Latest Publications

20200625 Wang AHJ Epub
Development of a Versatile and Modular Linker for Antibody-Drug Conjugates Based on Oligonucleotide Strand Pairing

Dr. Wang AH [...]

25
Jun
20200608 Wang YS research photo
Probing the Active Site of Deubiquitinase USP30 With Noncanonical Tryptophan Analogues

Dr. Wang YS & Dr. Tsai MD [...]

23
Jun
20200620 Wu SH Epub photo
Multimeric TAT Peptides Are Effective in Vitro Inhibitors of Staphylococcus Saprophyticus

Dr. Wu SH [...]

20
Jun
20200520 Khoo KH papaer photo
Strategic applications of negative mode LC-MS/MS analyses to expedite confident mass spectrometry-based identification of multiple glycosylated peptides

Dr. Khoo KH [...]

02
Jun
20200310 Khoo KH paper photo
Targeting glycosylated PD-1 induces potent anti-tumor immunity

Dr. Khoo KH [...]

01
Jun
20200526 Chi P research photo 1
Rad51 Facilitates Filament Assembly of Meiosis-Specific Dmc1 Recombinase

Dr. Chi P [...]

26
May
20200526 Tsai MD paper photo
Non-hydrolyzable Heptose Bis- And Monophosphate Analogues Modulate the Pro-Inflammatory TIFA- NF-κB Signalling

Dr. Tsai MD [...]

26
May
20200522 Yang WY paper photo
Vesicular Transport Mediates the Uptake of Cytoplasmic Proteins Into Mitochondria in Drosophila Melanogaster

Dr. Yang WY [...]

22
May
20200522 Lin S paper photo
Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Dr. Lin S [...]

22
May
20200505 Lowary TL paper photo
Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Dr. Lowary TL [...]

21
May
20200309 Lin CH paper photo 1
Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes

Dr. Lin CH [...]

14
May
20200505 Wang AHJ paper photo Epub
Biochemical and molecular dynamics studies of archaeal polyisoprenyl pyrophosphate phosphatase from Saccharolobus solfataricus

Dr. Wang AH [...]

05
May
20200504 Chen RH paper photo
Tumor Suppressor Death-Associated Protein Kinase 1 Inhibits Necroptosis by p38 MAPK Activation

Dr. Chen RH [...]

04
May
20200325 Wu SH paper photo
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Dr. Wu SH [...]

30
Apr
20200428 Lin HC paper photo 1
Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis

Dr. Lin HC & Dr. Lin CH & Dr. Liang SY [...]

28
Apr
20200419 Angata T paper photo
Preparation of Recombinant Siglecs and Identification of Their Ligands

Dr. Angata T [...]

19
Apr
20200417 Lin HC paper photo
Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis

Dr. Lin HC [...]

17
Apr
20200409 Khoo KH paper photo
Mycobacterium bovis BCG infection alters the macrophage N-glycome

Dr. Khoo KH [...]

09
Apr
20200306 Wang YS paper photo
Linker and N-terminal domain engineering of pyrrolysyl-tRNA synthetase for substrate range shifting and activity enhancement

Dr. Wang YS [...]

07
Apr
20200403 Wu SH paper photo
H-Phosphonate Synthesis and Biological Evaluation of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria

Dr. Wu SH [...]

03
Apr
20200401 Meng TC paper Photo
Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction

Dr. Meng TC & Dr. Hsu SD [...]

01
Apr
20200313 Lin CH paper photo 1
Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium

Dr. Lin CH [...]

13
Mar
2020310 Angata T paper photo
Siglecs that Associate with DAP12

Dr. Angata T [...]

10
Mar
20191219 Chen RH paper photo
Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Dr. Chen RH [...]

20
Feb
20200205 Hsu STD paper photo
A High-Throughput Interbacterial Competition Screen Identifies ClpAP in Enhancing Recipient Susceptibility to Type VI Secretion System-Mediated Attack by Agrobacterium tumefaciens

Dr. Hsu STD [...]

05
Feb
2020 02 04 Ho MC paper photo 1
Constructing a yeast to express the largest cellulosome complex on the cell surface

Dr. Ho MC [...]

04
Feb
2020 02 01 Hsu STD
Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses

Dr. Hsu SD [...]

01
Feb
20200128 Khoo KH paper photo
The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

Dr. Khoo KH [...]

28
Jan
2020 UU4 IBC PR slide En
Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans

Dr. Hsu STD & Dr. Khoo KH & Dr. Wu KP [...]

21
Jan
20200115 Chen RH paper photo
WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila

Dr. Huang F & Dr. Chen RH [...]

15
Jan
20191126 TsaiMD paper photo
Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Dr. Tsai MD [...]

09
Jan
20200107 Wang AHJ paper photo 0522
Structural basis of polyethylene glycol recognition by antibody

Dr. Wang AH [...]

07
Jan
20191205 Shih YL paper photo
Effector loading onto the VgrG carrier activates type VI secretion system assembly

Dr. Shih YL [...]

07
Jan
20200103 Angata T paper photo
Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Dr. Angata T [...]

03
Jan
20200103 Chen RH paper photo
Cullin 3 and Its Role in Tumorigenesis

Dr. Chen RH [...]

03
Jan
20190925 Lin CH paper photo
Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition

Dr. Lin CH & Dr. Yang WY [...]

01
Jan
2019 12 26 Tsai MD 1
Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions

Dr. Tsai MD [...]

26
Dec
20191216 Chen RH paper photo
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Dr. Chen RH [...]

16
Dec
aculene biosynthesis Hsiao Ching Lin 1
The Biosynthesis of Norsesquiterpene Aculenes Requires Three Cytochrome P450 Enzymes to Catalyze a Stepwise Demethylation Process

Dr. Lin HC [...]

16
Dec
JCI125212.ga
HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Dr. Angata T [...]

02
Dec
20191102 Wang AH
Chaetomella raphigera β-glucosidase D2-BGL has intriguing structural features and a high substrate affinity that renders it an efficient cellulase supplement for lignocellulosic biomass hydrolysis

Dr. Wang AH [...]

02
Nov
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Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Dr. Chen RH [...]

02
Nov
2019 08 12 Chen GC Research Photo
PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization

Dr. Chen GC [...]

31
Oct
F1.large
Sugar starvation-regulated MYBS2 and 14-3-3 protein interactions enhance plant growth, stress tolerance, and grain weight in rice

Dr. Lin SY [...]

22
Oct
20191021 ChenRH Research Photo
Ubiquitin-mediated regulation of autophagy

Dr. Chen RH [...]

21
Oct
Angata T 7/17 Research Photo
Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding

Dr. Angata T [...]

15
Oct
20191007 ANGATA T pub
Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

Dr. Angata T [...]

07
Oct
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Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Dr. Chen GC [...]

03
Oct
20190929 WU W J pub
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

Dr. Wu WJ [...]

26
Sep
Chen RH -2019 ASB11 Research Photo
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

Dr. Chen RH & Dr. Lin SY [...]

02
Sep
20190831 CHEN SHUI TEIN pub
Medicinal Mushroom Taiwanofungus camphoratus: A potential cure for cancer

Dr. Chen ST [...]

31
Aug
20190827 Khoo
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

Dr. Khoo KH [...]

27
Aug
Lin et al 2019 Angewandte Chemie International Edition
Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans

Dr. Angata T [...]

12
Aug
2019 08 11 Liang PH New Epub
Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma

Dr. Liang PH [...]

11
Aug
20190806 Chang CI- Resear Photo
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases

Dr. Chang CI & Dr. Ho MR [...]

06
Aug
1 s2 0 S0969212619301261 fx1 lrg
Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer

Dr. Hsu STD & Dr. Huang KF [...]

06
Aug
20190802 Lin CH Research Photo
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Dr. Lin CH [...]

02
Aug
18 2019 3145 Fig1 HTML
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level

Dr. Ho MC [...]

01
Aug
Liang PH 20190726 Research
Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther

Dr. Liang PH [...]

26
Jul
Yao 2019 07 18 Epub
A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Dr. Yao CK [...]

18
Jul
20190711 Chen RH New Research Photo
LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Dr. Chen RH [...]

11
Jul
2019 07 10 Meng TC's Publication
Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6

Dr. Meng TC [...]

10
Jul
20190705 Wang AH Research Photo
Enhancement of laccase activity by pre-incubation with organic solvents

Dr. Wang AH [...]

05
Jul
20190704 Chen RH Research Photo
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Dr. Chen RH [...]

04
Jul
20190624 Chen RH Research Photo
Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome

Dr. Chen RH [...]

24
Jun
42003 2019 458 Fig1 HTML
Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing

Dr. Tsai MD & Dr. Wu WJ & Dr. Wang AH & Dr. Maestre-Reyna M [...]

20
Jun
20190605 Lin CH Research Photo
Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins

Dr. Lin CH [...]

05
Jun
2019 1 2 Rita Chen1
Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils

Dr. Chen RP [...]

02
Jun
1 s2.0 S014181301836728X gr1
Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni

Dr. Huang KF [...]

01
Jun
2019 06 11WJW 英
Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-mediated Functions

Dr. Tsai MD & Dr. Wu WJ & Dr. Maestre-Reyna M & Dr. Bessho Y [...]

29
May
F1.large
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Dr. Chen RH & Dr. Lin SY [...]

17
May
20190516 Lee MT Research Photo
Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

Dr. Lee MT [...]

16
May
20190506 Lin CH Research Photo
Quantification and Imaging of Antigens on Cell Surface with Lipid-Encapsulated Fluorescent Nanodiamonds

Dr. Lin CH [...]

06
May
annrheumdis 2018 213799 F1.large
PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

Dr. Meng TC [...]

02
May
20190501 Lee MT Reaserch Photo
Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Dr. Lee MT [...]

01
May
2019 05 Wang AHJ
New paradigm of functional regulation by DNA mimic proteins: Recent updates

Dr. Wang AH [...]

01
May
2019 4 23 Shih1
Active Transport of Membrane Components by Self-Organization of the Min Proteins

Dr. Shih YL [...]

23
Apr
2019 04 17 Tsai MD
Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase

Dr. Tsai MD [...]

17
Apr
1 s2 0 S1046202318303013 gr1
Deriving a sub-nanomolar affinity peptide from TAP to enable smFRET analysis of RNA polymerase II complexes

Dr. Lin SY [...]

15
Apr
253 2019 9708 Fig1 HTML
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

Dr. Lin HC [...]

01
Apr
F3 large
TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins

Dr. Lin S [...]

19
Mar
1 s2.0 S0959440X1830068X fx1 lrg
Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity

Dr. Khoo KH [...]

15
Mar
2019 3 14 Wang AH
An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Dr. Wang AH [...]

14
Mar
41467 2019 8924 Fig1 HTML
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

Dr. Yang WY [...]

27
Feb
2019 2 19 Ho MC
Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence

Dr. Ho MC & Dr. Wu WJ [...]

19
Feb
20190103 1
One-Pot Bioconversion of L-Arabinose to L-Ribulose in an Enzymatic Cascade

Dr. Lin CH [...]

18
Feb
2019 2 15 Hsu STD
Untying a Protein Knot by Circular Permutation

Dr. Hsu SD [...]

15
Feb
2019 2 1 Liang PH
Engineer multi-functional cellulase/xylanase/β-glucosidase with improved efficacy to degrade rice straw

Dr. Liang PH [...]

01
Feb
cwy095f01
Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner

Dr. Lin CH [...]

01
Feb
20190201 1
Catalytic mechanism of DNA polymerases-Two metal ions or three?

Dr. Tsai MD [...]

01
Feb
ijms 20 00622 ag
Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation

Dr. Khoo KH [...]

31
Jan
c8ob02774a
Biosynthesis of bioactive natural products from Basidiomycota

Dr. Lin HC [...]

31
Jan
1 s2 0 S2589004218302517 fx1
Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly

Dr. Yang WY [...]

25
Jan
20190118 3
Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1′-Disaccharide Aminoglycosides

Dr. Lin CH [...]

18
Jan
20190118 2
Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

Dr. Tsai MD & Dr. Maestre-Reyna M & Dr. Bessho Y [...]

18
Jan
20190118 1
Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris

Dr. Wang AH [...]

18
Jan
2019 1 18 Wang AH
Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis

Dr. Wang AH [...]

18
Jan
wu201901
Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

Dr. Wu SH [...]

17
Jan
2019 1 18 Peter Chi
Promotion of homology-directed DNA repair by polyamines

Dr. Chi P [...]

08
Jan
mic 06 065 g003
Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Dr. Chi P [...]

07
Jan
432348 1 En 40 Fig1 HTML
Triggering Mitophagy with Photosensitizers

Dr. Yang WY [...]

05
Jan
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Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models

Dr. Wang AH [...]

03
Jan
2019 1 1 Chen H
SFRP3 negatively regulates placental extravillous trophoblast cell migration mediated by the GCM1-WNT10B-FZD7 axis

Dr. Chen Hungwen [...]

01
Jan
2018 12 21 Angata
Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses

Dr. Angata T & Dr. Hsu SD [...]

21
Dec
2018 12 14 Wang AH
The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activity

Dr. Wang AH & Dr. Ho MR [...]

14
Dec