Latest Publications – Institute of Biological Chemistry, Academia Sinica

Molecules 2020 Sep Yane Shih Wang R1

Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids

Dr. Wang YS [...]

20200814 Lin S Epub

A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo

Dr. Lin S [...]

20200731 Chi P Epub

Microcephaly family protein MCPH1 stabilizes RAD51 filaments

Dr. Chi P [...]

20200810 Hsiao C Epub

The study of isotopic enrichment of water in human plasma and erythrocyte

Dr. Hsiao C [...]

20200505 Wang AHJ paper photo Epub

Biochemical and molecular dynamics studies of archaeal polyisoprenyl pyrophosphate phosphatase from Saccharolobus solfataricus

Dr. Wang AH [...]

20200829 Wu SH paper photo

New Biscembranoids Sardigitolides A-D and Known Cembranoid-Related Compounds from Sarcophyton digitatum: Isolation, Structure Elucidation, and Bioactivities

Dr. Wu SH [...]

20200821 Bessho Y paper photo

Micro-liquid enclosure array and its semi-automated assembling system for x-ray free-electron laser diffractive imaging of samples in solution

Dr. Bessho Y [...]

20200820 Liao JC paper photo v2

Converting Escherichia coli to a Synthetic Methylotroph Growing Solely on Methanol

Dr. Liao JC [...]

20200714 Chen GC Epub photo

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss

Dr. Yao CK & Dr. Chen GC [...]

20200816 Ho MR epub photo

Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism

Dr. Ho MR [...]

20200724 Ho MC Epub photo

A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2

Dr. Ho MC [...]

20200804 Wu KP paper photo

Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease

Dr. Wu KP [...]

20200428 Lin HC paper photo 1

Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis

Dr. Lin HC & Dr. Lin CH [...]

20200409 Khoo KH paper photo

Mycobacterium bovis BCG infection alters the macrophage N-glycome

Dr. Khoo KH [...]

20200730 Chang MS paper photo

PHRF1 promotes migration and invasion by modulating ZEB1 expression

Dr. Chang MS [...]

20200729 Huang KF Epub photo

Cloning, expression, identification and characterization of borneol dehydrogenase isozymes in Pseudomonas sp. TCU-HL1

Dr. Huang KF [...]

20200625 Wang AHJ epub photo

Development of a Versatile and Modular Linker for Antibody-Drug Conjugates Based on Oligonucleotide Strand Pairing

Dr. Wang AH [...]

20200707 Lowary TL paper photo

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis

Dr. Lowary TL [...]

20200703 Khoo KH paper photo

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

Dr. Khoo KH [...]

20200702 Chang MS paper photo

An important role of PHRF1 in dendritic architecture and memory formation by modulating TGF-β signaling

Dr. Chang MS [...]

20200701 Ko TP paper photo

Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1

Dr. Huang KF & Dr. Ko TP [...]

20200608 Wang YS research photo

Probing the Active Site of Deubiquitinase USP30 With Noncanonical Tryptophan Analogues

Dr. Wang YS & Dr. Tsai MD [...]

20200620 Wu SH Epub photo

Multimeric TAT Peptides Are Effective in Vitro Inhibitors of Staphylococcus Saprophyticus

Dr. Wu SH [...]

20200615 Meng TC Epub photo 1

Eating right for a healthier heart: Food choice contributes to cardiometabolic benefits and reduction of carotid intima-media thickness

Dr. Meng TC [...]

20200520 Khoo KH papaer photo

Strategic applications of negative mode LC-MS/MS analyses to expedite confident mass spectrometry-based identification of multiple glycosylated peptides

Dr. Khoo KH [...]

20200310 Khoo KH paper photo

Targeting glycosylated PD-1 induces potent anti-tumor immunity

Dr. Khoo KH [...]

2019 08 11 Liang PH New Epub

Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma

Dr. Liang PH [...]

20200526 Chi P research photo 1

Rad51 Facilitates Filament Assembly of Meiosis-Specific Dmc1 Recombinase

Dr. Chi P [...]

20200526 Tsai MD paper photo

Non-hydrolyzable Heptose Bis- And Monophosphate Analogues Modulate the Pro-Inflammatory TIFA- NF-κB Signalling

Dr. Tsai MD [...]

20200522 Yang WY paper photo

Vesicular Transport Mediates the Uptake of Cytoplasmic Proteins Into Mitochondria in Drosophila Melanogaster

Dr. Yang WY [...]

20200522 Lin S paper photo

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Dr. Lin S [...]

20200505 Lowary TL paper photo

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Dr. Lowary TL [...]

20200309 Lin CH paper photo 1

Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes

Dr. Lin CH [...]

20200504 Chen RH paper photo

Tumor Suppressor Death-Associated Protein Kinase 1 Inhibits Necroptosis by p38 MAPK Activation

Dr. Chen RH [...]

20200325 Wu SH paper photo

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Dr. Wu SH [...]

20200419 Angata T paper photo

Preparation of Recombinant Siglecs and Identification of Their Ligands

Dr. Angata T [...]

20200417 Lin HC paper photo

Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis

Dr. Lin HC [...]

20200306 Wang YS paper photo

Linker and N-terminal domain engineering of pyrrolysyl-tRNA synthetase for substrate range shifting and activity enhancement

Dr. Wang YS [...]

20200403 Wu SH paper photo

H-Phosphonate Synthesis and Biological Evaluation of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria

Dr. Wu SH [...]

20200401 Meng TC paper Photo

Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction

Dr. Meng TC & Dr. Hsu SD [...]

20200313 Lin CH paper photo 1

Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium

Dr. Lin CH [...]

2020310 Angata T paper photo

Siglecs that Associate with DAP12

Dr. Angata T [...]

20191219 Chen RH paper photo

Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Dr. Chen RH [...]

20200207 Bessho Y paper photo

Design of a liquid cell toward three-dimensional imaging of unidirectionally-aligned particles in solution using X-ray free-electron lasers

Dr. Bessho Y [...]

20200205 Hsu STD paper photo

A High-Throughput Interbacterial Competition Screen Identifies ClpAP in Enhancing Recipient Susceptibility to Type VI Secretion System-Mediated Attack by Agrobacterium tumefaciens

Dr. Hsu STD [...]

2020 02 04 Ho MC paper photo 1

Constructing a yeast to express the largest cellulosome complex on the cell surface

Dr. Ho MC [...]

2020 02 01 Hsu STD

Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses

Dr. Hsu SD [...]

20200128 Khoo KH paper photo

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

Dr. Khoo KH [...]

2020 UU4 IBC PR slide En

Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans

Dr. Hsu STD & Dr. Khoo KH & Dr. Wu KP [...]

20200115 Chen RH paper photo

WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila

Dr. Huang F & Dr. Chen RH [...]

20191126 TsaiMD paper photo

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

Dr. Tsai MD [...]

20200107 Wang AHJ paper photo 0522

Structural basis of polyethylene glycol recognition by antibody

Dr. Wang AH [...]

20191205 Shih YL paper photo

Effector loading onto the VgrG carrier activates type VI secretion system assembly

Dr. Shih YL [...]

20200103 Angata T paper photo

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Dr. Angata T [...]

20200103 Chen RH paper photo

Cullin 3 and Its Role in Tumorigenesis

Dr. Chen RH [...]

20190925 Lin CH paper photo

Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition

Dr. Lin CH & Dr. Yang WY [...]

2019 12 26 Tsai MD 1

Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions

Dr. Tsai MD [...]

20191216 Chen RH paper photo

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Dr. Chen RH [...]

aculene biosynthesis Hsiao Ching Lin 1

The Biosynthesis of Norsesquiterpene Aculenes Requires Three Cytochrome P450 Enzymes to Catalyze a Stepwise Demethylation Process

Dr. Lin HC [...]

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HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Dr. Angata T [...]

20191102 Wang AH

Chaetomella raphigera β-glucosidase D2-BGL has intriguing structural features and a high substrate affinity that renders it an efficient cellulase supplement for lignocellulosic biomass hydrolysis

Dr. Wang AH [...]

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Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Dr. Chen RH [...]

2019 08 12 Chen GC Research Photo

PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization

Dr. Chen GC [...]

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Sugar starvation-regulated MYBS2 and 14-3-3 protein interactions enhance plant growth, stress tolerance, and grain weight in rice

Dr. Lin SY [...]

20191021 ChenRH Research Photo

Ubiquitin-mediated regulation of autophagy

Dr. Chen RH [...]

Angata T 7/17 Research Photo

Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding

Dr. Angata T [...]

20191007 ANGATA T pub

Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies

Dr. Angata T [...]

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Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Dr. Chen GC [...]

20190929 WU W J pub

Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

Dr. Wu WJ [...]

Chen RH -2019 ASB11 Research Photo

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

Dr. Chen RH & Dr. Lin SY [...]

20190831 CHEN SHUI TEIN pub

Medicinal Mushroom Taiwanofungus camphoratus: A potential cure for cancer

Dr. Chen ST [...]

20190827 Khoo

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

Dr. Khoo KH [...]

Lin et al 2019 Angewandte Chemie International Edition

Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans

Dr. Angata T [...]

20190806 Chang CI- Resear Photo

Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases

Dr. Chang CI & Dr. Ho MR [...]

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Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer

Dr. Hsu STD & Dr. Huang KF [...]

20190802 Lin CH Research Photo

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Dr. Lin CH [...]

18 2019 3145 Fig1 HTML

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level

Dr. Ho MC [...]

Liang PH 20190726 Research

Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther

Dr. Liang PH [...]

Yao 2019 07 18 Epub

A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Dr. Yao CK [...]

20190711 Chen RH New Research Photo

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Dr. Chen RH [...]

2019 07 10 Meng TC's Publication

Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6

Dr. Meng TC [...]

20190705 Wang AH Research Photo

Enhancement of laccase activity by pre-incubation with organic solvents

Dr. Wang AH [...]

20190704 Chen RH Research Photo

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Dr. Chen RH [...]

20190624 Chen RH Research Photo

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome

Dr. Chen RH [...]

42003 2019 458 Fig1 HTML

Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing

Dr. Tsai MD & Dr. Wu WJ & Dr. Wang AH & Dr. Maestre-Reyna M [...]

20190605 Lin CH Research Photo

Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins

Dr. Lin CH [...]

2019 1 2 Rita Chen1

Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils

Dr. Chen RP [...]

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Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni

Dr. Huang KF [...]

2019 06 11WJW 英

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-mediated Functions

Dr. Tsai MD & Dr. Wu WJ & Dr. Maestre-Reyna M & Dr. Bessho Y [...]

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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Dr. Chen RH & Dr. Lin SY [...]

20190516 Lee MT Research Photo

Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

Dr. Lee MT [...]

20190506 Lin CH Research Photo

Quantification and Imaging of Antigens on Cell Surface with Lipid-Encapsulated Fluorescent Nanodiamonds

Dr. Lin CH [...]

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PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

Dr. Meng TC [...]

20190501 Lee MT Reaserch Photo

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Dr. Lee MT [...]

2019 05 Wang AHJ

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Dr. Wang AH [...]

2019 4 23 Shih1

Active Transport of Membrane Components by Self-Organization of the Min Proteins

Dr. Shih YL [...]

2019 04 17 Tsai MD

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase

Dr. Tsai MD [...]

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Deriving a sub-nanomolar affinity peptide from TAP to enable smFRET analysis of RNA polymerase II complexes

Dr. Lin SY [...]

253 2019 9708 Fig1 HTML

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

Dr. Lin HC [...]

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TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins

Dr. Lin S [...]

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Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity

Dr. Khoo KH [...]

2019 3 14 Wang AH

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Dr. Wang AH [...]

41467 2019 8924 Fig1 HTML

Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

Dr. Yang WY [...]

2019 2 19 Ho MC

Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence

Dr. Ho MC & Dr. Wu WJ [...]

20190103 1

One-Pot Bioconversion of L-Arabinose to L-Ribulose in an Enzymatic Cascade

Dr. Lin CH [...]

2019 2 15 Hsu STD

Untying a Protein Knot by Circular Permutation

Dr. Hsu SD [...]

2019 2 1 Liang PH

Engineer multi-functional cellulase/xylanase/β-glucosidase with improved efficacy to degrade rice straw

Dr. Liang PH [...]

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Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner

Dr. Lin CH [...]

20190201 1

Catalytic mechanism of DNA polymerases-Two metal ions or three?

Dr. Tsai MD [...]

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Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation

Dr. Khoo KH [...]

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Biosynthesis of bioactive natural products from Basidiomycota

Dr. Lin HC [...]

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Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly

Dr. Yang WY [...]

20190118 3

Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1′-Disaccharide Aminoglycosides

Dr. Lin CH [...]

20190118 2

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

Dr. Tsai MD & Dr. Maestre-Reyna M & Dr. Bessho Y [...]

20190118 1

Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris

Dr. Wang AH [...]

2019 1 18 Wang AH

Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis

Dr. Wang AH [...]

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Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

Dr. Wu SH [...]

2019 1 18 Peter Chi

Promotion of homology-directed DNA repair by polyamines

Dr. Chi P [...]

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Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Dr. Chi P [...]

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Triggering Mitophagy with Photosensitizers

Dr. Yang WY [...]

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Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models

Dr. Wang AH [...]

2019 1 1 Chen H

SFRP3 negatively regulates placental extravillous trophoblast cell migration mediated by the GCM1-WNT10B-FZD7 axis

Dr. Chen Hungwen [...]

2018 12 21 Angata

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses

Dr. Angata T & Dr. Hsu SD [...]

2018 12 14 Wang AH

The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activity

Dr. Wang AH & Dr. Ho MR [...]