Research

Dr. Meng contributed to the fundamental principle that governs redox regulation of cysteine enzymes. His works illustrated how cysteine oxidation or S-nitrosylation could suppress the activity of endogenous phosphatases and caspases under various pathophysiological conditions including cancer, atherosclerosis, acute myocardial ischemia and neuronal disorder. Since 2002 he has published more than 20 original research articles in this field, thus establishing himself as a renowned expert in redox biology and medicine. His recent research focuses on X-ray crystallography and cryoEM-based structural study in protein complexes involved in redox regulation of cell signaling. He also initiated precision medicine research program to tackle host-microbiome interaction from oxidative stress point of view, aiming to understand the influence of gut microbiota on the health and disease of host epithelia.

Degrees and Positions Held
Positions Held
  • 2014 – present   Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2017 – 2019   Acting Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 2008 – 2014   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2003 – 2008   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1999 – 2003   Post-doctoral Research Fellow, Cold Spring Harbor Laboratory, NY, USA
Degrees
  • 1995 – 1999   Ph.D., Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
  • 1992 – 1994   M.S., Toxicology, National Taiwan University College of Medicine
  • 1985 – 1989   B.S., Agricultural Chemistry, National Taiwan University College of Agriculture
Selected Publications
Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD*, Haj FG*, and Meng TC*
Free Rad Biol Med (2016)
Chen KE, Li MY, Chou CC, Ho MR, Chen GC, Meng TC*, Wang AH*
Structure (2015)
Santhanam A, Peng WH, Yu YT, Sang TK, Chen GC* Meng TC*
Mol. Cell. Biol. (2014)
Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, Meng TC*, Khoo KH*
Antioxidant and Redox Signaling (2014)
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC*, Wang AH*
Science Signaling (2014)
Lai YC, Pan KT, Chang GF, Hsu CH, Khoo KH, Hung CH, Jiang YJ, Ho FM, Meng TC
Circulation research (2011)
Ku HY, Wu CL, Rabinow L, Chen GC, Meng TC
Molecular and Cellular Biology (2009)
Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC
J. Biol. Chem. (2008)
Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC
Journal of Proteome Research (2008)
M. Halle, Y. C. Liu, S. Hardy, J. F. Theberge, C. Blanchetot, A. Bourdeau, T. C. Meng and M. L. Tremblay
Mol Cell Biol (2007)
Publications List
  1. Yang CF, Chen YY, Singh JP, Hsu SF, Liu YW, Yang CY, Chang CW, Chen SN, Shih RH, Hsu SD, Jou YS, Cheng CF, (Meng TC)  (2020-04)  Cardiovascular research  116(5), 1032-1046  "Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction."
  2. Chen YJ, Liu YC, Liu YW, Lee YB, Huang HC, Chen YY, Shih YH, Lee YC, Cheng CF, (Meng TC)  (2019-07)  Antioxidants & redox signaling  31(2), 109-126  "Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6."
  3. Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, (Meng TC), Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N  (2019-05)  Annals of the rheumatic diseases  78(5), 600-609  "PTPN14 phosphatase and YAP promote TGF beta signalling in rheumatoid synoviocytes."
  4. Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM, (Meng TC)  (2018-05)  The FEBS journal  285(9), 1593-1610  "Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1."
  5. Willoughby LF, Manent J, Allan K, Lee H, Portela M, Wiede F, Warr C, (Meng TC), Tiganis T, Richardson HE  (2017-07)  The FEBS journal  284(14), 2231-2250  "Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants."
  6. Huang YJ, Yang CK, Wei PL, Huynh TT, Whang-Peng J, (Meng TC), Hsiao M, Tzeng YM, Wu AT, Yen Y  (2017-02)  Journal of hematology & oncology  10(1), 60  "Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways."
  7. Huang YJ, Th Wu A, Chiou HY, Chuang MT, (Meng TC), Chien LN, Yen Y  (2017-01)  Oncotarget  8(4), 6642-6651  "Interactive role of diabetes mellitus and female sex in the risk of cholangiocarcinoma: A population-based nested case-control study."
  8. Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD, Haj FG, (Meng TC)  (2016-10)  Free Radical Biology and Medicine  99, 199-213  "S-Nitrosylation of Endogenous Protein Tyrosine Phosphatases in Endothelial Insulin Signaling"
  9. Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, (Meng TC), Chen GC  (2015-07)  Oncogene  34(29), 3791-3803  "Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation."
  10. Hatzihristidis T, Desai N, Hutchins AP, (Meng TC), Tremblay ML, Miranda-Saavedra D  (2015-04)  FEBS letters  589(9), 951-966  "A Drosophila-centric view of protein tyrosine phosphatases."
  11. Chen KE, Li MY, Chou CC, Ho MR, Chen GC, (Meng TC), Wang AH  (2015-04)  Structure  23(4), 653-664  "Substrate Specificity and Plasticity of FERM-Containing Protein Tyrosine Phosphatases."
  12. Tchankouo-Nguetcheu S, Udinotti M, Durand M, (Meng TC), Taouis M, Rabinow L  (2014-10)  Molecular genetics and genomics  289(5), 795-806  "Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B."
  13. Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, (Tzu-Ching Meng), and Andrew H. -J. Wang  (2014-10)  Science Signaling  7(347), ra98  "Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation"
  14. Santhanam A, Peng WH, Yu YT, Sang TK, Chen GC, (Meng TC)  (2014-05)  Molecular and cellular biology  34(9), 1594-1606  "Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis."
  15. Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, (Meng TC), Khoo KH  (2014-03)  ANTIOXIDANTS & REDOX SIGNALING  20(9), 1365-1381  "Mass Spectrometry-Based Quantitative Proteomics for Dissecting Multiplexed Redox Cysteine Modifications in Nitric Oxide-Protected Cardiomyocyte Under Hypoxia."
  16. Chang YC, Tang HW, Liang SY, Pu TH, (Meng TC), Khoo KH, Chen GC  (2013-05)  Journal of proteome research  12(5), 2138-2150  "Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation."
  17. Buszard BJ, Johnson TK, (Meng TC), Burke R, Warr CG, Tiganis T  (2013-04)  Molecular and cellular biology  33(7), 1345-1356  "The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity."
  18. Santhanam A, Liang SY, Chen DY, Chen GC*, (Meng TC)*  (2013-01)  The FEBS journal  280(2), 476-488  "Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition."
  19. Chen DY, Li MY, Wu SY, Lin YL, Tsai SP, Lai PL, Lin YT, Kuo JC, (Meng TC), Chen GC  (2012)  Journal of cell science  125(20), 4841-4852.  "The Bro1 domain-containing Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration."
  20. Lai YC, Pan KT, Chang GF, Hsu CH, Khoo KH, Hung CH, Jiang YJ, Ho FM, (Meng TC)  (2011-12)  Circulation research  109,1375-1386  "Nitrite-Mediated S-Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction."
  21. Wu CL, Buszard B, Teng CH, Chen WL, Warr C, Tiganis T, (Meng TC)  (2011-10)  Biochemical journal  439(1), 151-159  "Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signaling."
  22. Yu-Chiang Chao, Shih-De Yeh, Hsiao-Wen Zan, Gao-Fong Chang, Hsin-Fei Meng, Chen-Hsiung Hung, (Tzu-Ching Meng)  (2011-05)  ORGANIC ELECTRONICS  12(5), 751-755  "Integrated semiconductor optoelectronic devices for real-time and indicator-free detection of aqueous nitric oxide."
  23. Chao Y.C., Yeh S.D., Zan H.W., Hong Y.R., Wu M.C., Chang G.F., Tsai P.Y., Meng H.F., Hung C.H., (Meng T.C.), Hsu C.S., and Horng S.F.  (2010-06)  APPLIED PHYSICS LETTERS  96, 223702(1-3)  "Real-time and indicator-free detection of aqueous nitric oxide with hydrogel film."
  24. Hsu MF, (Meng TC)  (2010-03)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(11), 7919-7928  "Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases."
  25. Hsu M.F., Lou Y.W., Chen Y.Y. and (Meng T.C.)*  (2010-02)  Handbook of Cell Signaling 2nd Edition by Elsevier  2010, 855-862  "PTP oxidation."
  26. Ku HY, Wu CL, Rabinow L, Chen GC, Meng TC  (2009)  Molecular and Cellular Biology  29(13), 3623-3632  "Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl."
  27. Chien-Cheng Liu, Jan-Hao Li, Cheng-Chung Chang,Yu-Chiang Chao, Hsin-Fei Meng, Sheng-Fu Horng,Cheng-Hsiung Hung and Tzu-Ching Meng  (2009)  JOURNAL OF PHYSICS D-APPLIED PHYSICS  42, 155105 (4 pages)  "Selective real-time nitric oxide detection by functionalized zinc oxide"
  28. Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC  (2008)  J. Biol. Chem.  283(50), 35265-35272  "Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation."
  29. Y. W. Lou, Y. Y. Chen, S. F. Hsu, R. K. Chen, C. L. Lee, K. H. Khoo, N. K. Tonks and T. C. Meng  (2008)  FEBS J  275(1), 69-88  "Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells"
  30. Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC  (2008)  Journal of Proteome Research  7(3), 1055-1066  "Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy."
  31. M. Halle, Y. C. Liu, S. Hardy, J. F. Theberge, C. Blanchetot, A. Bourdeau, T. C. Meng and M. L. Tremblay  (2007)  Mol Cell Biol  27(3), 1172-1190  "Caspase-3 Regulates Catalytic Activity and Scaffolding Functions of the Protein Tyrosine Phosphatase PEST, a Novel Modulator of the Apoptotic Response"
  32. Y. Y. Chen, Y. F. Huang, K. H. Khoo and T. C. Meng  (2007)  Methods  42(3), 243-249  "Mass spectrometry-based analyses for identifying and characterizing S-nitrosylation of protein tyrosine phosphatases"
  33. M. Hallé, M. L. Tremblay and T. C. Meng  (2007)  Cell Cycle  6(22), 2773-2781  "Protein Tyrosine Phosphatases: Emerging Regulators of Apoptosis"
  34. Chun-Hung Teng, Wen-Nin Huang and Tzu-Ching Meng  (2007)  J. Biol. Chem  282(39), 28395-28407  "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress"
  35. C. H. Chen, T. H. Cheng, H. Lin, N. L. Shih, Y. L. Chen, Y. S. Chen, C. F. Cheng, W. S. Lian, T. C. Meng, W. T. Chiu and J. J. Chen  (2006)  Mol Pharmacol  69(4), 1347-1355  "Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts."
  36. K. K. Nelson, S. Subbaram, K. M. Connor, J. Dasgupta, X. F. Ha, T. C. Meng, N. K. Tonks and J. A. Melendez  (2006)  J Biol Chem  281(20), 14100-14110  "Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs"
  37. T. C. Meng, S. F. Hsu and N. K. Tonks  (2005)  Methods  35(1), 28-36  "Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo"
  38. T. C. Meng, D. A. Buckley, S. Galic, T. Tiganis and N. K. Tonks  (2004)  J Biol Chem  279, 37716-37725  "Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B"
  39. T. C. Meng, N. K. Tonks  (2003)  Methods in Enzymology  366, 304-318  "Analysis of the regulation of protein tyrosine phosphatases in vivo by reversible oxidation"
  40. A. Salmeen, J. N. Andersen, M. P. Myers, T. C. Meng, J. A. Hinks, N. K. Tonks and D. Barford  (2003)  Nature  423, 769-773  "Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate"
  41. S. Galic, M. Klingler Hoffmann, M. T. Fodero Tavoletti, M. A. Puryer, T. C. Meng, N. K. Tonks and T. Tiganis  (2003)  Mol Cell Biol  23, 2096-2108  "Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP"
  42. T. C. Meng, T. Fukada and N. K. Tonks  (2002)  Mol Cell  9, 387-399  "Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo"
  43. M. F. Lin, M. S. Lee, X. W. Zhou, J. C. Andressen, T. C. Meng, S. L. Johansson, W. W. West, R. J. Taylor, J. R. Anderson and F. F. Lin  (2001)  JOURNAL OF UROLOGY  166, 1943-1950  "Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of human prostate cancer cells"
  44. T. C. Meng, M. S. Lee and M. F. Lin  (2000)  Oncogene  19, 2664-2677  "Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells"
  45. M. F. Lin, T. C. Meng, P. S. Rao, C. Chang, A. H. Schonthal and F. F. Lin  (1998)  J Biol Chem  273, 5939-5947  "Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines"
  46. T. C. Meng and M. F. Lin  (1998)  J. Biol. Chem  273, 22096-22104  "Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells"
  47. M. L. Kuo, Y. W. Chou, Y. P. Chau and T. C. Meng  (1996)  Biochem Pharmacol  52, 481-488  "Differential induction of apoptosis in oncogene-transformed NIH 3T3 cells by methylmethanesulfonate"
  48. M. L. Kuo, T. C. Meng and J. K. Lin  (1996)  Carcinogenesis  17, 815-820  "Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells"
  49. M. F. Lin, T. C. Meng  (1996)  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  226, 206-213  "Tyrosine phosphorylation of a 185 kDa phosphoprotein (pp185) inversely correlates with the cellular activity of human prostatic acid phosphatase"

Dr. Meng contributed to the fundamental principle that governs redox regulation of cysteine enzymes. His works illustrated how cysteine oxidation or S-nitrosylation could suppress the activity of endogenous phosphatases and caspases under various pathophysiological conditions including cancer, atherosclerosis, acute myocardial ischemia and neuronal disorder. Since 2002 he has published more than 20 original research articles in this field, thus establishing himself as a renowned expert in redox biology and medicine. His recent research focuses on X-ray crystallography and cryoEM-based structural study in protein complexes involved in redox regulation of cell signaling. He also initiated precision medicine research program to tackle host-microbiome interaction from oxidative stress point of view, aiming to understand the influence of gut microbiota on the health and disease of host epithelia.

Positions Held
  • 2014 – present   Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2017 – 2019   Acting Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 2008 – 2014   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2003 – 2008   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1999 – 2003   Post-doctoral Research Fellow, Cold Spring Harbor Laboratory, NY, USA
Degrees
  • 1995 – 1999   Ph.D., Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
  • 1992 – 1994   M.S., Toxicology, National Taiwan University College of Medicine
  • 1985 – 1989   B.S., Agricultural Chemistry, National Taiwan University College of Agriculture
Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD*, Haj FG*, and Meng TC*
Free Rad Biol Med (2016)
Chen KE, Li MY, Chou CC, Ho MR, Chen GC, Meng TC*, Wang AH*
Structure (2015)
Santhanam A, Peng WH, Yu YT, Sang TK, Chen GC* Meng TC*
Mol. Cell. Biol. (2014)
Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, Meng TC*, Khoo KH*
Antioxidant and Redox Signaling (2014)
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC*, Wang AH*
Science Signaling (2014)
Lai YC, Pan KT, Chang GF, Hsu CH, Khoo KH, Hung CH, Jiang YJ, Ho FM, Meng TC
Circulation research (2011)
Ku HY, Wu CL, Rabinow L, Chen GC, Meng TC
Molecular and Cellular Biology (2009)
Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC
J. Biol. Chem. (2008)
Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC
Journal of Proteome Research (2008)
M. Halle, Y. C. Liu, S. Hardy, J. F. Theberge, C. Blanchetot, A. Bourdeau, T. C. Meng and M. L. Tremblay
Mol Cell Biol (2007)
  1. Yang CF, Chen YY, Singh JP, Hsu SF, Liu YW, Yang CY, Chang CW, Chen SN, Shih RH, Hsu SD, Jou YS, Cheng CF, (Meng TC)  (2020-04)  Cardiovascular research  116(5), 1032-1046  "Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction."
  2. Chen YJ, Liu YC, Liu YW, Lee YB, Huang HC, Chen YY, Shih YH, Lee YC, Cheng CF, (Meng TC)  (2019-07)  Antioxidants & redox signaling  31(2), 109-126  "Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6."
  3. Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, (Meng TC), Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N  (2019-05)  Annals of the rheumatic diseases  78(5), 600-609  "PTPN14 phosphatase and YAP promote TGF beta signalling in rheumatoid synoviocytes."
  4. Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM, (Meng TC)  (2018-05)  The FEBS journal  285(9), 1593-1610  "Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1."
  5. Willoughby LF, Manent J, Allan K, Lee H, Portela M, Wiede F, Warr C, (Meng TC), Tiganis T, Richardson HE  (2017-07)  The FEBS journal  284(14), 2231-2250  "Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants."
  6. Huang YJ, Yang CK, Wei PL, Huynh TT, Whang-Peng J, (Meng TC), Hsiao M, Tzeng YM, Wu AT, Yen Y  (2017-02)  Journal of hematology & oncology  10(1), 60  "Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways."
  7. Huang YJ, Th Wu A, Chiou HY, Chuang MT, (Meng TC), Chien LN, Yen Y  (2017-01)  Oncotarget  8(4), 6642-6651  "Interactive role of diabetes mellitus and female sex in the risk of cholangiocarcinoma: A population-based nested case-control study."
  8. Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD, Haj FG, (Meng TC)  (2016-10)  Free Radical Biology and Medicine  99, 199-213  "S-Nitrosylation of Endogenous Protein Tyrosine Phosphatases in Endothelial Insulin Signaling"
  9. Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, (Meng TC), Chen GC  (2015-07)  Oncogene  34(29), 3791-3803  "Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation."
  10. Hatzihristidis T, Desai N, Hutchins AP, (Meng TC), Tremblay ML, Miranda-Saavedra D  (2015-04)  FEBS letters  589(9), 951-966  "A Drosophila-centric view of protein tyrosine phosphatases."
  11. Chen KE, Li MY, Chou CC, Ho MR, Chen GC, (Meng TC), Wang AH  (2015-04)  Structure  23(4), 653-664  "Substrate Specificity and Plasticity of FERM-Containing Protein Tyrosine Phosphatases."
  12. Tchankouo-Nguetcheu S, Udinotti M, Durand M, (Meng TC), Taouis M, Rabinow L  (2014-10)  Molecular genetics and genomics  289(5), 795-806  "Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B."
  13. Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, (Tzu-Ching Meng), and Andrew H. -J. Wang  (2014-10)  Science Signaling  7(347), ra98  "Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation"
  14. Santhanam A, Peng WH, Yu YT, Sang TK, Chen GC, (Meng TC)  (2014-05)  Molecular and cellular biology  34(9), 1594-1606  "Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis."
  15. Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, (Meng TC), Khoo KH  (2014-03)  ANTIOXIDANTS & REDOX SIGNALING  20(9), 1365-1381  "Mass Spectrometry-Based Quantitative Proteomics for Dissecting Multiplexed Redox Cysteine Modifications in Nitric Oxide-Protected Cardiomyocyte Under Hypoxia."
  16. Chang YC, Tang HW, Liang SY, Pu TH, (Meng TC), Khoo KH, Chen GC  (2013-05)  Journal of proteome research  12(5), 2138-2150  "Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation."
  17. Buszard BJ, Johnson TK, (Meng TC), Burke R, Warr CG, Tiganis T  (2013-04)  Molecular and cellular biology  33(7), 1345-1356  "The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity."
  18. Santhanam A, Liang SY, Chen DY, Chen GC*, (Meng TC)*  (2013-01)  The FEBS journal  280(2), 476-488  "Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition."
  19. Chen DY, Li MY, Wu SY, Lin YL, Tsai SP, Lai PL, Lin YT, Kuo JC, (Meng TC), Chen GC  (2012)  Journal of cell science  125(20), 4841-4852.  "The Bro1 domain-containing Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration."
  20. Lai YC, Pan KT, Chang GF, Hsu CH, Khoo KH, Hung CH, Jiang YJ, Ho FM, (Meng TC)  (2011-12)  Circulation research  109,1375-1386  "Nitrite-Mediated S-Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction."
  21. Wu CL, Buszard B, Teng CH, Chen WL, Warr C, Tiganis T, (Meng TC)  (2011-10)  Biochemical journal  439(1), 151-159  "Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signaling."
  22. Yu-Chiang Chao, Shih-De Yeh, Hsiao-Wen Zan, Gao-Fong Chang, Hsin-Fei Meng, Chen-Hsiung Hung, (Tzu-Ching Meng)  (2011-05)  ORGANIC ELECTRONICS  12(5), 751-755  "Integrated semiconductor optoelectronic devices for real-time and indicator-free detection of aqueous nitric oxide."
  23. Chao Y.C., Yeh S.D., Zan H.W., Hong Y.R., Wu M.C., Chang G.F., Tsai P.Y., Meng H.F., Hung C.H., (Meng T.C.), Hsu C.S., and Horng S.F.  (2010-06)  APPLIED PHYSICS LETTERS  96, 223702(1-3)  "Real-time and indicator-free detection of aqueous nitric oxide with hydrogel film."
  24. Hsu MF, (Meng TC)  (2010-03)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(11), 7919-7928  "Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases."
  25. Hsu M.F., Lou Y.W., Chen Y.Y. and (Meng T.C.)*  (2010-02)  Handbook of Cell Signaling 2nd Edition by Elsevier  2010, 855-862  "PTP oxidation."
  26. Ku HY, Wu CL, Rabinow L, Chen GC, Meng TC  (2009)  Molecular and Cellular Biology  29(13), 3623-3632  "Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl."
  27. Chien-Cheng Liu, Jan-Hao Li, Cheng-Chung Chang,Yu-Chiang Chao, Hsin-Fei Meng, Sheng-Fu Horng,Cheng-Hsiung Hung and Tzu-Ching Meng  (2009)  JOURNAL OF PHYSICS D-APPLIED PHYSICS  42, 155105 (4 pages)  "Selective real-time nitric oxide detection by functionalized zinc oxide"
  28. Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC  (2008)  J. Biol. Chem.  283(50), 35265-35272  "Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation."
  29. Y. W. Lou, Y. Y. Chen, S. F. Hsu, R. K. Chen, C. L. Lee, K. H. Khoo, N. K. Tonks and T. C. Meng  (2008)  FEBS J  275(1), 69-88  "Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells"
  30. Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC  (2008)  Journal of Proteome Research  7(3), 1055-1066  "Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy."
  31. M. Halle, Y. C. Liu, S. Hardy, J. F. Theberge, C. Blanchetot, A. Bourdeau, T. C. Meng and M. L. Tremblay  (2007)  Mol Cell Biol  27(3), 1172-1190  "Caspase-3 Regulates Catalytic Activity and Scaffolding Functions of the Protein Tyrosine Phosphatase PEST, a Novel Modulator of the Apoptotic Response"
  32. Y. Y. Chen, Y. F. Huang, K. H. Khoo and T. C. Meng  (2007)  Methods  42(3), 243-249  "Mass spectrometry-based analyses for identifying and characterizing S-nitrosylation of protein tyrosine phosphatases"
  33. M. Hallé, M. L. Tremblay and T. C. Meng  (2007)  Cell Cycle  6(22), 2773-2781  "Protein Tyrosine Phosphatases: Emerging Regulators of Apoptosis"
  34. Chun-Hung Teng, Wen-Nin Huang and Tzu-Ching Meng  (2007)  J. Biol. Chem  282(39), 28395-28407  "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress"
  35. C. H. Chen, T. H. Cheng, H. Lin, N. L. Shih, Y. L. Chen, Y. S. Chen, C. F. Cheng, W. S. Lian, T. C. Meng, W. T. Chiu and J. J. Chen  (2006)  Mol Pharmacol  69(4), 1347-1355  "Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts."
  36. K. K. Nelson, S. Subbaram, K. M. Connor, J. Dasgupta, X. F. Ha, T. C. Meng, N. K. Tonks and J. A. Melendez  (2006)  J Biol Chem  281(20), 14100-14110  "Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs"
  37. T. C. Meng, S. F. Hsu and N. K. Tonks  (2005)  Methods  35(1), 28-36  "Development of a modified in-gel assay to identify protein tyrosine phosphatases that are oxidized and inactivated in vivo"
  38. T. C. Meng, D. A. Buckley, S. Galic, T. Tiganis and N. K. Tonks  (2004)  J Biol Chem  279, 37716-37725  "Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B"
  39. T. C. Meng, N. K. Tonks  (2003)  Methods in Enzymology  366, 304-318  "Analysis of the regulation of protein tyrosine phosphatases in vivo by reversible oxidation"
  40. A. Salmeen, J. N. Andersen, M. P. Myers, T. C. Meng, J. A. Hinks, N. K. Tonks and D. Barford  (2003)  Nature  423, 769-773  "Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate"
  41. S. Galic, M. Klingler Hoffmann, M. T. Fodero Tavoletti, M. A. Puryer, T. C. Meng, N. K. Tonks and T. Tiganis  (2003)  Mol Cell Biol  23, 2096-2108  "Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP"
  42. T. C. Meng, T. Fukada and N. K. Tonks  (2002)  Mol Cell  9, 387-399  "Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo"
  43. M. F. Lin, M. S. Lee, X. W. Zhou, J. C. Andressen, T. C. Meng, S. L. Johansson, W. W. West, R. J. Taylor, J. R. Anderson and F. F. Lin  (2001)  JOURNAL OF UROLOGY  166, 1943-1950  "Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of human prostate cancer cells"
  44. T. C. Meng, M. S. Lee and M. F. Lin  (2000)  Oncogene  19, 2664-2677  "Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells"
  45. M. F. Lin, T. C. Meng, P. S. Rao, C. Chang, A. H. Schonthal and F. F. Lin  (1998)  J Biol Chem  273, 5939-5947  "Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines"
  46. T. C. Meng and M. F. Lin  (1998)  J. Biol. Chem  273, 22096-22104  "Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells"
  47. M. L. Kuo, Y. W. Chou, Y. P. Chau and T. C. Meng  (1996)  Biochem Pharmacol  52, 481-488  "Differential induction of apoptosis in oncogene-transformed NIH 3T3 cells by methylmethanesulfonate"
  48. M. L. Kuo, T. C. Meng and J. K. Lin  (1996)  Carcinogenesis  17, 815-820  "Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells"
  49. M. F. Lin, T. C. Meng  (1996)  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  226, 206-213  "Tyrosine phosphorylation of a 185 kDa phosphoprotein (pp185) inversely correlates with the cellular activity of human prostatic acid phosphatase"