Our laboratory is specialized in structural proteomics, and uses it to study the functions of important bio-systems. Our primary methodologies are high-throughput synchrotron protein crystallography, proteomics as well as bioinformatics. Other advanced technologies, e.g., NMR spectroscopy, SAXS, EM, biophysical or immunological methods are used if necessary. The following domains are our primary interests:

1. Structural enzymology: Several enzymes as potential targets for drug discovery are under investigation. For developing new antibiotics, we focused on prenyltransferases. For anticancer agents, we analyzed phosphatases (in signal transduction). Studies of potential targets for diabetics and Alzheimer’s disease are also in progress.
2. Protein-DNA interactions: Besides investigating the effect of small drug molecules in gene transcription, we further devoted to another new gene regulation mechanism by DNA mimic proteins.
3. Causative microorganisms and cancer: In these issues, we focused on the regulation of bacterial anti-drug gene and biofilm as well as the cancer-related kinases and phosphatases.
4. Development of potential pharmaceutical proteins: We also involved in the protein drug discovery by investigating membrane proteins, antigens and antibodies.

Positions Held

• 2016 – Present   Visiting Chair Professor, Institute of Biological Chemistry, Academia Sinica
• 2015 – 2016   Vice President, Academia Sinica
• 2011 – 2015   Distinguished Research Fellow , Institute of Biological Chemistry, Academia Sinica
• 2006 – 2011   Distinguished Research Fellow and Vice President (Academic), Academia Sinica
• 2000 – 2006   Distinguished Research Fellow and Director, Institute of Biological Chemistry, Academia Sinica
• 1992 – 1999   Adjunct Research Fellow, Institute of Molecular Biology, Academia Sinica
• 1988 – 1996   Advisory Board Members, Institute of Molecular Biology, Academia Sinica
• 1988 – 1989   Professor, University of Illinois at Urbana-Champaign
• 1985 – 1988   Senior Research Scientist, MIT
• 1982 – 1985   Principal Research Scientist, MIT
• 1980 – 1982   Research Scientist, MIT
• 1974 – 1980   Postdoctoral Research Associate , MIT

Degrees

• 1974   Ph.D., University of Illinois at Urbana-Champaign
• 1970   M.S. , National Taiwan University
• 1967   B.S., National Taiwan University

1. Hsu NS, Lee CC, Kuo WC, Chang YW, Lo SY, (Wang AH)*  (2020-06 accepted)  Bioconjugate chemistry  "Development of a Versatile and Modular Linker for Antibody-Drug Conjugates Based on Oligonucleotide Strand Pairing."
   
2. Chiang CY, Chou CC, Chang HY, Hsu MF, Pao PJ, Chiang MH, (Wang AH)*  (2020-05 accepted)  Enzyme and Microbial Technology  "Biochemical and molecular dynamics studies of archaeal polyisoprenyl pyrophosphate phosphatase from Saccharolobus solfataricus"
   
3. Lee CC, Su YC, Ko TP, Lin LL, Yang CY, Chang SS, Roffler SR, (Wang AH)  (2020-01)  Journal of biomedical science  27(1), 12  "Structural basis of polyethylene glycol recognition by antibody."
   
4. Kao MR, Kuo HW, Lee CC, Huang KY, Huang TY, Li CW, Chen CW, (Wang AH), Yu SM, Ho TD  (2019-11)  Biotechnology for biofuels  12(1), 258  "Chaetomella raphigera beta-glucosidase D2-BGL has intriguing structural features and a high substrate affinity that renders it an efficient cellulase supplement for lignocellulosic biomass hydrolysis."
   
5. Wu MH, Lin MC, Lee CC, Yu SM, (Wang AH), Ho TD  (2019-07)  Scientific reports  9(1), 9754  "Enhancement of laccase activity by pre-incubation with organic solvents."
   
6. LinWu SW, Tu YH, Tsai TY, Maestre-Reyna M, Liu MS, Wu WJ, Huang JY, Chi HW, Chang WH, Chiou CF, (Wang AH), Lee J, Tsai MD  (2019-06)  Communications Biology  2(1), 224  "Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing."
   
7. Wang HC, Chou CC, Hsu KC, Lee CH, (Wang AH)  (2019-05)  IUBMB life  71(5), 539-548  "New paradigm of functional regulation by DNA mimic proteins: Recent updates."
   
8. Lee CC, Yang CY, Lin LL, Ko TP, Chang AH, Chang SS, (Wang AH)  (2019-03)  Scientific reports  9(1), 4546  "An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells."
   
9. Kuo WY, Hsu HJ, Wu CY, Chen HS, Chou YC, Tsou YL, Peng HP, Jian JW, Yu CM, Chiu YK, Chen IC, Tung CP, Hsiao M, Lin CL, Wang YA, (Wang AH), Yang AS  (2019-01)  mAbs  11(1), 153-165  "Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models."
   
10. Lee CC, Ko TP, Chen CT, Chan YT, Lo SY, Chang JY, Chen YW, Chung TF, Hsieh HJ, Hsiao CD, (Wang AH)  (2019-01)  Chembiochem  20(2), 193-202  "Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis."
    
11. Jeng WY, Liu CI, Lu TJ, Lin HJ, Wang NC, (Wang AH)  (2019-01)  Chembiochem  20(2), 295-307  "Crystal structures of the C-terminally truncated endoglucanase Cel9Q from Clostridium thermocellum complexed with cellodextrins and Tris."
    
12. Lee CH, Shih YP, Ho MR, (Wang AH)  (2018-12)  Nucleic acids research  46(22), 11806-11821  "The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zalpha DNA-binding activity."
    
13. Wu MH, Lee CC, Hsiao AS, Yu SM, (Wang AH), Ho TD  (2018-08)  FEBS open bio  8(8), 1230-1246  "Kinetic analysis and structural studies of a high-efficiency laccase from Cerrena sp. RSD1."
    
14. Chen IC, Chiu YK, Yu CM, Lee CC, Tung CP, Tsou YL, Huang YJ, Lin CL, Chen HS, (Wang AH), Yang AS  (2017-10)  Scientific reports  7(1), 14455  "High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries."
    
15. Chang HY, Chou CC, Wu ML, (Wang AHJ)  (2017-05)  Protein expression and purification  133, 121-131  "Expression, purification and enzymatic characterization of undecaprenyl pyrophosphate phosphatase from Vibrio vulnificus."
    
16. Maestre-Reyna M, Wu SM, Chang YC, Chen CC, Maestre-Reyna A, (Wang AH), Chang HY  (2017-04)  Scientific reports  7, 46022  "In search of tail-anchored protein machinery in plants: reevaluating the role of arsenite transporters."
    
17. Chou CC, Modi JP, Wang CY, Hsu PC, Lee YH, Huang KF, (Wang AH), Nan C, Huang X, Prentice H, Wei J, Wu JY  (2017-03)  Molecular neurobiology  54(2), 866-873  "Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95)."
    
18. Chan YT, Ko TP, Yao SH, Chen YW, Lee CC, (Wang AH)  (2017-03)  ACS OMEGA  2(3), 930–936  "Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase."
    
19. Lee IM, Tu IF, Yang FL, Ko TP, Liao JH, Lin NT, Wu CY, Ren CT, (Wang AH), Chang CM, Huang KF, Wu SH  (2017-02)  Scientific reports  7, 42711  "Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage PhiAB6 tailspike protein."
    
20. Lin BL, Chen CY, Huang CH, Ko TP, Chiang CH, Lin KF, Chang YC, Lin PY, Tsai HG, (Wang AH)  (2017-01)  PloS one  12(1), e0169627  "The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA."
    
21. Hou SC, Chen HS, Lin HW, Chao WT, Chen YS, Fu CY, Yu CM, Huang KF, (Wang AH), Yang AS  (2016-08)  Scientific reports  6, 31878  "High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries."
    
22. Yin SY, Efferth T, Jian FY, Chen YH, Liu CI, (Wang AH), Chen YR, Hsiao PW, Yang NS  (2016-07)  Oncotarget  7(28), 43629-43653  "Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1."
    
23. Wang HC, Ho CH, Chou CC, Ko TP, Huang MF, Hsu KC, (Wang AH)  (2016-05)  Nucleic acids research  44(9), 4440-4409  "Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase."
    
24. Zhang L, Chen CC, Ko TP, Huang JW, Zheng Y, Liu W, Wang I, Malwal SR, Feng X, Wang K, Huang CH, Hsu ST, (Wang AH), Oldfield E, Guo RT  (2016-04)  Angewandte Chemie-International Edition  55(15), 4716-4720  "Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5."
    
25. Chang CJ, Lee CC, Chan YT, Trudeau DL, Wu MH, Tsai CH, Yu SM, Ho TH, (Wang AH), Hsiao CD, Arnold FH, Chao YC  (2016-03)  PloS one  11(3), e0147485  "Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination."
    
26. Hou MH, Chuang CY, Ko TP, Hu NJ, Chou CC, Shih YP, Ho CL, (Wang AH)  (2016-01)  Insect biochemistry and molecular biology  68, 79-88  "Crystal structure of vespid phospholipase A reveals insights into the mechanism for cause of membrane dysfunction."
    
27. Hsu MF, Fu HY, Cai CJ, Yi HP, Yang CS, (Wang AH)  (2015-12)  The Journal of biological chemistry  290(49), 29567-29577  "Structural and Functional Studies of a Newly Grouped Haloquadratum walsbyi Bacteriorhodopsin Reveal the Acid-resistant Light-driven Proton Pumping Activity."
    
28. Lee CH, Chou CC, Hsu MF, (Wang AH)  (2015-10)  Scientific reports  5, 15086  "Determining the N-terminal orientations of recombinant transmembrane proteins in the Escherichia coli plasma membrane."
    
29. Smith DR, Maestre-Reyna M, Lee G, Gerard H, (Wang AH), Watnick PI  (2015-08)  Proceedings of the National Academy of Sciences of the United States of America  112(33), 10491-10496  "In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment."
    
30. Lee CT, Chen IT, Yang YT, Ko TP, Huang YT, Huang JY, Huang MF, Lin SJ, Chen CY, Lin SS, Lightner DV, Wang HC, (Wang AH), Wang HC, Hor LI, Lo CF  (2015-08)  Proceedings of the National Academy of Sciences of the United States of America  112(34), 10798-10803  "The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin."
    
31. Chiang CY, Lee CC, Lo SY, (Wang AH), Tsai HJ  (2015-07)  PloS one  10(7), e0134108  "Chromophore Deprotonation State Alters the Optical Properties of Blue Chromoprotein."
    
32. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, (Wang AH), Yu CM, Chen IC, Tung CP, Chen TH, Ping Chiu K, Ma C, Yuan Wu C, Lin SW, Yang AS  (2015-07)  Scientific reports  5, 12411  "Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens."
    
33. Chou CC, (Wang AH)  (2015-07)  Molecular bioSystems  11(8), 2144-2151  "Structural D/E-rich repeats play multiple roles especially in gene regulation through DNA/RNA mimicry."
    
34. Seib KL, Jen FE, Tan A, Scott AL, Kumar R, Power PM, Chen LT, Wu HJ, (Wang AH), Hill DM, Luyten YA, Morgan RD, Roberts RJ, Maiden MC, Boitano M, Clark TA, Korlach J, Rao DN, Jennings MP  (2015-04)  Nucleic acids research  43(8), 4150-4162  "Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis."
    
35. Maestre-Reyna M, Liu WC, Jeng WY, Lee CC, Hsu CA, Wen TN, (Wang AH), Shyur LF  (2015-04)  PloS one  10(4), e0120601  "Structural and functional roles of glycosylation in fungal laccase from Lentinus sp."
    
36. Chen KE, Li MY, Chou CC, Ho MR, Chen GC, Meng TC, (Wang AH)  (2015-04)  Structure  23(4), 653-664  "Substrate Specificity and Plasticity of FERM-Containing Protein Tyrosine Phosphatases."
    
37. Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, (Wang AH), Liang PH, Guo RT, Ma Y  (2015-01)  Proteins  83(1), 37-45  "Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms."
    
38. Yang HC, Chuang JY, Jeng WY, Liu CI, (Wang AH), Lu PJ, Chang WC, Hung JJ  (2014-12)  Nucleic acids research  42(22), 13573-13587  "Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis."
    
39. Lee CC, Maestre-Reyna M, Hsu KC, Wang HC, Liu CI, Jeng WY, Lin LL, Wood R, Chou CC, Yang JM, (Wang AH)  (2014-11)  Angewandte Chemie - International Edition  53(48), 13054-13058  "Crowning Proteins: Modulating the Protein Surface Properties using Crown Ethers."
    
40. Zheng Y, Ko TP, Sun H, Huang CH, Pei J, Qiu R, (Wang AH), Wiegel J, Shao W, Guo RT  (2014-11)  Journal of structural biology  188(3), 195-204  "Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes."
    
41. Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, Tzu-Ching Meng, and (Andrew H. -J. Wang)  (2014-10)  Science Signaling  7(347), ra98  "Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation"
    
42. Yang CH, Wang CY, Grumezescu AM, (Wang AH), Hsiao CJ, Chen ZY, Huang KS  (2014-09)  Electrophoresis  35(18), 2673-2680  "Core-shell structure microcapsules with dual pH-responsive drug release function."
    
43. Yang Y, Ko TP, Liu L, Li J, Huang CH, Chan HC, Ren F, Jia D, (Wang AH), Guo RT, Chen J, Du G  (2014-09)  Chembiochem : a European journal of chemical biology  15(13), 1882-1886  "Structural insights into enzymatic degradation of oxidized polyvinyl alcohol."
    
44. Ho CH, Wang HC, Ko TP, Chang YC, (Wang AH)  (2014-09)  The Journal of biological chemistry  289(39), 27046-27054  "The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS."
    
45. Yu TF, Maestre-Reyna M, Ko CY, Ko TP, Sun YJ, Lin TY, Shaw JF, (Wang AH)  (2014-08)  PloS one  9(8), e105821  "Structural insights of the ssDNA binding site in the multifunctional endonuclease AtBFN2 from Arabidopsis thaliana."
    
46. Chang HY, Chou CC, Hsu MF, (Wang AH)  (2014-07)  The Journal of biological chemistry  289(27), 18719-18735  "Proposed carrier lipid-binding site of undecaprenyl pyrophosphate phosphatase from Escherichia coli."
    
47. Wang HC, Ho CH, Hsu KC, Yang JM, (Wang AH)  (2014-05)  Biochemistry  53(18), 2865-2874  "DNA mimic proteins: functions, structures, and bioinformatic analysis."
    
48. Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, (Wang AH), Docampo R, Li K, Liu YL, Oldfield E, Guo RT  (2014-05)  PLoS pathogens  10(5), e1004114  "Squalene synthase as a target for Chagas disease therapeutics."
    
49. Shih YP, Chou CC, Chen YL, Huang KF, (Wang AH)  (2014-04)  PloS one  9(4), e94812  "Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo."
    
50. Chang YM, Ho CH, Chen CK, Maestre-Reyna M, Chang-Chien MW, (Wang AH)  (2014-04)  Nucleic acids research  42(8), 5314-5321  "TcaR-ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins."
    
51. Huang KF, Hsu HL, Karim S, (Wang AH)  (2014-03)  Acta crystallographica Section D - Biological crystallography  70(Pt 3), 789-801  "Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding."
    
52. Liu CI, Jeng WY, Chang WJ, Shih MF, Ko TP, (Wang AH)  (2014-02)  Acta crystallographica Section D- Biological crystallography  70(2), 231-241  "Structural insights into the catalytic mechanism of human squalene synthase."
    
53. Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, (Wang AH), Oldfield E, Guo RT  (2014-02)  Journal of the American Chemical Society  136(7), 2892-2896  "Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis."
    
54. Wang HC, Hsu KC, Yang JM, Wu ML, Ko TP, Lin SR, (Wang AH)  (2014-01)  Nucleic acids research  42(2), 1354-1364  "Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor."
    
55. Wei Peng, Tzu-Ping Ko, Yunyun Yang, Yingying Zheng, Chun-Chi Chen, Zhen Zhu, Chun-Hsiang Huang, Yi-Fang Zeng, Jian-Wen Huang, (Andrew H.-J. Wang), Je-Ruei Liu and Rey-Ting Guo  (2014)  RSC ADVANCES  4(107), 62321-62325  "Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea"
    
56. Maestre-Reyna M, Wu WJ, (Wang AH)  (2013-12)  PloS one  8(12), e82458  "Structural Insights into RbmA, a Biofilm Scaffolding Protein of V. Cholerae."
    
57. Lee CC, Lin LL, Chan WE, Ko TP, Lai JS, (Wang AH)  (2013-10)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  69(Pt 10), 1935-1945  "Structural basis for the antibody neutralization of Herpes simplex virus."
    
58. Safo MK, Ko TP, Abdulmalik O, He Z, (Wang AH), Schreiter ER, Russell JE  (2013-10)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  69(Pt 10), 2061-2071  "Structure of fully liganded Hb zetabeta trapped in a tense conformation."
    
59. Tao-Hsin Chang, Shu-Jung Chang, Fu-Lien Hsieh, Tzu-Ping Ko, Cheng-Tse Lin, Meng-Ru Ho, Iren Wang, Shang-Te Danny Hsu, Rey-Ting Guo, Wen Chang, (Andrew H. J. Wang)  (2013-08)  PLoS Pathogens  9(8), e1003563  "Crystal Structure of Vaccinia Viral A27 Protein Reveals a Novel Structure Critical for Its Function and Complex Formation with A26 Protein."
    
60. Chih-Yu Wang, Chih-Hui Yang, Keng-Shiang Huang, Chen-Sheng Yeh, Andrew H.-J. Wang, Chih-Hsin Chen  (2013-02)  Journal of Materials Chemistry B  16(1), 2205-2212  "Electrostatic droplets assisted in situ synthesis of superparamagnetic chitosan microparticles for magnetic-responsive controlled drug release and copper ion removal."
    
61. Chou TL, Wu CH, Huang KF, (Wang AH)  (2013)  Toxicon : official journal of the International Society on Toxinology  71, 140-146  "Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors."
    
62. Wang HC, Wu ML, Ko TP, (Wang AH)  (2013)  Nucleic acids research  41(9), 5127-5138  "Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein."
    
63. Chang YM, Chen CK, Ko TP, Chang-Chien MW, (Wang AH)  (2013)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  69(Pt 6), 1138-1149  "Structural analysis of the antibiotic-recognition mechanism of MarR proteins."
    
64. Hsu MF, Yu TF, Chou CC, Fu HY, Yang CS, (Wang AH)  (2013)  PloS one  8(2), e56363  "Using Haloarcula marismortui bacteriorhodopsin as a fusion tag for enhancing and visible expression of integral membrane proteins in Escherichia coli."
    
65. Chen SC, Wu PH, Su YC, Wen TN, Wei YS, Wang NC, Hsu CA, (Wang AH), Shyur LF  (2012-11)  Protein engineering design & selection  25(11), 761-769  "Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1."
    
66. Liu WC, Lin YS, Jeng WY, Chen JH, (Wang AH), Shyur LF  (2012-11)  Protein engineering design & selection  25(11), 771-780  "Engineering of dual-functional hybrid glucanases."
    
67. Yang CH, Wang CY, Huang KS, Yeh CS, (Wang AH), Wang WT, Lin MY  (2012-11)  PloS one  7(11), e49329  "Facile synthesis of radial-like macroporous superparamagnetic chitosan spheres with in-situ co-precipitation and gelation of ferro-gels."
    
68. Wang CY, Ku SC, Lee CC, (Wang AH)  (2012-11)  Protein engineering design & selection  25(11), 741-749  "Modulating the function of human serine racemase and human serine dehydratase by protein engineering."
    
69. Lee HL, Chang CK, Jeng WY, (Wang AH), Liang PH  (2012-11)  Protein engineering design & selection  25(11), 733-740  "Mutations in the substrate entrance region of beta-glucosidase from Trichoderma reesei improve enzyme activity and thermostability."
    
70. (Wang AH)  (2012-11)  Protein engineering design & selection  25(11), 679-680  "The 20th INPEC Conference Report and Special Issue."
    
71. Chang YM, Chen CK, Chang YC, Jeng WY, Hou MH, (Wang AH)  (2012-09)  PloS one  7(9), e45665  "Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis."
    
72. Cheng YS, Ko TP, Huang JW, Wu TH, Lin CY, Luo W, Li Q, Ma Y, Huang CH, (Wang AH), Liu JR, Guo RT  (2012-08)  Applied microbiology and biotechnology  95(3), 661-669  "Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop."
    
73. Jeng WY, Wang NC, Lin CT, Chang WJ, Liu CI, (Wang AH)  (2012-07)  Acta crystallographica Section D-Biological crystallography  68(Pt 7), 829-838  "High-resolution structures of Neotermes koshunensis beta-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates."
    
74. Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, (Wang AH), Shyy JY, Tsai MD  (2012-07)  Molecular and cellular biology  32(14), 2664-2673  "Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-kappaB activation."
    
75. Wang HC, Ko TP, Wu ML, Ku SC, Wu HJ, (Wang AH)  (2012-07)  Nucleic acids research  40(12), 5718-5730  "Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor."
    
76. LinWu SW, Wu CA, Peng FC, (Wang AH)  (2012-06)  Biochemical pharmacology  83(12), 1690-1699  "Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis."
    
77. Liu CI, Jeng WY, Chang WJ, Ko TP, (Wang AH)  (2012-05)  The Journal of biological chemistry  287(22), 18750-18757  "Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase."
    
78. Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, (Wang AH), Oldfield E, Guo RT  (2012-04)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  51(17), 4157-4160  "Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes."
    
79. Chen YL, Huang KF, Kuo WC, Lo YC, Lee YM, (Wang AH)  (2012-03)  Biochemical journal  442(2), 403-412  "Inhibition of Glutaminyl Cyclase Attenuates Cell Migration Modulated by Monocyte Chemoattractant Proteins."
    
80. Jeng WY, Wang NC, Lin CT, Shyur LF, (Wang AH)  (2011-12)  Journal of biological chemistry  286(52), 45030-45040  "Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for beta-1,3 and beta-1,4 glucan selection."
    
81. Jeng WY, Wang NC, Lin MH, Lin CT, Liaw YC, Chang WJ, Liu CI, Liang PH, (Wang AH)  (2011-01)  Journal of structural biology  173(1), 46-56  "Structural and functional analysis of three beta-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis."
    
82. Li TN, Chin KH, Fung KM, Yang MT, (Wang AH), Chou SH  (2011)  PloS one  6(7), e22036  "A novel tetrameric PilZ domain structure from xanthomonads."
    
83. Chen YY, Ko TP, Lin CH, Chen WH, (Wang AH)  (2011)  Journal of structural biology  175(3), 300-310  "Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance."
    
84. Cheng YS, Ko TP, Wu TH, Ma Y, Huang CH, Lai HL, (Wang AH), Liu JR, Guo RT  (2011)  Proteins  79(4), 1193-1204  "Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima."
    
85. Chou CY, Ko TP, Wu KJ, Huang KF, Lin CH, Wong CH, (Wang AH)  (2011)  Journal of biological chemistry  286(16), 14057-14064  "Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251."
    
86. Hsieh FL, Chang TH, Ko TP, (Wang AH)  (2011)  Plant physiology  155(3), 1079-1090  "Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase."
    
87. Pai CH, Wu HJ, Lin CH, (Wang AH)  (2011)  Protein science  20(3), 557-566  "Structure and mechanism of Escherichia coli glutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidases."
    
88. Kao TH, Chen Y, Pai CH, Chang MC, (Wang AH)  (2011)  Journal of structural biology  174(3), 485-493  "Structure of a NADPH-dependent blue fluorescent protein revealed the unique role of Gly176 on the fluorescence enhancement."
    
89. Huang KF, Liaw SS, Huang WL, Chia CY, Lo YC, Chen YL, (Wang AH)  (2011)  Journal of biological chemistry  286(14), 12439-12449  "Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding."
    
90. Tseng CW, Ko TP, Guo RT, Huang JW, Wang HC, Huang CH, Cheng YS,(Wang AH), Liu JR  (2011)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  67(Pt 10), 1189-1194  "Substrate binding of a GH5 endoglucanase from the ruminal fungus Piromyces rhizinflata."
    
91. Lo YC, Su WC, Ko TP, Wang NC, (Wang AH)  (2011)  Journal of biomolecular structure & dynamics  29(2), 267-282  "Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine."
    
92. Hsu CH, (Wang AH)  (2011)  Nucleic acids research  39(15), 6764-6774  "The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea."
    
93. Lee CC, Lin TW, Ko TP, (Wang AH)  (2011)  PloS one  6(5), e19961  "The hexameric structures of human heat shock protein 90."
    
94. Chen CK, Chan NL, (Wang AH)  (2011)  Trends in biochemical sciences  36(10), 553-561  "The many blades of the beta-propeller proteins: conserved but versatile."
    
95. Yang CY, Chin KH, Chuah ML, Liang ZX, (Wang AH), Chou SH  (2011)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  67(Pt 12), 997-1008  "The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site."
    
96. Hsieh FL, Chang TH, Ko TP, (Wang AH)  (2010-12)  Journal of molecular biology  404(5), 859-873  "Enhanced specificity of mint geranyl pyrophosphate synthase by modifying the R-loop interactions."
    
97. Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, (Wang AH), Oldfield E  (2010-12)  Proceedings of the National Academy of Sciences of the United States of America  107(50), 21337-21342  "Mechanism of action and inhibition of dehydrosqualene synthase."
    
98. Chen HL, Hsu JC, Viet MH, Li MS, Hu CK, Liu CH, Luh FY, Chen SS, Chang ES, (Wang AH), Hsu MF, Fann W, Chen RP  (2010-11)  Proteins  78(14), 2973-2983  "Studying submicrosecond protein folding kinetics using a photolabile caging strategy and time-resolved photoacoustic calorimetry."
    
99. Chu HM, Chen FY, Ko TP, (Wang AH)  (2010-09)  FEBS letters  584(18), 4083-4088  "Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates."
    
100. Chang SH, Han JL, Tseng SY, Lee HY, Lin CW, Lin YC, Jeng WY, (Wang AH), Wu CY, Wong CH  (2010-09)  Journal of the American Chemical Society  132(38), 13371-13380  "Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry."
     
101. Chung KM, Cheng JH, Suen CS, Huang CH, Tsai CH, Huang LH, Chen YR, (Wang AH), Jiaang WT, Hwang MJ, Chen X  (2010-09)  PROTEIN SCIENCE  19(9), 1627-1638  "The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities."
     
102. Huang WL, Wang YR, Ko TP, Chia CY, Huang KF*, (Wang AH)*  (2010-08)  Journal of molecular biology  401(3), 374-388  "Crystal Structure and Functional Analysis of the Glutaminyl Cyclase from Xanthomonas campestris."
     
103. LinWu SW, (Wang AH), Peng FC  (2010-08)  Expert opinion on drug metabolism & toxicology  6(8), 967-981  "Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine."
     
104. Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, (Wang AH), Lin CH  (2010-08)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(33), 25345-25353  "Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION."
     
105. Chen LT, (Wang AH)  (2010-07)  Nucleic acids research  38(13), 4361-4371  "A rationally designed peptide enhances homologous recombination in vitro and resistance to DNA damaging agents in vivo."
     
106. Su YC, Chin KH, Hung HC, Shen GH, (Wang AH), Chou SH  (2010-06)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  66(Pt 6), 636-642  "Structure of Stenotrophomonas maltophilia FeoA complexed with zinc: a unique prokaryotic SH3-domain protein that possibly acts as a bacterial ferrous iron-transport activating factor."
     
107. Chang YS, Liu WJ, Lee CC, Chou TL, Lee YT, Wu TS, Huang JY, Huang WT, Lee TL, Kou GH, (Wang AH), Lo CF  (2010-05)  PloS one  5(5), e10718  "A 3D model of the membrane protein complex formed by the white spot syndrome virus structural proteins."
     
108. Chang YM, Jeng WY, Ko TP, Yeh YJ, Chen CK, (Wang AH)  (2010-05)  Proceedings of the National Academy of Sciences of the United States of America  107(19), 8617-22  "Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis."
     
109. Hsing-Mao Chu, Tzu-Ping Ko and (Andrew H.-J. Wang)  (2010-03)  Nucleic Acids Research  38(5), 1738-48  "Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides."
     
110. Hsing-Ju Wu, Kate L. Seib, Yogitha N. Srikhanta, Jennifer Edwards, Stephen P. Kidd, Tina L. Maguire, Amanda Hamilton, Kuan-Tin Pan, He-Hsuan Hsiao, Chen-Wen Yao, Sean M. Grimmond, Michael A. Apicella, Alastair G. McEwan,( Andrew H-J. Wang) and Michael P. Jennings  (2010-03)  Journal of Proteomics  73(5), 899-916  "Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae"
     
111. Chang TH, Hsieh FL, Ko TP, Teng KH, Liang PH, (Wang AH)  (2010-02)  PLANT CELL  22(2), 454-67  "Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation."
     
112. Ko TP, Jeng WY, Liu CI, Lai MD, Wu CL, Chang WJ, Shr HL, Lu TJ, (Wang AH)  (2010-02)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  66(Pt 2), 145-154  "Structures of human MST3 kinase in complex with adenine, ADP and Mn2+."
     
113. Ko-Hsin Chin, Yen-Chung Lee, Zhi-Le Tu, Chih-Hua Chen, Yi-Hsiung Tseng, Jinn-Moon Yang, Robert P. Ryan, Yvonne McCarthy, J. Maxwell Dow, (Andrew H.-J. Wang) and Shan-Ho Chou  (2010-02)  Journal of Molecular Biology  396(3), 646-662  "The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris."
     
114. Chen YY, Ko TP, Chen WH, Lo LP, Lin CH, (Wang AH).  (2010-01)  Journal of structural biology  169(1), 25-35  "Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism."
     
115. T. F. Kuo, H. C. Lin, A. T. Hung, K. C. Yang, H. F. Lin, T. K. Tanng, S. T. Chen, (Andrew H.-J. Wang)  (2010)  BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS  22(6), 535-547  "Gelatin-chondroitin-hyaluronan tri-copolymer scaffold seeded with dental bud cells for odontogenesis:an ex vivo study on nude mice."
     
116. Hsing-Ju Wu, Ching-Wen Ho, Tzu-Ping Ko, Shinde D. Popat, Chun-Hung Lin, (Andrew H.-J. Wang)  (2010)  Angewandte Chemie International Edition  49(2), 337-340  "Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range"
     
117. Linwu SW, Syu CJ, Chen YL, Wang AH, Peng FC  (2009)  Biochemical pharmacology  78(1), 96-103  "Characterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines."
     
118. Yang CY, Chin KH, Yang MT, Wang AH, Chou SH  (2009)  Proteins  74(2), 530-7  "Crystal structure of RecX: a potent regulatory protein of RecA from Xanthomonas campestris."
     
119. Tso-Ning Li, Ko-Hsin Chin, Hui-Ling Shih, (Andrew H. -J. Wang), Shan-Ho Chou   (2009)  Acta Crystallographica Section F: Structural Biology and Crystallization Communications  65(10): 1056-1059  "Crystallization and preliminary X-ray diffraction characterization of an essential protein from Xanthomonas campestris that contains a noncanonical PilZ signature motif yet is critical for pathogenicity."
     
120. Lin XY, Liao SJ, Chin KH, Shih HL, Shen GH, (Wang AH), Chou SH  (2009)  Acta crystallographica. Section F, Structural biology and crystallization communications  65(10), 1021-1023  "Crystallization and preliminary X-ray diffraction characterization of RpfF, a key DSF synthase from Stenotrophomonas maltophilia."
     
121. Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E  (2009)  Journal of medicinal chemistry  52(13), 3869-80  "Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results."
     
122. Liao SJ, Yang CY, Chin KH, Wang AH, Chou SH  (2009)  Journal of molecular biology  390(5), 951-66  "Insights into the alkyl peroxide reduction pathway of Xanthomonas campestris bacterioferritin comigratory protein from the trapped intermediate-ligand complex structures."
     
123. Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E  (2009)  Journal of the American Chemical Society  131(14), 5153-62  "Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation."
     
124. Yogitha N. Srikhanta, Stefanie J. Dowideit, Jennifer L. Edwards, Megan L. Falsetta, Hsing-Ju Wu, Odile B. Harrison, Kate L. Fox, Kate L. Seib, Tina L. Maguire, Andrew H.-J. Wang, Martin C. Maiden, Sean M. Grimmond, Michael A. Apicella, and Michael P. Jennings   (2009)  PLoS Pathogens  5(4): e1000400  "Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria."
     
125. Lee CC, Kuo CJ, Ko TP, Hsu MF, Tsui YC, Chang SC, Yang S, Chen SJ, Chen HC, Hsu MC, Shih SR, Liang PH, Wang AH  (2009)  The Journal of biological chemistry  284(12), 7646-7655  "Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds."
     
126. Sheau Ling Ho and (Andrew H.-J. Wang)  (2009)  Journal of the Taiwan Institute of Chemical Engineers  40(2), 123-129  "Structural bioinformatics analysis of free cysteines in protein environments."
     
127. Chen CK, Lee GC, Ko TP, Guo RT, Huang LM, Liu HJ, Ho YF, Shaw JF, Wang AH  (2009)  Journal of molecular biology  390(4), 672-85  "Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding."
     
128. Chen HJ, Ko TP, Lee CY, Wang NC, Wang AH  (2009)  Structure  17(4), 517-29  "Structure, assembly, and mechanism of a PLP-dependent dodecameric L-aspartate beta-decarboxylase."
     
129. Lo YC, Ko TP, Su WC, Su TL, Wang AH  (2009)  Journal of inorganic biochemistry  103(7), 1082-92  "Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1."
     
130. Chang YW, Ko TP, Lee CD, Chang YC, Lin KA, Chang CS, Wang AH, Wang TF  (2009)  PloS one  4(3), e4890  "Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity."
     
131. Tu JL, Chin KH, Wang AH, Chou SH  (2009)  Journal of molecular biology  385(4), 1113-1126  "Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacterium."
     
132. Lee HH, Uen YH, Tian YF, Sun CS, Sheu MJ, Kuo HT, Koay LB, Lin CY, Tzeng CC, Cheng CJ, Tang LY, Tsai SL, Wang AH  (2009)  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION  18(5), 1562-9  "Wnt-1 protein as a prognostic biomarker for hepatitis B-related and hepatitis C-related hepatocellular carcinoma after surgery."
     
133. Tsai TY, Yang CY, Shih HL, Wang AH, Chou SH  (2009)  Proteins  76(4), 1042-8  "Xanthomonas campestris PqqD in the pyrroloquinoline quinone biosynthesis operon adopts a novel saddle-like fold that possibly serves as a PQQ carrier."
     
134. Li TN, Chin KH, Liu JH, Wang AH, Chou SH  (2009)  Proteins  75(2), 282-8  "XC1028 from Xanthomonas campestris adopts a PilZ domain-like structure without a c-di-GMP switch."
     
135. Chia-I Liu, George Y. Liu, Yongcheng Song, Fenglin Yin, Mary E. Hensler, Wen-Yih Jeng, Victor Nizet, Andrew H.-J. Wang and Eric Oldfield  (2008)  Science  319(5868), 1391-1394  "A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence"
     
136. K. F. Huang, Y. R. Wang, E. C. Chang, T. L. Chou and A. H. Wang  (2008)  Biochem J  411(1), 181-190  "A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis."
     
137. Sun CS, Wu KT, Lee HH, Uen YH, Tian YF, Tzeng CC, Wang AH, Cheng CJ, Tsai SL  (2008)  Journal of biomedical science  15(5), 633-43  "Anti-sense morpholino oligonucleotide assay shows critical involvement for NF-kappaB activation in the production of Wnt-1 protein by HepG2 cells: oncology implications."
     
138. Wang TF, Chang YC, Lee CD, Chen L, Chang CS, Wang AH  (2008)  BioEssays : news and reviews in molecular, cellular and developmental biology  30(11-12), 1254-5  "Authors' reply to correspondence from Egelman."
     
139. Liao CJ, Chin KH, Lin CH, Tsai PS, Lyu PC, Young CC, Wang AH, Chou SH  (2008)  Proteins  73(2), 362-71  "Crystal structure of DFA0005 complexed with alpha-ketoglutarate: a novel member of the ICL/PEPM superfamily from alkali-tolerant Deinococcus ficus."
     
140. W. Y. Jeng, T. P. Ko, C. I. Liu, R. T. Guo, C. L. Liu, H. L. Shr and A. H. Wang  (2008)  Nucleic Acids Res  36(5), 1567-1577  "Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis"
     
141. Kuo WT, Chin KH, Lo WT, Wang AH, Chou SH  (2008)  Journal of molecular biology  381(1), 189-99  "Crystal structure of the C-terminal domain of a flagellar hook-capping protein from Xanthomonas campestris."
     
142. Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC  (2008)  The Journal of biological chemistry  283(50), 35265-72  "Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation."
     
143. Wu HJ, Wang AH, Jennings MP  (2008)  Current opinion in chemical biology  12(1), 93-101  "Discovery of virulence factors of pathogenic bacteria."
     
144. K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E  (2008)  Journal of medicinal chemistry  51(18), 5594-607  "Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation."
     
145. Lin SY, Chen YY, Fan YY, Lin CW, Chen ST, Wang AH, Khoo KH  (2008)  Journal of proteome research  7(8), 3293-303  "Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics."
     
146. Natalie G Ahn and (Andrew H.-J. Wang)  (2008)  Current Opinion in Chemical Biology  12(1), 1-3  "Proteomics and genomics: perspectives on drug and target discovery."
     
147. Wang TF, Chen LT, Wang AH  (2008)  BioEssays : news and reviews in molecular, cellular and developmental biology  30(1), 48-56  "Right or left turn? RecA family protein filaments promote homologous recombination through clockwise axial rotation."
     
148. Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH  (2008)  Structure  16(11), 1714-1723  "Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2."
     
149. Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH  (2008)  Journal of biomedicine & biotechnology  2008, 841312  "Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases."
     
150. Cao R, Chen CK, Guo RT, Wang AH, Oldfield E  (2008)  Proteins  73(2), 431-9  "Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases."
     
151. Liao PC, Wang AH, Chen ST  (2008)  MOLECULAR & CELLULAR PROTEOMICS  7(8), 1584-5  "Taiwan proteomics society: an organization affiliated with HUPO."
     
152. Chen CN, Chin KH, Wang AH, Chou SH  (2008)  Journal of molecular biology  384(3), 604-14  "The first crystal structure of gluconolactonase important in the glucose secondary metabolic pathways."
     
153. Wang HC, Wang HC, Ko TP, Lee YM, Leu JH, Ho CH, Huang WP, Lo CF, Wang AH  (2008)  Proceedings of the National Academy of Sciences of the United States of America  105(52), 20758-63  "White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly."
     
154. R. T. Guo, R. Cao, P. H. Liang, T. P. Ko, T. H. Chang, M. P. Hudock, W. Y. Jeng, C. K. Chen, Y. Zhang, Y. Song, C. J. Kuo, F. Yin, E. Oldfield and A. H. Wang  (2007)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  104(24), 10022-10027  "Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases"
     
155. T. W. Lin, C. W. Lo, S. Y. Lai, R. J. Fan, C. J. Lo, Y. M. Chou, R. Thiruvengadam, A. H. Wang and M. Y. Wang  (2007)  J Virol  81(16), 8730-8741  "Chicken Heat Shock Protein 90 is a Component of the Putative Cellular Receptor Complex for Infectious Bursal Disease Virus"
     
156. H. H. Hsiao, H. Y. Hsieh, C. C. Chou, S. Y. Lin, A. H. Wang and K. H. Khoo  (2007)  J Proteome Res  6(4), 1313-1324  "Concerted Experimental Approach for Sequential Mapping of Peptides and Phosphopeptides Using C18-Functionalized Magnetic Nanoparticles"
     
157. L. T. Chen, T. P. Ko, Y. C. Chang, K. A. Lin, C. S. Chang, A. H. Wang and T. F. Wang  (2007)  Nucleic Acids Res  35(6), 1787-1801  "Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins"
     
158. Chu HM, Wang AH  (2007)  Proteins  66(4), 996-1003  "Enzyme-substrate interactions revealed by the crystal structures of the archaeal Sulfolobus PTP-fold phosphatase and its phosphopeptide complexes."
     
159. W. L. Chou, L. M. Chuang, C. C. Chou, A. H. Wang, J. A. Lawson, G. A. Fitzgerald and Z. F. Chang  (2007)  J Biol Chem  282(25), 18162-18172  "Identification of a Novel Prostaglandin Reductase Reveals the Involvement of Prostaglandin E2 Catabolism in Regulation of Peroxisome Proliferator-activated Receptor {gamma} Activation"
     
160. T. D. Pfister, A. Y. Mirarefi, A. J. Gengenbach, X. Zhao, C. Danstrom, N. Conatser, Y. G. Gao, H. Robinson, C. F. Zukoski, A. H. Wang and Y. Lu  (2007)  J Biol Inorg Chem  12(1), 126-137  "Kinetic and crystallographic studies of a redesigned manganese-binding site in cytochrome c peroxidase"
     
161. S.K. Ruan, K H. Chin, H. L. Shr, P. C. Lyu, A. H. Wang and S. H. Chou  (2007)  Acta Crystallograph Sect F Struct Biol Cryst Commun  63(Pt 1), 30-33  "Preliminary X-ray analysis of XC5848, a hypothetical ORFan protein with an Sm-like motif from Xanthomonas campestris"
     
162. H. C. Wang, H. C. Wang, J. H. Leu, G. H. Kou, A. H. Wang and C. F. Lo  (2007)  Dev Comp Immunol  31(7), 672-686  "Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection"
     
163. Chen LT, Ko TP, Chang YW, Lin KA, Wang AH, Wang TF  (2007)  PloS one  2(9), e858  "Structural and functional analyses of five conserved positively charged residues in the L1 and N-terminal DNA binding motifs of archaeal RADA protein."
     
164. Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH  (2007)  FEBS letters  581(28), 5454-8  "Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors."
     
165. H. Y. Sun, S. W. Lin, T. P. Ko, J. F. Pan, C. L. Liu, C. N. Lin, A. H. Wang and C. H. Lin  (2007)  J Biol Chem  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design."
     
166. Y. M. Shao, W. B. Yang, H. P. Peng, M. F. Hsu, K. C. Tsai, T. H. Kuo, A. H. Wang, P. H. Liang, C. H. Lin, A. S. Yang and C. H. Wong  (2007)  Chembiochem  8(14), 1654-1657  "Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors"
     
167. K. H. Chin, Y. D. Tsai, N. L. Chan, K. F. Huang, A. H. Wang and S. H. Chou  (2007)  Proteins  69(3), 665-671  "The crystal structure of XC1258 from Xanthomonas campestris: A putative procaryotic Nit protein with an arsenic adduct in the active site"
     
168. J. L. Tu, K. H. Chin, A. H. Wang and S. H. Chou SH  (2007)  Acta Crystallograph Sect F Struct Biol Cryst Commun  63(Pt 5), 438-442  "The crystallization of apo-form UMP kinase from Xanthomonas campestris is significantly improved in a strong magnetic field"
     
169. Liu WJ, Chang YS, Wang AH, Kou GH, Lo CF  (2007)  Journal of virology  81(3), 1461-71  "White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1."
     
170. K. H. Chin, S. K. Ruan, A. H. Wang and S. H. Chou  (2007)  Proteins  68(4), 1006-1010  "XC5848, an ORFan protein from Xanthomonas campestris, adopts a novel variant of Sm-like motif"
     
171. Lin CH, Chin KH, Gao FP, Lyu PC, Shr HL, Wang AH, Chou SH  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 11), 1113-1115  "Cloning, crystallization and preliminary X-ray studies of XC2981 from Xanthomonas campestris, a putative CutA1 protein involved in copper-ion homeostasis."
     
172. Tsai YD, Chin KH, Shr HL, Gao FP, Lyu PC, Wang AH, Chou SH  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 10), 999-1002  "Cloning, crystallization and preliminary X-ray study of XC1258, a CN-hydrolase superfamily protein from Xanthomonas campestris."
     
173. K. H. Chin, C. C. Chou, A. H. Wang and S. H. Chou SH.  (2006)  Proteins  64(3), 823-826  "Crystal structure of a putative acyl-CoA thioesterase from Xanthomonas campestris (XC229) adopts a tetrameric hotdog fold of epsilongamma mode"
     
174. Lee CC, Ko TP, Chou CC, Yoshimura M, Doong SR, Wang MY, Wang AH  (2006)  Journal of structural biology  155(1), 74-86  "Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: implications in virion assembly and immunogenicity."
     
175. Chang TH, Guo RT, Ko TP, Wang AH, Liang PH  (2006)  The Journal of biological chemistry  281(21), 14991-5000  "Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination."
     
176. Chin KH, Chou CC, Wang AH, Chou SH  (2006)  Proteins  65(4), 1046-50  "Crystal structure of XC5357 from Xanthomonas campestris: a putative tetracenomycin polyketide synthesis protein adopting a novel cupin subfamily structure."
     
177. Lo WT, Chin KH, Shr HL, Gao FP, Lyu PC, Wang AH, Chou SH  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 12), 1263-1265  "Crystallization and preliminary X-ray analysis of XC1015, a histidine triad-like protein from Xanthomonas campestris."
     
178. R. Tashiro, A. H. Wang and H. Sugiyama  (2006)  Nucleic Acids Symp Ser  50, 149-150  "Detection of photoinduced electron transfer from Sso7d to DNA"
     
179. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH  (2006)  The EMBO journal  25(24), 5970-5982  "Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase."
     
180. Tzong-Hsien Lee, Dar-In Tai, Cha-Ju Cheng, Chi-Shu Sun, Ching-Yih Lin, Ming-Jen Sheu, Wei-Ping Lee, Cheng-Yuan Peng, Andrew H-J Wang and Sun-Lung Tsai  (2006)  Journal of biomedical science  13(1), 27-39  "Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B- and C-related hepatocarcinogenesis: identification by functional proteomics."
     
181. Tsai JM, Wang HC, Leu JH, Wang AH, Zhuang Y, Walker PJ, Kou GH, Lo CF  (2006)  Journal of virology  80(6), 3021-9  "Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion."
     
182. R. Tashiro, A. H. Wang and H. Sugiyama  (2006)  Proceedings of the National Academy of Sciences of the United States of America  103(45), 16655-16659  "Photoreactivation of DNA by an Archaeal nucleoprotein Sso7d"
     
183. Lin YH, Li HT, Huang YC, Hsieh YC, Guan HH, Liu MY, Chang T, Wang AH, Chen CJ  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 6), 522-524  "Purification, crystallization and preliminary X-ray crystallographic analysis of rice Bowman-Birk inhibitor from Oryza sativa."
     
184. Safo MK, Ko TP, Musayev FN, Zhao Q, Wang AH, Archer GL  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 4), 320-324  "Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec."
     
185. Yang CY, Chin KH, Chou CC, Wang AH, Chou SH  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 6), 498-503  "Structure of XC6422 from Xanthomonas campestris at 1.6 A resolution: a small serine alpha/beta-hydrolase."
     
186. S. Yang, S. J. Chen, M. F. Hsu, J. D. Wu, C. T. Tseng, Y. F. Liu, H. C. Chen, C. W. Kuo, C. S. Wu, L. W. Chang, W. C. Chen, S. Y. Liao, T. Y. Chang, H. H. Hung, H. L. Shr, C. Y. Liu, Y. A. Huang, L. Y. Chang, J. C. Hsu, C. J. Peters, A. H. Wang and M. C. Hsu  (2006)  J Med Chem  49(16), 4971-4980  "Synthesis, Crystal Structure, Structure-Activity Relationships, and Antiviral Activity of a Potent SARS Coronavirus 3CL Protease Inhibitor"
     
187. Chio KC, Chin KH, Gao FP, Lyu PC, Shr HL, Wang AH, Chou SH  (2006)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  62(Pt 10), 1046-1048  "The cloning, crystallization and preliminary X-ray analysis of XC2113, a YaeQ protein from Xanthomonas campestris."
     
188. K. H. Chin, Z. L. Tu, J. N. Li, C. C. Chou, A. H. Wang and S. H. Chou  (2006)  Proteins  65(1), 239-242  "The crystal structure of XC1739: a putative multiple antibiotic-resistance repressor (MarR) from Xanthomonas campestris at 1.8 A resolution"
     
189. Chin KH, Yang CY, Chou CC, Wang AH, Chou SH  (2006)  Proteins  65(4), 1036-1040  "The crystal structure of XC847 from Xanthomonas campestris: a 3'-5' oligoribonuclease of DnaQ fold family with a novel opposingly shifted helix."
     
190. W. J. Liu, Y. S. Chang, A. H. Wang, G. H. Kou, C. F. Lo  (2006)  J Virol  81(3), 1461-1471  "White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1."
     
191. Chen YY, Lin SY, Yeh YY, Hsiao HH, Wu CY, Chen ST, Wang AH  (2005)  Electrophoresis  26(11), 2117-27  "A modified protein precipitation procedure for efficient removal of albumin from serum."
     
192. Chu CL, Chin KH, Lin FY, Chou CC, Lee CC, Shr HL, Lyu PC, Wang AH, Chou SH  (2005)   Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 7), 697-699  "A putative polyketide-synthesis protein XC5357 from Xanthomonas campestris: heterologous expression, crystallization and preliminary X-ray analysis."
     
193. Tang TK, Wu MP, Chen ST, Hou MH, Hong MH, Pan FM, Yu HM, Chen JH, Yao CW, Wang AH  (2005)  Proteomics  5(4), 925-37  "Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses."
     
194. Huang KF, Liu YL, Wang AH  (2005)  Protein expression and purification  43(1), 65-72  "Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme."
     
195. Tu ZL, Li JN, Chin KH, Chou CC, Lee CC, Shr HL, Lyu PC, Gao FP, Wang AH, Chou SH  (2005)   Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 7), 706-708  "Cloning, expression, crystallization and preliminary X-ray analysis of a putative multiple antibiotic resistance repressor protein (MarR) from Xanthomonas campestris."
     
196. Yang CY, Chin KH, Chou CC, Shr HL, Gao FP, Lyu PC, Wang AH, Chou SH  (2005)   Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 7), 703-705  "Cloning, purification crystallization and preliminary X-ray characterization of a conserved hypothetical protein XC6422 from Xanthomonas campestris."
     
197. Chin KH, Kuo WT, Chou CC, Shr HL, Lyu PC, Wang AH, Chou SH  (2005)  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS  61(Pt 7), 694-6  "Cloning, purification, crystallization and preliminary X-ray analysis of XC229, a conserved hypothetical protein from Xanthomonas campestris."
     
198. Wu YY, Chin KH, Chou CC, Lee CC, Shr HL, Gao FP, Lyu PC, Wang AH, Chou SH  (2005)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 10), 902-905  "Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris."
     
199. Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH.  (2005)  Proceedings of the National Academy of Sciences of the United States of America  102(37), 13117-22  "Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation."
     
200. M. K. Safo, Q. Zhao, T. P. Ko, F. N. Musayev, H. Robinson, N. Scarsdale, A.H.J. Wang and G. L. Archer  (2005)  J Bacteriol  187, 1833-1844  "Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons"
     
201. R. T. Guo, T. P. Ko, A. P. Chen, C. J. Kuo, A.H.J. Wang and P. H. Liang  (2005)  J Biol Chem  280(21), 20762-20774  "Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis"
     
202. Sz-Wei Wu, Tzu-Ping Ko, Chia-Cheng Chou, Andrew H.-J. Wang  (2005)  Proteins  60(4), 617-28  "Design and characterization of a multimeric DNA binding protein using Sac7d and GCN4 as templates."
     
203. Chou SH, Chin KH, Wang AH  (2005)  Trends in biochemical sciences  30(5), 231-4  "DNA aptamers as potential anti-HIV agents."
     
204. Han-Yu Sun, Tzu-Ping Ko, Chih-Jung Kuo, Rey-Ting Guo Chia-Cheng Chou Po-Huang Liang and Andrew H.-J. Wang  (2005)  Journal of Bacteriology  187(23), 8137-8148  "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures."
     
205. Hsu MF, Kuo CJ, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wang AH, Liang PH  (2005)  The Journal of biological chemistry  280(35), 31257-66  "Mechanism of the maturation process of SARS-CoV 3CL protease."
     
206. Hou MH, Wang AH  (2005)  Nucleic acids research  33(4), 1352-61  "Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicity."
     
207. Chin KH, Chou CC, Lee CC, Shr HL, Lyu PC, Wang AH, Chou SH  (2005)   Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 7), 700-702  "Preparation, crystallization and preliminary X-ray analysis of XC2382, an ApaG protein of unknown structure from Xanthomonas campestris."
     
208. Chin KH, Huang ZW, Wei KC, Chou CC, Lee CC, Shr HL, Gao FP, Lyu PC, Wang AH, Chou SH  (2005)   Acta Crystallographica Section F-Structural Biology and Crystallization Communications  61(Pt 7), 691-693  "Preparation, crystallization and preliminary X-ray characterization of a conserved hypothetical protein XC1692 from Xanthomonas campestris."
     
209. Chen CY, Ko TP, Lin TW, Chou CC, Chen CJ, Wang AH  (2005)  Nucleic acids research  33(1), 430-8  "Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d."
     
210. Y. P. Shih, H. C. Wu, S. M. Hu, T. F. Wang and A.H.J. Wang  (2005)  Protein Sci  14(4), 936-941  "Self-cleavage of fusion protein in vivo using TEV protease to yield native protein"
     
211. Chen AP, Chang SY, Lin YC, Sun YS, Chen CT, Wang AH, Liang PH  (2005)  The Biochemical journal  386(Pt 1), 169-76  "Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase."
     
212. Leu JH, Tsai JM, Wang HC, Wang AH, Wang CH, Kou GH, Lo CF  (2005)  Journal of virology  79(1), 140-9  "The unique stacked rings in the nucleocapsid of the white spot syndrome virus virion are formed by the major structural protein VP664, the largest viral structural protein ever found."
     
213. Guo RT, Kuo CJ, Ko TP, Chou CC, Liang PH, Wang AH  (2004)  Biochemistry  43(24), 7678-86  "A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products."
     
214. Huang KF, Ko TP, Hung CC, Chu J, Wang AH, Chiou SH  (2004)  The Biochemical journal  378(Pt 2), 399-407  "Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus)."
     
215. Guo RT, Kuo CJ, Chou CC, Ko TP, Shr HL, Liang PH, Wang AH  (2004)  The Journal of biological chemistry  279(6), 4903-12  "Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination."
     
216. Hou MH, Robinson H, Gao YG, Wang AH  (2004)  Nucleic acids research  32(7), 2214-22  "Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion."
     
217. Huang WC, Ko TP, Li SS, Wang AH  (2004)  EUROPEAN JOURNAL OF BIOCHEMISTRY  271(20), 4114-22  "Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins."
     
218. Wu HS, Hsieh YC, Su IJ, Lin TH, Chiu SC, Hsu YF, Lin JH, Wang MC, Chen JY, Hsiao PW, Chang GD, Wang AH, Ting HW, Chou CM, Huang CJ  (2004)  Journal of biomedical science  11(1), 117-26  "Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients."
     
219. Yang JM, Wang AH  (2004)  Journal of biomolecular structure & dynamics  21(4), 513-26  "Engineering a thermostable protein with two DNA-binding domains using the hyperthermophile protein Sac7d."
     
220. Jyh-Ming Tsai, Han-Ching Wang, Jiann-Horng Leu, He-Hsuan Hsiao, Andrew H.-J. Wang, Guang-Hsiung Kou and Chu-Fang Lo  (2004)  Journal of virology  78(20), 11360-70  "Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus."
     
221. Chen YK, Leng CH, Olivares H, Lee MH, Chang YC, Kung WM, Ti SC, Lo YH, Wang AH, Chang CS, Bishop DK, Hsueh YP, Wang TF  (2004)  Proceedings of the National Academy of Sciences of the United States of America  101(29), 10572-7  "Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation."
     
222. Hsu CH, Ko TP, Yu HM, Tang TK, Chen ST, Wang AH  (2004)  Biochemical and biophysical research communications  324(2), 761-7  "Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein."
     
223. Chung TL, Hsiao HH, Yeh YY, Shia HL, Chen YL, Liang PH, Wang AH, Khoo KH, Shoei-Lung Li S  (2004)  The Journal of biological chemistry  279(38), 39653-62  "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides."
     
224. Dostal L, Chen CY, Wang AH, Welfle H  (2004)  Biochemistry  43(30), 9600-9  "Partial B-to-A DNA transition upon minor groove binding of protein Sac7d monitored by Raman spectroscopy."
     
225. Lee MH, Leng CH, Chang YC, Chou CC, Chen YK, Hsu FF, Chang CS, Wang AH, Wang TF  (2004)  Biochemical and biophysical research communications  323(3), 845-51  "Self-polymerization of archaeal RadA protein into long and fine helical filaments."
     
226. Chu HM, Guo RT, Lin TW, Chou CC, Shr HL, Lai HL, Tang TY, Cheng KJ, Selinger BL, Wang AH  (2004)  STRUCTURE  12(11), 2015-24  "Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis."
     
227. Ko TP, Chu HM, Chen CY, Chou CC, Wang AH.  (2004)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  60(Pt 8), 1381-7  "Structures of the hyperthermophilic chromosomal protein Sac7d in complex with DNA decamers."
     
228. Chang SY, Ko TP, Chen AP, Wang AH, Liang PH  (2004)  PROTEIN SCIENCE  13(4), 971-8  "Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies."
     
229. Lai WL, Chou LY, Ting CY, Kirby R, Tsai YC, Wang AH, Liaw SH  (2004)  The Journal of biological chemistry  279(14), 13962-7  "The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation."
     
230. Chang, S.-Y., Ko, T.-P., Liang, P.-H. and Wang, A. H.-J.  (2003)  The Journal of biological chemistry  278(31), 29298-307  "Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton."
     
231. Liaw SH, Chen SJ, Ko TP, Hsu CS, Chen CJ, Wang AH, Tsai YC  (2003)  The Journal of biological chemistry  278(7), 4957-62  "Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism."
     
232. Chou CC, Lin TW, Chen CY, Wang AH  (2003)  Journal of bacteriology  185(14), 4066-73  "Crystal structure of the hyperthermophilic archaeal DNA-binding protein Sso10b2 at a resolution of 1.85 Angstroms."
     
233. Ko TP, Lin JJ, Hu CY, Hsu YH, Wang AH, Liaw SH  (2003)  The Journal of biological chemistry  278(21), 19111-7  "Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution."
     
234. Chang SY, Chen YK, Wang AH, Liang PH  (2003)  Biochemistry  42(49), 14452-9  "Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase."
     
235. Guo RT, Ko TP, Chou CC, Shr HL, Chu HM, Tsai YH, Liang PH, Wang AH.  (2003)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  59(Pt 12), 2265-8  "Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli."
     
236. Lee CC, Ko TP, Lee MS, Chou CC, Lai SY, Wang AH, Wang MY  (2003)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  59(Pt 7), 1234-7  "Purification, crystallization and preliminary X-ray analysis of immunogenic virus-like particles formed by infectious bursal disease virus (IBDV) structural protein VP2."
     
237. Lee CL, Hsiao HH, Lin CW, Wu SP, Huang SY, Wu CY, Wang AH, Khoo KH  (2003)  Proteomics  3(12), 2472-86  "Strategic shotgun proteomics approach for efficient construction of an expression map of targeted protein families in hepatoma cell lines."
     
238. Ko TP, Robinson H, Gao YG, Cheng CH, DeVries AL, Wang AH  (2003)  Biophysical journal  84(2 Pt 1), 1228-37  "The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation."
     
239. Wu SP, Hwang TS, Ko TP, Wang AH, Tsai H  (2003)  Biochimica et biophysica acta  1647(1-2), 390-394  "The structural interpretations of residue Ser297 in catalytic efficiency of Escherichia coli phenylalanine aminotransferase."
     
240. Chou SH, Chin KH, Wang AH  (2003)  Nucleic acids research  31(10), 2461-74  "Unusual DNA duplex and hairpin motifs."
     
241. Hou, M.-H., Robinson, H., Gao, Y.-G. and Wang, A. H.-J.  (2002)  Nucleic acids research  30(22), 4910-7  "Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases."
     
242. Hsu CS, Chen SJ, Tsai YC, Lin TW, Liaw SH, Wang AH  (2002)  Acta Crystallographica Section D-Biological Crystallography  58(Pt 9), 1482-1483  "Crystallization and preliminary crystallographic analysis of a D-aminoacylase from Alcaligenes faecalis DA1."
     
243. Huang KF, Chiou SH, Ko TP, Wang AH  (2002)  European journal of biochemistry / FEBS  269(12), 3047-3056  "Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues."
     
244. Shih YP, Kung WM, Chen JC, Yeh CH, Wang AH, Wang TF  (2002)  PROTEIN SCIENCE  11(7), 1714-9  "High-throughput screening of soluble recombinant proteins."
     
245. Oyoshi T, Wang AH, Sugiyama H  (2002)  Journal of the American Chemical Society  124(10), 2086-7  "Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side."
     
246. Chen YH, Chen AP, Chen CT, Wang AH, Liang PH  (2002)  The Journal of biological chemistry  277(9), 7369-76  "Probing the conformational change of Escherichia coli undecaprenyl pyrophosphate synthase during catalysis using an inhibitor and tryptophan mutants."
     
247. Liang PH, Ko TP, Wang AH  (2002)  EUROPEAN JOURNAL OF BIOCHEMISTRY  269(14), 3339-54  "Structure, mechanism and function of prenyltransferases."
     
248. Huang KF, Chiou SH, Ko TP, Yuann JM, Wang AH  (2002)  Acta Crystallographica Section D-Biological Crystallography  58(Pt 7), 1118-1128  "The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium."
     
249. Robinson H, Gao YG, Yang X, Sanishvili R, Joachimiak A, Wang AH  (2001)  Biochemistry  40(19), 5587-92  "Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG."
     
250. Hou MH, Lin SB, Yuann JM, Lin WC, Wang AH, Kan Ls L  (2001)  Nucleic acids research  29(24), 5121-8  "Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure."
     
251. Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH  (2001)  The Journal of biological chemistry  276(50), 47474-82  "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis."
     
252. X. L. Yang, H. Robinson, Y. G. Gao and A.H.J. Wang  (2000)  Biochemistry  39, 10950-10957  "Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms"
     
253. S. Su, Y. G. Gao, H. Robinson, Y. C. Liaw, S. P. Edmondson, J. W. Shriver and A.H.J. Wang  (2000)  J Mol Biol  303, 395-403  "Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs"
     
254. K. Hakansson, D. Broder, A.H.J. Wang and C. G. Miller  (2000)  Acta Crystallographica Section D-Biological Crystallography  56, 924-926  "Crystallization of peptidase T from Salmonella typhimurium"
     
255. H. Robinson, Y. G. Gao, R. Sanishvili, A. Joachimiak and A.H.J. Wang  (2000)  Nucleic Acids Res  28, 1760-1766  "Hexahydrated magnesium ions bind in the deep major groove and at the outer mouth of A-form nucleic acid duplexes"
     
256. K. Hakansson, A.H.J. Wang and C. G. Miller  (2000)  Proceedings of the National Academy of Sciences of the United States of America  97, 14097-14102  "The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad"
     
257. T. Fujiwara, Z. F. Tao, Y. Ozeki, I. Saito, A.H.J. Wang, M. Lee and H. Sugiyama  (1999)  J Am Chem Soc  121, 7706-7707  "Modulation of Sequence Specificity of Duocarmycin-dependent DNA Alkylation by Pyrrole-imidazole Triamides."
     
258. Teuben JM; Bauer C; Wang AH; Reedijk J.  (1999)  Biochemistry  38(38), 12305-12  "Solution structure of a DNA duplex containing a cis-diammineplatinum(II) 1,3-d(GTG) intrastrand cross-link, a major adduct in cells treated with the anticancer drug carboplatin."
     
259. H. Robinson, M. C. Ang, Y. G. Gao, M. T. Hay, Y. Lu and A.H.J. Wang  (1999)  Biochemistry  38, 5677-5683  "Structural basis of electron transfer modulation in the purple CuA center"
     
260. Y. G. Gao, H. Robinson, R. Sanishvili, A. Joachimiak and A.H.J. Wang  (1999)  Biochemistry  38, 16452-16460  "Structure and recognition of sheared tandem G x A base pairs associated with human centromere DNA sequence at atomic resolution"
     
261. H. Robinson, Y. G. Gao, C. Bauer, C. Roberts, C. Switzer and A.H.J. Wang  (1998)  Biochemistry  37, 10897-10905  "2'-Deoxyisoguanosine adopts more than one tautomer to form base pairs with thymidine observed by high-resolution crystal structure analysis"
     
262. R. Dutta, Y. G. Gao, W. Priebe and A.H.J. Wang  (1998)  Nucleic Acids Res  26, 3001-3005  "Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes"
     
263. Y. G. Gao, A.H.J. Wang  (1998)  Nucleosides and Nucleotides  17, 2093-2102  "Crystal Structures of Four A-DNA Decamers That Contain C5-propyne-cytosines."
     
264. D.Yang, J. T. Strode, H. P.Spielmann, A.H.J. Wang and T. G. Burke  (1998)  J Am Chem Soc  120, 2979-2980  "DNA Interactions of Two Clinical Camptothecin Drugs Stabilize Their Active Lactone Forms."
     
265. Y. G. Gao, H. Robinson, Y. Guan, Y. C. Liaw, J. H. van Boom, G. A. van der Marel and A.H.J. Wang  (1998)  J Biomol Struct Dyn  16, 69-76  "Molecular structure of two crystal forms of cyclic triadenylic acid at 1A resolution"
     
266. C. Bauer, T. Peleg-Shulman, D. Gibson and A.H.J. Wang  (1998)  Eur J Biochem  256, 253-260  "Monofunctional platinum amine complexes destabilize DNA significantly"
     
267. Y. Guan, J. M. Benevides, Y. G. Gao, A.H.J. Wang and G. J. Thomas, Jr.  (1998)  Nucleic Acids Res  26, 3892-3899  "Structural polymorphism and raman conformation markers of cyclic deoxytriadenylic acid"
     
268. X. L. Yang, H. Sugiyama, S. Ikeda, I. Saito and A.H.J. Wang  (1998)  Biophys J  75, 1163-1171  "Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy"
     
269. Y. G. Gao, S. Y. Su, H. Robinson, S. Padmanabhan, L. Lim, B. S. McCrary, S. P. Edmondson, J. W. Shriver and A.H.J. Wang  (1998)  Nat Struct Biol  5, 782-786  "The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA"
     
270. H. Robinson, Y. G. Gao, B. S. McCrary, S. P. Edmondson, J. W. Shriver and A.H.J. Wang  (1998)  Nature  392, 202-205  "The hyperthermophile chromosomal protein Sac7d sharply kinks DNA"
     
271. Su, S., Gao, Y., Zhang, H., Terwilliger, T. C., & Wang, A. H.-J.  (1997)  Protein Science  6, 771-780  "Analyses of the stability and function of three surface mutants (R82C, K69H and L32R) of the gene V protein from Ff phage by x-ray crystallography."
     
272. Y. G. Gao, H. Robinson, E. R. Wjsman, G. van der Marel, J. H. van Boom and A.H.J. Wang  (1997)  J Am Chem Soc  119, 1496-1497  "Binding of daunorubicin to β-D-Glucosylated DNA found in protozoa Trypanosoma brucei studied by x-ray crystallography."
     
273. H. Robinson, W. Priebe, J. B. Chaires and A.H.J. Wang  (1997)  Biochemistry  36, 8663-8670  "Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy"
     
274. Bauer, C. & Wang, A. H.-J.  (1997)  Journal of inorganic biochemistry  68(2), 129-35  "Bridged cobalt amine complexes induce DNA conformational changes effectively."
     
275. J. Caceres-Cortes, H. Sugiyama, K. Ikudome, I. Saito and A.H.J. Wang  (1997)  Biochemistry  36, 9995-10005  "Interactions of deglycosylated cobalt(III)-pepleomycin (green form) with DNA based on NMR structural studies"
     
276. X. L. Yang, A.H.J. Wang  (1997)  Biochemistry  36, 4258-4267  "Structural analysis of Z-Z DNA junctions with A:A and T:T mismatched base pairs by NMR"
     
277. Caceres-Cortes, J., Sugiyama, H., Ikudome, K., Saito, I., & Wang, A. H.-J.  (1997)  Eur. J. Biochem.  244, 818-828  "Structures of Cobalt(III)-Pepleomycin and Cobalt(III)-Deglycopepleomycin (green forms) Determined by NMR Studies"
     
278. B. Bhat, N. J. Leonard, H. Robinson and A.H.J. Wang  (1996)  J Am Chem Soc  118, 3065-3066  "2‘-Deoxy-3-isoadenosine Forms Hoogsteen-Type Base Pairs with Thymidine in the d(CG[iA]TCG)2 Duplex1"
     
279. J. Caceres-Cortes, A.H.J. Wang  (1996)  Biochemistry  35, 616-625  "Binding of the antitumor drug nogalamycin to bulged DNA structures"
     
280. Zhang, H., Skinner, M., Sandberg, W. S., Wang, A. H.-J. and Terwilliger, T. C.  (1996)  Journal of molecular biology  259(1), 148-59  "Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants."
     
281. B. Bhat, N. J. Leonard, H. Robinson and A.H.J. Wang  (1996)  J Am Chem Soc  118, 10744-10751  "Deoxyadenosine and thymidine bases held proximal and distal by means of a covalently-linked dimensional analogue of dA.dT: Intramolecular vs. intermolecular hydrogen bonding"
     
282. Sugiyama, H., Lian, C., Isomura, M., Saito, I. and Wang, A. H.-J.  (1996)  Proceedings of the National Academy of Sciences of the United States of America  93, 14405-14410  "Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A."
     
283. H. Ohishi, I. Nakanishi, K. Inubushi, G. van der Marel, J. H. van Boom, A. Rich, A.H.J. Wang, T. Hakoshima and K. Tomita  (1996)  FEBS Lett  391, 153-156  "Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex"
     
284. Ohishi, H., Terasoma, N., Nakanishi, I., van der Marel, G., van Boom, J.H., Rich, A., Wang, A.H.-J. Hakashima, T., Tomita, K.  (1996)  FEBS Lett.  398, 291-296  "Interaction between the left-handed Z-DNA and polyamine-3. The crystal structure of the d(CG) 3 and thermospemine complex."
     
285. H. Robinson, A.H.J. Wang  (1996)  Nucleic Acids Res  24, 676-682  "Neomycin, spermine and hexaamminecobalt (III) share common structural motifs in converting B- to A-DNA"
     
286. W. P. Chen, C. M. Cheng, A.H.J. Wang and T. T. Kuo  (1996)  Biochim Biophys Acta  1309, 147-155  "Single-stranded DNA binding protein from bacteriophage cf: characterization, gene localization and protein-ssDNA complex"
     
287. S.S.E.G. van Boom, D. Yang, J. Reedijk, G. A. van der Marel and A.H.J. Wang  (1996)  J Biomol Struct Dyn  13, 989-998  "Structural effect of intra-strand cisplatin-crosslink on palindromic DNA sequences."
     
288. D. Yang, A.H.J. Wang  (1996)  Progress in Biophysics & Molecular Biology  66, 81-111  "Structural studies of interactions between anticancer platinum drugs and DNA"
     
289. C. Lian, H. Robinson and A.H.J. Wang  (1996)  J Am Chem Soc  118, 8791-8801  "Structure of Actinomycin D bound with (GAAGCTTC)2 and (GATGCTTC)2 and Its Binding to the (CAG)n:(CTG)n Triplet Sequence As Determined by NMR Analysis"
     
290. M. Sriram, A.H.J. Wang  (1996)  Bioorganic Chemistry: Nucleic Acids  105-143  "Structure of DNA and RNA"
     
291. Y. G. Gao, W. Priebe and A.H.J. Wang  (1996)  Eur J Biochem  240, 331-335  "Substitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity"
     
292. H. Sugiyama, K. Kawai, A. Matsunaga, K. Fujimoto, I. Saito, H. Robinson and A.H.J. Wang  (1996)  Nucleic Acids Res  24, 1272-1278  "Synthesis, structure and thermodynamic properties of 8-methylguanine-containing oligonucleotides: Z-DNA under physiological salt conditions"
     
293. A.H.J. Wang  (1996)  Advances in DNA Sequence-Specific Agents  2, 59-100  "X-ray Crystallographic and NMR Structural Studies of Anthracycline Anticancer Drugs: Implication in Drug Design."
     
294. D. Yang, S. S. van Boom, J. Reedijk, J. H. van Boom, N. Farrell and A.H.J. Wang  (1995)  Nat Struct Biol  2, 577-578  "A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA"
     
295. Y. T.Wang, M. Chao and A.H.J. Wang  (1995)  American Chemical Society  168-182  "Adducts of DNA and Anthracycline Antibiotics: Structure, Function and Activities"
     
296. A.H.J. Wang, M.E.A. Churchill  (1995)  Nature Struct Biol  2, 934-936  "Bite-size DNA"
     
297. Y. G. Gao, A.H.J. Wang  (1995)  J Biomol Struct Dyn  13, 103-117  "Crystal structures of four morpholino-doxorubicin anticancer drugs complexed with d(CGTACG) and d(CGATCG): implications in drug-DNA crosslink"
     
298. H. Robinson, A.H.J. Wang  (1995)  J Am Chem Soc  117, 837-838  "DNA with 2'-5' Phosphodiester Bonds Forms a Duplex Structure in the A-type Conformation"
     
299. Y. Guan, H. Zhang and A.H.J. Wang  (1995)  Protein Sci  4, 187-197  "Electrostatic potential distribution of the gene V protein from Ff phage facilitates cooperative DNA binding: a model of the GVP-ssDNA complex"
     
300. Y. G. Gao, H. Robinson, J. H. van Boom and A.H.J. Wang  (1995)  Biophys J  69, 559-568  "Influence of counter-ions on the crystal structures of DNA decamers: binding of [Co(NH3)6]3+ and Ba2+ to A-DNA"
     
301. D. Yang, S. S. van Boom, J. Reedijk, J. H. van Boom and A.H.J. Wang  (1995)  Biochemistry  34, 12912-12920  "Structure and isomerization of an intrastrand cisplatin-cross-linked octamer DNA duplex by NMR analysis"
     
302. K. L. Greene, R. L. Jones, Y. Li, H. Robinson, A.H.J. Wang, G. Zon and W. D. Wilson  (1994)  Biochemistry  33, 1053-1062  "Solution structure of a GA mismatch DNA sequence, d(CCATGAATGG)2, determined by 2D NMR and structural refinement methods"