人類紅血球抗原的分子遺傳學。
我們研究室的興趣在於人類紅血球表面抗原的分子(基因)機制,以及這些抗原在人或族群間呈現的歧異性的分子遺傳學;我們研究的大多是醣抗原和其生合成相關的基因。近幾年我們研究的專題有ABO血型抗原基因與ABO稀有血型、Secretor a-1,2-fucosyltransferase基因和Lewis抗原表現型的關係、以及I b-1,6-N-acetylglucosaminyltransferase基因和I抗原表現及先天性白內障生成的分子遺傳學機制。除了基因型別與醣抗原表現型的關聯,我們也研究在細胞分化過程中,醣抗原表現的輪廓,以及相關醣抗原基因表現的調控機制。目前我們研究室專注於紅血球表面P1(Gala1-4GalNAcb1-3Gal)及Pk(Gala1-4Galb1-4Glc)抗原表現的分子遺傳機制,以及細胞分化過程中I醣抗原表現的變化和I基因表現的調控機制。
人類紅血球抗原的分子遺傳學。
我們研究室的興趣在於人類紅血球表面抗原的分子(基因)機制,以及這些抗原在人或族群間呈現的歧異性的分子遺傳學;我們研究的大多是醣抗原和其生合成相關的基因。近幾年我們研究的專題有ABO血型抗原基因與ABO稀有血型、Secretor a-1,2-fucosyltransferase基因和Lewis抗原表現型的關係、以及I b-1,6-N-acetylglucosaminyltransferase基因和I抗原表現及先天性白內障生成的分子遺傳學機制。除了基因型別與醣抗原表現型的關聯,我們也研究在細胞分化過程中,醣抗原表現的輪廓,以及相關醣抗原基因表現的調控機制。目前我們研究室專注於紅血球表面P1(Gala1-4GalNAcb1-3Gal)及Pk(Gala1-4Galb1-4Glc)抗原表現的分子遺傳機制,以及細胞分化過程中I醣抗原表現的變化和I基因表現的調控機制。
經歷
- 2008 – 迄今 教授, 臺灣大學生化科學研究所
- 2008 – 迄今 合聘副研究員, 中央研究院生物化學研究所
- 2003 – 2008 合聘助研究員, 中央研究院生物化學研究所
- 2002 – 2008 副教授, 臺灣大學生化科學研究所
- 1998 – 2002 研究員, 馬偕紀念醫院醫學研究科
- 1993 – 1997 副研究員, 馬偕紀念醫院醫學研究科
學歷
- 1989 – 1994 博士, 生化科學研究所, 臺灣大學
- 1985 – 1987 碩士, 生化科學研究所, 臺灣大學
- 1981 – 1985 學士, 動物學系, 臺灣大學
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Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, (Yu LC) (2018-08) Blood advances 2(15), 1854-1864 "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
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Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, (Yu LC) (2018-04) Transfusion 58(4), 1054-1064 "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
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Chen PT, Chen ZT, Hou WC, (Yu LC), Chen RP (2016-07) Scientific reports 6, 29760 "Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease."
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Lai YJ, Wu WY, Yang CM, Yang LR, Chu CC, Chan YS, Lin M, (Yu LC) (2014-12) Transfusion 54(12), 3222-3231 "A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P1 /P2 blood groups."
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Lu CH, Wu WY, Lai YJ, Yang CM, (Yu LC) (2014-04) Glycobiology 24(4), 359-367 "Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells."
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Li PT, Liao CJ, (Yu LC), Wu WG, Chu ST (2012-05) Fertility and sterility 97(5), 1206-1212.e3 "Localization of B4GALNT2 and its role in mouse embryo attachment."
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(Yu LC), Lin M (2011-11) Current opinion in hematology 18(6), 421-6 "Molecular genetics of the blood group I system and the regulation of I antigen expression during erythropoiesis and granulopoiesis."
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Li PT, Liao CJ, Wu WG, (Yu LC), Chu ST (2011-06) Fertility and sterility 95(7), 2404-2409.e3 "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice."
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Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, (Yu LC)* (2010-03) Blood 115(12), 2491 - 2499 "Phosphorylation status of transcription factor C/EBPα determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis"
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Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, (Yu LC), Khoo KH (2009) Glycobiology 19(4), 418-27 "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
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H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu (2008) Glycobiology 18(1), 104-113 "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status."
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Lin M, Yu LC (2008) Transfusion 48(8), 1768 "Frequencies of the JKnull (IVS5-1g>a) allele in Taiwanese, Fujian, Filipino, and Indonesian populations."
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Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo (2008) J Biol Chem 283(24), 16455-16468 "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
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Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu (2007) Blood 110(13), 4526-4534 "I branching formation in erythroid differentiation is regulated by transcription factor C/EBP{alpha}"
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Lin M, Hou MJ, (Yu LC) (2006) Transfusion 46(11), 1982-7 "A novel IGnT allele responsible for the adult i phenotype."
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Twu YC, Hsieh CY, (Yu LC) (2006) Transfusion 46(11), 1988-96 "Expression of the histo-blood group B gene predominates in AB-genotype cells."
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C. F. Sun, L. C. Yu, D. P. Chen, M. L. Chou, Y. C. Twu, W. T. Wang and M. Lin (2003) Transfusion 43, 1138-1144 "Molecular genetic analysis for the Ael and A3 alleles"
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C. F. Sun, D. P. Chen, K. T. Lin, W. T. Wang, Y. C. Wang and L. C. Yu (2003) Vox Sang 85, 216-220 "Molecular genetic analysis of the Bel phenotype"
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L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin (2003) Blood 101, 2081-2088 "The Molecular Genetics of the Human I Locus and Molecular Background Explain the Partial Association of the Adult i Phenotype with Congenital Cataracts"
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Y. C. Twu, M. L. Chou and L. C. Yu (2003) Biochem Biophys Res Commun 303, 868-876 "The molecular genetics of the mouse I b-1,6-N-acetylglucosaminyltransferase locus"
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L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin (2002) Blood 100, 1490-1492 "Molecular genetic analysis for the B(3) allele"
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L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin (2001) Blood 98, 3840-3845 "Molecular Basis of the Adult i Phenotype and the Gene Responsible for the Expression of Human Blood Group I Antigen"
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L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin (2001) J Biol Chem 276, 10247-10252 "Molecular Basis of the Kell-null Phenotype: A Mutation at the Splice Site of Human KEL Gene Abolishes the Expression of Kell Blood Group Antigens"
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L. C. Yu, C. C. Chu, Y. S. Chan, C. Y. Chang, Y. C. Twu and M. Lin (2001) Transfusion 41, 1279-1284 "Polymorphism and Distribution of the Secretor a(1,2)-Fucosyltransferase Gene in Various Taiwanese Populations"
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L. C. Yu, C. Y. Chang, Y. C. Twu and M. Lin (2000) Biochem Biophys Res Commun 273, 459-466 "Human Histo-blood Group ABO Glycosyltransferase Genes: Different Enhancer Structures with Different Transcriptional Activities"
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L. C. Yu, H. L. Lee, C. C. Chu, R. E. Broadberry and M. Lin (1999) Vox Sang 76, 115-119 "A Newly Identified Nonsecretor Allele of the Human Histo-Blood Group a(1,2)-Fucosyltransferase Gene (FUT2)"
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L. C. Yu, H. L. Lee, Y. S. Chan and M. Lin (1999) Biochem Biophys Res Commun 262, 487-493 "The Molecular Basis for the B(A) Allele: An Amino Acid Alteration in the Human Histoblood Group B a-(1,3)-Galactosyltransferase Increase Its Intrinsic a-(1,3)-N-Acetylgalactosaminyltransferase Activity"
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L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen and M. Lin (1997) Vox Sang 72, 36-40 "Heterogeneity of the Human H Blood Group a(1,2)Fucosyltransferase Gene among para-Bombay Individuals"
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L. C. Yu, Y. L. Hsiao, Y. H. Yang, M. Lin and Y. H. Chen (1997) Biochem Biophys Res Commun 231, 106-110 "The Genomic Structure of a Mouse Seminal Vesicle Autoantigen"
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L. C. Yu, R. E. Broadberry, Y. H. Yang, Y. H. Chen and M. Lin (1996) Biochem Biophys Res Commun 222, 390-394 "Heterogeneity of the Human Secretor a(1,2)Fucosyltransferase Gene among Lewis(a+b-) Non-secretors"
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L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen, Y. S. Chan and M. Lin (1995) Biochem J 312, 329-332 "Correlation of a Missense Mutation in the Human Secretor a(1,2)-Fucosyltransferase Gene with the Lewis(a+b+) Phenotype: A Potential Molecular Basis for the Weak Secretor Allele (Sew)"
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Y. H. Huang, C. W. Luo, L. C. Yu, S. T. Chu and Y. H. Chen (1995) Biophys J 69, 2084-2089 "The Protein Conformation and a Zinc-Binding Domain of an Autoantigen from Mouse Seminal Vesicle"
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L. C. Yu, J. L. Chen, W. B. Tsai and Y. H. Chen (1993) Biochem J 296, 571-576 "Primary Structure and Characterization of an Androgen-Stimulated Autoantigen from Mouse Seminal-Vesicle Secretion"
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L. C. Yu and Y. H. Chen (1993) Biochem J 296, 107-111 "The Developmental Profile of Lactoferrin in Mouse Epididymis"