我們研究團隊專注的領域有生物合成化學(特別是酵素糖類合成)、複雜寡糖的結構鑑定分析，以及探索新穎糖類酵素及其在複雜寡糖的合成應用性。實驗室成員(學生或是博後)利用化學合成以及酵素方法製備我們感興趣並且有生物應用潛力的化合物，並使用這些化合物探討其生物化學上的意義或是結構分析。

我們研究的長遠目標是持續發展當前最新的技術以合成自然界中所發現的、具重要生物意義的複雜糖類分子，並探究其生理活性。目前研究團隊主要的重點是人類母乳寡糖。研究方向可分為下列幾項，各項可為獨立研究題材或互為相輔方向：1) 發展新穎生物催化劑用在人類母乳寡糖類型的糖體合成；2) 以化學以及酵素方法完成人類母乳寡糖分子庫的全系列合成；3) 探究人類母乳寡糖與人體腸道菌相的相互關係，瞭解這些糖分子能夠抑制腸道內病原菌感染的原因與機制。

經歷

• 2022 – 迄今   副教授, 清華大學化學系
• 2021 – 迄今   合聘副研究員, 中央研究院生物化學研究所
• 2020 – 2022   副教授, 中正大學化學暨生物化學系
• 2015 – 2020   助理教授, 中正大學化學暨生物化學系
• 2014 – 2015   博士後研究員, Department of Chemistry, University of British Columbia, BC, Canada
• 2013 – 2014   博士後研究員, 清華大學化學系

學歷

• 2007 – 2012   博士, 化學系, 清華大學
• 2005 – 2007   碩士, 化學系, 清華大學
• 2001 – 2005   學士, 化學系, 彰化師範大學

1. Ooi KE, Zhang XW, Kuo CY, Liu YJ, (Yu CC)* (2022-05) Frontiers in Chemistry 10, 905105 “Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose.”
2. Pao YP, (Yu CC), Lin YZ, Chatterjee S, Saha S, Tiwari N, Huang YT, Wu CC*, Choi D*, Lin ZH* (2021-07) Nano Energy 85, 106008 “Carbohydrate-Protein Interactions Studied by Solid-Liquid Contact Electrification and its Use for Label-Free Bacterial Detection.”
3. Huang YT, Su YC, Wu HR, Huang HH, Lin EC, Tsai TW, Tseng HW, Fang JL, (Yu CC)* (2021-03) ACS Catalysis 11(5), 2631−2643 “Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides.”
4. Liou SW, Fang JL, Lin HW, Tsai TW, Huang HH, Liang CY, Yang, CR, Wei GT*, (Yu CC)* (2021-03) Chemistry – An Asian Journal 16(5), 492–497 “Effective separation of human milk glycosides using carbon dioxide supercritical fluid chromatography.”
5. Huang HH, Fang JL, Wang HK, Sun CY, Tsai TW, Huang YT, Kuo CY, Wang YJ, Liao CC, (Yu CC)* (2019-12) ACS Catalysis 9(12), 11794−11800 “Substrate Characterization of Bacteroides fragilis α1,3/4-Fucosyltransferase Enabling Access to Programmable One-Pot Enzymatic Synthesis of KH 1 Antigen.”
6. Tsai TW, Fang JL, Liang CY, Wang CJ, Huang YT, Wang YJ, Li JY, (Yu CC)* (2019-12) ACS Catalysis 9(12) 10712−10720 “Exploring the Synthetic Application of Helicobacter pylori α1,3/4-Fucosyltransferase FucTIII toward the Syntheses of Fucosylated Human Milk Glycans and Lewis Antigens.”
7. Zhang X, Chen F, Petrella A, Chacón-Huete F, Covone J, Tsai TW, (Yu CC), Forgione P, Kwan DH* (2019-04) ACS Chemical Biology 14(4), 715−724 “A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification.”
8. Fang JL, Tsai TW, Liang CY, Li JY, (Yu CC)* (2018-09) Advanced Synthesis & Catalysis 360(17), 3213–3219 “Enzymatic Synthesis of Human Milk Fucosides α1,2‐Fucosyl para‐Lacto‐N‐Hexaose and its Isomeric Derivatives.”
9. Kuo CS, Kao CR, Chen WJ, Lu MY, Cullen DA, Sneed BT, Chuang YC, (Yu CC), Kuo CH* (2018-07) Chemistry of Materials 30(13), 4448–4458 “Aqueous Synthesis of Concave Rh Nanotetrahedra with Defect-Rich Surfaces: Insights into Growth-, Defect-, and Plasmon-Enhanced Catalytic Energy Conversion.”
10. Hou KL, Chiang PY, Lin CH, Li BY, Chien WT, Huang YT, (Yu CC)*, Lin CC* (2018-06) Advanced Synthesis & Catalysis 360(12), 2313–2323 “Water-soluble Sulfo-Fluorous Affinity (SOFA) Tag-Assisted Enzymatic Synthesis of Oligosaccharides.”
11. 方嘉琳 (Jia-Lin Fang); 蔡騰緯 (Teng-Wei Tsai); 游景晴* (Ching-Ching Yu), 化學季刊, 75 卷 3 期 (2017/09/01), 219–228. “岩藻糖化人類母乳寡糖的功能、合成到應用 (Fucosylated Human Milk Oligosaccharides: Function, Synthesis and Applications)”
12. Adak AK, (Yu CC), Lin CC*, (2016) Glycochemical Synthesis: Strategies and Applications Chapter 16 “Synthesis and Applications of Glyconanoparticles, Glycodendrimers, and Glycoclusters in Biological Systems” Hung SC and Zulueta MML Ed., John Wiley & Sons, Inc.
13. Volkers G, Worrall LJ, Kwan DH, (Yu CC), Baumann L, Lameignere E, Wasney GA, Scott NE, Wakarchuk W, Foster LJ, Withers SG, Strynadka NCJ* (2015-08) Nature Structural & Molecular Biology 22(8), 627–635 “Structure of Human ST8SiaIII Sialyltransferase Provides Insight into Cell-Surface Polysialylation.”
14. (Yu CC), Withers SG* (2015-05) Advanced Synthesis & Catalysis 357(8), 1633–1654 “Recent Developments in Enzymatic Synthesis of Modified Sialic Acid Derivatives.”
15. Huang LD, Adak AK, (Yu CC), Hsiao WC, Lin HJ, Chen ML, Lin CC* (2015-01) Chemistry – An European Journal 21(10), 3956–3967 “Fabrication of Highly Stable Glyco-Gold Nanoparticles and Development of a Glyco-Gold Nanoparticle-Based Oriented-Immobilized Antibody Microarray for Lectin (GOAL) Assay.”
16. Li SP, Hsiao WC, (Yu CC), Chien WT, Lin HJ, Huang LD, Lin CH, Wu WL, Wu SH, Lin CC* (2014-10) Advanced Synthesis & Catalysis 356(14-15) 3199–3213 “Characterization of Meiothermus Taiwanensis Galactokinase and its Uses in the One-Pot Enzymatic Synthesis of Uridine Diphosphate-Galactose and The Chemoenzymatic Synthesis of the Carbohydrate Antigen Stage Specific Embryonic Antigen-3.”
17. Chien WT, Liang CF, (Yu CC), Lin CH, Li SP, Primadona I, Chen YJ, Mong KKT, Lin CC* (2014-04) Chemical Communications 50(43), 5786–5789 “Sequential One-Pot Enzymatic Synthesis of Oligo-N-Acetyllactosamine and its Multi-Sialylated Extensions.”
18. Wang HC, (Yu CC), Liang CF, Huang LD, Hwu JR, Lin CC* (2014-04) ChemBioChem 15(6), 829–835 “Site-Selective Protein Immobilization via 2-Cyanobenzothiazole-Cysteine Condensation.”
19. (Yu CC), Hill T, Kwan DH, Chen HM, Lin CC, Wakarchuk W, Withers SG* (2014-01) Analytical Biochemistry 444, 67–74 “A Plate Based High-Throughput Activity Assay for Polysialyltransferase from Neisseria meningitides.”
20. Adak AK, (Yu CC), Liang CF, Lin CC* (2013-12) Current Opinion in Chemistry Biology 17(6), 1030–1038 “Synthesis of Sialic Acid-Containing Saccharides.”
21. (Yu CC), Huang LD, Kwan D, Wakarchuk WW, Withers SG*, Lin CC* (2013-09) Chemical Communications 49(86), 10166–10168 “A Glyco-Gold Nanoparticle Based Assay for α-2,8-Polysialyltransferase from Neisseria meningitides.”
22. Lin PC*, (Yu CC), Wu HT, Lu YW, Han CL, Su AK, Chen YJ*, Lin CC* (2013-01) Biomacromolecules 14(1), 160–168 “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation.”
23. (Yu CC), Kuo YY, Liang CF, Chien WT, Wu HT, Chang TC, Jan FD, Lin CC* (2012-04) Bioconjugate Chemistry 23(4), 714–723 “Site-Specific Immobilization of Enzymes on Magnetic Nanoparticles and their Use in Organic Synthesis.”
24. Chien WT, Liang CF, (Yu CC), Lin JH, Wu HT, Lin CC* (2012-01) Advanced Synthesis & Catalysis 354(1), 123–132 “Glucose-1-phosphate Thymidylyltransferase in the Synthesis of UDP-Galactose and its Application in the Synthesis of LacNAc.”
25. Wei-Ting Chien, (Yu CC), Liang CF, Lai CH, Lin PC, Lin CC* (2011) Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines, ACS Symposium Series, Volume 1091, Chapter 2, 15–36 “Functionalized Glyconanoparticles for the Study of Glycobiology.” Huang X. Ed., American Chemical Society
26. Hsiao HY, Chen ML, Wu HT, Huang LD, Chien WT, (Yu CC), Jan FD, Sahabuddin S, Chang TC, Lin CC* (2011-01) Chemical Communications 47(4), 1187–1189 “Fabrication of Carbohydrate Microarrays through Boronate Formation.”
27. (Yu CC), Lin PC, Lin CC* (2008-01) Chemical Communications (11), 1308–1310 “Site-Specific Immobilization of CMP-Sialic Acid Synthetase on Magnetic Nanoparticles and its Use in the Synthesis of CMP-Sialic Acid.”
28. Lin PC, Ueng SH, Yu SC, Jan MD, Adak AK, (Yu CC), Lin CC* (2007-05) Organic Letters 9(11), 2131–2134 “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-Azide [2 + 3] Cycloaddition.”