研究領域與專長

細胞自噬、生物分子影像及活細胞影像

學經歷
經歷
  • 2014 – 迄今   副研究員, 中研院生化所
  • 2008 – 2014   助研究員, 中研院生化所
  • 2003 – 2007   博士後研究員, 哈佛大學化學系
學歷
  • 1997 – 2003   博士, 生物物理, 伊利諾州立大學香檳分校
  • 1993 – 1997   學士, 物理系, 臺灣大學
主要著作
Hsieh CW and Yang WY
Nature Communications (2019)
Hsieh CW and Yang WY
Methods in Molecular Biology (2019)
Chu YC, Hung YH, and Yang WY
Methods in Enzymology (2017)
Chen BC, Yang HJ, Chen HY, Chen GC, and Yang WY
Methods in Molecular Biology (2017)
Yang WY
Annals of the New York Academy of Sciences (2015)
Hsieh CW, Chu CH, Lee HM, and Yang WY
Scientific Reports (2015)
Yang JY and Yang WY
Nature Communications (2013)
Hung YH, Chen LMW, Yang JY, and Yang WY
Nature Communications (2013)
Yang JY and Yang WY
Autophagy (2011)
Yang JY and Yang WY
Journal of the American Chemical Society (2009)
著作列表
  1. Hong MH, Lin WH, Weng IC, Hung YH, Chen HL, Chen HY, Chen P, Lin CH, (Yang WY), Liu FT  (2020-01)  Glycobiology  30(1), 49-57  "Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition."
  2. Hsieh CW, (Yang WY)  (2019-02)  Nature Communications  10(1), 969  "Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy."
  3. Chen YC, Cheng TH, Lin WL, Chen CL, (Yang WY), Blackstone C, Chang CR  (2019-01)  iScience  11, 305-317  "Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly."
  4. Hsieh CW, (Yang WY)  (2019)  Methods in molecular biology  1880, 611-619  "Triggering Mitophagy with Photosensitizers."
  5. Chu YP, Hung YH, Chang HY, (Yang WY)  (2017)  Methods in enzymology  588, 231-244  "Assays to Monitor Lysophagy."
  6. Chen BH, Yang HJ, Chou HY, Chen GC, (Yang WY)  (2017)  Methods in molecular biology  1560, 231-236  "Staining of Lipid Droplets with Monodansylpentane."
  7. Klionsky DJ, Chen GC, (Yang WY) et al.  (2016)  Autophagy  12(1), 1-222  "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)."
  8. (Yang WY)  (2015)  Annals of the New York Academy of Sciences  1350, 48-51  "Optogenetic probing of mitochondrial damage responses."
  9. Hsieh CW, Chu CH, Lee HM, and (Yang WY)  (2015)  Scientific Reports  5, 10376  "Triggering mitophagy with far-red fluorescent photosensitizers."
  10. Yang JY, (Yang WY)  (2013)  Nature Communications  4, 2428  "Bit-by-bit autophagic removal of parkin-labelled mitochondria"
  11. Hung YH, Chen LMW, Yang JY, and (Yang WY)  (2013)  Nature Communications  4, 2111  "Spatiotemporally controlled induction of autophagy-mediated lysosome turnover"
  12. Klionsky DJ, Chen GC, (Yang WY) et al.  (2012)  Autophagy  8(4), 445-544  "Guidelines for the use and interpretation of assays for monitoring autophagy"
  13. Yang HJ, Hsu CL, Yang JY, and (Yang WY)  (2012)  PLoS One  7(3), e32693  "Monodansylpentane as a Blue-Fluorescent Lipid-Droplet Marker for Multi-Color Live-Cell Imaging"
  14. Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, Lopez-Otin C, (Yang WY), Reed JC, Broday L, Nizet V, Ronai ZA  (2012)  PLoS genetics  8(10), e1003007  "Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection."
  15. Yang JY and (Yang WY)  (2011)  Autophagy  7(10), 1230-1238  "Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells"
  16. Yang JY and (Yang WY)  (2009)  Journal of the American Chemical Society  131(33), 11644-11645  "Site-Specific Two-Color Protein Labeling for FRET Studies Using Split Inteins."
  17. (Yang WY) and Gruebele M  (2006)  Biophysical Journal  90(8), 2930-2937  "Binary and ternary aggregation within tethered protein constructs"
  18. Xie XS, Yu J and (Yang WY)  (2006)  Science  312(5771), 228-230  "Living cells as test tubes."
  19. (Yang WY) and Gruebele M  (2005)  Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences  363(1827), 565-573  "Kinetic equivalence of the heat and cold structural transitions of lambda6-85"
  20. Nan X, (Yang WY) and Xie XS  (2004-08)  Biophotonics International  11(8), 44-47  "CARS microscopy lights up lipids in living cells"
  21. E. Larios, (W. Y. Yang), K. Schulten and M. Gruebele  (2004)  Chemical Physics  307, 217-225  "A similarity measure for partially folded proteins: application to unfolded and native-like conformational fluctuations"
  22. (Yang WY) and Gruebele M  (2004)  Journal of the American Chemical Society  126, 7758-7759  "Detection-dependent kinetics probe folding landscape microstructure"
  23. (Yang WY) and Gruebele M  (2004)  Biophysical Journal  87, 596-608  "Folding lambda-repressor at its speed limit"
  24. (Yang WY), Pitera JW, Swopes WS and Gruebele M  (2004)  Journal of Molecular Biology  336, 241-251  "Heterogeneous folding of the trpzip hairpin: Full atom simulation and experiment"
  25. (Yang WY) and Gruebele M  (2004)  Biochemistry  43(41), 13018-13025  "Rate-temperature relationships in lambda-repressor fragment lambda 6-85 folding."
  26. (Yang WY), Gruebele M  (2003)  Nature  423(6936), 193-197  "Folding at the speed limit."
  27. (Yang WY), Larios E and Gruebele M  (2003)  Journal of the American Chemical Society  125, 16220-16227  "On the extended beta-structure propensity of polypeptides at high temperatures"
  28. (Yang WY), Prince RB, Sabelko J, Moore JS and Gruebele M  (2000)  Journal of the American Chemical Society  122, 3248-3249  "Transition from exponential to nonexponential kinetics during formation of a nonbiological helix"

細胞自噬、生物分子影像及活細胞影像

經歷
  • 2014 – 迄今   副研究員, 中研院生化所
  • 2008 – 2014   助研究員, 中研院生化所
  • 2003 – 2007   博士後研究員, 哈佛大學化學系
學歷
  • 1997 – 2003   博士, 生物物理, 伊利諾州立大學香檳分校
  • 1993 – 1997   學士, 物理系, 臺灣大學
Hsieh CW and Yang WY
Nature Communications (2019)
Hsieh CW and Yang WY
Methods in Molecular Biology (2019)
Chu YC, Hung YH, and Yang WY
Methods in Enzymology (2017)
Chen BC, Yang HJ, Chen HY, Chen GC, and Yang WY
Methods in Molecular Biology (2017)
Yang WY
Annals of the New York Academy of Sciences (2015)
Hsieh CW, Chu CH, Lee HM, and Yang WY
Scientific Reports (2015)
Yang JY and Yang WY
Nature Communications (2013)
Hung YH, Chen LMW, Yang JY, and Yang WY
Nature Communications (2013)
Yang JY and Yang WY
Autophagy (2011)
Yang JY and Yang WY
Journal of the American Chemical Society (2009)
  1. Hong MH, Lin WH, Weng IC, Hung YH, Chen HL, Chen HY, Chen P, Lin CH, (Yang WY), Liu FT  (2020-01)  Glycobiology  30(1), 49-57  "Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition."
  2. Hsieh CW, (Yang WY)  (2019-02)  Nature Communications  10(1), 969  "Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy."
  3. Chen YC, Cheng TH, Lin WL, Chen CL, (Yang WY), Blackstone C, Chang CR  (2019-01)  iScience  11, 305-317  "Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly."
  4. Hsieh CW, (Yang WY)  (2019)  Methods in molecular biology  1880, 611-619  "Triggering Mitophagy with Photosensitizers."
  5. Chu YP, Hung YH, Chang HY, (Yang WY)  (2017)  Methods in enzymology  588, 231-244  "Assays to Monitor Lysophagy."
  6. Chen BH, Yang HJ, Chou HY, Chen GC, (Yang WY)  (2017)  Methods in molecular biology  1560, 231-236  "Staining of Lipid Droplets with Monodansylpentane."
  7. Klionsky DJ, Chen GC, (Yang WY) et al.  (2016)  Autophagy  12(1), 1-222  "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)."
  8. (Yang WY)  (2015)  Annals of the New York Academy of Sciences  1350, 48-51  "Optogenetic probing of mitochondrial damage responses."
  9. Hsieh CW, Chu CH, Lee HM, and (Yang WY)  (2015)  Scientific Reports  5, 10376  "Triggering mitophagy with far-red fluorescent photosensitizers."
  10. Yang JY, (Yang WY)  (2013)  Nature Communications  4, 2428  "Bit-by-bit autophagic removal of parkin-labelled mitochondria"
  11. Hung YH, Chen LMW, Yang JY, and (Yang WY)  (2013)  Nature Communications  4, 2111  "Spatiotemporally controlled induction of autophagy-mediated lysosome turnover"
  12. Klionsky DJ, Chen GC, (Yang WY) et al.  (2012)  Autophagy  8(4), 445-544  "Guidelines for the use and interpretation of assays for monitoring autophagy"
  13. Yang HJ, Hsu CL, Yang JY, and (Yang WY)  (2012)  PLoS One  7(3), e32693  "Monodansylpentane as a Blue-Fluorescent Lipid-Droplet Marker for Multi-Color Live-Cell Imaging"
  14. Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, Lopez-Otin C, (Yang WY), Reed JC, Broday L, Nizet V, Ronai ZA  (2012)  PLoS genetics  8(10), e1003007  "Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection."
  15. Yang JY and (Yang WY)  (2011)  Autophagy  7(10), 1230-1238  "Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells"
  16. Yang JY and (Yang WY)  (2009)  Journal of the American Chemical Society  131(33), 11644-11645  "Site-Specific Two-Color Protein Labeling for FRET Studies Using Split Inteins."
  17. (Yang WY) and Gruebele M  (2006)  Biophysical Journal  90(8), 2930-2937  "Binary and ternary aggregation within tethered protein constructs"
  18. Xie XS, Yu J and (Yang WY)  (2006)  Science  312(5771), 228-230  "Living cells as test tubes."
  19. (Yang WY) and Gruebele M  (2005)  Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences  363(1827), 565-573  "Kinetic equivalence of the heat and cold structural transitions of lambda6-85"
  20. Nan X, (Yang WY) and Xie XS  (2004-08)  Biophotonics International  11(8), 44-47  "CARS microscopy lights up lipids in living cells"
  21. E. Larios, (W. Y. Yang), K. Schulten and M. Gruebele  (2004)  Chemical Physics  307, 217-225  "A similarity measure for partially folded proteins: application to unfolded and native-like conformational fluctuations"
  22. (Yang WY) and Gruebele M  (2004)  Journal of the American Chemical Society  126, 7758-7759  "Detection-dependent kinetics probe folding landscape microstructure"
  23. (Yang WY) and Gruebele M  (2004)  Biophysical Journal  87, 596-608  "Folding lambda-repressor at its speed limit"
  24. (Yang WY), Pitera JW, Swopes WS and Gruebele M  (2004)  Journal of Molecular Biology  336, 241-251  "Heterogeneous folding of the trpzip hairpin: Full atom simulation and experiment"
  25. (Yang WY) and Gruebele M  (2004)  Biochemistry  43(41), 13018-13025  "Rate-temperature relationships in lambda-repressor fragment lambda 6-85 folding."
  26. (Yang WY), Gruebele M  (2003)  Nature  423(6936), 193-197  "Folding at the speed limit."
  27. (Yang WY), Larios E and Gruebele M  (2003)  Journal of the American Chemical Society  125, 16220-16227  "On the extended beta-structure propensity of polypeptides at high temperatures"
  28. (Yang WY), Prince RB, Sabelko J, Moore JS and Gruebele M  (2000)  Journal of the American Chemical Society  122, 3248-3249  "Transition from exponential to nonexponential kinetics during formation of a nonbiological helix"