Latest Publications

20220916 Wang YS Epub
Ancestral Archaea Expanded the Genetic Code with Pyrrolysine

Dr. Wang YS [...]

22
Sep
20220826 Hsu JW Epub
AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation

Dr. Hsu JW [...]

15
Sep
20220709 Chi P Epub
Comparison of ATP-binding pockets and discovery of homologous recombination inhibitors

Dr. Chi P [...]

15
Sep
20220607 Angata T Epub
Ligand-assisted imprinting-probe-labeling strategy reveals Siglec-7 – glycoprotein interactions

Dr. Angata T [...]

11
Sep
20220825 Lowary TL Epub
Synthesis of the Mycobacterium tuberculosis Canetti Lipooligosaccharide II Nonasaccharide

Dr. Lowary TL [...]

09
Sep
20220705 Lin CH Epub
Galectin-3 facilitates cell-to-cell HIV-1 transmission by altering the composition of membrane lipid rafts in CD4 T cells

Dr. Lin CH [...]

01
Sep
20220829 Wu SH paper photo 1
High-efficiency decomposition of eggshell membrane by a keratinase from Meiothermus taiwanensis

Dr. Wu SH [...]

29
Aug
20220819 Hsu STD paper photo 1
In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM

Dr. Hsu STD & Dr. Khoo KH & Dr. Chang YC [...]

19
Aug
20220817 Yao CK Epub
Vav independently regulates synaptic growth and plasticity through distinct actin-based processes

Dr. Yao CK [...]

17
Aug
20220803 Wang YS Epub
Novel Two-Step Process in Cellulose Depolymerization: Hematite-Mediated Photocatalysis by Lytic Polysaccharide Monooxygenase and Fenton Reaction

Dr. Wang YS [...]

17
Aug
20220805 Lowary TL paper photo
A De Novo Route to 3,6-Dideoxy Sugars

Dr. Lowary TL [...]

05
Aug
20220509 Angata T Epub
Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia

Dr. Angata T [...]

05
Aug
20220803 Wu SH paper phot
2-Guanidinoethanesulfonyl sesquiterpenes from the marine sponge Agelas nakamurai

Dr. Wu SH [...]

03
Aug
20220720 Chen RP Epub 1
2.2 Å Cryo-EM Tetra-Protofilament Structure of the Hamster Prion 108-144 Fibril Reveals an Ordered Water Channel in the Center

Dr. Chen RP & Dr. Wu KP [...]

03
Aug
20220412 Chen GC Epub
Regulation of oxidative stress-induced autophagy by ATG9A ubiquitination

Dr. Chen GC [...]

01
Aug
20220620 Hsu STD Epub
Nickel superoxide dismutase protects nitrogen fixation in Trichodesmium

Dr. Hsu STD [...]

01
Aug
20210720 Chen RP Epub 1
Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein

Dr. Chen RP & Dr. Ho MR [...]

01
Aug
20220526 Angata T Epub
Combining CuAAC reaction enables sialylated Bi- and triantennary pseudo mannose N-glycans for investigating Siglec-7 interactions

Dr. Angata T [...]

01
Aug
20220711 Lin CH Epub 1
Metabolic Isolation, Stereochemical Determination, and Total Synthesis of Predominant Native Cholesteryl Phosphatidyl-α-glucoside from Carcinogenic Helicobacter pylori

Dr. Lin CH [...]

22
Jul
20220713 Khoo KH paper photo 1
An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9

Dr. Khoo KH [...]

13
Jul
20220707 Hsu ST paper photo
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Dr. Hsu ST [...]

07
Jul
20220706 Chen RH paper photo 1
Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression

Dr. Chen RH [...]

06
Jul
20220528 Chen RP Epub
Biodistribution analysis of an intranasal-delivered peptide by the nanoSPECT/CT imaging

Dr. Chen RP [...]

01
Jul
20220620 Chang CJ paper phot
Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits

Dr. Chang CJ & Dr. Lin S & Dr. Lin SW [...]

20
Jun
20220615 Khoo KH paper photo
Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan

Dr. Khoo KH [...]

15
Jun
20220526 Lin HC Epub 1
Biosynthesis of Piperazine-Derived Diazabicyclic Alkaloids Involves a Nonribosomal Peptide Synthetase and Subsequent Tailoring by a Multifunctional Cytochrome P450 Enzyme

Dr. Lin HC [...]

10
Jun
20220407 Tsai MD Epub
Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

Dr. Tsai MD & Dr. Maestre-Reyna M & Dr. Bessho Y & Dr. Wu WJ & Dr. Huang KF [...]

06
Jun
20220519 Highlight 2
Tumor suppressor BAP1 nuclear import is governed by transportin-1

Dr. Hsu STD & Dr. Lin S & Dr. Wu KP & Dr. Lin SY [...]

06
Jun
20220517 Chen RP Epub
Location of the cross-β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy

Dr. Chen RP [...]

01
Jun
20220531 Angata T paper photo
Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells

Dr. Angata T & Dr. Khoo KH [...]

31
May
20220531 Yu CC paper photo
Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose

Dr. Yu CC [...]

31
May
20220520 Lin S paper photo
Preparation of Cas9 Ribonucleoproteins for Genome Editing

Dr. Lin S & Dr. Lin SW [...]

20
May
20220518 Lin CH paper photo
Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations

Dr. Lin CH [...]

18
May
20220318 Liang PH Epub
SARS-CoV-2 3CLpro displays faster self-maturation in vitro than SARS-CoV 3CLpro due to faster C-terminal cleavage

Dr. Liang PH [...]

16
May
20220319 Hsu STD Epub
Impacts of cancer-associated mutations on the structure-activity relationship of BAP1

Dr. Hsu STD [...]

15
May
20220512 Huang KF paper photo 1
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors

Dr. Huang KF [...]

12
May
20220510 Chen RH paper photo
Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival

Dr. Chen RH [...]

10
May
20220501 Wu SH paper photo2
Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase

Dr. Wu SH & Dr. Huang KF [...]

01
May
20220407 Lowary TL Epub
The biosynthetic origin of ribofuranose in bacterial polysaccharides

Dr. Lowary TL [...]

01
May
ProteinScience KPWu 2022 0411
Structural basis for the helical filament formation of Escherichia coli glutamine synthetase

Dr. Wu KP & Dr. Ho MR [...]

01
May
20220205 Hsu STD Epub
BARD1 is an ATPase activating protein for OLA1

Dr. Hsu STD [...]

01
May
20220409 Hsu STD paper photo
Oxidation of catalytic cysteine of human deubiquitinase BAP1 triggers misfolding and aggregation in addition to functional loss

Dr. Hsu STD [...]

09
Apr
20220404 Weng JH paper photo
Zebrafish Establish Female Germ Cell Identity by Advancing Cell Proliferation and Meiosis

Dr. Weng JH [...]

04
Apr
20220402 Khoo KH Epub
Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis

Dr. Khoo KH [...]

02
Apr
20220401 Yen HY paper photo
Electrospray ionization of native membrane proteins proceeds via a charge equilibration step

Dr. Yen HY [...]

01
Apr
20220315 Lowary TL Epub
One-Pot Regioselective Diacylation of Pyranoside 1,2-cis Diols

Dr. Lowary TL [...]

01
Apr
2022 01 28 Lin S Epub
DNA-free CRISPR-Cas9 gene editing of wild tetraploid tomato Solanum peruvianum using protoplast regeneration

Dr. Lin S [...]

01
Apr
20220331 Wolf M paper photo
Assembly mechanism of the pleomorphic immature poxvirus scaffold

Dr. Wolf M [...]

31
Mar
20220325 Chen H paper photo
Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation

Dr. Chen H [...]

25
Mar
20220322 Lin SW paper photo
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

Dr. Lin SW [...]

22
Mar
20220321 Wu SH paper photo
Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases

Dr. Wu SH [...]

21
Mar
2022 01 25 Angata T Epub
Sugar nucleotide regeneration system for the synthesis of Bi- and triantennary N-glycans and exploring their activities against siglecs

Dr. Angata T [...]

15
Mar
20220224 Liao JC paper phot
A cell-free self-replenishing CO2-fixing system

Dr. Liao JC [...]

24
Feb
20220222 Chen GC paper photo
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

Dr. Chen GC & Dr. Lin SY & Dr. Hung CC [...]

22
Feb
20220217 Chang CI paper photo
Structural Basis for the Peptidoglycan-Editing Activity of YfiH

Dr. Chang CI [...]

15
Feb
20211128 Wu SH Epub
A hexasaccharide from capsular polysaccharide of carbapenem-resistant Klebsiella pneumoniae KN2 is a ligand of Toll-like receptor 4

Dr. Wu SH [...]

15
Feb
20220207 Wu SH paper photo
Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use

Dr. Wu WJ & Dr. Ho MR & Dr. Wang AH & Dr. Huang KF & Dr. Wu SH [...]

07
Feb
2022 02 06 Lin CH paper photo
Carbohydrate Ligands for COVID-19 Spike Proteins

Dr. Lin CH & Dr. Tu ZJ [...]

06
Feb
20210909 Wang AH Epub
Structural basis of an epitope tagging system derived from Haloarcula marismortui bacteriorhodopsin I D94N and its monoclonal antibody GD-26

Dr. Wang AH [...]

01
Feb
2021 10 30 Khoo KH Epub
Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants

Dr. Khoo KH & Dr. Hsu STD [...]

31
Jan
20211217 Tsai IH Epub
Sequence determination and bioinformatic comparison of ten venom serine proteases of Trimeresurus gracilis, a Taiwanese endemic pitviper with controversial taxonomy

Dr. Tsai IH [...]

30
Jan
20220112 Liang PH paper photo
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets

Dr. Liang PH [...]

12
Jan
20220110 Angata T paper photo
Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

Dr. Angata T [...]

10
Jan
20220110 Meng TC paper photo
The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1

Dr. Meng TC & Dr. Hsu STD [...]

10
Jan
20211109 Hsu STD Epub
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Dr. Lowary TL & Dr. Hsu STD [...]

03
Jan
20211215 Meng TC Epub
Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity

Dr. Meng TC [...]

28
Dec
20211220 Khoo KH paper photo
Discovery Sulfoglycomics and Identification of the Characteristic Fragment Ions for High-Sensitivity Precise Mapping of Adult Zebrafish Brain-Specific Glycotopes

Dr. Khoo KH [...]

20
Dec
20211004 Shih YL Epub
Harnessing fluorescent moenomycin A antibiotics for bacterial cell wall imaging studies

Dr. Shih YL [...]

10
Dec
20211123 Tsai MD Epub
Evidence for an Enzyme-Catalyzed Rauhut–Currier Reaction during the Biosynthesis of Spinosyn A

Dr. Tsai MD [...]

08
Dec
20211115 Khoo KH Epub
ZIC-cHILIC-Based StageTip for Simultaneous Glycopeptide Enrichment and Fractionation toward Large-Scale N-Sialoglycoproteomics

Dr. Khoo KH [...]

07
Dec
20211125 Wang YS paper photo
Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase

Dr. Wang YS [...]

25
Nov
20211124 Chi P paper photo
Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Dr. Chi P [...]

24
Nov
20211123 Wu KP paper photo 1
Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis

Dr. Wu KP [...]

23
Nov
20211018 Khoo KH Epub
Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands

Dr. Khoo KH [...]

19
Nov
20210921 Khoo KH Epub
Establishment of a novel monoclonal antibody against truncated glycoforms of α-dystroglycan lacking matriglycans

Dr. Khoo KH [...]

19
Nov
20210923 Lowary TL Epub
Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii

Dr. Lowary TL [...]

15
Nov
20211110 Chang CI paper photo
Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex

Dr. Chang CI & Dr.Huang KF [...]

10
Nov
20211105 Chi P paper photo
Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Dr. Chi P [...]

05
Nov
20211027 Lin CH paper photo
Enhanced enzymatic production of cholesteryl 6′-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori

Dr. Lin CH & Dr. Chen GC & Dr. Yang WY [...]

27
Oct
20211021 Hsu STD paper photo
Structure-guided antibody cocktail for prevention and treatment of COVID-19

Dr. Hsu STD & Dr. Chang YC [...]

21
Oct
20210906 Ho MC Epub
The Macromolecular Complexes of Histones Affect Protein Arginine Methyltransferase Activities

Dr. Ho MC [...]

20
Oct
20210918 Hsu STD Epub
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation

Dr. Hsu STD & Dr. Chang YC [...]

16
Oct
20210927 Lin S Epub
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration

Dr. Lin S [...]

15
Oct
20211015 Lowary TL paper photo
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA

Dr. Lowary TL [...]

15
Oct
20211015 Chang CI paper photo
Complete three-dimensional structures of the Lon protease translocating a protein substrate

Dr. Chang CI [...]

15
Oct
20201028 PTPN9 Chen GC Epub
PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation

Dr. Chen GC & Dr. Hung CC & Dr. Lin SY [...]

13
Oct
20211012 Lowary TL paper photo
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes

Dr. Lowary TL [...]

12
Oct
20211011 Chang CI paper photo
Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

Dr. Chang CI [...]

11
Oct
20210930 Chen RP paper photo
De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens

Dr. Chen RP [...]

30
Sep
20210813 Lowary TL Epub
Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes

Dr. Lowary TL [...]

28
Sep
20210916 Lin S paper photo
Ex Vivo Expansion and CRISPR-Cas9 Genome Editing of Primary Human Natural Killer Cells

Dr. Lin S [...]

16
Sep
20210915 Lin CH paper photo
Plectranthus amboinicus (Spreng.) Semi-purified Fractions with Selective β-Glucuronidase Inhibition Elucidated with gas chromatography-mass spectrometry and in silico docking

Dr. Lin CH [...]

15
Sep
20210812 Hsu STD Epub 1
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function

Dr. Hsu STD & Dr. Chang YC & Dr. Ho MR [...]

01
Sep
20210818 Chang MS paper photo
Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A stability and cell proliferation

Dr. Chang MS [...]

18
Aug
20210817 Chi P paper photo
Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks

Dr. Chi P [...]

17
Aug
20210803 Chen RP paper photo 1
Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Dr. Chen RP [...]

03
Aug
20210503 Tsai IH Epub
Structural and bioinformatic analyses of Azemiops venom serine proteases reveal close phylogeographic relationships to pitvipers from eastern China and the New World

Dr. Tsai IH & Dr. Lin SW & Dr. Huang KF [...]

30
Jul
20210729 Hsu STD paper photo
Generation and Characterization of a Spike Glycoprotein Domain A-Specific Neutralizing Single-Chain Variable Fragment against Porcine Epidemic Diarrhea Virus

Dr. Hsu STD [...]

29
Jul
20210727 Lin CH paper photo
Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans

Dr. Lin CH [...]

27
Jul
20210726 Chang YC paper photo
Preparation of High-Temperature Sample Grids for Cryo-EM

Dr. Tsai MD & Dr. Chang YC [...]

26
Jul
20210606 Lowary TL Epub
Structure-activity relationship of avocadyne

Dr. Lowary TL [...]

21
Jul
20210708 Tsai MD paper photo
TIFA protein expression is associated with pulmonary arterial hypertension

Dr. Tsai MD [...]

08
Jul
20210506 Lowary TL Epub
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage

Dr. Lowary TL [...]

01
Jul
20210601 Wu SH paper photo 2
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability

Dr. Wu SH & Dr. Huang KF [...]

25
Jun
20210325 Huang KF Epub
A unique carboxylic-acid hydrogen-bond network (CAHBN) confers glutaminyl cyclase activity on M28 family enzymes

Dr. Huang KF & Dr. Wang AH [...]

25
Jun
20210618 Chen RP paper photo
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii

Dr. Chen RP & Dr. Lin CH [...]

18
Jun
20210503 Liang PH Epub
Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library

Dr. Liang PH [...]

15
Jun
20210514 Tsai MD Epub
Synthesis of a biotinylated heptose 1,7-bisphosphate analogue, a probe to study immunity and inflammation

Dr. Tsai MD [...]

14
Jun
20210423 Chen RP Epub
Probiotic Bacillus Affect Enterococcus faecalis Antibiotic Resistance Transfer by Interfering with Pheromone Signaling Cascades

Dr. Chen RP [...]

11
Jun
20210607 Liao JC paper photo
Identification of COVID-19 B-cell epitopes with phage-displayed peptide library

Dr. Liao JC [...]

07
Jun
20210605 Chang CJ paper photo
The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

Dr. Chang CJ & Dr. Lin S & Dr. Lin SW [...]

05
Jun
20210604 Hsu STD paper photo
Structural polymorphism and substrate promiscuity of a ribosome-associated molecular chaperone

Dr. Hsu STD & Dr. Ho MR [...]

04
Jun
20210601 Wu SH paper photo
Peptidomic analysis of low molecular weight antioxidative peptides prepared by lotus (Nelumbo nucifera Gaertn.) seed protein hydrolysates

Dr. Wu SH [...]

01
Jun
20210401 Hsu SD Epub
Converging experimental and computational views of the knotting mechanism of a small knotted protein

Dr. Hsu STD [...]

01
Jun
20210226 Kuan YS Epub
Three-dimensional multi-gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula

Dr. Kuan YS [...]

01
Jun
20210526 Liang PH paper photo
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

Dr. Liang PH & Dr. Wu KP [...]

26
May
20210524 Hsu STD paper photo
Tying up the Loose Ends: A Mathematically Knotted Protein

Dr. Hsu STD [...]

24
May
20210504 Wolf M paper photo
COVID-19 serological survey using micro blood sampling

Dr. Wolf M [...]

04
May
20210501 Lin CH paper photo
Development of a Tri-Functional Nanoprobe for Background-Free SERS Detection of Sialic Acid on the Cell Surface

Dr. Lin CH & Dr. Tu Z [...]

01
May
20201214 Liao JC
Role of cyanobacterial phosphoketolase in energy regulation and glucose secretion under dark anaerobic and osmotic stress conditions

Dr. Liao JC [...]

01
May
20210430 Chang CI paper
Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

Dr. Chang CI [...]

30
Apr
20210428 Wolf M paper photo
N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection

Dr. Wolf M [...]

28
Apr
20210427 Lin S paper photo
A Crucial Role of Mitochondrial Dynamics in Dehydration Resistance in Saccharomyces cerevisiae

Dr. Lin S [...]

27
Apr
20210416 Hsu SD paper photo
Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress

Dr. Hsu STD [...]

16
Apr
20210315 Hsu STD Cover Epub 1
Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein

Dr. Hsu STD & Dr. Wu KP & Dr. Ho MR [...]

13
Apr
20210414 Shih YL paper photo
Probing bacterial cell wall growth by tracing wall-anchored protein complexes

Dr. Shih YL [...]

12
Apr
20210326 Yang WY paper photo
A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane

Dr. Yang WY [...]

26
Mar
20210310 Khoo KH Epub
Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli

Dr. Khoo KH [...]

24
Mar
20210201 Liang PH Epub
Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2

Dr. Liang PH [...]

18
Mar
20210308 Yao CK paper photo
ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival

Dr. Yao CK [...]

08
Mar
20210211 Lin HC Epub
An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B

Dr. Wu SH & Dr. Lin HC [...]

05
Mar
20210304 Lin CH paper photo
Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Dr. Lin CH & Dr. Tu Z [...]

04
Mar
20210112 Lin S Epub
A robust platform for expansion and genome editing of primary human natural killer cells

Dr. Lin S [...]

01
Mar
20210210 Jao SC Epub
Insertion of Pro-Hyp-Gly provides 2 kcal mol -1 stability but attenuates the specific assembly of ABC heterotrimeric collagen triple helices

Dr. Jao SC [...]

28
Feb
20210226 Chen RH paper photo 1
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Dr. Chen RH & Dr. Chen GC & Dr. Wu KP & Dr. Lin SY [...]

26
Feb
20210226 Angata T Epub
Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells

Dr. Angata T [...]

26
Feb
20210223 Wang AH paper photo
DMTMM-Mediated Intramolecular Cyclization of Acidic Residues in Peptides/Proteins

Dr. Wang AH [...]

23
Feb
20210223 Chi P paper photo
Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences

Dr. Chi P [...]

23
Feb
20210113 Ho MC Epub
Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme

Dr. Ho MC [...]

19
Feb
20201222 Wang AH Epub
Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP

Dr. Wang AH [...]

19
Feb
20210212 Chen RH paper photo
Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization

Dr. Chen RH & Dr. Lin SY [...]

12
Feb
20210201 Hunag F Epub
Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription

Dr. Huang F [...]

01
Feb
20201228 Wang AH Epub
Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate‐dependent autoproteolysis activity

Dr. Wang AH & Dr. Maestre-Reyna M & Dr. Tsai MD & Dr. Wu WJ & Dr. Bessho Y [...]

01
Feb
20201113 Huang CJ Epub
Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression

Dr. Huang CJ [...]

01
Feb
20201229 Liang PH Epub
Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing

Dr. Liang PH [...]

26
Jan
2020 11 19 Chi P Epub
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA

Dr. Chi P [...]

15
Jan
20201231 Lowary TL Epub
Use of Synthetic Glycolipids to Probe the Number and Position of Arabinan Chains on Mycobacterial Arabinogalactan

Dr. Lowary TL [...]

15
Jan
20201221 Wang AH Epub
Crystal structure of the N-terminal domain of TagH reveals a potential drug targeting site

Dr. Wang AH [...]

15
Jan
20210114 Tsai MD paper photo 1
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

Dr. Tsai MD & Dr. Chi P & Dr. Ho MC & Dr. Wu WJ [...]

14
Jan
20201106 Lin S Epub
Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection

Dr. Lin S [...]

11
Jan
20210105 Angata T paper photo
Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Dr. Angata T [...]

05
Jan
20210102 Wu SH paper photo
New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral Sarcophyton tenuispiculatum

Dr. Wu SH [...]

02
Jan
20201127 Wang AH Epub
Structure, catalysis, and inhibition mechanism of prenyltransferase

Dr. Wang AH [...]

02
Jan
20201111 Khoo KH Epub
Sialylation of CD55 by ST3GAL1 facilitates immune evasion in cancer

Dr. Khoo KH [...]

02
Jan
20210101 Ho MC paper photo
Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

Dr. Ho MC [...]

01
Jan
20201119 Angata T Epub 1
A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides

Dr. Angata T [...]

01
Jan
20201215 Lin CH Epub
Threshold of Thioglycoside Reactivity Difference Is Critical for Efficient Synthesis of Type I Oligosaccharides by Chemoselective Glycosylation

Dr. Lin CH & Dr. Tu Z [...]

01
Jan
20201016 Lin CH Epub
Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease

Dr. Lin CH [...]

01
Jan
20200620 Wu SH Epub photo
Multimeric TAT Peptides Are Effective in Vitro Inhibitors of Staphylococcus Saprophyticus

Dr. Wu SH [...]

27
Dec
20201221 Liang PH cancers paper
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Dr. Liang PH [...]

21
Dec
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Dr. Shih YL [...]

16
Dec
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Phagocytosis enhancement, endotoxin tolerance, and signal mechanisms of immunologically active glucuronoxylomannan from Auricularia auricula-judae

Dr. Wu SH [...]

15
Dec
20200825 Lin CH Epub
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Dr. Lin CH [...]

15
Dec
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A positive feedback loop between Flower and PI(4,5)P 2 at periactive zones controls bulk endocytosis in Drosophila

Dr. Yao CK [...]

10
Dec
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Dr. Liao JC [...]

01
Dec
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Effect of membrane fusion protein AdeT1 on the antimicrobial resistance of Escherichia coli

Dr. Wu SH [...]

24
Nov
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Dr. Wu SH [...]

18
Nov
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Dr. Lowary TL [...]

17
Nov
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Branched Ubiquitination: Detection Methods, Biological Functions and Chemical Synthesis

Dr. Wang YS & Dr. Wu KP & Dr. Chen RH [...]

09
Nov
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Dr. Lowary TL [...]

02
Nov
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Cloning, expression, identification and characterization of borneol dehydrogenase isozymes in Pseudomonas sp. TCU-HL1

Dr. Huang KF [...]

01
Nov
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Dr. Yao CK [...]

27
Oct
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Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes

Dr. Yang WY & Dr. Lin S [...]

19
Oct
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Nonhydrolyzable Heptose Bis- and Monophosphate Analogues Modulate Pro-inflammatory TIFA-NF-κB Signaling

Dr. Tsai MD [...]

15
Oct
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Revealing USP7 Deubiquitinase Substrate Specificity by Unbiased Synthesis of Ubiquitin Tagged SUMO2

Dr. Wang YS & Dr. Lin SY [...]

13
Oct
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Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates

Dr. Chen RP [...]

08
Oct
20200816 Ho MR epub photo
Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism

Dr. Ho MR [...]

07
Oct
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Dr. Wu SH [...]

02
Oct
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Synthesis of a Highly Branched Nonasaccharide Chlorella Virus N-Glycan Using a “Counterclockwise” Assembly Approach

Dr. Lowary TL [...]

02
Oct
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Dr. Meng TC [...]

01
Oct
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TRIM28 Regulates Dlk1 Expression in Adipogenesis

Dr. Chang CJ & Dr. Lin SW [...]

30
Sep
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Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells

Dr. Wang AH [...]

28
Sep
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Dr. Wang YS [...]

25
Sep
20200814 Lin S Epub
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo

Dr. Lin S [...]

25
Sep
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Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance

Dr. Lin HC [...]

21
Sep
20200731 Chi P Epub
Microcephaly family protein MCPH1 stabilizes RAD51 filaments

Dr. Chi P [...]

18
Sep
20200810 Hsiao C Epub
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Dr. Hsiao C [...]

01
Sep
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Biochemical and molecular dynamics studies of archaeal polyisoprenyl pyrophosphate phosphatase from Saccharolobus solfataricus

Dr. Wang AH [...]

01
Sep
20200829 Wu SH paper photo
New Biscembranoids Sardigitolides A-D and Known Cembranoid-Related Compounds from Sarcophyton digitatum: Isolation, Structure Elucidation, and Bioactivities

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29
Aug
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Micro-liquid enclosure array and its semi-automated assembling system for x-ray free-electron laser diffractive imaging of samples in solution

Dr. Bessho Y [...]

21
Aug
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Converting Escherichia coli to a Synthetic Methylotroph Growing Solely on Methanol

Dr. Liao JC [...]

20
Aug
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Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss

Dr. Yao CK & Dr. Chen GC [...]

18
Aug
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A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2

Dr. Ho MC [...]

11
Aug
20200804 Wu KP paper photo
Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease

Dr. Wu KP [...]

04
Aug
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Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis

Dr. Lin HC & Dr. Lin CH [...]

03
Aug
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Mycobacterium bovis BCG infection alters the macrophage N-glycome

Dr. Khoo KH [...]

01
Aug
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PHRF1 promotes migration and invasion by modulating ZEB1 expression

Dr. Chang MS [...]

30
Jul
20200625 Wang AHJ epub photo
Development of a Versatile and Modular Linker for Antibody-Drug Conjugates Based on Oligonucleotide Strand Pairing

Dr. Wang AH [...]

15
Jul
20200707 Lowary TL paper photo
Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis

Dr. Lowary TL [...]

07
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Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

Dr. Khoo KH [...]

03
Jul
20200702 Chang MS paper photo
An important role of PHRF1 in dendritic architecture and memory formation by modulating TGF-β signaling

Dr. Chang MS [...]

02
Jul
20200701 Ko TP paper photo
Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1

Dr. Huang KF & Dr. Ko TP [...]

01
Jul
20200608 Wang YS research photo
Probing the Active Site of Deubiquitinase USP30 With Noncanonical Tryptophan Analogues

Dr. Wang YS & Dr. Tsai MD [...]

23
Jun
20200520 Khoo KH papaer photo
Strategic applications of negative mode LC-MS/MS analyses to expedite confident mass spectrometry-based identification of multiple glycosylated peptides

Dr. Khoo KH [...]

02
Jun
20200310 Khoo KH paper photo
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Dr. Khoo KH [...]

01
Jun
2019 08 11 Liang PH New Epub
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Dr. Liang PH [...]

31
May
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Rad51 Facilitates Filament Assembly of Meiosis-Specific Dmc1 Recombinase

Dr. Chi P [...]

26
May
20200522 Yang WY paper photo
Vesicular Transport Mediates the Uptake of Cytoplasmic Proteins Into Mitochondria in Drosophila Melanogaster

Dr. Yang WY [...]

22
May
20200522 Lin S paper photo
Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Dr. Lin S [...]

22
May
20200505 Lowary TL paper photo
Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Dr. Lowary TL [...]

21
May
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Negative Ion Mode nanoLC-ESI-MS/MS Analyses of Permethylated Sulfated Glycans

Dr. Khoo KH [...]

20
May
20200520 Khoo KH paper photo 1
Permethylation and Microfractionation of Sulfated Glycans for MS Analysis

Dr. Khoo KH [...]

20
May
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Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes

Dr. Lin CH [...]

14
May
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Tumor Suppressor Death-Associated Protein Kinase 1 Inhibits Necroptosis by p38 MAPK Activation

Dr. Chen RH [...]

04
May
20200325 Wu SH paper photo
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Dr. Wu SH [...]

30
Apr
20200419 Angata T paper photo
Preparation of Recombinant Siglecs and Identification of Their Ligands

Dr. Angata T [...]

19
Apr
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Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis

Dr. Lin HC [...]

17
Apr
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Linker and N-terminal domain engineering of pyrrolysyl-tRNA synthetase for substrate range shifting and activity enhancement

Dr. Wang YS [...]

07
Apr
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H-Phosphonate Synthesis and Biological Evaluation of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria

Dr. Wu SH [...]

03
Apr
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Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction

Dr. Meng TC & Dr. Hsu SD [...]

01
Apr
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Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium

Dr. Lin CH [...]

13
Mar
2020310 Angata T paper photo
Siglecs that Associate with DAP12

Dr. Angata T [...]

10
Mar
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Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Dr. Chen RH [...]

20
Feb
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Design of a liquid cell toward three-dimensional imaging of unidirectionally-aligned particles in solution using X-ray free-electron lasers

Dr. Bessho Y [...]

07
Feb
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A High-Throughput Interbacterial Competition Screen Identifies ClpAP in Enhancing Recipient Susceptibility to Type VI Secretion System-Mediated Attack by Agrobacterium tumefaciens

Dr. Hsu STD [...]

05
Feb
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Constructing a yeast to express the largest cellulosome complex on the cell surface

Dr. Ho MC [...]

04
Feb
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Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses

Dr. Hsu SD [...]

01
Feb
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The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

Dr. Khoo KH [...]

28
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2020 UU4 IBC PR slide En
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Dr. Hsu STD & Dr. Khoo KH & Dr. Wu KP [...]

21
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WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila

Dr. Huang F & Dr. Chen RH [...]

15
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20191126 TsaiMD paper photo
Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Dr. Tsai MD [...]

09
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Structural basis of polyethylene glycol recognition by antibody

Dr. Wang AH [...]

07
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Effector loading onto the VgrG carrier activates type VI secretion system assembly

Dr. Shih YL [...]

07
Jan
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Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Dr. Angata T [...]

03
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Cullin 3 and Its Role in Tumorigenesis

Dr. Chen RH [...]

03
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Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition

Dr. Lin CH & Dr. Yang WY [...]

01
Jan
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Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions

Dr. Tsai MD [...]

26
Dec
20191216 Chen RH paper photo
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Dr. Chen RH [...]

16
Dec
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The Biosynthesis of Norsesquiterpene Aculenes Requires Three Cytochrome P450 Enzymes to Catalyze a Stepwise Demethylation Process

Dr. Lin HC [...]

16
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JCI125212.ga
HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Dr. Angata T [...]

02
Dec
20191102 Wang AH
Chaetomella raphigera β-glucosidase D2-BGL has intriguing structural features and a high substrate affinity that renders it an efficient cellulase supplement for lignocellulosic biomass hydrolysis

Dr. Wang AH [...]

02
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kaup a 1596484 f0001 oc
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Dr. Chen RH [...]

02
Nov
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PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization

Dr. Chen GC [...]

31
Oct
F1.large
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Dr. Lin SY [...]

22
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20191021 ChenRH Research Photo
Ubiquitin-mediated regulation of autophagy

Dr. Chen RH [...]

21
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Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding

Dr. Angata T [...]

15
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Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

Dr. Angata T [...]

07
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kaup a 1634444 f0001 c
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Dr. Chen GC [...]

03
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20190929 WU W J pub
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

Dr. Wu WJ [...]

26
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Chen RH -2019 ASB11 Research Photo
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

Dr. Chen RH & Dr. Lin SY [...]

02
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20190831 CHEN SHUI TEIN pub
Medicinal Mushroom Taiwanofungus camphoratus: A potential cure for cancer

Dr. Chen ST [...]

31
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20190827 Khoo
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

Dr. Khoo KH [...]

27
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Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans

Dr. Angata T [...]

12
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20190806 Chang CI- Resear Photo
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases

Dr. Chang CI & Dr. Ho MR [...]

06
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Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer

Dr. Hsu STD & Dr. Huang KF [...]

06
Aug
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Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Dr. Lin CH [...]

02
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Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level

Dr. Ho MC [...]

01
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Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther

Dr. Liang PH [...]

26
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A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Dr. Yao CK [...]

18
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LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Dr. Chen RH [...]

11
Jul
2019 07 10 Meng TC's Publication
Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6

Dr. Meng TC [...]

10
Jul
20190705 Wang AH Research Photo
Enhancement of laccase activity by pre-incubation with organic solvents

Dr. Wang AH [...]

05
Jul
20190704 Chen RH Research Photo
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Dr. Chen RH [...]

04
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Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome

Dr. Chen RH [...]

24
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42003 2019 458 Fig1 HTML
Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing

Dr. Tsai MD & Dr. Wu WJ & Dr. Wang AH & Dr. Maestre-Reyna M [...]

20
Jun
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Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins

Dr. Lin CH [...]

05
Jun
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Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils

Dr. Chen RP [...]

02
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1 s2.0 S014181301836728X gr1
Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni

Dr. Huang KF [...]

01
Jun
2019 06 11WJW 英
Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-mediated Functions

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29
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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Dr. Chen RH & Dr. Lin SY [...]

17
May
20190516 Lee MT Research Photo
Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

Dr. Lee MT [...]

16
May
20190506 Lin CH Research Photo
Quantification and Imaging of Antigens on Cell Surface with Lipid-Encapsulated Fluorescent Nanodiamonds

Dr. Lin CH [...]

06
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annrheumdis 2018 213799 F1.large
PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

Dr. Meng TC [...]

02
May
20190501 Lee MT Reaserch Photo
Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Dr. Lee MT [...]

01
May
2019 05 Wang AHJ
New paradigm of functional regulation by DNA mimic proteins: Recent updates

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01
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2019 4 23 Shih1
Active Transport of Membrane Components by Self-Organization of the Min Proteins

Dr. Shih YL [...]

23
Apr
2019 04 17 Tsai MD
Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase

Dr. Tsai MD [...]

17
Apr
1 s2 0 S1046202318303013 gr1
Deriving a sub-nanomolar affinity peptide from TAP to enable smFRET analysis of RNA polymerase II complexes

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15
Apr
253 2019 9708 Fig1 HTML
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

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01
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F3 large
TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins

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19
Mar
1 s2.0 S0959440X1830068X fx1 lrg
Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity

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15
Mar
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An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

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14
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41467 2019 8924 Fig1 HTML
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

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27
Feb
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Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence

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19
Feb
20190103 1
One-Pot Bioconversion of L-Arabinose to L-Ribulose in an Enzymatic Cascade

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18
Feb
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Untying a Protein Knot by Circular Permutation

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15
Feb
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Engineer multi-functional cellulase/xylanase/β-glucosidase with improved efficacy to degrade rice straw

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01
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cwy095f01
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01
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Catalytic mechanism of DNA polymerases-Two metal ions or three?

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01
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Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation

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31
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c8ob02774a
Biosynthesis of bioactive natural products from Basidiomycota

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31
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Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly

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25
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Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1′-Disaccharide Aminoglycosides

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18
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Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

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18
Jan
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Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris

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18
Jan
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Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis

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18
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wu201901
Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

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17
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Promotion of homology-directed DNA repair by polyamines

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08
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mic 06 065 g003
Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

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07
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Triggering Mitophagy with Photosensitizers

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05
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kmab a 1541370 f0001 c
Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models

Dr. Wang AH [...]

03
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SFRP3 negatively regulates placental extravillous trophoblast cell migration mediated by the GCM1-WNT10B-FZD7 axis

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01
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21
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The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activity

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14
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