The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions.
Liao JH, Wu TH, Chen MY, Chen WT, Lu SY, Wang YH, Wang SP, Hsu YM, Huang YS, Huang ZY, Lin YC, Chang CM, Huang FY, Wu SH

Scientific Reports   DOI: 10.1038/srep17614

Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Chen KE, Li MY, Chou CC, Ho MR, Chen GC, Meng TC, Wang AH

Structure   DOI: 10.1016/j.str.2015.01.017







High-resolution structures of Neotermes koshunensis beta-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates.
Jeng WY, Wang NC, Lin CT, Chang WJ, Liu CI, Wang AH.

Acta Crystallogr D Biol Crystallogr.   DOI: 10.1107/S0907444912013224

In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method.
Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, Lin CH.

Angew Chem Int Ed Engl.   DOI: 10.1002/anie.201200321

miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4.
Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT*, Chen RH*

Cancer Res.   DOI: 10.1158/0008-5472.CAN-12-0667



The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.
Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH.

Angew Chem Int Ed Engl.  DOI: 10.1002/anie.201100717

Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.
Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC.

EMBO J.   DOI: 10.1038/emboj.2010.338

A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.
Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH.

Cancer Cell.   DOI: 10.1016/j.ccr.2011.07.008



Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range.
Wu HJ, Ho CW, Ko TP, Popat SD, Lin CH, Wang AH.

Angew Chem Int Ed Engl.   DOI: 10.1002/anie.200905597

Mechanism of action and inhibition of dehydrosqualene synthase.
Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E.

Proc Natl Acad Sci U S A.   DOI: 10.1073/pnas.1010907107

Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation.
Chang TH, Hsieh FL, Ko TP, Teng KH, Liang PH, Wang AH.

Plant Cell.   DOI: 10.1105/tpc.109.071738

The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH.

EMBO J.   DOI: 10.1038/emboj.2010.62



Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.
Liu TW, Ho CW, Huang HH, Chang SM, Popat SD, Wang YT, Wu MS, Chen YJ, Lin CH.

Proc Natl Acad Sci U S A.   DOI: 10.1073/pnas.0903286106

Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence.
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.

Mol Cell Proteomics.   DOI: 10.1074/mcp.M900276-MCP200

Glycomics and proteomics analyses of mouse uterine luminal fluid revealed a predominance of Lewis Y and X epitopes on specific protein carriers.
Kuo CW, Chen CM, Lee YC, Chu ST, Khoo KH.

Mol Cell Proteomics.  DOI: 10.1074/mcp.M800320-MCP200