The interactions among different biological molecules play a central role in modulating cellular physiology. However, deciphering such complexed and dynamic interactions and their functional impact have turned out to be a challenging task. The merit of native mass spectrometry, which enables proteins and their complexes to survive in the gas phase, offers a unique opportunity in gaining a deeper insight into various biological systems. In our group, we dedicate in understanding the structural mechanisms of GPCRs and their regulations using native mass spectrometry as our central technique. Our research focus is to investigate the regulation of neurological GPCRs, and their physiological and pathological connections with various diseases. The utility of native mass spectrometry can provide unparalleled information on structural dynamics of GPCRs, and their association with native environment in particular. Ultimately, decoding the native interactome of receptors, including lipids, metabolites and partner proteins, will offer a novel perspective in GPCR biology, such as deorphanization, allosteric modulators and lipid-based drug design. Our tenet is to develop state-of-the-art mass spectrometry and apply it to a range of intractable systems.
Researchgate : https://www.researchgate.net/profile/Hsin-Yung-Yen
OMass Therapeutics : https://www.omass.com/team/