- Providing training and technical expertise to IBC investigators interested in using microscopy, flow cytometer and scientific imaging in their research
- Modalities and techniques including laser scanning confocal microscopy, wide-field fluorescence microscopy, live cell imaging
- In depth collaboration on select projects involving advanced microscopy techniques and methodologies
- Maintenance of the instrumentation and associated infrastructure
- Assistance with educational microscopy courses conducted at IBC
Research
- Providing training and technical expertise to IBC investigators interested in using microscopy, flow cytometer and scientific imaging in their research
- Modalities and techniques including laser scanning confocal microscopy, wide-field fluorescence microscopy, live cell imaging
- In depth collaboration on select projects involving advanced microscopy techniques and methodologies
- Maintenance of the instrumentation and associated infrastructure
- Assistance with educational microscopy courses conducted at IBC
Degrees and Positions Held
Positions Held
- 2014 – present Associate Research Specialist, Institute of Biological Chemistry, Academia Sinica
- 2009 – 2014 Assistant Research Specialist, Inst. of Biological Chemistry, Academia Sinica
- 1992 – 2008 Research Assistant, Inst. of Biological Chemistry, Academia Sinica
Degrees
- 2001 Ph.D., Biological Chemistry, National Taiwan University
Selected Publications
Molecular and cellular biology (2012)
Bioorganic & medicinal chemistry letters (2010)
Anticancer research (2010)
Developmental dynamics (2009)
Anticancer research (2008)
FEBS letters (2007)
Biochemical and biophysical research communications (2006)
The Biochemical journal (2004)
Publications List
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Chou HY, Lee YT, Lin YJ, Wen JK, Peng WH, Hsieh PL, Lin SY, (Hung CC), Chen GC (2020-10 accepted) Autophagy "PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation."
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Wen JK, Wang YT, Chan CC, Hsieh CW, Liao HM, (Hung CC), Chen GC (2017-11) eLife 6, e29338 "Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila"
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Tsai PH, Cheng CH, Lin CY, Huang YT, Lee LT, Kandaswami CC, Lin YC, Lee KP, (Hung CC), Hwang JJ, Ke FC, Chang GD, Lee MT (2016-12) Anticancer research 36(12), 6367-6380 "Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells."
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Lien HW, Yuan RY, Chou CM, Chen YC, (Hung CC), Hu CH, Hwang SP, Hwang PP, Shen CN, Chen CL, Cheng CH, Huang CJ (2016-06) Scientific reports 6, 28297 "Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2alpha."
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Wu BK, Yuan RY, Lien HW, (Hung CC), Hwang PP, Chen RP, Chang CC, Liao YF, Huang CJ (2016-02) Journal of biomedical science 23, 25 "Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo."
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Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, (Hung CC), Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH (2014-05) Molecular cell 54(4), 586-600 "K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking."
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Han HW, Chou CM, Chu CY, Cheng CH, Yang CH, (Hung CC), Hwang PP, Lee SJ, Liao YF, Huang CJ (2014) PloS one 9(1), e86345 "The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor."
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Lien HW, Yang CH, Cheng CH, (Hung CC), Liao WH, Hwang PP, Han YS, Huang CJ (2013-09) International journal of biological sciences 9(9), 872-886 "A novel zinc finger protein 219-like (ZNF219L) is involved in the regulation of collagen type 2 alpha 1a (col2a1a) gene expression in zebrafish notochord."
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Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, (Hung CC), Chen ST, Wang AH, Shyy JY, Tsai MD (2012-07) Molecular and cellular biology 32(14), 2664-2673 "Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-kappaB activation."
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Huang KY, Chen GD, Cheng CH, Liao KY, (Hung CC), Chang GD, Hwang PP, Lin SY, Tsai MC, Khoo KH, Lee MT, Huang CJ (2011) PloS one 6(10), e26461 "Phosphorylation of the zebrafish M6Ab at serine 263 contributes to filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos."
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Chen SH, Lin CY, Lee LT, Chang GD, Lee PP, (Hung CC), Kao WT, Tsai PH, Schally AV, Hwang JJ, Lee MT (2010-10) Anticancer research 30(10), 4177-4186 "Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells."
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Li WS, More SV, Wang CH, Jen YC, Yao CF, Wang TF, (Hung CC), Jao SC (2010-02) Bioorganic & medicinal chemistry letters 20(3), 1148-1152 "Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents."
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Chen YC, Cheng CH, Chen GD, Hung CC, Yang CH, Hwang SP, Kawakami K, Wu BK, Huang CJ (2009) Developmental dynamics 238(3), 746-754 "Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene."
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Kao WT, Lin CY, Lee LT, Lee PP, Hung CC, Lin YS, Chen SH, Ke FC, Hwang JJ, Lee MT (2008) Anticancer research 28(4B), 2109-2120 "Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a Boyden chamber assay."
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Chu CY, Cheng CH, Chen GD, Chen YC, Hung CC, Huang KY, Huang CJ (2007) FEBS letters 581(22), 4265-4271 "The zebrafish erythropoietin: functional identification and biochemical characterization."
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Chen GD, Chou CM, Hwang SP, Wang FF, Chen YC, Hung CC, Chen JY, Huang CJ (2006) Biochemical and biophysical research communications 344(1), 272-282 "Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay."
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Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS (2004) Cancer research 64(4), 1444-1451 "3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells."
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Huang KF, Ko TP, Hung CC, Chu J, Wang AH, Chiou SH (2004) The Biochemical journal 378(Pt 2), 399-407 "Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus)."
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Hung CC, Chiou SH (2001) Biochemical and biophysical research communications 281(4), 1012-1018 "Fibrinogenolytic proteases isolated from the snake venom of Taiwan habu: serine proteases with kallikrein-like and angiotensin-degrading activities."
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Hung CC, Chiou SH (2000) Biochemical and biophysical research communications 275(3), 924-930 "Expression of a kallikrein-like protease from the snake venom: engineering of autocatalytic site in the fusion protein to facilitate protein refolding."
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Juan HF, Hung CC, Wang KT, Chiou SH (1999) Biochemical and biophysical research communications 257(2), 500-510 "Comparison of three classes of snake neurotoxins by homology modeling and computer simulation graphics."
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Huang KF, Hung CC, Wu SH, Chiou SH (1998) Biochemical and biophysical research communications 248(3), 562-568 "Characterization of three endogenous peptide inhibitors for multiple metalloproteinases with fibrinogenolytic activity from the venom of Taiwan habu (Trimeresurus mucrosquamatus)."
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Liao JH, Hung CC, Lee JS, Wu SH, Chiou SH (1998) Biochemical and biophysical research communications 244(1), 131-137 "Characterization, cloning, and expression of porcine alpha B crystallin."
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Hung CC, Wu SH, Chiou SH (1998) Journal of protein chemistry 17(2), 107-114 "Two novel alpha-neurotoxins isolated from Taiwan cobra: sequence characterization and phylogenetic comparison of homologous neurotoxins."
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Huang KF, Hung CC, Pan FM, Chow LP, Tsugita A, Chiou SH (1995) Biochemical and biophysical research communications 216(1), 223-233 "Characterization of multiple metalloproteinases with fibrinogenolytic activity from the venom of Taiwan habu (Trimeresurus mucrosquamatus): protein microsequencing coupled with cDNA sequence analysis."
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Chiou SH, Hung CC, Huang HC, Chen ST, Wang KT, Yang CC (1995) Biochemical and biophysical research communications 206(1), 22-32 "Sequence comparison and computer modelling of cardiotoxins and cobrotoxin isolated from Taiwan cobra."
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Hung CC, Huang KF, Chiou SH (1994) Biochemical and biophysical research communications 205(3), 1707-1715 "Characterization of one novel venom protease with beta-fibrinogenase activity from the Taiwan habu (Trimeresurus mucrosquamatus): purification and cDNA sequence analysis."
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Hung CC, Chiou SH (1994) Biochemical and biophysical research communications 201(3), 1414-1423 "Isolation of multiple isoforms of alpha-fibrinogenase from the Western diamondback rattlesnake, Crotalus atrox: N-terminal sequence homology with ancrod, an antithrombotic agent from Malayan viper."
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Chiou SH, Hung CC, Lin CW (1992) Biochimica et biophysica acta 1160(3), 317-324 "Biochemical characterization of crystallins from pigeon lenses: structural and sequence analysis of pigeon delta-crystallin."