研究領域與專長

人類紅血球抗原的分子遺傳學。
我們研究室的興趣在於人類紅血球表面抗原的分子(基因)機制,以及這些抗原在人或族群間呈現的歧異性的分子遺傳學;我們研究的大多是醣抗原和其生合成相關的基因。近幾年我們研究的專題有ABO血型抗原基因與ABO稀有血型、Secretor a-1,2-fucosyltransferase基因和Lewis抗原表現型的關係、以及I b-1,6-N-acetylglucosaminyltransferase基因和I抗原表現及先天性白內障生成的分子遺傳學機制。除了基因型別與醣抗原表現型的關聯,我們也研究在細胞分化過程中,醣抗原表現的輪廓,以及相關醣抗原基因表現的調控機制。目前我們研究室專注於紅血球表面P1(Gala1-4GalNAcb1-3Gal)及Pk(Gala1-4Galb1-4Glc)抗原表現的分子遺傳機制,以及細胞分化過程中I醣抗原表現的變化和I基因表現的調控機制。

學經歷
經歷
  • 2008 – 迄今   教授, 臺灣大學生化科學研究所
  • 2008 – 迄今   合聘副研究員, 中央研究院生物化學研究所
  • 2003 – 2008   合聘助研究員, 中央研究院生物化學研究所
  • 2002 – 2008   副教授, 臺灣大學生化科學研究所
  • 1998 – 2002   研究員, 馬偕紀念醫院醫學研究科
  • 1993 – 1997   副研究員, 馬偕紀念醫院醫學研究科
學歷
  • 1989 – 1994   博士, 生化科學研究所, 臺灣大學
  • 1985 – 1987   碩士, 生化科學研究所, 臺灣大學
  • 1981 – 1985   學士, 動物學系, 臺灣大學
主要著作
Yu LC, Lin M
Current opinion in hematology (2011)
Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC
Blood (2010)
H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu
Glycobiology (2008)
Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu
Blood (2007)
Lin M, Hou MJ, Yu LC
Transfusion (2006)
Twu YC, Hsieh CY, Yu LC
Transfusion (2006)
L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin
Blood (2003)
L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin
Blood (2002)
L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin
Blood (2001)
L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin
J Biol Chem (2001)
著作列表
  1. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, (Yu LC)  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  2. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, (Yu LC)  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  3. Chen PT, Chen ZT, Hou WC, (Yu LC), Chen RP  (2016-07)  Scientific reports  6, 29760  "Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease."
  4. Lai YJ, Wu WY, Yang CM, Yang LR, Chu CC, Chan YS, Lin M, (Yu LC)  (2014-12)  Transfusion  54(12), 3222-3231  "A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P1 /P2 blood groups."
  5. Lu CH, Wu WY, Lai YJ, Yang CM, (Yu LC)  (2014-04)  Glycobiology  24(4), 359-367  "Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells."
  6. Li PT, Liao CJ, (Yu LC), Wu WG, Chu ST  (2012-05)  Fertility and sterility  97(5), 1206-1212.e3  "Localization of B4GALNT2 and its role in mouse embryo attachment."
  7. (Yu LC), Lin M  (2011-11)  Current opinion in hematology  18(6), 421-6  "Molecular genetics of the blood group I system and the regulation of I antigen expression during erythropoiesis and granulopoiesis."
  8. Li PT, Liao CJ, Wu WG, (Yu LC), Chu ST  (2011-06)  Fertility and sterility  95(7), 2404-2409.e3  "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice."
  9. Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, (Yu LC)*   (2010-03)  Blood  115(12), 2491 - 2499  "Phosphorylation status of transcription factor C/EBPα determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis"
  10. Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, (Yu LC), Khoo KH  (2009)  Glycobiology  19(4), 418-27  "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
  11. H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu  (2008)  Glycobiology  18(1), 104-113  "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status."
  12. Lin M, Yu LC  (2008)  Transfusion  48(8), 1768  "Frequencies of the JKnull (IVS5-1g>a) allele in Taiwanese, Fujian, Filipino, and Indonesian populations."
  13. Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo  (2008)  J Biol Chem  283(24), 16455-16468  "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
  14. Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu  (2007)  Blood  110(13), 4526-4534  "I branching formation in erythroid differentiation is regulated by transcription factor C/EBP{alpha}"
  15. Lin M, Hou MJ, (Yu LC)  (2006)  Transfusion  46(11), 1982-7  "A novel IGnT allele responsible for the adult i phenotype."
  16. Twu YC, Hsieh CY, (Yu LC)  (2006)  Transfusion  46(11), 1988-96  "Expression of the histo-blood group B gene predominates in AB-genotype cells."
  17. C. F. Sun, L. C. Yu, D. P. Chen, M. L. Chou, Y. C. Twu, W. T. Wang and M. Lin  (2003)  Transfusion  43, 1138-1144  "Molecular genetic analysis for the Ael and A3 alleles"
  18. C. F. Sun, D. P. Chen, K. T. Lin, W. T. Wang, Y. C. Wang and L. C. Yu  (2003)  Vox Sang  85, 216-220  "Molecular genetic analysis of the Bel phenotype"
  19. L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin  (2003)  Blood  101, 2081-2088  "The Molecular Genetics of the Human I Locus and Molecular Background Explain the Partial Association of the Adult i Phenotype with Congenital Cataracts"
  20. Y. C. Twu, M. L. Chou and L. C. Yu  (2003)  Biochem Biophys Res Commun  303, 868-876  "The molecular genetics of the mouse I b-1,6-N-acetylglucosaminyltransferase locus"
  21. L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin  (2002)  Blood  100, 1490-1492  "Molecular genetic analysis for the B(3) allele"
  22. L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin  (2001)  Blood  98, 3840-3845  "Molecular Basis of the Adult i Phenotype and the Gene Responsible for the Expression of Human Blood Group I Antigen"
  23. L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin  (2001)  J Biol Chem  276, 10247-10252  "Molecular Basis of the Kell-null Phenotype: A Mutation at the Splice Site of Human KEL Gene Abolishes the Expression of Kell Blood Group Antigens"
  24. L. C. Yu, C. C. Chu, Y. S. Chan, C. Y. Chang, Y. C. Twu and M. Lin  (2001)  Transfusion  41, 1279-1284  "Polymorphism and Distribution of the Secretor a(1,2)-Fucosyltransferase Gene in Various Taiwanese Populations"
  25. L. C. Yu, C. Y. Chang, Y. C. Twu and M. Lin  (2000)  Biochem Biophys Res Commun  273, 459-466  "Human Histo-blood Group ABO Glycosyltransferase Genes: Different Enhancer Structures with Different Transcriptional Activities"
  26. L. C. Yu, H. L. Lee, C. C. Chu, R. E. Broadberry and M. Lin  (1999)  Vox Sang  76, 115-119  "A Newly Identified Nonsecretor Allele of the Human Histo-Blood Group a(1,2)-Fucosyltransferase Gene (FUT2)"
  27. L. C. Yu, H. L. Lee, Y. S. Chan and M. Lin  (1999)  Biochem Biophys Res Commun  262, 487-493  "The Molecular Basis for the B(A) Allele: An Amino Acid Alteration in the Human Histoblood Group B a-(1,3)-Galactosyltransferase Increase Its Intrinsic a-(1,3)-N-Acetylgalactosaminyltransferase Activity"
  28. L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen and M. Lin  (1997)  Vox Sang  72, 36-40  "Heterogeneity of the Human H Blood Group a(1,2)Fucosyltransferase Gene among para-Bombay Individuals"
  29. L. C. Yu, Y. L. Hsiao, Y. H. Yang, M. Lin and Y. H. Chen  (1997)  Biochem Biophys Res Commun  231, 106-110  "The Genomic Structure of a Mouse Seminal Vesicle Autoantigen"
  30. L. C. Yu, R. E. Broadberry, Y. H. Yang, Y. H. Chen and M. Lin  (1996)  Biochem Biophys Res Commun  222, 390-394  "Heterogeneity of the Human Secretor a(1,2)Fucosyltransferase Gene among Lewis(a+b-) Non-secretors"
  31. L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen, Y. S. Chan and M. Lin  (1995)  Biochem J  312, 329-332  "Correlation of a Missense Mutation in the Human Secretor a(1,2)-Fucosyltransferase Gene with the Lewis(a+b+) Phenotype: A Potential Molecular Basis for the Weak Secretor Allele (Sew)"
  32. Y. H. Huang, C. W. Luo, L. C. Yu, S. T. Chu and Y. H. Chen  (1995)  Biophys J  69, 2084-2089  "The Protein Conformation and a Zinc-Binding Domain of an Autoantigen from Mouse Seminal Vesicle"
  33. L. C. Yu, J. L. Chen, W. B. Tsai and Y. H. Chen  (1993)  Biochem J  296, 571-576  "Primary Structure and Characterization of an Androgen-Stimulated Autoantigen from Mouse Seminal-Vesicle Secretion"
  34. L. C. Yu and Y. H. Chen  (1993)  Biochem J  296, 107-111  "The Developmental Profile of Lactoferrin in Mouse Epididymis"

人類紅血球抗原的分子遺傳學。
我們研究室的興趣在於人類紅血球表面抗原的分子(基因)機制,以及這些抗原在人或族群間呈現的歧異性的分子遺傳學;我們研究的大多是醣抗原和其生合成相關的基因。近幾年我們研究的專題有ABO血型抗原基因與ABO稀有血型、Secretor a-1,2-fucosyltransferase基因和Lewis抗原表現型的關係、以及I b-1,6-N-acetylglucosaminyltransferase基因和I抗原表現及先天性白內障生成的分子遺傳學機制。除了基因型別與醣抗原表現型的關聯,我們也研究在細胞分化過程中,醣抗原表現的輪廓,以及相關醣抗原基因表現的調控機制。目前我們研究室專注於紅血球表面P1(Gala1-4GalNAcb1-3Gal)及Pk(Gala1-4Galb1-4Glc)抗原表現的分子遺傳機制,以及細胞分化過程中I醣抗原表現的變化和I基因表現的調控機制。

經歷
  • 2008 – 迄今   教授, 臺灣大學生化科學研究所
  • 2008 – 迄今   合聘副研究員, 中央研究院生物化學研究所
  • 2003 – 2008   合聘助研究員, 中央研究院生物化學研究所
  • 2002 – 2008   副教授, 臺灣大學生化科學研究所
  • 1998 – 2002   研究員, 馬偕紀念醫院醫學研究科
  • 1993 – 1997   副研究員, 馬偕紀念醫院醫學研究科
學歷
  • 1989 – 1994   博士, 生化科學研究所, 臺灣大學
  • 1985 – 1987   碩士, 生化科學研究所, 臺灣大學
  • 1981 – 1985   學士, 動物學系, 臺灣大學
Yu LC, Lin M
Current opinion in hematology (2011)
Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC
Blood (2010)
H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu
Glycobiology (2008)
Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu
Blood (2007)
Lin M, Hou MJ, Yu LC
Transfusion (2006)
Twu YC, Hsieh CY, Yu LC
Transfusion (2006)
L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin
Blood (2003)
L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin
Blood (2002)
L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin
Blood (2001)
L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin
J Biol Chem (2001)
  1. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, (Yu LC)  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  2. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, (Yu LC)  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  3. Chen PT, Chen ZT, Hou WC, (Yu LC), Chen RP  (2016-07)  Scientific reports  6, 29760  "Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease."
  4. Lai YJ, Wu WY, Yang CM, Yang LR, Chu CC, Chan YS, Lin M, (Yu LC)  (2014-12)  Transfusion  54(12), 3222-3231  "A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P1 /P2 blood groups."
  5. Lu CH, Wu WY, Lai YJ, Yang CM, (Yu LC)  (2014-04)  Glycobiology  24(4), 359-367  "Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells."
  6. Li PT, Liao CJ, (Yu LC), Wu WG, Chu ST  (2012-05)  Fertility and sterility  97(5), 1206-1212.e3  "Localization of B4GALNT2 and its role in mouse embryo attachment."
  7. (Yu LC), Lin M  (2011-11)  Current opinion in hematology  18(6), 421-6  "Molecular genetics of the blood group I system and the regulation of I antigen expression during erythropoiesis and granulopoiesis."
  8. Li PT, Liao CJ, Wu WG, (Yu LC), Chu ST  (2011-06)  Fertility and sterility  95(7), 2404-2409.e3  "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice."
  9. Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, (Yu LC)*   (2010-03)  Blood  115(12), 2491 - 2499  "Phosphorylation status of transcription factor C/EBPα determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis"
  10. Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, (Yu LC), Khoo KH  (2009)  Glycobiology  19(4), 418-27  "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
  11. H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu  (2008)  Glycobiology  18(1), 104-113  "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status."
  12. Lin M, Yu LC  (2008)  Transfusion  48(8), 1768  "Frequencies of the JKnull (IVS5-1g>a) allele in Taiwanese, Fujian, Filipino, and Indonesian populations."
  13. Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo  (2008)  J Biol Chem  283(24), 16455-16468  "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
  14. Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu  (2007)  Blood  110(13), 4526-4534  "I branching formation in erythroid differentiation is regulated by transcription factor C/EBP{alpha}"
  15. Lin M, Hou MJ, (Yu LC)  (2006)  Transfusion  46(11), 1982-7  "A novel IGnT allele responsible for the adult i phenotype."
  16. Twu YC, Hsieh CY, (Yu LC)  (2006)  Transfusion  46(11), 1988-96  "Expression of the histo-blood group B gene predominates in AB-genotype cells."
  17. C. F. Sun, L. C. Yu, D. P. Chen, M. L. Chou, Y. C. Twu, W. T. Wang and M. Lin  (2003)  Transfusion  43, 1138-1144  "Molecular genetic analysis for the Ael and A3 alleles"
  18. C. F. Sun, D. P. Chen, K. T. Lin, W. T. Wang, Y. C. Wang and L. C. Yu  (2003)  Vox Sang  85, 216-220  "Molecular genetic analysis of the Bel phenotype"
  19. L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin  (2003)  Blood  101, 2081-2088  "The Molecular Genetics of the Human I Locus and Molecular Background Explain the Partial Association of the Adult i Phenotype with Congenital Cataracts"
  20. Y. C. Twu, M. L. Chou and L. C. Yu  (2003)  Biochem Biophys Res Commun  303, 868-876  "The molecular genetics of the mouse I b-1,6-N-acetylglucosaminyltransferase locus"
  21. L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin  (2002)  Blood  100, 1490-1492  "Molecular genetic analysis for the B(3) allele"
  22. L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin  (2001)  Blood  98, 3840-3845  "Molecular Basis of the Adult i Phenotype and the Gene Responsible for the Expression of Human Blood Group I Antigen"
  23. L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin  (2001)  J Biol Chem  276, 10247-10252  "Molecular Basis of the Kell-null Phenotype: A Mutation at the Splice Site of Human KEL Gene Abolishes the Expression of Kell Blood Group Antigens"
  24. L. C. Yu, C. C. Chu, Y. S. Chan, C. Y. Chang, Y. C. Twu and M. Lin  (2001)  Transfusion  41, 1279-1284  "Polymorphism and Distribution of the Secretor a(1,2)-Fucosyltransferase Gene in Various Taiwanese Populations"
  25. L. C. Yu, C. Y. Chang, Y. C. Twu and M. Lin  (2000)  Biochem Biophys Res Commun  273, 459-466  "Human Histo-blood Group ABO Glycosyltransferase Genes: Different Enhancer Structures with Different Transcriptional Activities"
  26. L. C. Yu, H. L. Lee, C. C. Chu, R. E. Broadberry and M. Lin  (1999)  Vox Sang  76, 115-119  "A Newly Identified Nonsecretor Allele of the Human Histo-Blood Group a(1,2)-Fucosyltransferase Gene (FUT2)"
  27. L. C. Yu, H. L. Lee, Y. S. Chan and M. Lin  (1999)  Biochem Biophys Res Commun  262, 487-493  "The Molecular Basis for the B(A) Allele: An Amino Acid Alteration in the Human Histoblood Group B a-(1,3)-Galactosyltransferase Increase Its Intrinsic a-(1,3)-N-Acetylgalactosaminyltransferase Activity"
  28. L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen and M. Lin  (1997)  Vox Sang  72, 36-40  "Heterogeneity of the Human H Blood Group a(1,2)Fucosyltransferase Gene among para-Bombay Individuals"
  29. L. C. Yu, Y. L. Hsiao, Y. H. Yang, M. Lin and Y. H. Chen  (1997)  Biochem Biophys Res Commun  231, 106-110  "The Genomic Structure of a Mouse Seminal Vesicle Autoantigen"
  30. L. C. Yu, R. E. Broadberry, Y. H. Yang, Y. H. Chen and M. Lin  (1996)  Biochem Biophys Res Commun  222, 390-394  "Heterogeneity of the Human Secretor a(1,2)Fucosyltransferase Gene among Lewis(a+b-) Non-secretors"
  31. L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen, Y. S. Chan and M. Lin  (1995)  Biochem J  312, 329-332  "Correlation of a Missense Mutation in the Human Secretor a(1,2)-Fucosyltransferase Gene with the Lewis(a+b+) Phenotype: A Potential Molecular Basis for the Weak Secretor Allele (Sew)"
  32. Y. H. Huang, C. W. Luo, L. C. Yu, S. T. Chu and Y. H. Chen  (1995)  Biophys J  69, 2084-2089  "The Protein Conformation and a Zinc-Binding Domain of an Autoantigen from Mouse Seminal Vesicle"
  33. L. C. Yu, J. L. Chen, W. B. Tsai and Y. H. Chen  (1993)  Biochem J  296, 571-576  "Primary Structure and Characterization of an Androgen-Stimulated Autoantigen from Mouse Seminal-Vesicle Secretion"
  34. L. C. Yu and Y. H. Chen  (1993)  Biochem J  296, 107-111  "The Developmental Profile of Lactoferrin in Mouse Epididymis"