研究領域與專長
  1. 系統生物學研究: 系統生物學可同時整合基因體學、蛋白質體學及生物資訊學等研究,以系統性的方法分析生物體或細胞中各種基因和功能性蛋白質間複雜的交互關係,並瞭解這些關係是如何運作。

  2. 酵素催化有機合成: a.用酵素催化合成光學活性胺基酸、蛋白質及醫藥中間體。 b.高穩定性酵素之篩選及新酵素合成法之開發。

  3. 以化學法研究蛋白質工程:利用電腦模擬及化學合成進行蛋白質工程研究 a.以組合研究法研究酵素之特異選擇性。 b.研究與設計酵素之抑制劑。 c.開發新醣蛋白合成方法。 d.蛋白質受體分離及三度空間結構決定。

  4. 增進醫藥傳送及療效 a.增加腦神經藥之腦膜穿透效果。 b.用生長激素釋放的抑制因子受體來輸送抗癌藥物入癌細胞。 c.用葉酸受體來輸送抗癌藥物入癌細胞。 d.用肝細胞受體來輸送Antisense DNA或RNA。

學經歷
經歷
  • 2018 – 2019   兼任研究員, 中央研究院生物化學研究
  • 2016 – 2017   兼任研究員, 中央研究院生物化學研究
  • 1996 – 2016   研究員, 中央研究院生物化學研究所
  • 1990 – 1996   副研究員, 中央研究院生物化學研究
  • 1988 – 1989   客座研究學者, 德州農工大學化學系
  • 1985 – 1990   助研究員, 中央研究院生物化學研究所
學歷
  • 1986 – 1989   博士, 生化科學, 臺灣大學生化科學研究所
  • 1983 – 1985   碩士, 有機化學, Univ. of Nevada. Reno(USA)
  • 1973 – 1978   學士, 化學工程, 淡江大學(Taiwan)
主要著作
Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer.
Tsai, H.Y.; Boonyapra, K.; Sriyam, S.; Yu, C.J.; Wu, S.W.; Khoo, K.H.; Phutrakul, S.; Chen, S.T.
Proteomics (2011)
One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3-triazoles as anticancer agents.
Lee, W.T.; Tai, H.R.; Chen, S.T.
ACS Comb Sci. (2011)
Dierent sample preparation and detection methods for normal and lung cancer urinary proteome analysis.
Sinchaikul, S.; Tantipaiboonwong, P.; Sriyam, S.; Tzao, C.; Phutrakul, S.; Chen, S.T.
Methods Mol Biol. (2010)
Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.
Chen, C.J.; Vijaya, K.R.; Tsai, C.C.; Wu, W.H.; Chao, L.K.; Hwang, K.H.; Chien, C.M.; Chang, H.Y.; Chen, S.T.
Bioorg Med Chem. (2010)
Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome.
Chen, S.T.; Pan, T.L.; Juan, H.F.; Chen, T.Y.; Lin, Y.S.; Huang, C.M.
J. Proteome Res. (2008)
Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters.
Lin, Y.S.; Tangpradit, R.; Sinchaikul, S.; An, F.M.; Liu, D.Z.; Phutrakul, S.; Chen, S.T.
J. Med. Chem. (2008)
A New Application of Microwave Technology to Proteomics.
Juan, H.F.; Chang, S.C.; Topanurak, S.; Chen, S.T.
Proteomics (2005)
Dierent techniques for urinary protein analysis of normal and cancer patients.
Tantipaiboonwong, P.; Sinchaikul, S.; Sriyam, S.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
Functional proteomics and correlated signaling pathway of thermophilic bacterium Bacillus stearothermophilus TLS33 under cold shock stress.
Topanurak, S.; Sinchaikul, S.; Sookkheo, B.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
Proteomics viewed on stress response of thermophilic bacterium Bacillus stearothermophilus TLS33.
Topanurak, S.; Sinchaikul, S.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
著作列表
  1. Lee IS, Kirschner R, (Chen ST)  (2019-08)  Functional Foods in Health and Disease  9(8), 508-520  "Medicinal Mushroom Taiwanofungus camphoratus: A potential cure for cancer."
  2. Chao OY, Chen HW, Ho CH, Chou JC, Yuan YT, Ho CL, Hsueh HT, (Chen ST), Liao PC, Chao LK  (2018-04)  Journal of Cleaner Production  180, 349-359  "Value chain analysis of algal bioenergy and carbon capture integrated with a biotechnology innovation."
  3. Hsieh YY, Huang TC, Lo HL, Jhan JY, (Chen ST), Yang PM  (2016-05)  Oncotarget  7(19), 27363-27378  "Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine."
  4. Chen TY, Kuo SH, (Chen ST), Hwang DF  (2016-03)  Food chemistry  194, 529-537  "Differential proteomics to explore the inhibitory effects of acidic, slightly acidic electrolysed water and sodium hypochlorite solution on Vibrio parahaemolyticus."
  5. Ka SM, Kuoping Chao L, Lin JC, (Chen ST), Li WT, Lin CN, Cheng JC, Jheng HL, Chen A, Hua KF  (2016-02)  Free radical biology & medicine  91, 10-24  "A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways."
  6. Chen YC, Chen CC, (Chen ST), Hsieh JF   (2016-01)  Food Hydrocolloids  52, 137-143  "Proteomic profiling of the coagulation of milk proteins induced by glucono-delta-lactone"
  7. Lin CR, Wei TW, Tsai HY, Wu YT, Wu PY, (Chen ST)  (2015-12)  FASEB journal  29(12), 5006-5017  "Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation."
  8. Ma HT, Hsieh JF, (Chen ST)  (2015-06)  Phytochemistry  114, 109-113  "Anti-diabetic effects of Ganoderma lucidum."
  9. Chen CC, (Chen ST), Hsieh JF  (2015-04)  Molecules  20(5), 7737-7749  "Proteomic analysis of polysaccharide-milk protein interactions induced by chitosan."
  10. Potprommanee L, Ma HT, Shank L, Juan YH, Liao WY, (Chen ST), Yu CJ  (2015-01)  Journal of thoracic oncology  10(1), 102-109  "GM2-Activator Protein: A New Biomarker for Lung Cancer."
  11. Huang PJ, Chang KL, Hsieh JF, (Chen ST)  (2015)  BioMed Research International  2015, 409103  "Catalysis of rice straw hydrolysis by the combination of immobilized cellulase from Aspergillus niger on beta-cyclodextrin-Fe3O4 nanoparticles and ionic liquid."
  12. Lin SH, Chen WC, Lu KH, Chen PJ, Hsieh SC, Pan TM, (Chen ST), Sheen LY  (2014-10)  Journal of agricultural and food chemistry  62(43), 10493-10503  "Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume."
  13. Kuo-Jen Hwang, Hung-Yuan Tsai, (Shui-Tein Chen)   (2014-03)  Journal of Membrane Science  454, 418-425  "Enzymatic hydrolysis suspension cross-flow diafiltration using polysulfone hollow fiber module."
  14. Jung-Feng Hsieh, Chia-Jung Yu, Je-Yu Chang, (Shui-Tein Chen), Hsien-Yu Tsai  (2014-03)  Food Hydrocolloids  35, 678-685  "Microbial transglutaminase-induced polymerization of β-conglycinin and glycinin in soymilk: A proteomics approach"
  15. Wu YH, Kuo WC, Wu YJ, Yang KT, (Chen ST), Jiang ST, Gordy C, He YW, Lai MZ  (2014-03)  Cell death and differentiation  21(3), 451-461  "Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation."
  16. Ken-Lin Chang, Chih-Cheng Chen, Jun-Hong Lin, Jung-Feng Hsien, Yin Wang, Feng Zhao, Yi-Hsuan Shih, Zhen-jiao Xing, (Shui-Tein Chen)  (2014-02)  New Carbon Materials  29(1), 47-54  "Rice straw-derived activated carbons for the removal of carbofuran from an aqueous solution."
  17. Lo TF, Tsai WC, (Chen ST)  (2013-09)  PloS one  8(9), e75628  "MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth."
  18. Tsai CC, Lin CR, Tsai HY, Chen CJ, Li WT, Yu HM, Ke YY, Hsieh WY, Chang CY, Wu CY, (Chen ST), Wong CH  (2013-06)  Journal of Biological Chemistry  288(24), 17689-17697  "The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling."
  19. Ken-Lin Chang, Jung-Feng Hsieh, Bay-Ming Ou, Min-Hsuan Chang, Wei-Ying Hseih, Jun-Hong Lin, Po-Jung Huang, Kam-Fei Wong and (Shui-Tein Chen)  (2012)  Separation Science and Technology  47(10), 1514-1521  "Adsorption Studies on the Removal of an Endocrine-Disrupting Compound (Bisphenol A) using Activated Carbon from Rice Straw Agricultural Waste"
  20. Wu WH, Chen TY, Lu RW, (Chen ST), Chang CC  (2012)  Phytochemistry  83, 110-5  "Benzoxazinoids from Scoparia dulcis (sweet broomweed) with antiproliferative activity against the DU-145 human prostate cancer cell line."
  21. Lin YP, Chen TY, Tseng HW, Lee MH, (Chen ST)  (2012)  Phytochemistry  84, 102-15  "Chemical and biological evaluation of nephrocizin in protecting nerve growth factor-differentiated PC12 cells by 6-hydroxydopamine-induced neurotoxicity."
  22. Satitmanwiwat S, Ratanakhanokchai K, Laohakunjit N, Chao LK, (Chen ST), Pason P, Tachaapaikoon C, Kyu KL  (2012)  Journal of agricultural and food chemistry  60(21), 5423-30  "Improved purity and immunostimulatory activity of beta-(1-->3)(1-->6)-glucan from Pleurotus sajor-caju using cell wall-degrading enzymes."
  23. Chen CY, (Chen ST), Juan HF, Huang HC  (2012)  BIOINFORMATICS  28(24), 3178-3181  "Lengthening of 3'UTR increases with morphological complexity in animal evolution."
  24. Tsai CC, Yang FL, Huang ZY, Chen CS, Yang YL, Hua KF, Li J, (Chen ST), Wu SH  (2012)  Journal of agricultural and food chemistry  60(11), 2830-7  "Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells."
  25. Kuo-Jen Hwang, Kuan-Chung Chen, (Shui-Tein Chen) and Ken-Lin Chang   (2012)  Separation Science and Technology  47(1), 52-61  "Sugar Purification from Enzymatic Rice Straw Hydrolysis Products using Cross-Flow Diafiltration"
  26. R. Tungpradit, S. Sinchaikul, S. Phutrakul, W. Wongkham and (S. T. Chen)  (2011)  Chiang Mai Journal of Science  38(1), 85-94  "Antiproliferative Activity of Berberine from Coscinium fenestratum on NCI-H838 Cell Line"
  27. W. Chiangjong, S. Sinchaikul, (S. T. Chen), V. Thongboonkerd  (2011)  Mol Biosyst.  7(6), 1917-1925  "Calcium oxalate dihydrate crystal induced changes in glycoproteome of distal renal tubular epithelial cells."
  28. C. Y. Chen, (S. T. Chen), C. S. Fuh, H. F. Juan, H. C. Huang  (2011)  BMC Bioinformatics  12 Suppl 1, S41  "Coregulation of transcription factors and microRNAs in human transcriptional regulatory network"
  29. H. H. Liao, Y. C. Wang, M. C. Chen, H. Y. Tsai, J. Lin, (S. T. Chen), G. J. Tsay, S. L. Cheng  (2011)  BMC Immunol.  12, 16  "Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells"
  30. K. L. Chang, T.-A. Jiladda, J. F. Hsieh, B. M. Ou, S. H. Chen, K. Ratanakhanokchai, P. J. Huang, (S. T. Chen)  (2011)  Biomass & Bioenergy  35(1), 90-95  "Enhanced enzymatic conversion with freeze pretreatment of rice straw"
  31. J. W. Hsu, H. C. Huang, (S. T. Chen), C. H. Wong, H. F. Juan.  (2011)  Evidence-based Complementary and Alternative Medicine  2011, 358717  "Ganoderma lucidum Polysaccharides Induce Macrophage-like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation"
  32. Boonyapranai K, Tsai HY, Chen MC, Sriyam S, Sinchaikul S, Phutrakul S, (Chen ST)  (2011)  Electrophoresis  32(12), 1422-1432  "Glycoproteomic analysis and molecular modeling of haptoglobin multimers."
  33. H. Y. Tsai, K. Boonyapranai, S. Sriyam, C. J. Yu, S. W. Wu, K. H. Khoo, S. Phutrakul, (S. T. Chen)  (2011)  Proteomics.  11(11), 2162-2170  "Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer."
  34. C. Y. Li, L. K. Chao, S. C. Wang, H. Z. Chang, M. L. Tsai, S. H. Fang, P. C. Liao, C. L. Ho, (S. T. Chen), W. C. Cheng, C. S. Chiang, K. F. Hua, I. C. Hsu  (2011)  J Cell Physiol.  226(9), 2338-2349  "Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells"
  35. K. L. Chang, T.-A. Jiladda, S. H. Chen, J. F. Hsieh, K. Ratanakhanokchai, P. J. Huang, T. C. Lin, (S. T. Chen)  (2011)  BIORESOURCE TECHNOLOGY  102(2), 519-523  "Improving the remaining activity of lignocellulolytic enzymes by membrane entrapment"
  36. W. T. Li, W. H. Wu, C. H. Tang, R. Tai, (S. T. Chen)  (2011)  ACS Combinatorial Science  13(1), 72-78  "One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3-triazoles as anticancer agents"
  37. T. L. Pan, P. W. Wang, (S. T. Chen), J. Y. Fang, T. K. Hsu, N. Sintupisut, S. Goto, C. L. Chen  (2011)  Clin Chim Acta  412(7-8), 604-613  "Prospective highlights of serum glycoproteins in spontaneous tolerance after orthotopic liver transplantation."
  38. Lin CM, Lin RD, (Chen ST), Lin YP, Chiu WT, Lin JW, Hsu FL, Lee MH  (2010-12)  Phytochemistry  71(17-18), 2147-2156  "Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells."
  39. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-10)  Journal of proteome research  9(10), 4960-4971  "The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells."
  40. Pattanakitsakul SN, Poungsawai J, Kanlaya R, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-09)  Journal of proteome research  9(9), 4640-4648  "Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells."
  41. Chen CJ, Vijaya Krishna R, Tsai CC, Wu WH, Chao LK, Hwang KH, Chien CM, Chang HY, (Chen ST)  (2010-09)  Bioorganic & medicinal chemistry  18(18), 6896-6904  "Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation."
  42. Singhto N, Sintiprungrat K, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-08)  Journal of proteome research  9(8), 3980-3988  "Proteome changes in human monocytes upon interaction with calcium oxalate monohydrate crystals."
  43. Moongkarndi P, Srisawat C, Saetun P, Jantaravinid J, Peerapittayamongkol C, Soi-ampornkul R, Junnu S, Sinchaikul S, (Chen ST), Charoensilp P, Thongboonkerd V, Neungton N  (2010-05)  Journal of proteome research  9(5), 2076-2086  "Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells."
  44. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-05)  Molecular bioSystems  6(5), 795-806  "Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release."
  45. Li YZ, Ho YP, (Chen ST), Shiuan D  (2010-04)  Applied biochemistry and biotechnology  160(8), 2248-2255  "Proteomic Analysis of the Interactions between Mycoplasma hyopneumoniae and Porcine Tracheal Ciliated Cells."
  46. Pan TL, Hung YC, Wang PW, (Chen ST), Hsu TK, Sintupisut N, Cheng CS, Lyu PC  (2010-03)  Proteomics  10(5), 914-929  "Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells."
  47. Sintiprungrat K, Singhto N, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-01)  Journal of proteomics  73(3), 602-618  "Alterations in cellular proteome and secretome upon differentiation from monocyte to macrophage by treatment with phorbol myristate acetate: Insights into biological processes."
  48. Opatrna S, Chiangjong W, Korabecna M, Sintiprungrat K, Sinchaikul S, (Chen ST), Matejovic M, Thongboonkerd V  (2010-01)  Clinical biochemistry  43(1-2), 142-149  "Plasma proteome profiling of von Hippel-Lindau disease after total and subtotal nephrectomy: a preliminary study."
  49. Sinchaikul S, Tantipaiboonwong P, Sriyam S, Tzao C, Phutrakul S, (Chen ST)  (2010)  Methods in molecular biology (Clifton, N.J.)  641, 65-88  "Different sample preparation and detection methods for normal and lung cancer urinary proteome analysis."
  50. Eric S. L. Hsiao, Jeff C. F. Chen, Hsien-Yu Tsai, Kay-Hooi Khoo, Shui-Tein Chen and Jason T. C. Tzen  (2009-08)  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  57(15), 6757–6763  "Determination of N-Glycosylation Site and Glycan Structures of Pectin Methylesterase in Jelly Fig (Ficus awkeotsang) Achenes"
  51. Thongboonkerd V, Chiangjong W, Saetun P, Sinchaikul S, Chen ST, Kositanont U  (2009-07)  Proteomics  9(13), 3522-3534  "Analysis of differential proteomes in pathogenic and non-pathogenic Leptospira: potential pathogenic and virulence factors"
  52. Pumirat P, Saetun P, Sinchaikul S, Chen ST, Korbsrisate S, Thongboonkerd V  (2009-06)  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS  1794(6), 898-904  "Altered secretome of Burkholderia pseudomallei induced by salt stress"
  53. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, Chen ST, Thongboonkerd V  (2009-05)  J Proteome Res.  8(5), 2551-2562  "Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration"
  54. Thongboonkerd V, Chiangjong W, Mares J, Moravec J, Tuma Z, Karvunidis T, Sinchaikul S, Chen ST, Opatrný K, Matejovic M.  (2009-05)  CLINICAL SCIENCE  116(9), 721-730  "Altered plasma proteome during an early phase of peritonitis-induced sepsis"
  55. Chen YJ, Yu CC, "Chen ST", Chen TY, Liao HF*  (2009-05)  PROTEOMICS CLINICAL APPLICATIONS  3(5), 563-573  "Functional regulation and proteomic characterization of human natural killer cells through recombinant human granulocyte-colony stimulating factor treatment"
  56. Chen YR, Y-Y R, Lin TY, Huang CP, Tang WC, Chen ST, Lin SB  (2009-05)  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  57(6), 2200-2205  "Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis"
  57. Tavichakorntrakool R, Sriboonlue P, Prasongwattana V, Puapairoj A, Yenchitsomanus PT, Sinchaikul S, Chen ST, Wongkham C, Thongboonkerd V  (2009-05)  J Proteome Res.  8(5), 2586-2593  "Metabolic enzymes, antioxidants, and cytoskeletal proteins are significantly altered in vastus lateralis muscle of K-depleted cadaveric subjects"
  58. Hongsachart P, Huang-Liu R, Sinchaikul S, Pan FM, Phutrakul S, Chuang YM, Yu CJ, (Chen ST)  (2009-04)  Electrophoresis.  30(7), 1206-1220  "Glycoproteomic analysis of WGA-bound glycoprotein biomarkers in sera from patients with lung adenocarcinoma"
  59. Li YZ, Ho YP, Chen ST, Chiou TW, Li ZS, Shiuan D  (2009-02)  BIOCHEMISTRY-MOSCOW  74(2), 215-220  "Proteomic comparative analysis of pathogenic strain 232 and avirulent strain J of Mycoplasma hyopneumoniae"
  60. Nawarak J, Huang-Liu R, Kao SH, Liao HH, Sinchaikul S, Chen ST, Cheng SL  (2009-02)  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS  1794(2), 159-167  "Proteomics analysis of A375 human malignant melanoma cells in response to arbutin treatment"
  61. Chen CM, Chen, Chiung-Mei, Hou YT, Hou, Yi-Ting, Liu JY , Wu YR, Lin CH, Fung HC, Hsu WC, Hsu YY, Lee SH, Hsieh-Li HM, Su MT, (Chen ST) , Lane HY, Lee-Chen GJ  (2009-01)  AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS  150B(1), 124-129  "PPP2R2B CAG Repeat Length in the Han Chinese in Taiwan: Association Analyses in Neurological and Psychiatric Disorders and Potential Functional Implications"
  62. Tai-Yuan Chen, Ya-Hui Lu, Jen-Yu Li, Chia-Jung Chen, Wei-Humg Hsu, Hong-Yu Lin, Deng-Fwu Hwang and (Shui-Tein Chen)  (2009)  Journal of Food and Drug Analysis  17(5), 363-375  "Comparative Proteomics on Resting and Activated Human Basophilic Leukemic KU812 upon Stimulation with PMA plus A23187."
  63. Yi-Pei Lin, Tai-Yuan Chen, Hsiang-Wen Tseng, Mei-Hsien Leed and Shui-Tein Chen  (2009)  Phytochemistry  70(9), 1173-81  "Neural cell protective compounds isolated from Phoenix hanceana var. formosana"
  64. Ming-Cheng Lin, Jiraporn Nawarak, Tai-Yuan Chen, Hsien-Yu Tsai, Jung-Feng Hsieh, Supachok Sinchaikul, and Shui-Tein Chen  (2009)  Biomicrofluidics  3, 034101  "Rapid detection of natriuretic peptides by a microfluidic LabChip analyzer with DNA aptamers: application of natriuretic peptide detection"
  65. C. C. Tsai, C. J. Chen, H. W. Tseng, K. F. Hua, R. Y. Tsai, M. H. Lai, L. K. Chao, S. T. Chen  (2008-12)  Combinatorial Chemistry & High Throughput Screening  11(10), 834-842  "Cytomic screening of immuno-modulating activity compounds from Calocedrus formosana"
  66. Y.S. Lin, R. Tungpradit, S. Sinchaikul, F. M. An, D. Z. Liu, S. Phutrakul, S. T. Chen  (2008-12)  J Med Chem  51(23), 7428-41  "Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters"
  67. Thongboonkerd V, Semangoen T, Sinchaikul S, Chen ST  (2008-11)  J Proteome Res  7(11), 4689-4700  "Proteomic analysis of calcium oxalate monohydrate crystal-induced cytotoxicity in distal renal tubular cells"
  68. S. Y. Lin, Y. Y. Chen, Y. Y. Fan, C. W. Lin, S. T. Chen, A. H. Wang, K. H. Khoo  (2008-08)  J. Proteome Res.  7(8), 3293-3303  "Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics"
  69. T. Semangoen, S. Sinchaikul, S. T. Chen, V. Thongboonkerd  (2008)  J. Proteome Res  7(7), 2889-96  "Altered Proteins in MDCK Renal Tubular Cells in Response to Calcium Oxalate Dihydrate Crystal Adhesion: A Proteomics Approach"
  70. S. T.Chen, T. L. Pan, H. F. Juan, T. Y. Chen, Y. S. Lin, C. M. Huang  (2008)  J. Proteome Res.  7(4), 1379-87  "Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome"
  71. Louis K. P. Chao, K. F. Hua, H. Y. Hsu, S. S. Cheng, I. F. Lin, C. J. Chen, S. T. Chen, S. T. Chang  (2008)  Food Chem Toxicol  46(1), 220-31  "Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling"
  72. S. Sinchaikul, P. Hongsachart, S. Sriyam, P. Tantipaiboonwong, S. Phutrakul, S. T. Chen  (2008)  Chang Gung medical journal  31(5), 417-430  "Current proteomic analysis and post-translational modifications of biomarkers in human lung cancer materials"
  73. S. Noisakran. S. Sengsai. V. Thongboonkerd. R. Kanlaya. S. Sinchaikul. S. T. Chen. C. Puttikhunt. W. Kasinrerk. T. Limjindaporn. W. Wongwiwat. P. Malasit. P. Yenchitsomanus  (2008)  Biochemical and Biophysical Research Communications  372(1), 67-72  "Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein"
  74. Semangoen. S, Sinchaikul. S. T. Chen, Thongboonkerd V.  (2008)  Proteomics Clinical Applications  2(7-8), 1099-1109  "Proteomic analysis of altered proteins in distal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion: Implications for kidney stone disease"
  75. J. Nawarak, Rosa H. Liu, S. H. Kao, H. H. Liao, S. Sinchaikul, S. T. Chen, S. Lo. Cheng.  (2008)  J. Proteome Res  7(9), 3737-3746  "Proteomics Analysis of Kojic Acid Treated A375 Human Malignant Melanoma Cells"
  76. Liao PC, Wang AH, (Chen ST)  (2008)  Molecular & cellular proteomics : MCP  7(8), 1584-5  "Taiwan proteomics society: an organization affiliated with HUPO."
  77. V. Thongboonkerd, M. Vanaporn, N. Songtawee, R. Kanlaya, S. Sinchaikul, S. T. Chen, K. Easton, K. Chu, G. J. Bancroft, S. Korbsrisate.  (2007)  Journal of Proteome Research  6, 1334-41  "Altered Proteome in Burkholderia pseudomallei rpoE Operon Knockout Mutant: Insights into Mechanisms of rpoE Operon in Stress Tolerance, Survival, and Virulence"
  78. T. C. Huanga, H. C.Huang, C. C. Chang, H. Y. Chang, C. H. Ou, C. H. Hsu, S. T. Chen, H. F. Juan.  (2007)  FEBS Lett  581, 3517-22  "An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells"
  79. M. Y. Chang, Y. H. Kung, S. T. Chen.  (2007)  Journal of the Chinese Chemical Society  54, 1645-1649  "BF3-OEt2/Et3SiH-mediated Rearrangement of 4-Aryl-5,5-diphenylazapan-4-ols"
  80. J. F. Hsieh, S. T. Chen  (2007)  Biomicrofluidics  1(1), 14102  "Comparative studies on the analysis of glycoproteins and lipopolysaccharides by the gel-based microchip and SDS-PAGE"
  81. S. Sriyam, S. Sinchaikul, P. Tantipaiboonwong, C. Tzao, S. Phutrakul and S. T. Chen  (2007)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  849(1-2), 91-104  "Enhanced detectability in proteome studies"
  82. K. F. Hua, H. Y. Hsu, L. K. Chao, S. T. Chen, W. B. Yang, J. Hsu and C. H. Wong  (2007)  J Cell Physiol  212(2), 537-550  "Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression"
  83. K. C. Cheng, H. C. Huang, J. H. Chen, J. W. Hsu, H. C. Cheng, C. H. Ou, W. B.Yang, S. T. Chen, C. H. Wong, H. F. Juan.  (2007)  BMC Genomics  8, 411-27  "Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction"
  84. R. H. Liu, S. L. Cheng, K. C. Ueng, D. J. Wu, S. T. Chen, S. Sinchaikul and T. H. Lee  (2007)  J Biomed Sci  14(3), 383-393  "Gene expression analysis in LLC-PK1 renal tubular cells by atrial natriuretic peptide (ANP): correlation of homologous human genes with renal response"
  85. Yang CW, Hung SI, Juo CG, Lin YP, Fang WH, Lu IH, (Chen ST), Chen YT  (2007)  The Journal of allergy and clinical immunology  120(4), 870-877  "HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome."
  86. S. N. Attanakitsakul, K. Rungrojcharoenkit. R. Kanlaya. S. Sinchaikul. S. Noisakran. S. T. Chen, P. Malasit. V. Thongboonkerd  (2007)  J Proteome Res  6(12), 4592-600  "Proteomic analysis of host responses in HepG2 cells during dengue virus infection"
  87. S. Sritippayawan, W. Chiangjong, T. Semangoen, N. Aiyasanon, P. Jaetanawanitch, S. Sinchaikul, S. T. Chen, S. Vasuvattakul, V. Thongboonkerd.  (2007)  J. Proteome Res.  6(11), 4356-62  "Proteomic Analysis of Peritoneal Dialysate Fluid in Patients with Different Types of Peritoneal Membranes"
  88. P. Aobchey, S. Sinchaikul, S. Phutrakul, S. T. Chen.  (2007)  Chiang Mai J. Sci.  34(3), 329-337  "Simple purification of indirubin from Indigofera tinctoria Linn. and inhibitory effect on MCF-7 human breast cancer cells"
  89. D. Z. Liu, S. Sinchaikul, P. V. G. Reddy, M. Y. Chang, S.T. Chen  (2007)  Bioorg. Med. Chem. Lett  17, 617-20  "Synthesis of 2´-paclitaxel methyl 2-glucopyronosyl succinate for specific targeted delivery to cancer cells"
  90. M. Y. Chang, Y. H. Kung, C. C. Ma, S. T. Chen  (2007)  Tetrahedron  63, 39-44  "Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols"
  91. Chang, Meng-Yang, Kung, Yung-Hua, Ma, Chih-Chong, (Chen, Shui-Tein)  (2007)  Tetrahedron  63 (6), 1339-1344  "Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols."
  92. J. F. Hsieh, S. H. Wu, Y. L. Yang, K. F. Choong and S. T. Chen  (2007)  Bioorganic & Medicinal Chemistry  15(10), 3450-3456  "The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors"
  93. S. L. Cheng, Rosa H. Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul, Gregory J. Tsay  (2007)  Journal of Biomedical Science  14(1), 87–105  "Toxicogenomics of A375 human malignant melanoma cells treated with arbutin"
  94. S. L. Cheng, R. H. Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul, G. J. Tsay.  (2007)  Pharmacogenomics  8, 1017-36  "Toxicogenomics of A375 human malignant melanoma cells."
  95. C. J. Chen, C. C. Tsai, J. F. Hsieh, C. M. Chien, T. H. Wu and S. T. Chen  (2006)  Comb Chem High Throughput Screen  9(10), 777-784  "A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells"
  96. H. W. Tseng, H. F.Juan, H. C.Huang, John Y. C. Lin, S. Sinchaikul, T. C.Lai, C. F. Chen, S. T .Chen, G. J. Wang  (2006)  Proteomics  6, 5915-28  "Lipopolysaccharide-stimulated responses in rat aortic endothelial cells by a systems biology approach"
  97. V. Thongboonkerd, R. Kanlaya, S. Sinchaikul, P. Parichatikanond, S. T. Chen and P. Malasit  (2006)  J Proteome Res  5(12), 3326-3335  "Proteomic Identification of Altered Proteins in Skeletal Muscle During Chronic Potassium Depletion: Implications for Hypokalemic Myopathy"
  98. H. F. Juan, I. H. Wang, T. C. Huang, J. J. Li, S. T. Chen and H. C. Huang  (2006)  Proteomics  6(10), 2991-3000  "Proteomics analysis of a novel compound: Cyclic RGD in breast carcinoma cell line MCF-7"
  99. S. L. Cheng, R. Huang Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul and G. J. Tsay  (2006)  Biol Pharm Bull  29(4), 655-669  "Toxicogenomics of kojic Acid on gene expression profiling of a375 human malignant melanoma cells"
  100. Hsueh-Fen Juan, Shing-Chuan Chang, Hsuan-Cheng Huang and Shui-Tein Chen  (2005)  Proteomics  5(4), 840-842  "A new application of microwave technology to proteomics"
  101. Payungsak Tantipaiboonwong, Supachok Sinchaikul, Supawadee Sriyam, Suree Phutrakul and Shui-Tein Chen  (2005)  Proteomics  5(4), 1140-1149  "Different techniques for urinary protein analysis of normal and lung cancer patients"
  102. S. Topanurak, S. Sinchaikul, B. Sookkheo, S. Phutrakul and S. T. Chen  (2005)  Proteomics  5(17), 4456-4471  "Functional proteomics and correlated signaling pathway of the thermophilic bacterium Bacillus stearothermophilus TLS33 under cold-shock stress"
  103. J. Svasti, C. Srisomsap, P. Subhasitanont, S. Keeratichamroen, D. Chokchaichamnankit, L. Ngiwsara, N. Chimnoi, S. Pisutjaroenpong, S. Techasakul and S. T. Chen  (2005)  Proteomics  5(17), 4504-4509  "Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis"
  104. Supachai Topanurak, Supachok Sinchaikul, Suree Phutrakul , Boonyaras Sookkheo and Shui-Tein Chen  (2005)  Proteomics  5(14), 3722-3730  "Proteomics viewed on stress response of thermophilic bacterium Bacillus stearothermophilus TLS33"
  105. Y. T. Wu, W. T. Jiaang, K. G. Lin, C. M. Huang, C. H. Chang, Y. L. Sun, K. H. Fan, W. C. Hsu, H. E. Wang, S. B. Lin, S. T. Chen  (2004)  Curr Drug Deliv  1, 119-127  "A New N-Acetylgalactosamine containing peptide as Targeting Vehicle for Mammalian Hepatocytes via Asialoglycoprotein Receptor Endocytosis"
  106. J. Nawarak, S. Phutrakul, M. Y. Liao and S. T. Chen  (2004)  J Proteome Res  3, 383-392  "Analysis of lectin-bound glycoproteins in snake venom from the Elapidae and Viperidae families"
  107. H. M. Yu, M. J. Tseng, J. M. Fang, S. Phutrakul and S. T. Chen  (2004)  Electrophoresis  25, 1034-1041  "Capillary electrophoresis using immobilized whole cells with overexpressed endothelin receptor for specific ligand screening"
  108. C. W. Cheng, K. C. Lin, F. M. Pan, S. Sinchaikul, C. H. Wong and S. T. Chen  (2004)  Bioorg Med Chem Lett  14, 187-190  "Facile Synthesis of Metal-Chelating Peptide on Chip for Protein Array"
  109. C. C. Wu, H. C. Huang, H. F. Juan and S. T. Chen  (2004)  Bioinformatics  20(18), 3691-3693  "GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data"
  110. C. M. Chien, J. L. Cheng, W. T. Chang, M. H. Tien, C. M. Tsao, Y. H. Chang, H. Y. Chang, J. F. Hsieh, C. H. Wong and S. T. Chen  (2004)  Bioorganic & Medicinal Chemistry  12(21), 5603-5609  "Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56(+) NK-cell cytotoxicity in cord blood"
  111. A. Trisiriroj, N. Jeyachok and S. T. Chen  (2004)  Proteomics  4, 2047-2057  "Proteomics Characterization of Different bran proteins between aromatic and non-aromatic rice (Oryza sativa L. subspecies indica)"
  112. C. Y. Wu, J. T. Jan, S. H. Ma, C. J. Kuo, H. F. Juan, Y. S. Cheng, H. H. Hsu, H. C. Huang, D. Wu, A. Brik, F. S. Liang, R. S. Liu, J. M. Fang, S. T. Chen, P. H. Liang and C. H. Wong  (2004)  Proc Natl Acad Sci U S A  101, 10012-10017  "Small molecules Targeting severe acute respiratory syndrome human coronavirus"
  113. Chien CM, Cheng JL, Chang WT, Tien MH, Wu WY, Chang YH, Chang HY, Chen ST.  (2003)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  795(1), 1-8  "Cell phenotype analysis using a cell fluid-based microchip with high sensitivity and accurate quantitation."
  114. Y. M. Hsu, N. Chin, C. F. Chang and Y. F. Chang  (2003)  DNA Sequence  14, 169-181  "Cloning and characterization of the Actinobacillus pleuropneumoniae fur gene and its role in regulation of ApxI and AfuABC expression"
  115. S. S. Huang, F. M. Tang, Y. H. Huang, I. H. Liu, S. C. Hsu, S. T. Chen and J. S. Huang  (2003)  J Biol Chem  278(44), 43855-43869  "Cloning, expression, characterization and role in autocrine cell growth of cell surface retention sequence binding protein-1"
  116. I. L. Lu, C. Y. Lin, S. B. Lin, S. T. Chen, L. Y. Yeh, F. Y. Yang and L. C. Au  (2003)  Gene Ther  10, 1910-1916  "Correction/mutation of acid alpha-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies"
  117. T. L. Chen, Y. C. Lo, W. T. Hu, M. C. Wu, S. T. Chen and H. M. Chang  (2003)  Journal of Agricultural and Food Chemistry  51, 1671-1675  "Microencapsulation and Modification of Synthetic Peptides of Food Proteins Reduces the Blood Pressure of Spontaneously Hypertensive Rates"
  118. J. Nawarak, S. Sinchaikul, C. Y. Wu, M. Y. Liau, S. Phutrakul and S. T. Chen  (2003)  Electrophoresis  24, 2838-2854  "Proteomics of snake venoms from Elapidae and Viperidae families by multidimensional chromatographic methods"
  119. M. Y. Chang, S. T. Chen and N. -C. Chang  (2003)  Heterocycles  60, 99-112  "Regioselective Reduction of N-Alkyl-3-sulfonyl-glutarimide. Formal Synthesis of 1,2,3,4,6,7,12,12b-Octahydroindolo[2,3-α]quinolizine and Homobaclofen"
  120. M. Y. Chang, John, Y. -C. Lin, S. T. Chen and N. -C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 1015-1024  "1,8-Diazabicyclo[5.4.0]undec-7-ene: A Re markable Base in the Debromination of 4- or 5-Substituted N-Benzyl α-Bromo-α-p-toluenesulfonylglutarimide"
  121. M. Y. Chang, C. H. Chang, S. T. Chen and N. C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 383-385  "A Synthesis of Thalidomide"
  122. M. Y. Chang, S. T. Chen and Nein-Chen Chang  (2002)  Heterocycles  57, 2321-2334  "An efficient synthesis of N-aikyl-4-substituted 3H-pyridine-2,6-dione. Synthesis of isoguvacine and MDL-11,939"
  123. S. Sinchaikul, B. Sookkheo, S. Topanuruk, H. F. Juan, S. Phutrakul and S. T. Chen  (2002)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  771, 261-287  "Bioinformatics, functional genomics, and proteomics study of Bacillus sp"
  124. H. F. Juan, J. Y. Lin, W. H. Chang, C. Y. Wu, T. L. Pan, M. J. Tseng, K. H. Khoo and S. T. Chen  (2002)  Electrophoresis  23, 2490-2504  "Biomic study of human myeloid leukemia cells differentiation to macrophages using DNA array, proteomic, and bioinformatic analytical methods"
  125. S. Sinchaikul, J. D. A. Tyndall, L. A. Fothergill-Gilmore, P. Tatlor, S. Phutrakul, S. T. Chen, M. Walkinshaw  (2002)  Acta Crystallographica Section D-Biological Crystallography  58, 182-185  "Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1"
  126. M. Y. Chang, B. R. Chang, C. H. Chang, S. T. Chen and N. C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 233-237  "Formal Synthesis of Isodihydronepetalactone"
  127. J. Tokamolthom, S. T. Chen, N. Jeyashoke and K. Krisnangkura  (2002)  Analytic Chimic ACTA  465, 299-307  "Gas chromatographic separation of R/S-alpha-hydroxy fatty acid esters"
  128. M. Y. Chang, S. T. Chen and N. C. Chang  (2002)  Tetrahedron  58, 3623-3628  "New Synthesis of 3-Aryl-N-n-propyl-piperidines"
  129. B. Sookkheo, S. Sinchaikul, H. Thannan, O. Thongprasong, S. Phutrakul and S. T. Chen  (2002)  Proteomics  2, 1311-1315  "Proteomic analysis of a thermostable superoxide dismutase from Bacillus stearothermophilus TLS33"
  130. S. Sinchaikul, B. Sookkheo, S. Phutrakul, F. M. Pan and S. T. Chen  (2002)  Proteomics  2, 1316-1324  "Proteomic study of cold shock protein in Bacillus stearothermophilus P1: Comparison of temperature downshifts"
  131. S. T. Chen, T. L. Pan, Y. C. Tsai and C. M. Huang  (2002)  Cancer Lett  181, 95-107  "Proteomics reveals protein profile changes in doxorubicin--treated MCF-7 human breast cancer cells"
  132. M. J. Tseng, M. N. Yapb, K. Ratanakhanokchai, K Kyu and S. T. Chen  (2002)  Enzyme and Microbial Technology  30, 590-595  "Purification and Characterization of Two Cellulase Free Xylanases from an Alkaliphilic Bacillus firmus"
  133. M. Y. Chang, S. T. Chen and N. C. Chang  (2002)  Tetrahedron  58, 5075-5080  "Reaction of Different -Sulfonyl Acetamides with Methyl Acrylate"
  134. H. C. Yeh, C. H. Yu, J. S. Wang, S. T. Chen, Y. O. Su and W. Y Lin  (2002)  J. Biol. Inorg. Chem  7, 113-119  "Stopped-flow Kinetic study of the peroxidase reactions of mangano-microperoxidase-8"
  135. Y. Y. Wang, K. H. Khoo, S. T. Chen, C. C. Lin, C. H. Wong and C. H. Lin  (2002)  Bioorg Med Chem  10, 1057-1062  "Studies on the immuno-Modulating and Antitumor Activity of Ganoderma Lucidum (Reishi) Polysaccharides: Functional and Proteomic Analysis of a Fucose-containing Glycoprotein Responsible for the Activity"
  136. M. Y. Chang, John, Y. -C. Lin, S. T. Chen and N. -C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 1079-1088  "Synthetic Study of 4-Substituted Piperidine Ring in Elarofiban, RWJ-50042, Tirofiban and Paroxetine"
  137. M. -Y. Chang and S. T. Chen  (2001)  Journal of the Chinese Chemical Society  48, 133-135  "Concise Synthesis of Sibrafiban and Lamifiban, two Non-Peptide Fibrinogen Receptor (GP IIb/IIIa) Antagonists"
  138. P. H. Tseng, W. T. Jiaang, M. Y. Chang and S. T. Chen  (2001)  Chemistry-A European Journal  7, 585-590  "Facile solid-phase synthesis of an antifreeze glycoprotein"
  139. S. Sinchaikul, B. Sookkheo, S. Phutrakul, F. M. Pan and S. T. Chen  (2001)  Protein Expr Purif  22, 388-98  "Optimization of a thermostable lipase from Bacillus stearothermophilus P1:Overexpression, purification and characterizations"
  140. Y. C. Lee, S. D. Lin, H. M. Yu, S. T. Chen and S. T. Chu  (2001)  J Protein Chem  20, 563-569  "Phosphorylation of the 24p3 protein secreted from mouse uterus in vitro and in vivo"
  141. C. M. Huang, H. A. Shui, Y. T. Wu, P. W. Chu, K. G. Lin, L. S. Kao and S. T. Chen  (2001)  Molecular Brain Research  92, 181-192  "Proteomic analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-kDa chromogranin B-derived fragment during neuronal differentiation"
  142. C. -Y. Wu, C. -C. Hsu, S. T. Chen and Y. -C. Tsai  (2001)  Biochemical and Biophysical Research Communications  284, 466-469  "Soyasaponin I, a Potent and Specific Sialyltransferase Inhibitor"
  143. S. Sinchaikul, B. Sookkheo, S. Phutrakul, Y. T. Wu, F. M. Pan and S. T. Chen  (2001)  Biochem Biophys Res Commun  283, 868-875  "Structural modeling and characterization of a thermostable lipase from Bacillus stearothermophilus P1"
  144. M. Y. Chang, S. T. Chen and N. C. Chang  (2001)  Journal of the Chinese Chemical Society  48, 1153-1156  "Synthesis of 2,6-Dioxatetracyclo [6.3.0.01,10.07,8] undecane and 2,7,12- Trioxatetracyclo[6.3.1.04,11.05,9]dodecane"
  145. M. Y. Chang, C. L. Lin and S. T. Chen  (2001)  Journal of the Chinese Chemical Society  48, 787-794  "Synthesis of 5-Hexadecanolide, 6-Acetoxy-5-hexadecanolide and Tanikolide"
  146. Y. Y. Charng, S. J. Chou, W. T. Jiaang, S. T. Chen and S. F. Yang  (2001)  Archives of biochemistry and biophysics  385, 179-185  "The Catalytic Mechanism of 1-Aminocyclopane-1-Carboxylic Acid Oxidase"
  147. P. W. Chu, M. N. Yap, C. Y. Wu, C. M. Huang, F. M. Pan, M. J. Tseng and S. T. Chen  (2000)  Electrophoresis  21, 1740-1745  "A proteomic analysis of secreted proteins from xylan-induced Bacillus sp. strain K-1"
  148. J. H. Leu, S. J. Yan, T. F. Lee, C. M. Chou, S. T. Chen, P. P. Hwang, C. K. Chou and C. J. Huang  (2000)  DNA Cell Biol  19, 431-446  "Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes"
  149. B. Sookkheo, S. Sinchaikul, S. Phutrakul and S. T.Chen  (2000)  Protein Expr Purif  20, 142-151  "Purification and Characterization of the highly Thermostable Proteases from Bacillus Stearothermophilus TLS33"
  150. C. M. Huang, Y. T. Wu and S. T. Chen  (2000)  Chem Biol  7, 453-461  "Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis"
  151. H. P. Hsieh, Y. T. Wu, S. T. Chen and K. T. Wang  (1999)  Bioorganic & Medicinal Chemistry  7, 1797-1803  "Direct solid-phase synthesis of octreotide conjugates: precursors for use as tumor-targeted radiopharmaceuticals"
  152. C. Y. Wu, H. J. Lee, S. H. Wu, S. T. Chen, S. H. Chiou and G. G. Chang  (1998)  Biochem J  333, 327-334  "Chemical mechanism of the endogenous argininosuccinate lyase activity of duck lens delta2-crystallin"
  153. J. H. Leu, M. S. Chang, C. W. Yao, C. K. Chou, S. T. Chen and C. J. Huang  (1998)  Biochimica et Biophysica Acta-Gene Structure and Expression  1395, 50-56  "Genomic organization and characterization of the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) JAK1 kinase gene"
  154. H. W. Huang, W. C. Chen, C. Y. Wu, H. C. Yu, W. Y. Lin, S. T. Chen and K. T. Wang  (1997)  Protein Eng  10, 1227-1233  "Kinetic studies of the inhibitory effects of propeptides subtilisin BPN' and Carlsberg to bacterial serine proteases"
  155. C. Y. Wu, W. C. Chen, C. L. Ho, S. T. Chen and K. T. Wang  (1997)  Biochemical and Biophysical Research Communications  233, 713-716  "The role of the N-terminal leucine residue in snake venom cardiotoxin II (Naja naja atra)"
  156. S. T. Chen, S. Y. Chen, C. C. Tu, S. H. Chiou and K. T. Wang  (1995)  J Protein Chem  14, 205-215  "Physicochemical properties of alkaline serine proteases in alcohol"
  157. S. T. Chen, C. C. Tu, S. Y. Chen, H. C. Huang and K. T. Wang  (1993)  Bioorg Med Chem  1, 361-367  "Investigating the s-2 subsite selectivity of alkaline proteases in hydrolysis of diastereo-peptide esters and molecular-modeling interpretation"
  158. H. M. Yu, T. M. Wu, S. T. Chen, C. L. Ho, G. R. Her and K. T. Wang  (1993)  Biochem Mol Biol Int  29, 241-246  "Mastoparan B, synthesis and its physical and biological properties"
  159. S. T. Chen, S. Y. Chen, S. C. Hsiao and K. T. Wang  (1991)  Biomed Biochim Acta  50, S181-186  "Application of industrial protease ""Alcalase"" in peptide synthesis"
  160. S. T. Chen, L. C. Lo, S. H. Wu and K. T. Wang  (1990)  Int J Pept Protein Res  35, 52-54  "Side reaction in peptide synthesis. Formation of oxazolidone derivatives"
  1. 系統生物學研究: 系統生物學可同時整合基因體學、蛋白質體學及生物資訊學等研究,以系統性的方法分析生物體或細胞中各種基因和功能性蛋白質間複雜的交互關係,並瞭解這些關係是如何運作。

  2. 酵素催化有機合成: a.用酵素催化合成光學活性胺基酸、蛋白質及醫藥中間體。 b.高穩定性酵素之篩選及新酵素合成法之開發。

  3. 以化學法研究蛋白質工程:利用電腦模擬及化學合成進行蛋白質工程研究 a.以組合研究法研究酵素之特異選擇性。 b.研究與設計酵素之抑制劑。 c.開發新醣蛋白合成方法。 d.蛋白質受體分離及三度空間結構決定。

  4. 增進醫藥傳送及療效 a.增加腦神經藥之腦膜穿透效果。 b.用生長激素釋放的抑制因子受體來輸送抗癌藥物入癌細胞。 c.用葉酸受體來輸送抗癌藥物入癌細胞。 d.用肝細胞受體來輸送Antisense DNA或RNA。

經歷
  • 2018 – 2019   兼任研究員, 中央研究院生物化學研究
  • 2016 – 2017   兼任研究員, 中央研究院生物化學研究
  • 1996 – 2016   研究員, 中央研究院生物化學研究所
  • 1990 – 1996   副研究員, 中央研究院生物化學研究
  • 1988 – 1989   客座研究學者, 德州農工大學化學系
  • 1985 – 1990   助研究員, 中央研究院生物化學研究所
學歷
  • 1986 – 1989   博士, 生化科學, 臺灣大學生化科學研究所
  • 1983 – 1985   碩士, 有機化學, Univ. of Nevada. Reno(USA)
  • 1973 – 1978   學士, 化學工程, 淡江大學(Taiwan)
Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer.
Tsai, H.Y.; Boonyapra, K.; Sriyam, S.; Yu, C.J.; Wu, S.W.; Khoo, K.H.; Phutrakul, S.; Chen, S.T.
Proteomics (2011)
One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3-triazoles as anticancer agents.
Lee, W.T.; Tai, H.R.; Chen, S.T.
ACS Comb Sci. (2011)
Dierent sample preparation and detection methods for normal and lung cancer urinary proteome analysis.
Sinchaikul, S.; Tantipaiboonwong, P.; Sriyam, S.; Tzao, C.; Phutrakul, S.; Chen, S.T.
Methods Mol Biol. (2010)
Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.
Chen, C.J.; Vijaya, K.R.; Tsai, C.C.; Wu, W.H.; Chao, L.K.; Hwang, K.H.; Chien, C.M.; Chang, H.Y.; Chen, S.T.
Bioorg Med Chem. (2010)
Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome.
Chen, S.T.; Pan, T.L.; Juan, H.F.; Chen, T.Y.; Lin, Y.S.; Huang, C.M.
J. Proteome Res. (2008)
Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters.
Lin, Y.S.; Tangpradit, R.; Sinchaikul, S.; An, F.M.; Liu, D.Z.; Phutrakul, S.; Chen, S.T.
J. Med. Chem. (2008)
A New Application of Microwave Technology to Proteomics.
Juan, H.F.; Chang, S.C.; Topanurak, S.; Chen, S.T.
Proteomics (2005)
Dierent techniques for urinary protein analysis of normal and cancer patients.
Tantipaiboonwong, P.; Sinchaikul, S.; Sriyam, S.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
Functional proteomics and correlated signaling pathway of thermophilic bacterium Bacillus stearothermophilus TLS33 under cold shock stress.
Topanurak, S.; Sinchaikul, S.; Sookkheo, B.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
Proteomics viewed on stress response of thermophilic bacterium Bacillus stearothermophilus TLS33.
Topanurak, S.; Sinchaikul, S.; Phutrakul, S.; Chen, S.T.
Proteomics (2005)
  1. Lee IS, Kirschner R, (Chen ST)  (2019-08)  Functional Foods in Health and Disease  9(8), 508-520  "Medicinal Mushroom Taiwanofungus camphoratus: A potential cure for cancer."
  2. Chao OY, Chen HW, Ho CH, Chou JC, Yuan YT, Ho CL, Hsueh HT, (Chen ST), Liao PC, Chao LK  (2018-04)  Journal of Cleaner Production  180, 349-359  "Value chain analysis of algal bioenergy and carbon capture integrated with a biotechnology innovation."
  3. Hsieh YY, Huang TC, Lo HL, Jhan JY, (Chen ST), Yang PM  (2016-05)  Oncotarget  7(19), 27363-27378  "Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine."
  4. Chen TY, Kuo SH, (Chen ST), Hwang DF  (2016-03)  Food chemistry  194, 529-537  "Differential proteomics to explore the inhibitory effects of acidic, slightly acidic electrolysed water and sodium hypochlorite solution on Vibrio parahaemolyticus."
  5. Ka SM, Kuoping Chao L, Lin JC, (Chen ST), Li WT, Lin CN, Cheng JC, Jheng HL, Chen A, Hua KF  (2016-02)  Free radical biology & medicine  91, 10-24  "A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways."
  6. Chen YC, Chen CC, (Chen ST), Hsieh JF   (2016-01)  Food Hydrocolloids  52, 137-143  "Proteomic profiling of the coagulation of milk proteins induced by glucono-delta-lactone"
  7. Lin CR, Wei TW, Tsai HY, Wu YT, Wu PY, (Chen ST)  (2015-12)  FASEB journal  29(12), 5006-5017  "Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation."
  8. Ma HT, Hsieh JF, (Chen ST)  (2015-06)  Phytochemistry  114, 109-113  "Anti-diabetic effects of Ganoderma lucidum."
  9. Chen CC, (Chen ST), Hsieh JF  (2015-04)  Molecules  20(5), 7737-7749  "Proteomic analysis of polysaccharide-milk protein interactions induced by chitosan."
  10. Potprommanee L, Ma HT, Shank L, Juan YH, Liao WY, (Chen ST), Yu CJ  (2015-01)  Journal of thoracic oncology  10(1), 102-109  "GM2-Activator Protein: A New Biomarker for Lung Cancer."
  11. Huang PJ, Chang KL, Hsieh JF, (Chen ST)  (2015)  BioMed Research International  2015, 409103  "Catalysis of rice straw hydrolysis by the combination of immobilized cellulase from Aspergillus niger on beta-cyclodextrin-Fe3O4 nanoparticles and ionic liquid."
  12. Lin SH, Chen WC, Lu KH, Chen PJ, Hsieh SC, Pan TM, (Chen ST), Sheen LY  (2014-10)  Journal of agricultural and food chemistry  62(43), 10493-10503  "Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume."
  13. Kuo-Jen Hwang, Hung-Yuan Tsai, (Shui-Tein Chen)   (2014-03)  Journal of Membrane Science  454, 418-425  "Enzymatic hydrolysis suspension cross-flow diafiltration using polysulfone hollow fiber module."
  14. Jung-Feng Hsieh, Chia-Jung Yu, Je-Yu Chang, (Shui-Tein Chen), Hsien-Yu Tsai  (2014-03)  Food Hydrocolloids  35, 678-685  "Microbial transglutaminase-induced polymerization of β-conglycinin and glycinin in soymilk: A proteomics approach"
  15. Wu YH, Kuo WC, Wu YJ, Yang KT, (Chen ST), Jiang ST, Gordy C, He YW, Lai MZ  (2014-03)  Cell death and differentiation  21(3), 451-461  "Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation."
  16. Ken-Lin Chang, Chih-Cheng Chen, Jun-Hong Lin, Jung-Feng Hsien, Yin Wang, Feng Zhao, Yi-Hsuan Shih, Zhen-jiao Xing, (Shui-Tein Chen)  (2014-02)  New Carbon Materials  29(1), 47-54  "Rice straw-derived activated carbons for the removal of carbofuran from an aqueous solution."
  17. Lo TF, Tsai WC, (Chen ST)  (2013-09)  PloS one  8(9), e75628  "MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth."
  18. Tsai CC, Lin CR, Tsai HY, Chen CJ, Li WT, Yu HM, Ke YY, Hsieh WY, Chang CY, Wu CY, (Chen ST), Wong CH  (2013-06)  Journal of Biological Chemistry  288(24), 17689-17697  "The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling."
  19. Ken-Lin Chang, Jung-Feng Hsieh, Bay-Ming Ou, Min-Hsuan Chang, Wei-Ying Hseih, Jun-Hong Lin, Po-Jung Huang, Kam-Fei Wong and (Shui-Tein Chen)  (2012)  Separation Science and Technology  47(10), 1514-1521  "Adsorption Studies on the Removal of an Endocrine-Disrupting Compound (Bisphenol A) using Activated Carbon from Rice Straw Agricultural Waste"
  20. Wu WH, Chen TY, Lu RW, (Chen ST), Chang CC  (2012)  Phytochemistry  83, 110-5  "Benzoxazinoids from Scoparia dulcis (sweet broomweed) with antiproliferative activity against the DU-145 human prostate cancer cell line."
  21. Lin YP, Chen TY, Tseng HW, Lee MH, (Chen ST)  (2012)  Phytochemistry  84, 102-15  "Chemical and biological evaluation of nephrocizin in protecting nerve growth factor-differentiated PC12 cells by 6-hydroxydopamine-induced neurotoxicity."
  22. Satitmanwiwat S, Ratanakhanokchai K, Laohakunjit N, Chao LK, (Chen ST), Pason P, Tachaapaikoon C, Kyu KL  (2012)  Journal of agricultural and food chemistry  60(21), 5423-30  "Improved purity and immunostimulatory activity of beta-(1-->3)(1-->6)-glucan from Pleurotus sajor-caju using cell wall-degrading enzymes."
  23. Chen CY, (Chen ST), Juan HF, Huang HC  (2012)  BIOINFORMATICS  28(24), 3178-3181  "Lengthening of 3'UTR increases with morphological complexity in animal evolution."
  24. Tsai CC, Yang FL, Huang ZY, Chen CS, Yang YL, Hua KF, Li J, (Chen ST), Wu SH  (2012)  Journal of agricultural and food chemistry  60(11), 2830-7  "Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells."
  25. Kuo-Jen Hwang, Kuan-Chung Chen, (Shui-Tein Chen) and Ken-Lin Chang   (2012)  Separation Science and Technology  47(1), 52-61  "Sugar Purification from Enzymatic Rice Straw Hydrolysis Products using Cross-Flow Diafiltration"
  26. R. Tungpradit, S. Sinchaikul, S. Phutrakul, W. Wongkham and (S. T. Chen)  (2011)  Chiang Mai Journal of Science  38(1), 85-94  "Antiproliferative Activity of Berberine from Coscinium fenestratum on NCI-H838 Cell Line"
  27. W. Chiangjong, S. Sinchaikul, (S. T. Chen), V. Thongboonkerd  (2011)  Mol Biosyst.  7(6), 1917-1925  "Calcium oxalate dihydrate crystal induced changes in glycoproteome of distal renal tubular epithelial cells."
  28. C. Y. Chen, (S. T. Chen), C. S. Fuh, H. F. Juan, H. C. Huang  (2011)  BMC Bioinformatics  12 Suppl 1, S41  "Coregulation of transcription factors and microRNAs in human transcriptional regulatory network"
  29. H. H. Liao, Y. C. Wang, M. C. Chen, H. Y. Tsai, J. Lin, (S. T. Chen), G. J. Tsay, S. L. Cheng  (2011)  BMC Immunol.  12, 16  "Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells"
  30. K. L. Chang, T.-A. Jiladda, J. F. Hsieh, B. M. Ou, S. H. Chen, K. Ratanakhanokchai, P. J. Huang, (S. T. Chen)  (2011)  Biomass & Bioenergy  35(1), 90-95  "Enhanced enzymatic conversion with freeze pretreatment of rice straw"
  31. J. W. Hsu, H. C. Huang, (S. T. Chen), C. H. Wong, H. F. Juan.  (2011)  Evidence-based Complementary and Alternative Medicine  2011, 358717  "Ganoderma lucidum Polysaccharides Induce Macrophage-like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation"
  32. Boonyapranai K, Tsai HY, Chen MC, Sriyam S, Sinchaikul S, Phutrakul S, (Chen ST)  (2011)  Electrophoresis  32(12), 1422-1432  "Glycoproteomic analysis and molecular modeling of haptoglobin multimers."
  33. H. Y. Tsai, K. Boonyapranai, S. Sriyam, C. J. Yu, S. W. Wu, K. H. Khoo, S. Phutrakul, (S. T. Chen)  (2011)  Proteomics.  11(11), 2162-2170  "Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer."
  34. C. Y. Li, L. K. Chao, S. C. Wang, H. Z. Chang, M. L. Tsai, S. H. Fang, P. C. Liao, C. L. Ho, (S. T. Chen), W. C. Cheng, C. S. Chiang, K. F. Hua, I. C. Hsu  (2011)  J Cell Physiol.  226(9), 2338-2349  "Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells"
  35. K. L. Chang, T.-A. Jiladda, S. H. Chen, J. F. Hsieh, K. Ratanakhanokchai, P. J. Huang, T. C. Lin, (S. T. Chen)  (2011)  BIORESOURCE TECHNOLOGY  102(2), 519-523  "Improving the remaining activity of lignocellulolytic enzymes by membrane entrapment"
  36. W. T. Li, W. H. Wu, C. H. Tang, R. Tai, (S. T. Chen)  (2011)  ACS Combinatorial Science  13(1), 72-78  "One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3-triazoles as anticancer agents"
  37. T. L. Pan, P. W. Wang, (S. T. Chen), J. Y. Fang, T. K. Hsu, N. Sintupisut, S. Goto, C. L. Chen  (2011)  Clin Chim Acta  412(7-8), 604-613  "Prospective highlights of serum glycoproteins in spontaneous tolerance after orthotopic liver transplantation."
  38. Lin CM, Lin RD, (Chen ST), Lin YP, Chiu WT, Lin JW, Hsu FL, Lee MH  (2010-12)  Phytochemistry  71(17-18), 2147-2156  "Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells."
  39. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-10)  Journal of proteome research  9(10), 4960-4971  "The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells."
  40. Pattanakitsakul SN, Poungsawai J, Kanlaya R, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-09)  Journal of proteome research  9(9), 4640-4648  "Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells."
  41. Chen CJ, Vijaya Krishna R, Tsai CC, Wu WH, Chao LK, Hwang KH, Chien CM, Chang HY, (Chen ST)  (2010-09)  Bioorganic & medicinal chemistry  18(18), 6896-6904  "Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation."
  42. Singhto N, Sintiprungrat K, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-08)  Journal of proteome research  9(8), 3980-3988  "Proteome changes in human monocytes upon interaction with calcium oxalate monohydrate crystals."
  43. Moongkarndi P, Srisawat C, Saetun P, Jantaravinid J, Peerapittayamongkol C, Soi-ampornkul R, Junnu S, Sinchaikul S, (Chen ST), Charoensilp P, Thongboonkerd V, Neungton N  (2010-05)  Journal of proteome research  9(5), 2076-2086  "Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells."
  44. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-05)  Molecular bioSystems  6(5), 795-806  "Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release."
  45. Li YZ, Ho YP, (Chen ST), Shiuan D  (2010-04)  Applied biochemistry and biotechnology  160(8), 2248-2255  "Proteomic Analysis of the Interactions between Mycoplasma hyopneumoniae and Porcine Tracheal Ciliated Cells."
  46. Pan TL, Hung YC, Wang PW, (Chen ST), Hsu TK, Sintupisut N, Cheng CS, Lyu PC  (2010-03)  Proteomics  10(5), 914-929  "Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells."
  47. Sintiprungrat K, Singhto N, Sinchaikul S, (Chen ST), Thongboonkerd V  (2010-01)  Journal of proteomics  73(3), 602-618  "Alterations in cellular proteome and secretome upon differentiation from monocyte to macrophage by treatment with phorbol myristate acetate: Insights into biological processes."
  48. Opatrna S, Chiangjong W, Korabecna M, Sintiprungrat K, Sinchaikul S, (Chen ST), Matejovic M, Thongboonkerd V  (2010-01)  Clinical biochemistry  43(1-2), 142-149  "Plasma proteome profiling of von Hippel-Lindau disease after total and subtotal nephrectomy: a preliminary study."
  49. Sinchaikul S, Tantipaiboonwong P, Sriyam S, Tzao C, Phutrakul S, (Chen ST)  (2010)  Methods in molecular biology (Clifton, N.J.)  641, 65-88  "Different sample preparation and detection methods for normal and lung cancer urinary proteome analysis."
  50. Eric S. L. Hsiao, Jeff C. F. Chen, Hsien-Yu Tsai, Kay-Hooi Khoo, Shui-Tein Chen and Jason T. C. Tzen  (2009-08)  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  57(15), 6757–6763  "Determination of N-Glycosylation Site and Glycan Structures of Pectin Methylesterase in Jelly Fig (Ficus awkeotsang) Achenes"
  51. Thongboonkerd V, Chiangjong W, Saetun P, Sinchaikul S, Chen ST, Kositanont U  (2009-07)  Proteomics  9(13), 3522-3534  "Analysis of differential proteomes in pathogenic and non-pathogenic Leptospira: potential pathogenic and virulence factors"
  52. Pumirat P, Saetun P, Sinchaikul S, Chen ST, Korbsrisate S, Thongboonkerd V  (2009-06)  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS  1794(6), 898-904  "Altered secretome of Burkholderia pseudomallei induced by salt stress"
  53. Kanlaya R, Pattanakitsakul SN, Sinchaikul S, Chen ST, Thongboonkerd V  (2009-05)  J Proteome Res.  8(5), 2551-2562  "Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration"
  54. Thongboonkerd V, Chiangjong W, Mares J, Moravec J, Tuma Z, Karvunidis T, Sinchaikul S, Chen ST, Opatrný K, Matejovic M.  (2009-05)  CLINICAL SCIENCE  116(9), 721-730  "Altered plasma proteome during an early phase of peritonitis-induced sepsis"
  55. Chen YJ, Yu CC, "Chen ST", Chen TY, Liao HF*  (2009-05)  PROTEOMICS CLINICAL APPLICATIONS  3(5), 563-573  "Functional regulation and proteomic characterization of human natural killer cells through recombinant human granulocyte-colony stimulating factor treatment"
  56. Chen YR, Y-Y R, Lin TY, Huang CP, Tang WC, Chen ST, Lin SB  (2009-05)  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  57(6), 2200-2205  "Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis"
  57. Tavichakorntrakool R, Sriboonlue P, Prasongwattana V, Puapairoj A, Yenchitsomanus PT, Sinchaikul S, Chen ST, Wongkham C, Thongboonkerd V  (2009-05)  J Proteome Res.  8(5), 2586-2593  "Metabolic enzymes, antioxidants, and cytoskeletal proteins are significantly altered in vastus lateralis muscle of K-depleted cadaveric subjects"
  58. Hongsachart P, Huang-Liu R, Sinchaikul S, Pan FM, Phutrakul S, Chuang YM, Yu CJ, (Chen ST)  (2009-04)  Electrophoresis.  30(7), 1206-1220  "Glycoproteomic analysis of WGA-bound glycoprotein biomarkers in sera from patients with lung adenocarcinoma"
  59. Li YZ, Ho YP, Chen ST, Chiou TW, Li ZS, Shiuan D  (2009-02)  BIOCHEMISTRY-MOSCOW  74(2), 215-220  "Proteomic comparative analysis of pathogenic strain 232 and avirulent strain J of Mycoplasma hyopneumoniae"
  60. Nawarak J, Huang-Liu R, Kao SH, Liao HH, Sinchaikul S, Chen ST, Cheng SL  (2009-02)  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS  1794(2), 159-167  "Proteomics analysis of A375 human malignant melanoma cells in response to arbutin treatment"
  61. Chen CM, Chen, Chiung-Mei, Hou YT, Hou, Yi-Ting, Liu JY , Wu YR, Lin CH, Fung HC, Hsu WC, Hsu YY, Lee SH, Hsieh-Li HM, Su MT, (Chen ST) , Lane HY, Lee-Chen GJ  (2009-01)  AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS  150B(1), 124-129  "PPP2R2B CAG Repeat Length in the Han Chinese in Taiwan: Association Analyses in Neurological and Psychiatric Disorders and Potential Functional Implications"
  62. Tai-Yuan Chen, Ya-Hui Lu, Jen-Yu Li, Chia-Jung Chen, Wei-Humg Hsu, Hong-Yu Lin, Deng-Fwu Hwang and (Shui-Tein Chen)  (2009)  Journal of Food and Drug Analysis  17(5), 363-375  "Comparative Proteomics on Resting and Activated Human Basophilic Leukemic KU812 upon Stimulation with PMA plus A23187."
  63. Yi-Pei Lin, Tai-Yuan Chen, Hsiang-Wen Tseng, Mei-Hsien Leed and Shui-Tein Chen  (2009)  Phytochemistry  70(9), 1173-81  "Neural cell protective compounds isolated from Phoenix hanceana var. formosana"
  64. Ming-Cheng Lin, Jiraporn Nawarak, Tai-Yuan Chen, Hsien-Yu Tsai, Jung-Feng Hsieh, Supachok Sinchaikul, and Shui-Tein Chen  (2009)  Biomicrofluidics  3, 034101  "Rapid detection of natriuretic peptides by a microfluidic LabChip analyzer with DNA aptamers: application of natriuretic peptide detection"
  65. C. C. Tsai, C. J. Chen, H. W. Tseng, K. F. Hua, R. Y. Tsai, M. H. Lai, L. K. Chao, S. T. Chen  (2008-12)  Combinatorial Chemistry & High Throughput Screening  11(10), 834-842  "Cytomic screening of immuno-modulating activity compounds from Calocedrus formosana"
  66. Y.S. Lin, R. Tungpradit, S. Sinchaikul, F. M. An, D. Z. Liu, S. Phutrakul, S. T. Chen  (2008-12)  J Med Chem  51(23), 7428-41  "Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters"
  67. Thongboonkerd V, Semangoen T, Sinchaikul S, Chen ST  (2008-11)  J Proteome Res  7(11), 4689-4700  "Proteomic analysis of calcium oxalate monohydrate crystal-induced cytotoxicity in distal renal tubular cells"
  68. S. Y. Lin, Y. Y. Chen, Y. Y. Fan, C. W. Lin, S. T. Chen, A. H. Wang, K. H. Khoo  (2008-08)  J. Proteome Res.  7(8), 3293-3303  "Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics"
  69. T. Semangoen, S. Sinchaikul, S. T. Chen, V. Thongboonkerd  (2008)  J. Proteome Res  7(7), 2889-96  "Altered Proteins in MDCK Renal Tubular Cells in Response to Calcium Oxalate Dihydrate Crystal Adhesion: A Proteomics Approach"
  70. S. T.Chen, T. L. Pan, H. F. Juan, T. Y. Chen, Y. S. Lin, C. M. Huang  (2008)  J. Proteome Res.  7(4), 1379-87  "Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome"
  71. Louis K. P. Chao, K. F. Hua, H. Y. Hsu, S. S. Cheng, I. F. Lin, C. J. Chen, S. T. Chen, S. T. Chang  (2008)  Food Chem Toxicol  46(1), 220-31  "Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling"
  72. S. Sinchaikul, P. Hongsachart, S. Sriyam, P. Tantipaiboonwong, S. Phutrakul, S. T. Chen  (2008)  Chang Gung medical journal  31(5), 417-430  "Current proteomic analysis and post-translational modifications of biomarkers in human lung cancer materials"
  73. S. Noisakran. S. Sengsai. V. Thongboonkerd. R. Kanlaya. S. Sinchaikul. S. T. Chen. C. Puttikhunt. W. Kasinrerk. T. Limjindaporn. W. Wongwiwat. P. Malasit. P. Yenchitsomanus  (2008)  Biochemical and Biophysical Research Communications  372(1), 67-72  "Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein"
  74. Semangoen. S, Sinchaikul. S. T. Chen, Thongboonkerd V.  (2008)  Proteomics Clinical Applications  2(7-8), 1099-1109  "Proteomic analysis of altered proteins in distal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion: Implications for kidney stone disease"
  75. J. Nawarak, Rosa H. Liu, S. H. Kao, H. H. Liao, S. Sinchaikul, S. T. Chen, S. Lo. Cheng.  (2008)  J. Proteome Res  7(9), 3737-3746  "Proteomics Analysis of Kojic Acid Treated A375 Human Malignant Melanoma Cells"
  76. Liao PC, Wang AH, (Chen ST)  (2008)  Molecular & cellular proteomics : MCP  7(8), 1584-5  "Taiwan proteomics society: an organization affiliated with HUPO."
  77. V. Thongboonkerd, M. Vanaporn, N. Songtawee, R. Kanlaya, S. Sinchaikul, S. T. Chen, K. Easton, K. Chu, G. J. Bancroft, S. Korbsrisate.  (2007)  Journal of Proteome Research  6, 1334-41  "Altered Proteome in Burkholderia pseudomallei rpoE Operon Knockout Mutant: Insights into Mechanisms of rpoE Operon in Stress Tolerance, Survival, and Virulence"
  78. T. C. Huanga, H. C.Huang, C. C. Chang, H. Y. Chang, C. H. Ou, C. H. Hsu, S. T. Chen, H. F. Juan.  (2007)  FEBS Lett  581, 3517-22  "An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells"
  79. M. Y. Chang, Y. H. Kung, S. T. Chen.  (2007)  Journal of the Chinese Chemical Society  54, 1645-1649  "BF3-OEt2/Et3SiH-mediated Rearrangement of 4-Aryl-5,5-diphenylazapan-4-ols"
  80. J. F. Hsieh, S. T. Chen  (2007)  Biomicrofluidics  1(1), 14102  "Comparative studies on the analysis of glycoproteins and lipopolysaccharides by the gel-based microchip and SDS-PAGE"
  81. S. Sriyam, S. Sinchaikul, P. Tantipaiboonwong, C. Tzao, S. Phutrakul and S. T. Chen  (2007)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  849(1-2), 91-104  "Enhanced detectability in proteome studies"
  82. K. F. Hua, H. Y. Hsu, L. K. Chao, S. T. Chen, W. B. Yang, J. Hsu and C. H. Wong  (2007)  J Cell Physiol  212(2), 537-550  "Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression"
  83. K. C. Cheng, H. C. Huang, J. H. Chen, J. W. Hsu, H. C. Cheng, C. H. Ou, W. B.Yang, S. T. Chen, C. H. Wong, H. F. Juan.  (2007)  BMC Genomics  8, 411-27  "Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction"
  84. R. H. Liu, S. L. Cheng, K. C. Ueng, D. J. Wu, S. T. Chen, S. Sinchaikul and T. H. Lee  (2007)  J Biomed Sci  14(3), 383-393  "Gene expression analysis in LLC-PK1 renal tubular cells by atrial natriuretic peptide (ANP): correlation of homologous human genes with renal response"
  85. Yang CW, Hung SI, Juo CG, Lin YP, Fang WH, Lu IH, (Chen ST), Chen YT  (2007)  The Journal of allergy and clinical immunology  120(4), 870-877  "HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome."
  86. S. N. Attanakitsakul, K. Rungrojcharoenkit. R. Kanlaya. S. Sinchaikul. S. Noisakran. S. T. Chen, P. Malasit. V. Thongboonkerd  (2007)  J Proteome Res  6(12), 4592-600  "Proteomic analysis of host responses in HepG2 cells during dengue virus infection"
  87. S. Sritippayawan, W. Chiangjong, T. Semangoen, N. Aiyasanon, P. Jaetanawanitch, S. Sinchaikul, S. T. Chen, S. Vasuvattakul, V. Thongboonkerd.  (2007)  J. Proteome Res.  6(11), 4356-62  "Proteomic Analysis of Peritoneal Dialysate Fluid in Patients with Different Types of Peritoneal Membranes"
  88. P. Aobchey, S. Sinchaikul, S. Phutrakul, S. T. Chen.  (2007)  Chiang Mai J. Sci.  34(3), 329-337  "Simple purification of indirubin from Indigofera tinctoria Linn. and inhibitory effect on MCF-7 human breast cancer cells"
  89. D. Z. Liu, S. Sinchaikul, P. V. G. Reddy, M. Y. Chang, S.T. Chen  (2007)  Bioorg. Med. Chem. Lett  17, 617-20  "Synthesis of 2´-paclitaxel methyl 2-glucopyronosyl succinate for specific targeted delivery to cancer cells"
  90. M. Y. Chang, Y. H. Kung, C. C. Ma, S. T. Chen  (2007)  Tetrahedron  63, 39-44  "Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols"
  91. Chang, Meng-Yang, Kung, Yung-Hua, Ma, Chih-Chong, (Chen, Shui-Tein)  (2007)  Tetrahedron  63 (6), 1339-1344  "Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols."
  92. J. F. Hsieh, S. H. Wu, Y. L. Yang, K. F. Choong and S. T. Chen  (2007)  Bioorganic & Medicinal Chemistry  15(10), 3450-3456  "The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors"
  93. S. L. Cheng, Rosa H. Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul, Gregory J. Tsay  (2007)  Journal of Biomedical Science  14(1), 87–105  "Toxicogenomics of A375 human malignant melanoma cells treated with arbutin"
  94. S. L. Cheng, R. H. Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul, G. J. Tsay.  (2007)  Pharmacogenomics  8, 1017-36  "Toxicogenomics of A375 human malignant melanoma cells."
  95. C. J. Chen, C. C. Tsai, J. F. Hsieh, C. M. Chien, T. H. Wu and S. T. Chen  (2006)  Comb Chem High Throughput Screen  9(10), 777-784  "A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells"
  96. H. W. Tseng, H. F.Juan, H. C.Huang, John Y. C. Lin, S. Sinchaikul, T. C.Lai, C. F. Chen, S. T .Chen, G. J. Wang  (2006)  Proteomics  6, 5915-28  "Lipopolysaccharide-stimulated responses in rat aortic endothelial cells by a systems biology approach"
  97. V. Thongboonkerd, R. Kanlaya, S. Sinchaikul, P. Parichatikanond, S. T. Chen and P. Malasit  (2006)  J Proteome Res  5(12), 3326-3335  "Proteomic Identification of Altered Proteins in Skeletal Muscle During Chronic Potassium Depletion: Implications for Hypokalemic Myopathy"
  98. H. F. Juan, I. H. Wang, T. C. Huang, J. J. Li, S. T. Chen and H. C. Huang  (2006)  Proteomics  6(10), 2991-3000  "Proteomics analysis of a novel compound: Cyclic RGD in breast carcinoma cell line MCF-7"
  99. S. L. Cheng, R. Huang Liu, J. N. Sheu, S. T. Chen, S. Sinchaikul and G. J. Tsay  (2006)  Biol Pharm Bull  29(4), 655-669  "Toxicogenomics of kojic Acid on gene expression profiling of a375 human malignant melanoma cells"
  100. Hsueh-Fen Juan, Shing-Chuan Chang, Hsuan-Cheng Huang and Shui-Tein Chen  (2005)  Proteomics  5(4), 840-842  "A new application of microwave technology to proteomics"
  101. Payungsak Tantipaiboonwong, Supachok Sinchaikul, Supawadee Sriyam, Suree Phutrakul and Shui-Tein Chen  (2005)  Proteomics  5(4), 1140-1149  "Different techniques for urinary protein analysis of normal and lung cancer patients"
  102. S. Topanurak, S. Sinchaikul, B. Sookkheo, S. Phutrakul and S. T. Chen  (2005)  Proteomics  5(17), 4456-4471  "Functional proteomics and correlated signaling pathway of the thermophilic bacterium Bacillus stearothermophilus TLS33 under cold-shock stress"
  103. J. Svasti, C. Srisomsap, P. Subhasitanont, S. Keeratichamroen, D. Chokchaichamnankit, L. Ngiwsara, N. Chimnoi, S. Pisutjaroenpong, S. Techasakul and S. T. Chen  (2005)  Proteomics  5(17), 4504-4509  "Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis"
  104. Supachai Topanurak, Supachok Sinchaikul, Suree Phutrakul , Boonyaras Sookkheo and Shui-Tein Chen  (2005)  Proteomics  5(14), 3722-3730  "Proteomics viewed on stress response of thermophilic bacterium Bacillus stearothermophilus TLS33"
  105. Y. T. Wu, W. T. Jiaang, K. G. Lin, C. M. Huang, C. H. Chang, Y. L. Sun, K. H. Fan, W. C. Hsu, H. E. Wang, S. B. Lin, S. T. Chen  (2004)  Curr Drug Deliv  1, 119-127  "A New N-Acetylgalactosamine containing peptide as Targeting Vehicle for Mammalian Hepatocytes via Asialoglycoprotein Receptor Endocytosis"
  106. J. Nawarak, S. Phutrakul, M. Y. Liao and S. T. Chen  (2004)  J Proteome Res  3, 383-392  "Analysis of lectin-bound glycoproteins in snake venom from the Elapidae and Viperidae families"
  107. H. M. Yu, M. J. Tseng, J. M. Fang, S. Phutrakul and S. T. Chen  (2004)  Electrophoresis  25, 1034-1041  "Capillary electrophoresis using immobilized whole cells with overexpressed endothelin receptor for specific ligand screening"
  108. C. W. Cheng, K. C. Lin, F. M. Pan, S. Sinchaikul, C. H. Wong and S. T. Chen  (2004)  Bioorg Med Chem Lett  14, 187-190  "Facile Synthesis of Metal-Chelating Peptide on Chip for Protein Array"
  109. C. C. Wu, H. C. Huang, H. F. Juan and S. T. Chen  (2004)  Bioinformatics  20(18), 3691-3693  "GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data"
  110. C. M. Chien, J. L. Cheng, W. T. Chang, M. H. Tien, C. M. Tsao, Y. H. Chang, H. Y. Chang, J. F. Hsieh, C. H. Wong and S. T. Chen  (2004)  Bioorganic & Medicinal Chemistry  12(21), 5603-5609  "Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56(+) NK-cell cytotoxicity in cord blood"
  111. A. Trisiriroj, N. Jeyachok and S. T. Chen  (2004)  Proteomics  4, 2047-2057  "Proteomics Characterization of Different bran proteins between aromatic and non-aromatic rice (Oryza sativa L. subspecies indica)"
  112. C. Y. Wu, J. T. Jan, S. H. Ma, C. J. Kuo, H. F. Juan, Y. S. Cheng, H. H. Hsu, H. C. Huang, D. Wu, A. Brik, F. S. Liang, R. S. Liu, J. M. Fang, S. T. Chen, P. H. Liang and C. H. Wong  (2004)  Proc Natl Acad Sci U S A  101, 10012-10017  "Small molecules Targeting severe acute respiratory syndrome human coronavirus"
  113. Chien CM, Cheng JL, Chang WT, Tien MH, Wu WY, Chang YH, Chang HY, Chen ST.  (2003)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  795(1), 1-8  "Cell phenotype analysis using a cell fluid-based microchip with high sensitivity and accurate quantitation."
  114. Y. M. Hsu, N. Chin, C. F. Chang and Y. F. Chang  (2003)  DNA Sequence  14, 169-181  "Cloning and characterization of the Actinobacillus pleuropneumoniae fur gene and its role in regulation of ApxI and AfuABC expression"
  115. S. S. Huang, F. M. Tang, Y. H. Huang, I. H. Liu, S. C. Hsu, S. T. Chen and J. S. Huang  (2003)  J Biol Chem  278(44), 43855-43869  "Cloning, expression, characterization and role in autocrine cell growth of cell surface retention sequence binding protein-1"
  116. I. L. Lu, C. Y. Lin, S. B. Lin, S. T. Chen, L. Y. Yeh, F. Y. Yang and L. C. Au  (2003)  Gene Ther  10, 1910-1916  "Correction/mutation of acid alpha-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies"
  117. T. L. Chen, Y. C. Lo, W. T. Hu, M. C. Wu, S. T. Chen and H. M. Chang  (2003)  Journal of Agricultural and Food Chemistry  51, 1671-1675  "Microencapsulation and Modification of Synthetic Peptides of Food Proteins Reduces the Blood Pressure of Spontaneously Hypertensive Rates"
  118. J. Nawarak, S. Sinchaikul, C. Y. Wu, M. Y. Liau, S. Phutrakul and S. T. Chen  (2003)  Electrophoresis  24, 2838-2854  "Proteomics of snake venoms from Elapidae and Viperidae families by multidimensional chromatographic methods"
  119. M. Y. Chang, S. T. Chen and N. -C. Chang  (2003)  Heterocycles  60, 99-112  "Regioselective Reduction of N-Alkyl-3-sulfonyl-glutarimide. Formal Synthesis of 1,2,3,4,6,7,12,12b-Octahydroindolo[2,3-α]quinolizine and Homobaclofen"
  120. M. Y. Chang, John, Y. -C. Lin, S. T. Chen and N. -C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 1015-1024  "1,8-Diazabicyclo[5.4.0]undec-7-ene: A Re markable Base in the Debromination of 4- or 5-Substituted N-Benzyl α-Bromo-α-p-toluenesulfonylglutarimide"
  121. M. Y. Chang, C. H. Chang, S. T. Chen and N. C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 383-385  "A Synthesis of Thalidomide"
  122. M. Y. Chang, S. T. Chen and Nein-Chen Chang  (2002)  Heterocycles  57, 2321-2334  "An efficient synthesis of N-aikyl-4-substituted 3H-pyridine-2,6-dione. Synthesis of isoguvacine and MDL-11,939"
  123. S. Sinchaikul, B. Sookkheo, S. Topanuruk, H. F. Juan, S. Phutrakul and S. T. Chen  (2002)  Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences  771, 261-287  "Bioinformatics, functional genomics, and proteomics study of Bacillus sp"
  124. H. F. Juan, J. Y. Lin, W. H. Chang, C. Y. Wu, T. L. Pan, M. J. Tseng, K. H. Khoo and S. T. Chen  (2002)  Electrophoresis  23, 2490-2504  "Biomic study of human myeloid leukemia cells differentiation to macrophages using DNA array, proteomic, and bioinformatic analytical methods"
  125. S. Sinchaikul, J. D. A. Tyndall, L. A. Fothergill-Gilmore, P. Tatlor, S. Phutrakul, S. T. Chen, M. Walkinshaw  (2002)  Acta Crystallographica Section D-Biological Crystallography  58, 182-185  "Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1"
  126. M. Y. Chang, B. R. Chang, C. H. Chang, S. T. Chen and N. C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 233-237  "Formal Synthesis of Isodihydronepetalactone"
  127. J. Tokamolthom, S. T. Chen, N. Jeyashoke and K. Krisnangkura  (2002)  Analytic Chimic ACTA  465, 299-307  "Gas chromatographic separation of R/S-alpha-hydroxy fatty acid esters"
  128. M. Y. Chang, S. T. Chen and N. C. Chang  (2002)  Tetrahedron  58, 3623-3628  "New Synthesis of 3-Aryl-N-n-propyl-piperidines"
  129. B. Sookkheo, S. Sinchaikul, H. Thannan, O. Thongprasong, S. Phutrakul and S. T. Chen  (2002)  Proteomics  2, 1311-1315  "Proteomic analysis of a thermostable superoxide dismutase from Bacillus stearothermophilus TLS33"
  130. S. Sinchaikul, B. Sookkheo, S. Phutrakul, F. M. Pan and S. T. Chen  (2002)  Proteomics  2, 1316-1324  "Proteomic study of cold shock protein in Bacillus stearothermophilus P1: Comparison of temperature downshifts"
  131. S. T. Chen, T. L. Pan, Y. C. Tsai and C. M. Huang  (2002)  Cancer Lett  181, 95-107  "Proteomics reveals protein profile changes in doxorubicin--treated MCF-7 human breast cancer cells"
  132. M. J. Tseng, M. N. Yapb, K. Ratanakhanokchai, K Kyu and S. T. Chen  (2002)  Enzyme and Microbial Technology  30, 590-595  "Purification and Characterization of Two Cellulase Free Xylanases from an Alkaliphilic Bacillus firmus"
  133. M. Y. Chang, S. T. Chen and N. C. Chang  (2002)  Tetrahedron  58, 5075-5080  "Reaction of Different -Sulfonyl Acetamides with Methyl Acrylate"
  134. H. C. Yeh, C. H. Yu, J. S. Wang, S. T. Chen, Y. O. Su and W. Y Lin  (2002)  J. Biol. Inorg. Chem  7, 113-119  "Stopped-flow Kinetic study of the peroxidase reactions of mangano-microperoxidase-8"
  135. Y. Y. Wang, K. H. Khoo, S. T. Chen, C. C. Lin, C. H. Wong and C. H. Lin  (2002)  Bioorg Med Chem  10, 1057-1062  "Studies on the immuno-Modulating and Antitumor Activity of Ganoderma Lucidum (Reishi) Polysaccharides: Functional and Proteomic Analysis of a Fucose-containing Glycoprotein Responsible for the Activity"
  136. M. Y. Chang, John, Y. -C. Lin, S. T. Chen and N. -C. Chang  (2002)  Journal of the Chinese Chemical Society  49, 1079-1088  "Synthetic Study of 4-Substituted Piperidine Ring in Elarofiban, RWJ-50042, Tirofiban and Paroxetine"
  137. M. -Y. Chang and S. T. Chen  (2001)  Journal of the Chinese Chemical Society  48, 133-135  "Concise Synthesis of Sibrafiban and Lamifiban, two Non-Peptide Fibrinogen Receptor (GP IIb/IIIa) Antagonists"
  138. P. H. Tseng, W. T. Jiaang, M. Y. Chang and S. T. Chen  (2001)  Chemistry-A European Journal  7, 585-590  "Facile solid-phase synthesis of an antifreeze glycoprotein"
  139. S. Sinchaikul, B. Sookkheo, S. Phutrakul, F. M. Pan and S. T. Chen  (2001)  Protein Expr Purif  22, 388-98  "Optimization of a thermostable lipase from Bacillus stearothermophilus P1:Overexpression, purification and characterizations"
  140. Y. C. Lee, S. D. Lin, H. M. Yu, S. T. Chen and S. T. Chu  (2001)  J Protein Chem  20, 563-569  "Phosphorylation of the 24p3 protein secreted from mouse uterus in vitro and in vivo"
  141. C. M. Huang, H. A. Shui, Y. T. Wu, P. W. Chu, K. G. Lin, L. S. Kao and S. T. Chen  (2001)  Molecular Brain Research  92, 181-192  "Proteomic analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-kDa chromogranin B-derived fragment during neuronal differentiation"
  142. C. -Y. Wu, C. -C. Hsu, S. T. Chen and Y. -C. Tsai  (2001)  Biochemical and Biophysical Research Communications  284, 466-469  "Soyasaponin I, a Potent and Specific Sialyltransferase Inhibitor"
  143. S. Sinchaikul, B. Sookkheo, S. Phutrakul, Y. T. Wu, F. M. Pan and S. T. Chen  (2001)  Biochem Biophys Res Commun  283, 868-875  "Structural modeling and characterization of a thermostable lipase from Bacillus stearothermophilus P1"
  144. M. Y. Chang, S. T. Chen and N. C. Chang  (2001)  Journal of the Chinese Chemical Society  48, 1153-1156  "Synthesis of 2,6-Dioxatetracyclo [6.3.0.01,10.07,8] undecane and 2,7,12- Trioxatetracyclo[6.3.1.04,11.05,9]dodecane"
  145. M. Y. Chang, C. L. Lin and S. T. Chen  (2001)  Journal of the Chinese Chemical Society  48, 787-794  "Synthesis of 5-Hexadecanolide, 6-Acetoxy-5-hexadecanolide and Tanikolide"
  146. Y. Y. Charng, S. J. Chou, W. T. Jiaang, S. T. Chen and S. F. Yang  (2001)  Archives of biochemistry and biophysics  385, 179-185  "The Catalytic Mechanism of 1-Aminocyclopane-1-Carboxylic Acid Oxidase"
  147. P. W. Chu, M. N. Yap, C. Y. Wu, C. M. Huang, F. M. Pan, M. J. Tseng and S. T. Chen  (2000)  Electrophoresis  21, 1740-1745  "A proteomic analysis of secreted proteins from xylan-induced Bacillus sp. strain K-1"
  148. J. H. Leu, S. J. Yan, T. F. Lee, C. M. Chou, S. T. Chen, P. P. Hwang, C. K. Chou and C. J. Huang  (2000)  DNA Cell Biol  19, 431-446  "Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes"
  149. B. Sookkheo, S. Sinchaikul, S. Phutrakul and S. T.Chen  (2000)  Protein Expr Purif  20, 142-151  "Purification and Characterization of the highly Thermostable Proteases from Bacillus Stearothermophilus TLS33"
  150. C. M. Huang, Y. T. Wu and S. T. Chen  (2000)  Chem Biol  7, 453-461  "Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis"
  151. H. P. Hsieh, Y. T. Wu, S. T. Chen and K. T. Wang  (1999)  Bioorganic & Medicinal Chemistry  7, 1797-1803  "Direct solid-phase synthesis of octreotide conjugates: precursors for use as tumor-targeted radiopharmaceuticals"
  152. C. Y. Wu, H. J. Lee, S. H. Wu, S. T. Chen, S. H. Chiou and G. G. Chang  (1998)  Biochem J  333, 327-334  "Chemical mechanism of the endogenous argininosuccinate lyase activity of duck lens delta2-crystallin"
  153. J. H. Leu, M. S. Chang, C. W. Yao, C. K. Chou, S. T. Chen and C. J. Huang  (1998)  Biochimica et Biophysica Acta-Gene Structure and Expression  1395, 50-56  "Genomic organization and characterization of the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) JAK1 kinase gene"
  154. H. W. Huang, W. C. Chen, C. Y. Wu, H. C. Yu, W. Y. Lin, S. T. Chen and K. T. Wang  (1997)  Protein Eng  10, 1227-1233  "Kinetic studies of the inhibitory effects of propeptides subtilisin BPN' and Carlsberg to bacterial serine proteases"
  155. C. Y. Wu, W. C. Chen, C. L. Ho, S. T. Chen and K. T. Wang  (1997)  Biochemical and Biophysical Research Communications  233, 713-716  "The role of the N-terminal leucine residue in snake venom cardiotoxin II (Naja naja atra)"
  156. S. T. Chen, S. Y. Chen, C. C. Tu, S. H. Chiou and K. T. Wang  (1995)  J Protein Chem  14, 205-215  "Physicochemical properties of alkaline serine proteases in alcohol"
  157. S. T. Chen, C. C. Tu, S. Y. Chen, H. C. Huang and K. T. Wang  (1993)  Bioorg Med Chem  1, 361-367  "Investigating the s-2 subsite selectivity of alkaline proteases in hydrolysis of diastereo-peptide esters and molecular-modeling interpretation"
  158. H. M. Yu, T. M. Wu, S. T. Chen, C. L. Ho, G. R. Her and K. T. Wang  (1993)  Biochem Mol Biol Int  29, 241-246  "Mastoparan B, synthesis and its physical and biological properties"
  159. S. T. Chen, S. Y. Chen, S. C. Hsiao and K. T. Wang  (1991)  Biomed Biochim Acta  50, S181-186  "Application of industrial protease ""Alcalase"" in peptide synthesis"
  160. S. T. Chen, L. C. Lo, S. H. Wu and K. T. Wang  (1990)  Int J Pept Protein Res  35, 52-54  "Side reaction in peptide synthesis. Formation of oxazolidone derivatives"