研究領域與專長

細胞的遺傳訊息(DNA)持續性遭受內生性自由基或外在性高能量紫外光的損害,特別是雙股DNA的斷裂,導致染色體的不穩定而進一步造成疾病的產生(例如癌症)。細胞可利用同源重組 ( Homologous Recombination ) 的方式來修復雙股斷 裂的DNA,但不適當的同源重組的調控也會造成染色體異常的排列、細胞週期的失控,甚至導致癌症的發生,所以細胞具有嚴密的機制來調控同源重組的反應。同源重組反應的啟始是由Rad51重組酵素來進行催化,當斷裂的雙股DNA進一步作用成單股DNA後,Rad51蛋白可結合單股DNA並促使下一步同源重組反應的進行以便完成DNA的修復。至今數個與Rad51結合的蛋白質在遺傳及細胞學的研究中被證明可以調控Rad51的酵素活性。為了要能闡釋Rad51結合蛋白質調控Rad51的作用機轉,我們實驗室將利用蛋白質純化技術和建立同源重組反應實驗,並配合細胞學的研究去探討它們可能的分子作用機轉。此研究的成果將有助於我們了解細胞如何利用Rad51結合蛋白質來調控同源重組反應而進一步的修復損傷之DNA及維持遺傳訊息的穩定性。我們也期待研究的成果有助於進一步預防或研發藥物來治療因同源重組反應失調所造成的人類疾病。

學經歷
經歷
  • 2019 – 迄今   教授, 臺灣大學生化科學研究所
  • 2018 – 迄今   合聘副研究員, 中央研究院生物化學所
  • 2014 – 2019   副教授, 臺灣大學生化科學研究所
  • 2010 – 2014   助理教授, 臺灣大學生化科學研究所
  • 2011 – 2018   合聘助研究員, 中央研究院生物化學所
  • 2010 – 2010   博士後研究, 美國耶魯大學, 分子生物物理生化系
  • 2008 – 2010   博士後研究, 美國洛克斐勒大學
學歷
  • 2003 – 2007   博士, 分子生物物理生化系, 美國耶魯大學
主要著作
Yeh HY, Lin SW, Wu YC, Chan NL, Chi P
Scientific Reports (2017)
Su GC, Yeh HY, Lin SW, Chung CI, Huang YS, Liu YC, Lyu PC, Chi P
Nucleic Acids Res. (2016)
Chang HY, Liao CY, Su GC, Lin SW, Wang HW, Chi P
J. Biol. Chem. (2015)
Su GC, Chung CI, Liao CY, Lin SW, Tsai CT, Huang T, Li HW, Chi P
Nucleic Acids Res. (2014)
Wilson MA, Kwon Y, Xu Y, Chung WH, Chi P, Niu H, Mayle R, Chen X, Malkova A, Sung P, Ira G
Nature (2013)
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P
Nucleic Acids Res. (2012)
Chi P, Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL
Nucleic acids research (2011)
Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, Chi P, Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P
Nature (2010)
Chi P, San Filippo J, Sehorn MG, Petukhova GV, Sung P
Genes & development (2007)
Chi P, Kwon Y, Seong C, Epshtein A, Lam I, Sung P, Klein HL
J. Biol. Chem. (2006)
著作列表
  1. Lee CY, Su GC, Huang WY, Ko MY, Yeh HY, Chang GD, Lin SJ, (Chi P) (2019-01) Nature Communications 10(1), 65 “Promotion of homology-directed DNA repair by polyamines.”
  2. Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, (Chi P), Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E (2019-01) Microbial cell 6(1), 65-101 “Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes.”
  3. Lu CH, Yeh HY, Su GC, Ito K, Kurokawa Y, Iwasaki H*, (Chi P)*, & Li HW* (2018-10) Proc. Nat. Acad. Sci. U.S.A. 115(43), E10059-E10068 “Swi5-Sfr1 Stimulates Rad51 Recombinase Filament Assembly by Modulating Rad51 Dissociation.”
  4. Huang WY, Lai SF, Chiu HY, Chang M, Plikus M, Chan CC, Chen YT, Tsao PN, Yang TL, Lee HS, (Chi P), and Lin SJ (2017-11) Cancer Research 77(22), 6083-6096 “Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy.”
  5. Yeh HY, Lin SW, Wu YC, Chan NL, and (Chi P)*. (2017-05) Scientific Reports 7(1), 2370 “Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C.”
  6. Chao A, Chang TC, Lapke N, Jung SM, (Chi P), Chen CH, Yang LY, Lin CT, Huang HJ, Chou HH, Liou JD, Chen SJ, Wang TH, and Lai CH (2016-12) Oncotarget 7(51), 85529-85541 “Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer.”
  7. Su GC, Yeh HY, Lin SW, Chung CI, Huang YS, Liu YC, Lyu PC, and (Chi P)*. (2016-07) Nucleic Acids Res. 44(13), 6242-6251 “Role of the RAD51-SWI5-SFR1 ensemble in homologous recombination.”
  8. Chang HY, Liao CY, Su GC, Lin SW, Wang HW, (Chi P) (2015-08) The Journal of biological chemistry 290(32), 19863-19873 “Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.”
  9. Huang YC, Chang HH, Mou Y, (Chi P), Chan JC, Luo SC (2014-08) Protein expression and purification 100, 26-32 “Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding protein.”
  10. Su GC, Chung CI, Liao CY, Lin SW, Tsai CT, Huang T, Li HW, (Chi P) (2014-01) NUCLEIC ACIDS RESEARCH 42(1), 349-358 “Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex”
  11. Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, (Chi P), Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P (2014-01) NUCLEIC ACIDS RESEARCH 42(2), 906-917 “Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing”
  12. Wilson MA, Kwon Y, Xu Y, Chung WH, (Chi P), Niu H, Mayle R, Chen X, Malkova A, Sung P, Ira G (2013-10) Nature 502(7471), 393-396 “Pif1 helicase and Poldelta promote recombination-coupled DNA synthesis via bubble migration.”
  13. Busygina, V., Gaines, W.A., Xu, Y., Kwon, Y., Williams, G.J., Lin, S.W., Chang, H.Y., (Chi, P.), Wang, H.W., and Sung, P (2013-09) DNA REPAIR 12(9), 707-12 “Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1”
  14. Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, (Chi P). (2012-08) Nucleic acids research 40(14), 6558-69 “Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.”
  15. Chen CH, Chu PC, Lee L, Lien HW, Lin TL, Fan CC, (Chi P), Huang CJ, Chang MS (2012) PloS one 7(3), e33538 “Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response.”
  16. (Chi P), Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL (2011) Nucleic acids research 39(15), 6511-22 “Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors.”
  17. Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, (Chi P), Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P (2010) Nature 467(7311), 108-11 “Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.”
  18. (Chi P), Kwon Y, Moses DN, Seong C, Sehorn MG, Singh AK, Tsubouchi H, Greene EC, Klein HL, Sung P (2009) DNA repair 8(2), 279-84 “Functional interactions of meiotic recombination factors Rdh54 and Dmc1.”
  19. Robertson RB, Moses DN, Kwon Y, Chan P, (Chi P), Klein H, Sung P, Greene EC (2009) Proceedings of the National Academy of Sciences of the United States of America 106(31), 12688-93 “Structural transitions within human Rad51 nucleoprotein filaments.”
  20. Robertson RB, Moses DN, Kwon Y, Chan P, Zhao W, (Chi P), Klein H, Sung P, Greene EC (2009) Journal of molecular biology 388(4), 703-20 “Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments.”
  21. Kwon Y, Seong C, (Chi P), Greene EC, Klein H, Sung P (2008) Journal of biological chemistry 283(16), 10445-52 “ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.”
  22. Seong C, Sehorn MG, Plate I, Shi I, Song B, (Chi P), Mortensen U, Sung P, Krejci L (2008) Journal of biological chemistry 283(18), 12166-74 “Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52.”
  23. Prasad TK, Robertson RB, Visnapuu ML, (Chi P), Sung P, Greene EC (2007) Journal of molecular biology 369(4), 940-53 “A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.”
  24. (Chi P), San Filippo J, Sehorn MG, Petukhova GV, Sung P (2007) Genes & development 21(14), 1747-57 “Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.”
  25. Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, (Chi P), Janscak P, Jasin M, Vogel H, Sung P, Luo G (2007) Genes & development 21(23), 3073-84 “RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.”
  26. Kwon Y, (Chi P), Roh DH, Klein H, Sung P (2007) DNA repair 6(10), 1496-506 “Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.”
  27. San Filippo J, (Chi P), Sehorn MG, Etchin J, Krejci L, Sung P (2006) Journal of biological chemistry 281(17), 11649-57 “Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.”
  28. (Chi P), Van Komen S, Sehorn MG, Sigurdsson S, Sung P (2006) DNA repair 5(3), 381-91 “Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.”
  29. (Chi P), Kwon Y, Seong C, Epshtein A, Lam I, Sung P, Klein HL (2006) Journal of biological chemistry 281(36), 26268-79 “Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA.”
  30. Raschle M, Van Komen S, (Chi P), Ellenberger T, Sung P (2004) Journal of biological chemistry 279(50), 51973-80 “Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54.”
  31. Chi WJ, Doong SL, Lin-Shiau SY, Boone CW, Kelloff GJ, Lin JK (1998) Carcinogenesis 19(12), 2133-8 “Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.”

細胞的遺傳訊息(DNA)持續性遭受內生性自由基或外在性高能量紫外光的損害,特別是雙股DNA的斷裂,導致染色體的不穩定而進一步造成疾病的產生(例如癌症)。細胞可利用同源重組 ( Homologous Recombination ) 的方式來修復雙股斷 裂的DNA,但不適當的同源重組的調控也會造成染色體異常的排列、細胞週期的失控,甚至導致癌症的發生,所以細胞具有嚴密的機制來調控同源重組的反應。同源重組反應的啟始是由Rad51重組酵素來進行催化,當斷裂的雙股DNA進一步作用成單股DNA後,Rad51蛋白可結合單股DNA並促使下一步同源重組反應的進行以便完成DNA的修復。至今數個與Rad51結合的蛋白質在遺傳及細胞學的研究中被證明可以調控Rad51的酵素活性。為了要能闡釋Rad51結合蛋白質調控Rad51的作用機轉,我們實驗室將利用蛋白質純化技術和建立同源重組反應實驗,並配合細胞學的研究去探討它們可能的分子作用機轉。此研究的成果將有助於我們了解細胞如何利用Rad51結合蛋白質來調控同源重組反應而進一步的修復損傷之DNA及維持遺傳訊息的穩定性。我們也期待研究的成果有助於進一步預防或研發藥物來治療因同源重組反應失調所造成的人類疾病。

經歷
  • 2019 – 迄今   教授, 臺灣大學生化科學研究所
  • 2018 – 迄今   合聘副研究員, 中央研究院生物化學所
  • 2014 – 2019   副教授, 臺灣大學生化科學研究所
  • 2010 – 2014   助理教授, 臺灣大學生化科學研究所
  • 2011 – 2018   合聘助研究員, 中央研究院生物化學所
  • 2010 – 2010   博士後研究, 美國耶魯大學, 分子生物物理生化系
  • 2008 – 2010   博士後研究, 美國洛克斐勒大學
學歷
  • 2003 – 2007   博士, 分子生物物理生化系, 美國耶魯大學
Yeh HY, Lin SW, Wu YC, Chan NL, Chi P
Scientific Reports (2017)
Su GC, Yeh HY, Lin SW, Chung CI, Huang YS, Liu YC, Lyu PC, Chi P
Nucleic Acids Res. (2016)
Chang HY, Liao CY, Su GC, Lin SW, Wang HW, Chi P
J. Biol. Chem. (2015)
Su GC, Chung CI, Liao CY, Lin SW, Tsai CT, Huang T, Li HW, Chi P
Nucleic Acids Res. (2014)
Wilson MA, Kwon Y, Xu Y, Chung WH, Chi P, Niu H, Mayle R, Chen X, Malkova A, Sung P, Ira G
Nature (2013)
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P
Nucleic Acids Res. (2012)
Chi P, Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL
Nucleic acids research (2011)
Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, Chi P, Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P
Nature (2010)
Chi P, San Filippo J, Sehorn MG, Petukhova GV, Sung P
Genes & development (2007)
Chi P, Kwon Y, Seong C, Epshtein A, Lam I, Sung P, Klein HL
J. Biol. Chem. (2006)
  1. Lee CY, Su GC, Huang WY, Ko MY, Yeh HY, Chang GD, Lin SJ, (Chi P) (2019-01) Nature Communications 10(1), 65 “Promotion of homology-directed DNA repair by polyamines.”
  2. Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, (Chi P), Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E (2019-01) Microbial cell 6(1), 65-101 “Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes.”
  3. Lu CH, Yeh HY, Su GC, Ito K, Kurokawa Y, Iwasaki H*, (Chi P)*, & Li HW* (2018-10) Proc. Nat. Acad. Sci. U.S.A. 115(43), E10059-E10068 “Swi5-Sfr1 Stimulates Rad51 Recombinase Filament Assembly by Modulating Rad51 Dissociation.”
  4. Huang WY, Lai SF, Chiu HY, Chang M, Plikus M, Chan CC, Chen YT, Tsao PN, Yang TL, Lee HS, (Chi P), and Lin SJ (2017-11) Cancer Research 77(22), 6083-6096 “Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy.”
  5. Yeh HY, Lin SW, Wu YC, Chan NL, and (Chi P)*. (2017-05) Scientific Reports 7(1), 2370 “Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C.”
  6. Chao A, Chang TC, Lapke N, Jung SM, (Chi P), Chen CH, Yang LY, Lin CT, Huang HJ, Chou HH, Liou JD, Chen SJ, Wang TH, and Lai CH (2016-12) Oncotarget 7(51), 85529-85541 “Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer.”
  7. Su GC, Yeh HY, Lin SW, Chung CI, Huang YS, Liu YC, Lyu PC, and (Chi P)*. (2016-07) Nucleic Acids Res. 44(13), 6242-6251 “Role of the RAD51-SWI5-SFR1 ensemble in homologous recombination.”
  8. Chang HY, Liao CY, Su GC, Lin SW, Wang HW, (Chi P) (2015-08) The Journal of biological chemistry 290(32), 19863-19873 “Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.”
  9. Huang YC, Chang HH, Mou Y, (Chi P), Chan JC, Luo SC (2014-08) Protein expression and purification 100, 26-32 “Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding protein.”
  10. Su GC, Chung CI, Liao CY, Lin SW, Tsai CT, Huang T, Li HW, (Chi P) (2014-01) NUCLEIC ACIDS RESEARCH 42(1), 349-358 “Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex”
  11. Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, (Chi P), Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P (2014-01) NUCLEIC ACIDS RESEARCH 42(2), 906-917 “Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing”
  12. Wilson MA, Kwon Y, Xu Y, Chung WH, (Chi P), Niu H, Mayle R, Chen X, Malkova A, Sung P, Ira G (2013-10) Nature 502(7471), 393-396 “Pif1 helicase and Poldelta promote recombination-coupled DNA synthesis via bubble migration.”
  13. Busygina, V., Gaines, W.A., Xu, Y., Kwon, Y., Williams, G.J., Lin, S.W., Chang, H.Y., (Chi, P.), Wang, H.W., and Sung, P (2013-09) DNA REPAIR 12(9), 707-12 “Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1”
  14. Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, (Chi P). (2012-08) Nucleic acids research 40(14), 6558-69 “Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.”
  15. Chen CH, Chu PC, Lee L, Lien HW, Lin TL, Fan CC, (Chi P), Huang CJ, Chang MS (2012) PloS one 7(3), e33538 “Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response.”
  16. (Chi P), Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL (2011) Nucleic acids research 39(15), 6511-22 “Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors.”
  17. Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, (Chi P), Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P (2010) Nature 467(7311), 108-11 “Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.”
  18. (Chi P), Kwon Y, Moses DN, Seong C, Sehorn MG, Singh AK, Tsubouchi H, Greene EC, Klein HL, Sung P (2009) DNA repair 8(2), 279-84 “Functional interactions of meiotic recombination factors Rdh54 and Dmc1.”
  19. Robertson RB, Moses DN, Kwon Y, Chan P, (Chi P), Klein H, Sung P, Greene EC (2009) Proceedings of the National Academy of Sciences of the United States of America 106(31), 12688-93 “Structural transitions within human Rad51 nucleoprotein filaments.”
  20. Robertson RB, Moses DN, Kwon Y, Chan P, Zhao W, (Chi P), Klein H, Sung P, Greene EC (2009) Journal of molecular biology 388(4), 703-20 “Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments.”
  21. Kwon Y, Seong C, (Chi P), Greene EC, Klein H, Sung P (2008) Journal of biological chemistry 283(16), 10445-52 “ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.”
  22. Seong C, Sehorn MG, Plate I, Shi I, Song B, (Chi P), Mortensen U, Sung P, Krejci L (2008) Journal of biological chemistry 283(18), 12166-74 “Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52.”
  23. Prasad TK, Robertson RB, Visnapuu ML, (Chi P), Sung P, Greene EC (2007) Journal of molecular biology 369(4), 940-53 “A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.”
  24. (Chi P), San Filippo J, Sehorn MG, Petukhova GV, Sung P (2007) Genes & development 21(14), 1747-57 “Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.”
  25. Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, (Chi P), Janscak P, Jasin M, Vogel H, Sung P, Luo G (2007) Genes & development 21(23), 3073-84 “RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.”
  26. Kwon Y, (Chi P), Roh DH, Klein H, Sung P (2007) DNA repair 6(10), 1496-506 “Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.”
  27. San Filippo J, (Chi P), Sehorn MG, Etchin J, Krejci L, Sung P (2006) Journal of biological chemistry 281(17), 11649-57 “Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.”
  28. (Chi P), Van Komen S, Sehorn MG, Sigurdsson S, Sung P (2006) DNA repair 5(3), 381-91 “Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.”
  29. (Chi P), Kwon Y, Seong C, Epshtein A, Lam I, Sung P, Klein HL (2006) Journal of biological chemistry 281(36), 26268-79 “Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA.”
  30. Raschle M, Van Komen S, (Chi P), Ellenberger T, Sung P (2004) Journal of biological chemistry 279(50), 51973-80 “Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54.”
  31. Chi WJ, Doong SL, Lin-Shiau SY, Boone CW, Kelloff GJ, Lin JK (1998) Carcinogenesis 19(12), 2133-8 “Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.”