Research
  1. Protein Chemistry: Cell culture, Molecular cloning, Site-directed mutagenesis, Protein expression, Protein purification, Enzyme kinetic analysis.
  2. Biophysical Instrument: Circular dichroism, Fluorescence spectroscopy, Analytic ultracentrifugation, Isothermal titration calorimetry, Surface plasmon resonance.
Degrees and Positions Held
Positions Held
  • 2019 – present   Associate Research Specialist, Institute of Biological Chemistry, Academia Sinica
  • 2010 – 2019   Assistant Research Specialist, Institute of Biological Chemistry, Academia Sinica
  • 2007 – 2009   Postdoctoral Fellow, Genomics Research Center, Academia Sinica
  • 2007 – 2007   Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2000 – 2005   Research Assistant, Institute of Biological Chemistry, Academia Sinica
Degrees
  • 2002 – 2007   Ph.D., Institute of Biochemical Sciences, National Taiwan University
  • 1997 – 1999   M.S., Biological Science and Technology, National Chiao Tung University
Selected Publications
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*
Nucleic acids research (2012)
Lin YN, Stein DB, Lin SW, Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*
ADVANCED SYNTHESIS & CATALYSIS (2012)
Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH
The Journal of biological chemistry (2007)
Lin SW, Yuan TM, Li JR, Lin CH
Biochemistry (2006)
Publications List
  1. Chen YW, Satange R, Wu PC, Jhan CR, Chang CK, Chung KR, Waring MJ, (Lin SW), Hsieh LC, Hou MH  (2018-09)  International journal of molecular sciences  19(9), 2796  "Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex."
  2. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, (Lin SW), Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  3. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, (Lin SW), Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  4. Yeh HY, (Lin SW), Wu YC, Chan NL, Chi P  (2017-05)  Scientific reports  7(1), 2370  "Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans."
  5. Teng KH, Hsu ET, Chang YH, (Lin SW), Liang PH  (2016)  Biochemistry  55(31), 4366-74  "Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors."
  6. Kumar V, Tan KP, Wang YM, (Lin SW), Liang PH  (2016)  Bioorganic & medicinal chemistry  24(13), 3035-3042  "Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors."
  7. Su GC, Yeh HY, (Lin SW), Chung CI, Huang YS, Liu YC, Lyu PC, Chi P  (2016)  Nucleic acids research  44(13), 6242-51  "Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination."
  8. Chang HY, Liao CY, Su GC, (Lin SW), Wang HW, Chi P  (2015-08)  The Journal of biological chemistry  290(32), 19863-19873  "Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1."
  9. Lin TW, Chang HT, Chen CH, Chen CH, (Lin SW), Hsu TL, Wong CH  (2015-08)  Journal of the American Chemical Society  137(30), 9685-9693  "Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis."
  10. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang AH, Yu CM, Chen IC, Tung CP, Chen TH, Ping Chiu K, Ma C, Yuan Wu C, (Lin SW), Yang AS  (2015-07)  Scientific reports  5, 12411  "Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens."
  11. Chen PC, Chuang PK, Chen CH, Chan YT, Chen JR, (Lin SW), Ma C, Hsu TL, Wong CH  (2014-07)  ACS chemical biology  9(7), 1437-1443  "Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors."
  12. Su GC, Chung CI, Liao CY, (Lin SW), Tsai CT, Huang T, Li HW, Chi P  (2014-01)  Nucleic acids research  42(1), 349-358  "Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex."
  13. Chang CK, Teng KH, (Lin SW), Chang TH, Liang PH  (2013)  Biochemistry  52(16), 2783-2792  "Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction."
  14. Busygina V, Gaines WA, Xu Y, Kwon Y, Williams GJ, (Lin SW), Chang HY, Chi P, Wang HW, Sung P  (2013)  DNA repair  12(9), 707-712  "Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1."
  15. Chen SH, (Lin SW), Lin SR, Liang PH, Yang JM  (2013)  Journal of chemical information and modeling  53(9), 2299-2311  "Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase."
  16. Lin YN, Stein DB, (Lin SW), Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*  (2012)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  17. Tsai SP, Su GC, (Lin SW), Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*  (2012)  Nucleic acids research  40(14), 6558-6569  "Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex."
  18. Sun HY, (Lin SW), Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH  (2007)  The Journal of biological chemistry  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design."
  19. (Lin SW), Yuan TM, Li JR, Lin CH  (2006)  BIOCHEMISTRY  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."
  1. Protein Chemistry: Cell culture, Molecular cloning, Site-directed mutagenesis, Protein expression, Protein purification, Enzyme kinetic analysis.
  2. Biophysical Instrument: Circular dichroism, Fluorescence spectroscopy, Analytic ultracentrifugation, Isothermal titration calorimetry, Surface plasmon resonance.
Positions Held
  • 2019 – present   Associate Research Specialist, Institute of Biological Chemistry, Academia Sinica
  • 2010 – 2019   Assistant Research Specialist, Institute of Biological Chemistry, Academia Sinica
  • 2007 – 2009   Postdoctoral Fellow, Genomics Research Center, Academia Sinica
  • 2007 – 2007   Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2000 – 2005   Research Assistant, Institute of Biological Chemistry, Academia Sinica
Degrees
  • 2002 – 2007   Ph.D., Institute of Biochemical Sciences, National Taiwan University
  • 1997 – 1999   M.S., Biological Science and Technology, National Chiao Tung University
Tsai SP, Su GC, Lin SW, Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*
Nucleic acids research (2012)
Lin YN, Stein DB, Lin SW, Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*
ADVANCED SYNTHESIS & CATALYSIS (2012)
Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH
The Journal of biological chemistry (2007)
Lin SW, Yuan TM, Li JR, Lin CH
Biochemistry (2006)
  1. Chen YW, Satange R, Wu PC, Jhan CR, Chang CK, Chung KR, Waring MJ, (Lin SW), Hsieh LC, Hou MH  (2018-09)  International journal of molecular sciences  19(9), 2796  "Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex."
  2. Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, (Lin SW), Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  3. Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, (Lin SW), Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  4. Yeh HY, (Lin SW), Wu YC, Chan NL, Chi P  (2017-05)  Scientific reports  7(1), 2370  "Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans."
  5. Teng KH, Hsu ET, Chang YH, (Lin SW), Liang PH  (2016)  Biochemistry  55(31), 4366-74  "Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors."
  6. Kumar V, Tan KP, Wang YM, (Lin SW), Liang PH  (2016)  Bioorganic & medicinal chemistry  24(13), 3035-3042  "Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors."
  7. Su GC, Yeh HY, (Lin SW), Chung CI, Huang YS, Liu YC, Lyu PC, Chi P  (2016)  Nucleic acids research  44(13), 6242-51  "Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination."
  8. Chang HY, Liao CY, Su GC, (Lin SW), Wang HW, Chi P  (2015-08)  The Journal of biological chemistry  290(32), 19863-19873  "Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1."
  9. Lin TW, Chang HT, Chen CH, Chen CH, (Lin SW), Hsu TL, Wong CH  (2015-08)  Journal of the American Chemical Society  137(30), 9685-9693  "Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis."
  10. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang AH, Yu CM, Chen IC, Tung CP, Chen TH, Ping Chiu K, Ma C, Yuan Wu C, (Lin SW), Yang AS  (2015-07)  Scientific reports  5, 12411  "Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens."
  11. Chen PC, Chuang PK, Chen CH, Chan YT, Chen JR, (Lin SW), Ma C, Hsu TL, Wong CH  (2014-07)  ACS chemical biology  9(7), 1437-1443  "Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors."
  12. Su GC, Chung CI, Liao CY, (Lin SW), Tsai CT, Huang T, Li HW, Chi P  (2014-01)  Nucleic acids research  42(1), 349-358  "Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex."
  13. Chang CK, Teng KH, (Lin SW), Chang TH, Liang PH  (2013)  Biochemistry  52(16), 2783-2792  "Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction."
  14. Busygina V, Gaines WA, Xu Y, Kwon Y, Williams GJ, (Lin SW), Chang HY, Chi P, Wang HW, Sung P  (2013)  DNA repair  12(9), 707-712  "Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1."
  15. Chen SH, (Lin SW), Lin SR, Liang PH, Yang JM  (2013)  Journal of chemical information and modeling  53(9), 2299-2311  "Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase."
  16. Lin YN, Stein DB, (Lin SW), Chang SM, Lin TC, Chuang YR, Narimatsu H, Lin CH*  (2012)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  17. Tsai SP, Su GC, (Lin SW), Chung CI, Xue X, Dunlop MH, Akamatsu Y, Jasin M, Sung P, Chi P*  (2012)  Nucleic acids research  40(14), 6558-6569  "Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex."
  18. Sun HY, (Lin SW), Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH  (2007)  The Journal of biological chemistry  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design."
  19. (Lin SW), Yuan TM, Li JR, Lin CH  (2006)  BIOCHEMISTRY  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."