journal 272(24), 6218-6227 "Purification and structural analysis of the novel glycoprotein allergen Cyn d 24, a pathogenesis-related protein PR-1, from Bermuda grass pollen."
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Chung TL, Hsiao HH, Yeh YY, Shia HL, Chen YL, Liang PH, Wang AH, Khoo KH, Shoei-Lung Li S (2004) The Journal of biological chemistry 279(38), 39653-39662 "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides."
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Kinoshita-Toyoda A, Yamada S, Haslam SM, Khoo KH, Sugiura M, Morris HR, Dell A, Sugahara K (2004) Biochemistry 43(34), 11063-11074 "Structural determination of five novel tetrasaccharides containing 3-O-sulfated D-glucuronic acid and two rare oligosaccharides containing a beta-D-glucose branch isolated from squid cartilage chondroitin sulfate E."
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Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH (2004) Bioorganic & medicinal chemistry 12(21), 5595-5601 "Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides."
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Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D (2004) The Journal of biological chemistry 279(39), 41227-41239 "Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis."
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Suzuki N, Khoo KH, Chen CM, Chen HC, Lee YC (2003) The Journal of biological chemistry 278(47), 46293-46306 "N-glycan structures of pigeon IgG: a major serum glycoprotein containing Galalpha1-4 Gal termini.."
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Takahashi N, Masuda K, Hiraki K, Yoshihara K, Huang HH, Khoo KH, Kato K (2003) European journal of biochemistry / FEBS 270(12), 2627-2632 "N-Glycan structures of squid rhodopsin."
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Lee CL, Hsiao HH, Lin CW, Wu SP, Huang SY, Wu CY, Wang AH, Khoo KH (2003) Proteomics 3(12), 2472-2486 "Strategic shotgun proteomics approach for efficient construction of an expression map of targeted protein families in hepatoma cell lines."
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Zhang N, Torrelles JB, McNeil MR, Escuyer VE, Khoo KH, Brennan PJ, Chatterjee D (2003) Molecular microbiology 50(1), 69-76 "The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region."
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Juan HF, Lin JY, Chang WH, Wu CY, Pan TL, Tseng MJ, Khoo KH, Chen ST (2002) Electrophoresis 23(15), 2490-2504 "Biomic study of human myeloid leukemia cells differentiation to macrophages using DNA array, proteomic, and bioinformatic analytical methods."
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Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH (2002) Bioorganic & medicinal chemistry 10(4), 1057-1062 "Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities."
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Khoo KH, Huang HH, Lee KM (2001) Glycobiology 11(2), 149-63 "Characteristic structural features of schistosome cercarial N-glycans: expression of Lewis X and core xylosylation."
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K. H. Khoo, A. Dell (2001) Adv Exp Med Biol 491, 185-205 "Glycoconjugates from parasitic helminths: structure diversity and immunobiological implications"
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Liao HF, Chou CJ, Wu SH, Khoo KH, Chen CF, Wang SY (2001) Anti-cancer drugs 12(10), 841-6 "Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells."
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Suzuki N, Khoo KH, Chen HC, Johnson JR, Lee YC (2001) The Journal of biological chemistry 276(26), 23221-9 "Isolation and characterization of major glycoproteins of pigeon egg white: ubiquitous presence of unique N-glycans containing Galalpha1-4Gal."
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Takahashi N, Khoo KH, Suzuki N, Johnson JR, Lee YC (2001) The Journal of biological chemistry 276(26), 23230-23239 "N-glycan structures from the major glycoproteins of pigeon egg white: predominance of terminal Galalpha(1)Gal."
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Huang HH, Tsai PL, Khoo KH (2001) Glycobiology 11(5), 395-406 "Selective expression of different fucosylated epitopes on two distinct sets of Schistosoma mansoni cercarial O-glycans: identification of a novel core type and Lewis X structure."
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Brown JR, Field RA, Barker A, Guy M, Grewal R, Khoo KH, Brennan PJ, Besra GS, Chatterjec D (2001) Bioorganic & medicinal chemistry 9(4), 815-24 "Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase."
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Escuyer VE, Lety MA, Torrelles JB, Khoo KH, Tang JB, Rithner CD, Frehel C, McNeil MR, Brennan PJ, Chatterjee D (2001) The Journal of biological chemistry 276(52), 48854-62 "The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan."
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Chatterjee D, Khoo KH (2001) CELLULAR AND MOLECULAR LIFE SCIENCES 58(14), 2018-42 "The surface glycopeptidolipids of mycobacteria: structures and biological properties."
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Khoo KH, Tang JB, Chatterjee D (2001) The Journal of biological chemistry 276(6), 3863-71 "Variation in mannose-capped terminal arabinan motifs of lipoarabinomannans from clinical isolates of Mycobacterium tuberculosis and Mycobacterium avium complex."
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Chang T, Kuo MC, Khoo KH, Inoue S, Inoue Y (2000) The Journal of biological chemistry 275(1), 129-34 "Developmentally regulated expression of a peptide:N-glycanase during germination of rice seeds (Oryza sativa) and its purification and characterization."
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Hwa KY, Khoo KH (2000) Molecular and biochemical parasitology 111(1), 173-84 "Structural analysis of the asparagine-linked glycans from the procyclic Trypanosoma brucei and its glycosylation mutants resistant to Concanavalin A killing."
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Khoo KH, Jarboe E, Barker A, Torrelles J, Kuo CW, Chatterjee D (1999) The Journal of biological chemistry 274(14), 9778-85 "Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex."
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Cheng MC, Wang KT, Inoue S, Inoue Y, Khoo KH, Wu SH (1999) Analytical biochemistry 267(2), 287-93 "Controlled acid hydrolysis of colominic acid under microwave irradiation."
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Dell A, Haslam SM, Morris HR, Khoo KH (1999) Biochimica et Biophysica Acta-Molecular Basis of Disease 1455(2-3), 353-362 "Immunogenic glycoconjugates implicated in parasitic nematode diseases."
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Hwa KY, Acosta-Serrano A, Khoo KH, Pearson T, Englund PT (1999) Glycobiology 9(2), 181-90 "Protein glycosylation mutants of procyclic Trypanosoma brucei: defects in the asparagine-glycosylation pathway."
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Cheng MC, Lin CH, Khoo K.H, Wu SH (1999) Angew Chem Int Edit 38(5), 686-689 "Regioselective lactonization of alpha-(2 -> 8)-trisialic acid."
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Ueoka C, Nadanaka S, Seno N, Khoo KH, Sugahara K (1999) Glycoconjugate journal 16(6), 291-305 "Structural determination of novel tetra- and hexasaccharide sequences isolated from chondroitin sulfate H (oversulfated dermatan sulfate) of hagfish notochord."
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Schaeffer ML, Khoo KH, Besra GS, Chatterjee D, Brennan PJ, Belisle JT, Inamine JM (1999) The Journal of biological chemistry 274(44), 31625-31 "The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis."
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Chatterjee D, Khoo KH (1998) Glycobiology 8(2), 113-120 "Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects."
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Haslam SM, Khoo KH, Houston KM, Harnett W, Morris HR, Dell A (1997) Molecular and biochemical parasitology 85(1), 53-66 "Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae."
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Xin Y, Lee RE, Scherman MS, Khoo KH, Besra GS, Brennan PJ, McNeil M (1997) Biochimica et Biophysica Acta-General Subjects 1335(3), 231-4 "Characterization of the in vitro synthesized arabinan of mycobacterial cell walls."
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Draper P, Khoo KH, Chatterjee D, Dell A, Morris HR (1997) The Biochemical journal 327 ( Pt 2), 519-25 "Galactosamine in walls of slow-growing mycobacteria."
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Khoo KH, Chatterjee D, Caulfield JP, Morris HR, Dell A (1997) Glycobiology 7(5), 653-61 "Structural characterization of glycophingolipids from the eggs of Schistosoma mansoni and Schistosoma japonicum."
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Khoo KH, Nieto A, Morris HR, Dell A (1997) Molecular and biochemical parasitology 86(2), 237-48 "Structural characterization of the N-glycans from Echinococcus granulosus hydatid cyst membrane and protoscoleces."
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Khoo KH, Chatterjee D, Caulfield JP, Morris HR, Dell A (1997) Glycobiology 7(5), 663-677 "Structural mapping of the glycans from the egg glycoproteins of Schistosoma mansoni and Schistosoma japonicum: identification of novel core structures and terminal sequences."
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Khoo KH, Suzuki R, Dell A, Morris HR, McNeil MR, Brennan PJ, Besra GS (1996) Biochemistry 35(36), 11812-9 "Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis."
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Dobos KM, Khoo KH, Swiderek KM, Brennan PJ, Belisle JT (1996) Journal of bacteriology 178(9), 2498-506 "Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis."
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Khoo KH, Chatterjee D, Dell A, Morris HR, Brennan PJ, Draper P (1996) The Journal of biological chemistry 271(21), 12333-42 "Novel O-methylated terminal glucuronic acid characterizes the polar glycopeptidolipids of Mycobacterium habana strain TMC 5135."
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Taguchi T, Iwasaki M, Muto Y, Kitajima K, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y (1996) EUROPEAN JOURNAL OF BIOCHEMISTRY 238(2), 357-67 "Occurrence and structural analysis of highly sulfated multiantennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis."
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Khoo KH, Douglas E, Azadi P, Inamine JM, Besra GS, Mikusova K, Brennan PJ, Chatterjee D (1996) The Journal of biological chemistry 271(45), 28682-90 "Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol."
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Besra GS, Khoo KH, McNeil MR, Dell A, Morris HR, Brennan PJ (1995) Biochemistry 34(13), 4257-66 "A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy."
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Taguchi T, Kitajima K, Muto Y, Inoue S, Khoo KH, Morris HR, Dell A, Wallace RA, Selman K, Inoue Y (1995) Glycobiology 5(6), 611-24 "A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel penta-antennary N-glycan chains with a bisecting N-acetylglucosaminyl residue."
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Khoo KH, Sarda S, Xu X, Caulfield JP, McNeil MR, Homans SW, Morris HR, Dell A (1995) The Journal of biological chemistry 270(29), 17114-23 "A unique multifucosylated -3GalNAc beta 1-->4GlcNAc beta 1-->3Gal alpha 1- motif constitutes the repeating unit of the complex O-glycans derived from the cercarial glycocalyx of Schistosoma mansoni."
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Dobos KM, Swiderek K, Khoo KH, Brennan PJ, Belisle JT (1995) Infection and immunity 63(8), 2846-53 "Evidence for glycosylation sites on the 45-kilodalton glycoprotein of Mycobacterium tuberculosis."
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Sjoberg ER, Chammas R, Ozawa H, Kawashima I, Khoo KH, Morris HR, Dell A, Tai T, Varki A (1995) The Journal of biological chemistry 270(7), 2921-30 "Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole."
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Song Y, Kitajima K, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y (1995) Glycobiology 5(2), 207-18 "Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification."
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Khoo KH, Dell A, Morris HR, Brennan PJ, Chatterjee D (1995) The Journal of biological chemistry 270(21), 12380-9 "Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium."
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Khoo KH, Dell A, Morris HR, Brennan PJ, Chatterjee D (1995) Glycobiology 5(1), 117-27 "Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: definition of a common anchor for lipomannan and lipoarabinomannan."
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Khoo KH, Suzuki R, Morris HR, Dell A, Brennan PJ, Besra GS (1995) Carbohydrate research 276(2), 449-55 "Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum."
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Yamada S, Oyama M, Kinugasa H, Nakagawa T, Kawasaki T, Nagasawa S, Khoo KH, Morris HR, Dell A, Sugahara K (1995) Glycobiology 5(3), 335-41 "The sulphated carbohydrate-protein linkage region isolated from chondroitin 4-sulphate chains of inter-alpha-trypsin inhibitor in human plasma."
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Besra GS, Gurcha SS, Khoo KH, Morris HR, Dell A, Hamid ME, Minnikin DE, Goodfellow M, Brennan PJ (1994) Zentralblatt fur Bakteriologie-International Journal of Medical Microbiology Virology Parasitology and Infectious Diseases 281(4), 415-432 "Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria."
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Sugahara K, Takemura Y, Sugiura M, Kohno Y, Yoshida K, Takeda K, Khoo KH, Morris HR, Dell A (1994) Carbohydrate research 255, 165-82 "Chondroitinase ABC-resistant sulfated trisaccharides isolated from digests of chondroitin/dermatan sulfate chains."
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Dell A, Reason AJ, Khoo KH, Panico M, McDowell RA, Morris HR (1994) Methods in enzymology 230, 108-32 "Mass spectrometry of carbohydrate-containing biopolymers."
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Besra GS, Khoo KH, Belisle JT, McNeil MR, Morris HR, Dell A, Brennan PJ (1994) Carbohydrate research 251, 99-114 "New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria."
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Taguchi T, Seko A, Kitajima K, Muto Y, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y (1994) The Journal of biological chemistry 269(12), 8762-71 "Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes."
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Sugahara K, Tohno-oka R, Yamada S, Khoo KH, Morris HR, Dell A (1994) Glycobiology 4(4), 535-44 "Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substrates."
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Yamada S, Sakamoto K, Tsuda H, Yoshida K, Sugahara K, Khoo KH, Morris HR, Dell A (1994) Glycobiology 4(1), 69-78 "Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates."
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Khoo KH, Morris HR, McDowell RA, Dell A, Maccarana M, Lindahl U (1993) Carbohydrate research 244(2), 205-223 "FABMS/derivatisation strategies for the analysis of heparin-derived oligosaccharides."
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Besra GS, McNeil MR, Rivoire B, Khoo KH, Morris HR, Dell A, Brennan PJ (1993) Biochemistry 32(1), 347-55 "Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi."
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Chatterjee D, Khoo KH, McNeil MR, Dell A, Morris HR, Brennan PJ (1993) Glycobiology 3(5), 497-506 "Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry."
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Taguchi T, Seko A, Kitajima K, Inoue S, Iwamatsu T, Khoo KH, Morris HR, Dell A, Inoue Y (1993) The Journal of biological chemistry 268(4), 2353-62 "Structural studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian Medaka fish, Oryzias melastigma."
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Yamada S, Yoshida K, Sugiura M, Sugahara K, Khoo KH, Morris HR, Dell A (1993) The Journal of biological chemistry 268(7), 4780-7 "Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin."
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Stephens L, Radenberg T, Thiel U, Vogel G, Khoo KH, Dell A, Jackson TR, Hawkins PT, Mayr GW (1993) The Journal of biological chemistry 268(6), 4009-15 "The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)."
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Besra GS, McNeil MR, Khoo KH, Dell A, Morris HR, Brennan PJ (1993) Biochemistry 32(47), 12705-14 "Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone."
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Woodward JR, Craik D, Dell A, Khoo KH, Munro SL, Clarke AE, Bacic A (1992) Glycobiology 2(3), 241-50 "Structural analysis of the N-linked glycan chains from a stylar glycoprotein associated with expression of self-incompatibility in Nicotiana alata."
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Sjoberg ER, Manzi AE, Khoo KH, Dell A, Varki A (1992) The Journal of biological chemistry 267(23), 16200-11 "Structural and immunological characterization of O-acetylated GD2. Evidence that GD2 is an acceptor for ganglioside O-acetyltransferase in human melanoma cells."
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Khoo KH, Maizels RM, Page AP, Taylor GW, Rendell NB, Dell A (1991) Glycobiology 1(2), 163-71 "Characterization of nematode glycoproteins: the major O-glycans of Toxocara excretory-secretory antigens are O-methylated trisaccharides."
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Williams DJ, Radding JA, Dell A, Khoo KH, Rogers ME, Richards FF, Armstrong MY (1991) Journal of Protozoology 38(4), 427-37 "Glucan synthesis in Pneumocystis carinii."
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Khoo KH, Dell A (1990) Glycobiology 1(1), 83-91 "Assignment of anomeric configurations of pyranose sugars in oligosaccharides using a sensitive FAB-MS strategy."