Research

The study on relationship of structure and function of biomolecules is the main theme of our research. The basic techniques used in our studies include NMR, GC-Mass and MS, BIAcore, CD, organic synthesis, cloning, site-directed mutagenesis and other physical methods and chromatographies. At present, our works focus on several topics described as follows:

  • Carbohydrate Chemistry and Glycobiology
  • Drug Discovery and Development from the Secondary metabolites of microorganisms
  • Studies on the structure-functional relationship of proteins and peptides by NMR and X-ray diffraction
  • Proteomic studies
Degrees and Positions Held
Positions Held
  • 2008 – present   Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1991 – present   Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
  • 2006 – 2012   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 1998 – 1999   General Secretary, Taiwan Society of Biochemistry and Molecular Biology
  • 1997 – 1999   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 1994 – 1995   Visiting Scholar, The Scripps Research Institute
  • 1991 – 2008   Research Fellow, Institute of Biological Chemistry
  • 1988 – 1991   Associate Research Fellow, Institute of Biological Chemistry
  • 1979 – 1988   Assistant Research Fellow, Institute of Biological Chemistry
  • 1978 – 1979   Group Leader, Panlabs Taiwan Ltd
Degrees
  • 1987   Ph.D., Pharmacy, University of Wisconsin, Madison.
  • 1977   M.S., Biochemistry, National Taiwan University
  • 1975   B.S., Botany, National Taiwan University
Selected Publications
Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, Wu SH
Molecular & Cellular Proteomics (2013)
Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, Wu SH
Journal of biological chemistry (2011)
Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, Wu SH
Inorganic chemistry (2011)
Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, Wu SH
Journal of biological chemistry (2011)
Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, Wu SH
Journal of medicinal chemistry (2010)
Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and S-H. Wu
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.
Mol Cell Proteomics (2009)
Chen SH, Suzuki CK, Wu SH
Nucleic acids research (2008)
Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and S. H. Wu
CHEMISTRY-A EUROPEAN JOURNAL (2007)
Publications List
  1. Susanto W, Kong KH, Hua KF, (Wu SH), Lam Y  (2019-01)  Tetrahedron Letters  60(3), 288-291  "Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae."
  2. Wu HY, Yang FL, Li LH, Rao YK, Ju TC, Wong WT, Hsieh CY, Pivkin MV, Hua KF, (Wu SH)  (2018-12)  Scientific reports  8(1), 17956  "Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells."
  3. Perera N, Yang FL, Lu YT, Li LH, Hua KF, (Wu SH)  (2018-07)  International journal of biological sciences  14(10), 1378-1388  "Antrodia cinnamomea Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4."
  4. Lee IM, Yang FL, Chen TL, Liao KS, Ren CT, Lin NT, Chang YP, Wu CY, (Wu SH)  (2018-07)  Journal of the American Chemical Society  140(28), 8639-8643  "Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity."
  5. Chern J, Lu CP, Fang Z, Chang CM, Hua KF, Chen YT, Ng CY, Chen YS, Lam Y, (Wu SH)  (2018-06)  Angewandte Chemie-International Edition  57(24), 7040-7045  "Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade."
  6. Perera N, Yang FL, Chern J, Chiu HW, Hsieh CY, Li LH, Zhang YL, Hua KF, (Wu SH)  (2018-06)  Chemical communications  54(51), 6995-6998  "Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae."
  7. Tseng TS, Tu IF, Chen HT, Lin LC, Tsai KC, (Wu SH), Chen C  (2018-06)  Chemical communications  54(49), 6372-6375  "Protein-DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA."
  8. Wang YC, Huang TW, Yang YS, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Chang FY, (Wu SH), How CK, Lee YT  (2018-05)  Scientific reports  8(1), 7289  "Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia."
  9. Liao JH, Tsai CH, Patel SG, Yang JT, Tu IF, Lo Cicero M, Lipka-Lloyd M, Wu WL, Shen WJ, Ho MR, Chou CC, Sharma GR, Okanishi H, Luk LYP, Tsai YH, (Wu SH)  (2017-11)  Frontiers in molecular biosciences  4, 77  "Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU."
  10. Chang YT, Wu CY, Tang JY, Huang CY, Liaw CC, (Wu SH), Sheu JH, Chang HW  (2017-09)  Environmental toxicology  32(9), 2124-2132  "Sinularin induces oxidative stress-mediated G2/M arrest and apoptosis in oral cancer cells."
  11. Chernikov OV, Wong WT, Li LH, Chikalovets IV, Molchanova VI, (Wu SH), Liao JH, Hua KF  (2017-07)  Scientific reports  7(1), 6315  "A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice."
  12. Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, (Wu SH)  (2017-07)  Organic letters  19(13), 3486-3489  "Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages."
  13. Wu WL, Chen MY, Tu IF, Lin YC, EswarKumar N, Chen MY, Ho MC, (Wu SH)  (2017-07)  Scientific reports  7(1), 4658  "The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles."
  14. Lai SJ, Tu IF, Wu WL, Yang JT, Luk LYP, Lai MC, Tsai YH, (Wu SH)  (2017-05)  BMC microbiology  17(1), 123  "Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance."
  15. Yang FL, Lou TC, Kuo SC, Wu WL, Chern J, Lee YT, Chen ST, Zou W, Lin NT, (Wu SH)  (2017-03)  Vaccine  35(10), 1440-1447  "A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate."
  16. Lee IM, Tu IF, Yang FL, Ko TP, Liao JH, Lin NT, Wu CY, Ren CT, Wang AH, Chang CM, Huang KF, (Wu SH)  (2017-02)  Scientific reports  7, 42711  "Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage PhiAB6 tailspike protein."
  17. Chang LC, Chen TC, Chen SJ, Chen CL, Lee CC, (Wu SH), Yen Y, Huang HS, Lin JJ  (2016-10)  Oncotarget  7(42), 67986-68001  "Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation."
  18. Hsu CR, Liao CH, Lin TL, Yang HR, Yang FL, Hsieh PF, (Wu SH), Wang JT  (2016-08)  Scientific reports  6, 31946  "Identification of a capsular variant and characterization of capsular acetylation in Klebsiella pneumoniae PLA-associated type K57."
  19. Liao HF, Lee HH, Chang YS, Lin CL, Liu TY, Chen YC, Yen JC, Lee YT, Lin CY, (Wu SH), Ko YC, Chang JG  (2016-06)  Scientific reports  6, 27350  "Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers."
  20. Wu WL, Lai SJ, Yang JT, Chern J, Liang SY, Chou CC, Kuo CH, Lai MC, (Wu SH)  (2016-06)  Scientific reports  6, 29013  "Phosphoproteomic analysis of Methanohalophilus portucalensis FDF1(T) identified the role of protein phosphorylation in methanogenesis and osmoregulation."
  21. Chang YT, Huang CY, Li KT, Li RN, Liaw CC, (Wu SH), Liu JR, Sheu JH, Chang HW  (2016-06)  Archives of oral biology  66, 147-154  "Sinuleptolide inhibits proliferation of oral cancer Ca9-22 cells involving apoptosis, oxidative stress, and DNA damage."
  22. Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, (Wu SH), Chang YC, Lim C, Chang CI  (2016-05)  Structure  24(5), 676-686  "Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease."
  23. Lin CC, Su SC, Su MY, Liang PH, Feng CC, (Wu SH), Chang CI  (2016-05)  Structure  24(5), 667-675  "Structural Insights into the Allosteric Operation of the Lon AAA+ Protease."
  24. Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, (Wu SH)  (2016-04)  Journal of the American Chemical Society  138(14), 4787-4795  "A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3."
  25. Liao JH, Huang YS, Lin YC, Huang FY, (Wu SH), Wu TH  (2016-03)  Journal of agricultural and food chemistry  64(10), 2080-2086  "Anticataractogenesis Mechanisms of Curcumin and a Comparison of Its Degradation Products: An in Vitro Study."
  26. Lai JH, Yang JT, Chern J, Chen TL, Wu WL, Liao JH, Tsai SF, Liang SY, Chou CC, (Wu SH)  (2016-01)  Molecular & cellular proteomics  15(1), 12-25  "Comparative phosphoproteomics reveals the role of AmpC beta-lactamase phosphorylation in the clinical imipenem-resistant strain Acinetobacter baumannii SK17."
  27. Chen YY, Yang FL, (Wu SH), Lin TL, Wang JT  (2016-01)  Frontiers in microbiology  6, 1458  "Mycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward Dictyostelium."
  28. Liao JH, Wu TH, Chen MY, Chen WT, Lu SY, Wang YH, Wang SP, Hsu YM, Huang YS, Huang ZY, Lin YC, Chang CM, Huang FY, (Wu SH)  (2015-12)  Scientific reports  5, 17614  "The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions."
  29. Hsu CH, Chang CF, Liao YD, (Wu SH), Chen C  (2015-10)  Archives of biochemistry and biophysics  584, 70-78  "Solution structure and base specificity of cytotoxic RC-RNase 2 from Rana catesbeiana."
  30. Lin CK, Tseng CK, Chen KH, (Wu SH), Liaw CC, Lee JC  (2015-09)  British journal of pharmacology  172(18), 4481-4492  "Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-kappaB- and MAPK-ERK1/2-mediated COX-2 expression."
  31. Hua KF, Yang FL, Chiu HW, Chou JC, Dong WC, Lin CN, Lin CY, Wang JT, Li LH, Chiu HW, Chiu YC, (Wu SH)  (2015-09)  Infection and immunity  83(9), 3396-3409  "Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1."
  32. Liaw CC, Yang YL, Lin CK, Lee JC, Liao WY, Shen CN, Sheu JH, (Wu SH)  (2015-05)  Organic letters  17(10), 2330-2333  "New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression."
  33. Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, (Wu SH), Chiu HW, Wong WT, Wang YF, Tsai CL, Ho CL, Lin CH  (2015-04)  Journal of cellular physiology  230(4), 863-874  "Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1beta Production."
  34. Kao TY, Chiu YC, Fang WC, Cheng CW, Kuo CY, Juan HF, (Wu SH), Lee AY  (2015-02)  Cell death & disease  6, e1642  "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex."
  35. Wang DY, Wang DW, Chen HA, Chen TR, Li SS, Yeh YC, Kuo TR, Liao JH, Chang YC, Chen WT, (Wu SH), Hu CC*, Chen CW*, Chen CC*  (2015-02)  Carbon  82, 24-30  "Photoluminescence quenching of graphene oxide by metal ions in aqueous media"
  36. Chang CM, Chern J, Chen MY, Huang KF, Chen CH, Yang YL, (Wu SH)  (2015-01)  Journal of the American Chemical Society  137(1), 267-275  "Avenaciolides: Potential MurA-Targeted Inhibitors Against Peptidoglycan Biosynthesis in Methicillin-Resistant Staphylococcus aureus (MRSA)."
  37. Hsieh PF, Wu MC, Yang FL, Chen CT, Lou TC, Chen YY, (Wu SH), Sheu JC, Wang JT  (2014-11)  Frontiers in Microbiology  5, 608  "D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design."
  38. Chen YD, (Wu SH), Hsu CH  (2014-10)  Biomolecular NMR assignments  8(2), 233-236  "Backbone resonance assignments of the alpha sub-domain of Brevibacillus thermoruber Lon protease."
  39. Si-Peng Li, Wei-Chen Hsiao, Ching-Ching Yu, Wei-Ting Chien, Hong-Jyune Lin, Li-De Huang, Chien-Hung Lin, Wan-Ling Wu, (Shih-Hsiung Wu) and Chun-Cheng Lin  (2014-10)  ADVANCED SYNTHESIS & CATALYSIS  356(14-15), 3199-3213  "Characterization of Meiothermus taiwanensis Galactokinase and its Use in the One-Pot Enzymatic Synthesis of Uridine Diphosphate-Galactose and the Chemoenzymatic Synthesis of the Carbohydrate Antigen Stage Specific Embryonic Antigen-3"
  40. Tu IF, Liao JH, Yang FL, Lin NT, Chan HL, (Wu SH)  (2014-10)  Helicobacter  19(5), 356-366  "Lon protease affects the RdxA nitroreductase activity and metronidazole susceptibility in Helicobacter pylori."
  41. Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, (Wu SH), Wang YF, Tsai CL, Chen A, Ka SM  (2014-08)  Free radical biology & medicine  73, 260-269  "Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kappaB-mediated COX-2 expression and apoptosis."
  42. Liao JH, Lin IL, Huang KF, Kuo PT, (Wu SH), Wu TH  (2014-06)  Journal of agricultural and food chemistry  62(25), 5932-5938  "Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation."
  43. Tai CH, Lu CP, (Wu SH), Lo LC  (2014-05)  Chemical communications  50(46), 6116-6119  "Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells."
  44. Chu YH, Chen CJ, (Wu SH), Hsieh JF  (2014-04)  Journal of agricultural and food chemistry  62(17), 3742-3749  "Inhibition of Xanthine Oxidase by Rhodiola crenulata Extracts and Their Phytochemicals."
  45. Lou YC, Wang I, Rajasekaran M, Kao YF, Ho MR, Hsu ST, Chou SH, (Wu SH), Chen C  (2014-04)  Nucleic acids research  42(6), 4080-4093  "Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae."
  46. Yung-Hung Chu, (Shih-Hsiung Wu), Jung-Feng Hsieh  (2014-03)  Food Research International  57, 8-14  "Isolation and characterization of α-glucosidase inhibitory constituents from Rhodiola crenulata"
  47. A. Y.-L. Lee, Y.-D. Chen, Y.-Y. Chang, Y.-C. Lin, C.-F. Chang, S.-J. Huang, (S.-H. Wu) and C.-H. Hsu  (2014-02)  Acta Crystallographica Section D-Biological Crystallography  D70(2), 218-230  "Structural basis for DNA-mediated allosteric regulation facilitated by the AAA+ module of Lon protease"
  48. Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, (Wu SH)  (2013-10)  Molecular & Cellular Proteomics  12(10), 2701-2713  "Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27."
  49. Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, (Wu SH)  (2013-10)  PloS one  8(10), e76754  "Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation."
  50. Li, J.-K., Liao, J.-H., Li, H., Kuo, C.-I, Huang, K.-F., Yang, L.-W., (Wu, S.-H.), and Chang, C.-I  (2013-09)  Acta Crystallographica Section D Biological Crystallography  D69(9), 1789-1797  "The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones"
  51. Chen YD, Chang YY, (Wu SH), Hsu CH  (2013-08)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  69(Pt 8), 899-901  "Crystallization and preliminary X-ray diffraction analysis of the alpha subdomain of Lon protease from Brevibacillus thermoruber."
  52. Liao, J.-H., Ihara, K., Kuo, C.-I, Huang, K.-F., Wakatsuki, S., (Wu, S.-H.), and Chang, C.-I  (2013-08)  Acta Crystallographica Section D Biological Crystallography  D69(8), 1395-1402  "Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors"
  53. Jiahn-Haur Liao, Yu-Huan Sun, Chun-Hua Hsu, Yu-Ching Lin, (Shih-Hsiung Wu),Chao-Jen Kuo, Chun-Hao Huang, Shyh-Horng Chiou   (2013-03)  Biochimie  95(6), 1136-1145  "Up-regulation of neutrophil activating protein in Helicobacter pylori under high-salt stress: Structural and phylogenetic comparison with bacterial iron-binding ferritins"
  54. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, (Wu SH), Yang SS, Lin SH, Chang JM, Chen A  (2013)  Free radical biology & medicine  61C, 285-297  "Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome."
  55. Hua KF, Liao PC, Fang Z, Yang FL, Yang YL, Chen YL, Chiu YC, Liu ML, Lam Y, (Wu SH)  (2013)  PloS one  8(6), e67603  "Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells."
  56. Lin HJ, Adak AK, Reddy LV, (Wu SH), Lin CC  (2013)  CHEMISTRY-A EUROPEAN JOURNAL  19(24), 7989-7898  "Total synthesis of an immunomodulatory phosphoglycolipid from thermophilic bacteria."
  57. Liao JH, Kuo CI, Huang YY, Lin YC, Lin YC, Yang CY, Wu WL, Chang WH, Liaw YC, Lin LH, Chang CI, (Wu SH)  (2012)  PloS one  7(7), e40226  "A Lon-Like Protease with No ATP-Powered Unfolding Activity."
  58. Lin TL, Yang FL, Yang AS, Peng HP, Li TL, Tsai MD, (Wu SH), Wang JT  (2012)  PloS one  7(10), e46783  "Amino Acid Substitutions of MagA in Klebsiella pneumoniae Affect the Biosynthesis of the Capsular Polysaccharide."
  59. Chen HW, Yang TS, Chen MJ, Chang YC, Lin CY, Wang EI, Ho CL, Huang KM, Yu CC, Yang FL, (Wu SH), Lu YC, Chao LK  (2012)  Bioresource technology  120, 256-263  "Application of power plant flue gas in a photobioreactor to grow Spirulina algae, and a bioactivity analysis of the algal water-soluble polysaccharides."
  60. Liao WY, Shen CN, Lin LH, Yang YL, Han HY, Chen JW, Kuo SC, (Wu SH), Liaw CC  (2012)  Journal of natural products  75(4), 630-635  "Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus."
  61. Chen CS, Yu YP, Hsu CH, Zou W, Fang JM, (Wu SH)  (2012)  Carbohydrate research  354, 87-93  "Evaluation of the regioselective delactonization of tri-sialic acid lactone by in-solution molecular dynamics simulation."
  62. Hsieh PF, Lin TL, Yang FL, Wu MC, Pan YJ, (Wu SH), Wang JT  (2012)  PloS one  7(3), e33155  "Lipopolysaccharide O1 antigen contributes to the virulence in Klebsiella pneumoniae causing pyogenic liver abscess."
  63. Tsai CC, Yang FL, Huang ZY, Chen CS, Yang YL, Hua KF, Li J, Chen ST, (Wu SH)  (2012)  Journal of agricultural and food chemistry  60(11), 2830-2837  "Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells."
  64. Hu CW, Lin MH, Huang HC, Ku WC, Yi TH, Tsai CF, Chen YJ, Sugiyama N, Ishihama Y, Juan HF, (Wu SH)  (2012)  Journal of proteome research  11(11), 5362-5375  "Phosphoproteomic Analysis of Rhodopseudomonas palustris Reveals the Role of Pyruvate Phosphate Dikinase Phosphorylation in Lipid Production."
  65. Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, (Wu SH)  (2011-01)  Inorganic chemistry  50(1), 365-377  "Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis."
  66. Timothy Eckert, Chun-Ping Lu, Chien-Sheng Chen, (Shih-Hsiung Wu), Jacquelyn Gervay-Hague  (2011-01)  Tetrahedron Letters  52, 2250-2253  "NMR studies of the reversible and regioselective lactonization of α-2,8-linked trisialic acid in aqueous acid."
  67. Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, (Wu SH)  (2011)  Journal of Biological Chemistry  286(20), 17736-17745  "A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2."
  68. Liao JH, Wu TH, Hsu FL, Huang YS, Chiang PH, Huang ZY, Huang CH, (Wu SH), Lin MH  (2011)  International journal of molecular sciences  12(10), 7059-7076  "Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent."
  69. P-F. Su1, C-J. Li, C-C. Hsu, S. Benson, S-Y. Wang, K. Aravindaram1, S. I. Chan, (S-H. Wu), F-L. Yang, W-C. Huang, L-F. Shyur, N-S. Yang  (2011)  EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE  2011, 731308  "Dioscorea Phytocompounds Enhance Murine Splenocyte Proliferation Ex Vivo and Improve Regeneration of Bone Marrow Cells In Vivo."
  70. Chu KC, Ren CT, Lu CP, Hsu CH, Sun TH, Han JL, Pal B, Chao TA, Lin YF, (Wu SH), Wong CH, Wu CY  (2011)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  50(40), 9391-9395  "Efficient and stereoselective synthesis of alpha(2-->9) oligosialic acids: from monomers to dodecamers."
  71. Ho JY, Lin TL, Li CY, Lee A, Cheng AN, Chen MC, (Wu SH), Wang JT, Li TL, Tsai MD  (2011)  PloS one  6(7), e21664  "Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044."
  72. Lu CP, Lin CT, Chang CM, (Wu SH), Lo LC  (2011)  Journal of agricultural and food chemistry  59(21), 11403-11406  "Nitrophenylboronic acids as highly chemoselective probes to detect hydrogen peroxide in foods and agricultural products."
  73. Lu TL, Chuang JY, Yang JS, Chiu ST, Hsiao NW, Wu MC, (Wu SH), Hsu CH  (2011)  Evidence-based Complementary and Alternative Medicine  2011, 283747  "Production of Active Nonglycosylated Recombinant B-Chain of Type-2 Ribosome-Inactivating Protein from Viscum articulatum and Its Biological Effects on Peripheral Blood Mononuclear Cells."
  74. Yang FL, Hassanbhai AM, Chen HY, Huang ZY, Lin TL, (Wu SH), Ho B  (2011)  Helicobacter  16(2), 89-98  "Proteomannans in biofilm of Helicobacter pylori ATCC 43504."
  75. Hu CC, Liao JH, Hsu KY, Lin IL, Tsai MH, Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, (Wu SH), Wu TH  (2011)  Molecular vision  17, 1862-1870  "Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo."
  76. Yang FL, Yang YL, (Wu SH)  (2011)  Advances in experimental medicine and biology  705, 367-380  "Structure and function of glycolipids in thermophilic bacteria."
  77. Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, (Wu SH)  (2011)  Journal of Biological Chemistry  286(24), 21041-21051  "Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4."
  78. Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, (Wu SH)  (2011)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  50(34), 7885-7891  "The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins."
  79. Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, (Wu SH)  (2010-11)  Journal of medicinal chemistry  53(22), 7967-7978  "Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis."
  80. Yang YL, Yang FL, Huang ZY, Tsai YH, Zou W, (Wu SH)  (2010-10)  Organic & biomolecular chemistry  8(19), 4252-4254  "Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures."
  81. J-H. Liao,Y-C. Lin,C-W. Hsu,Alan Y-L. Lee,T-A. Chen,C-H. Hsu,J-L. Chir,K-F. Hua,T-H. Wu,L-J. Hong,P-W. Yen,A. Chiou,(S-H. Wu*)  (2010-06)  Biophys. J.  98(1), 129-137  "Binding and cleavage of E. coli HUbeta by the E. coli Lon protease"
  82. Hsu CH, Pan YR, Liao YD, (Wu SH), Chen C  (2010-04)  Journal of biochemistry  148(2), 209-215  "NMR and biophysical elucidation of structural effects on extra N-terminal methionine residue of recombinant amphibian RNases from Rana catesbeiana."
  83. C-H. Huang1,I-L. Lee,I-J. Yeh,J-H. Liao, C-L. Ni, (S-H. Wu) and S-H. Chiou  (2010-04)  J. Biochem.  147(4), 535-543  "Upregulation of a non-heme iron-containing ferritin with dual ferroxidase and DNA-binding activities in Helicobacter pylori under acid stress"
  84. Y-C. Huang,T-L. Hwang, Y-L. Yang,(S-H. Wu), M-H. Hsu, J-P. Wang, S-C. Chen, L-J. Huang, C-C.Liaw  (2010-03)  PLANTA MEDICA  76(5), 447-53  "Acetogenin and Prenylated Flavonoids from Helminthostachy zeylanica with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils"
  85. Yu CC, Chen HW, Chen MJ, Chang YC, Chien SC, Kuo YH, Yang FL, (Wu SH), Chen J, Yu HH, Chao LK  (2010)  Natural product communications  5(12), 1941-1944  "Chemical composition and bioactivities of the marine alga Isochrysis galbana from Taiwan."
  86. Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.  (2009-12)  Mol Cell Proteomics  8(12), 2613-23  "Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence"
  87. Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and (S-H. Wu*)  (2009-11)  CHEMISTRY-A EUROPEAN JOURNAL  15(43), 11573-80  "Discovery of New Natural Products by Intact-cell Mass Spectrometry and LC-SPE-NMR--Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea"
  88. Liao JH, Chen CS, Maher TJ, Liu CY, Lin MH, Wu TH, "Wu SH*"  (2009)  Chemical research in toxicology  22 (3), 518–525  "Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis."
  89. Liao JH, Lee JS, "Wu SH", Chiou SH  (2009)  Molecular vision  15, 1429-1444  "COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine alphaB-crystallin."
  90. Lin YC, Lee HC, Wang I, Hsu CH, Liao JH, Lee AY, Chen C, "Wu SH*"  (2009)  Biochemical and biophysical research communications  388(1), 62-66  "DNA-binding specificity of the Lon protease alpha-domain from Brevibacillus thermoruber WR-249."
  91. Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, "Wu SH", Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL  (2009)  Infection and immunity  77(2), 615-621  "Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling."
  92. Y-P. Yu, A-T. Wu, W. Zou, C-S. Chen and (S-H. Wu*)  (2009)  Tetrahedron Lett.  50, 6130-6132  "Recognition between a Divalent Sialyl Molecule and Wheat Germ Agglutinin"
  93. Chir JL, Liao JH, Lin YC, "Wu SH*"  (2009)  Biochemical and biophysical research communications  382(4), 762-765  "The N-terminal sequence after residue 247 plays an important role in structure and function of Lon protease from Brevibacillus thermoruber WR-249."
  94. Chen CS, Yu YP, Lin BC, Jacquelyn GH, Fan JM, Hsu CP, (Wu SH*)   (2009)  European Journal of Organic Chemistry  2009(20), 3351-3356  "The Observation of the C-H···Osp3 Hydrogen Bond in Trisialic Acid Lactone and Its Implications for Cooperative Lactonization"
  95. P-H. Chuang,P-W. Hsieh,Y-L. Yang,K-F. Hua,F-R. Chang,Jentaie Shiea, (S-H Wu),Y-C. Wu  (2008)  J. Nat. Prod.  71, 1365-1370  "Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana"
  96. Liaw CC, Yang YL, Chen M, Chang FR, Chen SL, (Wu SH), Wu YC  (2008)  Journal of natural products  71(5), 764-771  "Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators."
  97. Yang YL, Hua KF, Chuang PH, (Wu SH), Wu KY, Chang FR, Wu YC  (2008)  Journal of agricultural and food chemistry  56(2), 386-392  "New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities."
  98. Liu JY, Yang FL, Lu CP, Yang YL, Wen CL, Hua KF, (Wu SH)*  (2008)  Journal of agricultural and food chemistry  56(21), 9892-9898  "Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways."
  99. Sandbhor M, Bhasin M, Williams DT, Hsieh M, (Wu SH), Zou W  (2008)  Carbohydrate research  343, 2878-2886  "Synthesis of iminoalditol analogues of galactofuranosides and their activities against glycosidases."
  100. Chen SH, Suzuki CK, (Wu SH)*  (2008)  Nucleic acids research  36(4), 1273-1287  "Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA."
  101. Yang FL, Hua KF, Yang YL, Zou W, Chen YP, Liang SM, Hsu HY, (Wu SH)*  (2008)  Glycoconjugate journal  25(5), 427-439  "TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria."
  102. Wang I, Lou YC, Lin YC, Lo SC, Lee AY, (Wu SH)*, Chen C  (2007)  Biomolecular NMR assignments  1(2), 201-203  "(1)H, (13)C and (15)N resonance assignments of alpha-domain for Bacillus subtilis Lon protease."
  103. Huang HC, Tsai WJ, Liaw CC, (Wu SH), Wu YC, Kuo YH  (2007)  Chemical & pharmaceutical bulletin  55(9), 1412-1415  "Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi."
  104. C-S. Chen, Y-P. Yu, C-H. Hsu, Y-T. Wu, W. Zou, J-M. Fang, and (S-H. Wu)*  (2007)  Eur. J. Org. Chem.  3648-3654  "Conformation of trisialic acid lactone : NMR spectroscopic analysis and molecular dynamics simulation"
  105. Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and (S. H. Wu)*  (2007)  CHEMISTRY-A EUROPEAN JOURNAL  13(24), 6985-6991  "Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora Thermophila: Elucidation of the Relationship between Cytotoxicity and Stereoconfiguration"
  106. Lu CP, Ren CT, (Wu SH)*, Chu CY, Lo LC  (2007)  CHEMBIOCHEM  8(18), 2187-2190  "Development of an activity-based probe for steroid sulfatases."
  107. Zou W, Wu AT, Bhasin M, Sandbhor M, (Wu SH)  (2007)  The Journal of organic chemistry  72(7), 2686-2689  "Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation."
  108. C. S. Chen, (S. H. Wu), Y. Y. Wu, J. M. Fang and T. H. Wu  (2007)  Org. Lett.  9(16), 2985-2988  "Properties of Astaxanthin/Ca(2+) Complex Formation in the Deceleration of Cis/Trans Isomerization"
  109. C. T. Ren, Y. H. Tsai, Y. L. Yang, W. Zou and (S. H. Wu)*  (2007)  J. Org. Chem.  72(14), 5427-5430  "Synthesis of a Tetrasaccharide Glycosyl Glycerol. Precursor to Glycolipids of Meiothermus taiwanensis ATCC BAA-400"
  110. Huang YC, Lin YM, Chang TW, Wu SJ, Lee YS, Chang MD, Chen C, (Wu SH), Liao YD  (2007)  J. Biol. Chem.  282(7), 4626-4633  "The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity."
  111. J. F. Hsieh, (S. H. Wu), Y. L. Yang, K. F. Choong and S. T. Chen  (2007)  BIOORGANIC & MEDICINAL CHEMISTRY  15(10), 3450-3456  "The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors"
  112. H. Shao, D. T. Williams, S. H. Wu and W. Zou  (2006)  Carbohydrate Research  341(14), 2434-2438  "C-Branched pyrrolidines from 2-C-acetylmethyl-glycosylazides. Reduction of imines formed by monosaccharide ring opening"
  113. Y. P. Yu, M. C. Cheng and S. H. Wu  (2006)  Electrophoresis  27(22), 4487-4499  "High-performance CE: An effective method to study lactonization of alpha2,8-linked oligosialic acid"
  114. A. T. Wu, T. Yi, H. Shao, "S. H. Wu*:, W. Zou*  (2006)  Can. J. Chem.  84(4): 597-602  "Stereoselective synthesis of dioxabicycles from 1-C-allyl-2-O-benzyl-glycosides — An intramolecular cyclization between 2-O-benzyl oxygen and the allyl double bond"
  115. Y. L. Yang, F. L. Yang, S. C. Jao, M. Y. Chen, S. S. Tsay, W. Zou and S. H. Wu  (2006)  J. Lipid Res.  47(8), 1823-1832  "Structural elucidation of phosphoglycolipids from strains of the bacterial thermophiles thermus and meiothermus"
  116. Huawu Shao, Sanchai Ekthawatchai, Chien-Sheng Chen, Shih-Hsiung Wu and Wei Zou  (2005)  J. Org. Chem.  70(12), 4726-4734  "1,2-Migration of 2'-Oxoalkyl Group and Concomitant Synthesis of 2-C-Branched O-, S-Glycosides and Glycosyl Azides via 1,2-Cyclopropanated Sugars"
  117. Y. Tian, A-T. Wu, "S-H Wu*", W. Zou*  (2005)  Tetrahedron  61: 11716-11722  "1-C-(2’-Oxoalkyl) glycosides as latentα,β-unsaturated conjugates."
  118. A. T. Wu, Y. P. Yu, C. T. Ren, W. Zou and S. H. Wu  (2005)  CARBOHYDRATE RESEARCH  340(6), 1219-1223  "9-O-Sulfation on alpha-NeuAc-(2-->8)-NeuAc and inter-residue lactonization"
  119. C. P. Lu, C. T. Ren, Y. N. Lai, S. H. Wu, W. M. Wang, J. Y. Chen and L. C. Lo  (2005)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  44(42), 6888-6892  "Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses"
  120. Iren Wang, Yuan-Chao Lou, Kuen-Phon Wu, Shih-Hsiung Wu, Wen-Chang Chang and Chinpan Chen  (2005)  Journal of Molecular Biology  346(4), 1071-1082  "Novel Solution Structure of Porcine β-Microseminoprotein"
  121. C. H. Hsu, C. Chen, M. L. Jou, A.Y.L. Lee, Y. C. Lin, Y. P. Yu, W. T. Huang and S. H. Wu  (2005)  Nucleic Acids Res.  33, 4053-4064  "Structural and DNA-binding studies on the bovine antimicrobial peptide, indolicidin: evidence for multiple conformations involved in binding to membranes and DNA"
  122. Tian Yi, Shih-Hsiung Wu and Wei Zou  (2005)  CARBOHYDRATE RESEARCH  340(2), 235-244  "Synthesis of C-5-thioglycopyranosides and their sulfonium derivatives from 1-C-(2′-oxoalkyl)-5-S-acetylglycofuranosides"
  123. Zou W, Shao H, "Wu SH*"  (2004-10)  CARBOHYDRATE RESEARCH  339(15), 2475-85.  "Intramolecular aldol cyclization of C-4-ulopyranosyl-2'-oxoalkanes controlled by steric effects. Asymmetric synthesis of substituted 8-oxabicyclo[3.2.1]octanones and -octenones and cyclopentenones"
  124. H. Shao, S. Ekthawatchai, S. H. Wu and W. Zou  (2004)  Org. Lett.  6(20), 3497-3499  "2-C-Branched Glycosides from 2'-Carbonylalkyl 2-O-Ms(Ts)-C-Glycosides. A Tandem S(N)2-S(N)2 Reaction via 1,2-Cyclopropanated Sugars"
  125. Chen HP, Hsui FC, Lin LY, Ren CT, Wu SH  (2004)  EUROPEAN JOURNAL OF BIOCHEMISTRY  271(21), 4293-4297  "Coexpression, purification and characterization of the E and S subunits of coenzyme B(12) and B(6) dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli."
  126. A.Y. Lee, C. H. Hsu and S. H. Wu  (2004)  J. Biol. Chem.  279, 34903-34912  "Functional domains of Brevibacillus thermoruber lon protease for oligomerization and DNA binding: role of N-terminal and sensor and substrate discrimination domains."
  127. M. C. Cheng, C. H. Lin, H. J. Lin, Y. P. Yu and S. H. Wu  (2004)  Glycobiology  14, 147-155  "Hydrolysis, lactonization, and identification of alpha(2 --> 8)/alpha(2 --> 9) alternatively linked tri-, tetra-, and polysialic acids"
  128. A. Y. Lee, S. S. Tsay, M. Y. Chen and S. H. Wu  (2004)  Eur. J. Biochem.  271, 834-844  "Identification of a gene encoding Lon protease from Brevibacillus thermoruber WR-249 and biochemical characterization of its thermostable recombinant enzyme"
  129. M. Y. Chen, S. H. Wu, G. H. Lin, C. P. Lu, Y. T. Lin, W. C. Chang and S. S. Tsay  (2004)  INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY  54(Pt 5), 1849-1855  "Rubrobacter taiwanensis sp. nov., a novel thermophilic, radiation-resistant species isolated from hot springs"
  130. Yang FL, Lu CP, Chen CS, Chen MY, Hsiao HL, Su Y, Tsay SS, Zou W, Wu SH.  (2004)  EUROPEAN JOURNAL OF BIOCHEMISTRY  271(22), 4545-4551  "Structural determination of the polar glycoglycerolipids from thermophilic bacteria Meiothermus taiwanensis"
  131. T. L. Lu, C. S. Chen, F. L. Yang, J. M. Fung, M. Y. Chen, S. S. Tsay, J. Li, W. Zou and S. H. Wu SH.  (2004)  CARBOHYDRATE RESEARCH  339(15), 2593-2598  "Structure of a major glycolipid from Thermus oshimai NTU-063"
  132. H. P. Chen, F. D. Lung, C. C. Yeh, H. L. Chen and S. H. Wu  (2004)  BIOORGANIC & MEDICINAL CHEMISTRY  12, 577-582  "The role of the conserved histidine-aspartate pair in the 'base-off' binding of cobalamins"
  133. Wang I, Yu TA, Wu SH, Chang WC, Chen C  (2003)  FEBS letters  541(1-3), 80-84  "Disulfide pairings and secondary structure of porcine beta-microseminoprotein."
  134. Z. Wang, H. Shao, E. Lacroix, S. H. Wu, H. J. Jennings and W. Zou  (2003)  J. Org. Chem.  68, 8097-8105  "Epimerization of 2'-carbonylalkyl-C-glycosides via enolation, beta-elimination and intramolecular cycloaddition"
  135. Hsu CH, Liao YD, Pan YR, Chen LW, "Wu SH", Leu YJ, Chen C  (2003)  Journal of molecular biology  326(4), 1189-1201  "Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana."
  136. C. T. Ren, C. S. Chen, Y. P. Yu, Y. F. Tsai, P. Y. Lin, Y. J. Chen, W. Zou and S. H. Wu  (2003)  CHEMISTRY-A EUROPEAN JOURNAL  9, 1085-1095  "Synthesis of alpha-(2-->5)Neu5Gc oligomers"
  137. W. Zou, E. Lacroix, Z. Wang, "S. H. Wu*"  (2003)  Tetrahedron Lett.  44: 4431-4433.  "Synthesis of thio-C-glycosides from 2’-carbonylalkyl C-glycosides by a tandemβ-elimination and intramolecular hetero-Michael addition"
  138. H. Shao, Z. Wang, E. Lacroix, "S. H. Wu", H. J. Jenning, W. Zou  (2002)  J. Am. Chem. Soc.  124: 2130-2131  "Novel zinc (II)-mediated epimerization of 2'-carbonylalkyl-α-C-glycopyranosides to their β-anomers"
  139. Wang I, "Wu SH*", Chang HK, Shieh RC, Yu HM, Chen C  (2002)  PROTEIN SCIENCE  11(2), 390-400  "Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei."
  140. Hsu CH, "Wu SH*", Chang DK, Chen C  (2002)  The Journal of biological chemistry  277(25), 22725-22733  "Structural characterizations of fusion peptide analogs of influenza virus hemagglutinin. Implication of the necessity of a helix-hinge-helix motif in fusion activity."
  141. C. T. Ren, C. S. Chen and S. H. Wu  (2002)  J. Org. Chem.  67, 1376-1379  "Synthesis of a sialic acid dimer derivative, 2'alpha-O-benzyl Neu5Ac-alph-(2-->5)Neu5Gc"
  142. C. Chen, C. H. Hsu, N. Y. Su, Y. C. Lin, S. H. Chiou and S. H. Wu  (2001)  J. Biol. Chem.  276, 45079-45087  "Solution structure of a Kunitz-type chymotrypsin inhibitor isolated from the elapid snake Bungarus fasciatus"
  143. M. C. Cheng, C. H. Lin, H. Y. Wang, H. R. Lin and S. H. Wu  (2000)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  39, 772-776  "Regioselective Lactonization of Tetrasialic Acid"
  144. T. P. Ko, M. K. Safo, F. N. Musayev, M. L. Di Salvo, C. Wang, S. H. Wu and D. J. Abraham  (2000)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  56, 241-245  "Structure of human erythrocyte catalase"
  145. M. C. Cheng, K. T. Wang, S. Inoue, Y. Inoue, K. H. Khoo and S. H. Wu  (1999)  Anal. Biochem.  267, 287-293  "Controlled acid hydrolysis of colominic acid under microwave irradiation"
  146. C. C. Chuang, S. H. Wu, S. H. Chiou and G. G. Chang  (1999)  Biophys J  76, 679-690  "Homology modeling of cephalopod lens S-crystallin: a natural mutant of sigma-class glutathione transferase with diminished endogenous activity"
  147. M. C. Cheng, C. H. Lin, K. H. Khoo and S. H. Wu  (1999)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  38, 686-689  "Regioselective Lactonization of α-(2→8)-Trisialic Acid"
  148. C. Y. Wu, H. J. Lee, S. H. Wu, S. T. Chen, S. H. Chiou and G. G. Chang  (1998)  Biochem J  333, 327-334  "Chemical mechanism of the endogenous argininosuccinate lyase activity of duck lens delta2-crystallin"
  149. M. C. Cheng, S. L. Lin, S. H. Wu, S. Inoue and Y. Inoue  (1998)  Anal. Biochem.  260, 154-159  "High-performance capillary electrophoretic characterization of different types of oligo- and polysialic acid chains"
  150. S. Inoue, S. L. Lin, T. Chang, S. H. Wu, C. W. Yao, T. Y. Chu, F. A. Troy 2nd and Y. Inoue  (1998)  J Biol Chem  273, 27199-27204  "Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells"
  151. L. C. Chuang, H. M. Yu, C. Chen, T. H. Huang, S. H. Wu and K. T. Wang  (1996)  Biochim Biophys Acta  1292, 145-155  "Determination of three-dimensional solution structure of waglerin I, a toxin from Trimeresurus wagleri, using 2D-NMR and molecular dynamics simulation"
  152. Y. M. Hsiao, C. C. Chuang, L. C. Chuang, H. M. Yu, K. T. Wang, S. H. Chiou and S. H. Wu  (1996)  Biochem Biophys Res Commun  227, 59-63  "Protein engineering of venom toxins by synthetic approach and NMR dynamic simulation: status of basic amino acid residues in waglerin I"
  153. L. C. Chuang, P. Y. Chen, C. Chen, T. H. Huang, K. T. Wang, S. H. Chiou and S. H. Wu  (1996)  Biochem Biophys Res Commun  220, 246-254  "Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin gamma with three disulfide bonds by 2D-NMR and computer graphics"
  154. S. Y. Liao, G. T. Ong, K. T. Wang and S. H. Wu  (1995)  Biochim Biophys Acta  1252, 312-320  "Conformation of polymyxin B analogs in DMSO from NMR spectra and molecular modeling"
  155. P. Y. Chen, S. H. Wu and K. T. Wang  (1994)  Protein Eng  7, 941-944  "Chemical synthesis of gamma-echistatin analogues: elucidation of status of C-terminal (45-49)"
  156. G. T. Ong, K. Y. Chang, S. H. Wu and K. T. Wang  (1994)  CARBOHYDRATE RESEARCH  265, 311-318  "Preparation of 2,3,6,2',3',4',6'-hepta-O-acetyl-maltose/cellobiose by enzymatic hydrolysis of maltose/cellobiose octaacetate"
  157. G. T. Ong, K. Y. Chang, S. H. Wu and K. T. Wang  (1993)  CARBOHYDRATE RESEARCH  241, 327-333  "Selective deacylation on the glucosyl moiety of octa-O-acetylsucrose by enzymic hydrolysis: formation of 2,1',3',4',6'-penta-O-acetylsucrose"
  158. K. Y. Chang, S. H. Wu and K. T. Wang  (1991)  CARBOHYDRATE RESEARCH  222, 121-129  "Regioselective enzymic deacetylation of octa-O-acetylsucrose: preparation of hepta-O-acetylsucroses"
  159. S. T. Chen, L. C. Lo, S. H. Wu and K. T. Wang  (1990)  Int J Pept Protein Res  35, 52-54  "Side reaction in peptide synthesis. Formation of oxazolidone derivatives"
  160. C. J. Sih, S. H. Wu  (1989)  Topics in Stereochemistry  19, 63-125  "Resolution of enantiomers via biocatalysis"

The study on relationship of structure and function of biomolecules is the main theme of our research. The basic techniques used in our studies include NMR, GC-Mass and MS, BIAcore, CD, organic synthesis, cloning, site-directed mutagenesis and other physical methods and chromatographies. At present, our works focus on several topics described as follows:

  • Carbohydrate Chemistry and Glycobiology
  • Drug Discovery and Development from the Secondary metabolites of microorganisms
  • Studies on the structure-functional relationship of proteins and peptides by NMR and X-ray diffraction
  • Proteomic studies
Positions Held
  • 2008 – present   Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1991 – present   Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
  • 2006 – 2012   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 1998 – 1999   General Secretary, Taiwan Society of Biochemistry and Molecular Biology
  • 1997 – 1999   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 1994 – 1995   Visiting Scholar, The Scripps Research Institute
  • 1991 – 2008   Research Fellow, Institute of Biological Chemistry
  • 1988 – 1991   Associate Research Fellow, Institute of Biological Chemistry
  • 1979 – 1988   Assistant Research Fellow, Institute of Biological Chemistry
  • 1978 – 1979   Group Leader, Panlabs Taiwan Ltd
Degrees
  • 1987   Ph.D., Pharmacy, University of Wisconsin, Madison.
  • 1977   M.S., Biochemistry, National Taiwan University
  • 1975   B.S., Botany, National Taiwan University
Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, Wu SH
Molecular & Cellular Proteomics (2013)
Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, Wu SH
Journal of biological chemistry (2011)
Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, Wu SH
Inorganic chemistry (2011)
Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, Wu SH
Journal of biological chemistry (2011)
Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, Wu SH
Journal of medicinal chemistry (2010)
Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and S-H. Wu
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.
Mol Cell Proteomics (2009)
Chen SH, Suzuki CK, Wu SH
Nucleic acids research (2008)
Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and S. H. Wu
CHEMISTRY-A EUROPEAN JOURNAL (2007)
  1. Susanto W, Kong KH, Hua KF, (Wu SH), Lam Y  (2019-01)  Tetrahedron Letters  60(3), 288-291  "Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae."
  2. Wu HY, Yang FL, Li LH, Rao YK, Ju TC, Wong WT, Hsieh CY, Pivkin MV, Hua KF, (Wu SH)  (2018-12)  Scientific reports  8(1), 17956  "Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells."
  3. Perera N, Yang FL, Lu YT, Li LH, Hua KF, (Wu SH)  (2018-07)  International journal of biological sciences  14(10), 1378-1388  "Antrodia cinnamomea Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4."
  4. Lee IM, Yang FL, Chen TL, Liao KS, Ren CT, Lin NT, Chang YP, Wu CY, (Wu SH)  (2018-07)  Journal of the American Chemical Society  140(28), 8639-8643  "Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity."
  5. Chern J, Lu CP, Fang Z, Chang CM, Hua KF, Chen YT, Ng CY, Chen YS, Lam Y, (Wu SH)  (2018-06)  Angewandte Chemie-International Edition  57(24), 7040-7045  "Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade."
  6. Perera N, Yang FL, Chern J, Chiu HW, Hsieh CY, Li LH, Zhang YL, Hua KF, (Wu SH)  (2018-06)  Chemical communications  54(51), 6995-6998  "Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae."
  7. Tseng TS, Tu IF, Chen HT, Lin LC, Tsai KC, (Wu SH), Chen C  (2018-06)  Chemical communications  54(49), 6372-6375  "Protein-DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA."
  8. Wang YC, Huang TW, Yang YS, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Chang FY, (Wu SH), How CK, Lee YT  (2018-05)  Scientific reports  8(1), 7289  "Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia."
  9. Liao JH, Tsai CH, Patel SG, Yang JT, Tu IF, Lo Cicero M, Lipka-Lloyd M, Wu WL, Shen WJ, Ho MR, Chou CC, Sharma GR, Okanishi H, Luk LYP, Tsai YH, (Wu SH)  (2017-11)  Frontiers in molecular biosciences  4, 77  "Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU."
  10. Chang YT, Wu CY, Tang JY, Huang CY, Liaw CC, (Wu SH), Sheu JH, Chang HW  (2017-09)  Environmental toxicology  32(9), 2124-2132  "Sinularin induces oxidative stress-mediated G2/M arrest and apoptosis in oral cancer cells."
  11. Chernikov OV, Wong WT, Li LH, Chikalovets IV, Molchanova VI, (Wu SH), Liao JH, Hua KF  (2017-07)  Scientific reports  7(1), 6315  "A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice."
  12. Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, (Wu SH)  (2017-07)  Organic letters  19(13), 3486-3489  "Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages."
  13. Wu WL, Chen MY, Tu IF, Lin YC, EswarKumar N, Chen MY, Ho MC, (Wu SH)  (2017-07)  Scientific reports  7(1), 4658  "The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles."
  14. Lai SJ, Tu IF, Wu WL, Yang JT, Luk LYP, Lai MC, Tsai YH, (Wu SH)  (2017-05)  BMC microbiology  17(1), 123  "Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance."
  15. Yang FL, Lou TC, Kuo SC, Wu WL, Chern J, Lee YT, Chen ST, Zou W, Lin NT, (Wu SH)  (2017-03)  Vaccine  35(10), 1440-1447  "A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate."
  16. Lee IM, Tu IF, Yang FL, Ko TP, Liao JH, Lin NT, Wu CY, Ren CT, Wang AH, Chang CM, Huang KF, (Wu SH)  (2017-02)  Scientific reports  7, 42711  "Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage PhiAB6 tailspike protein."
  17. Chang LC, Chen TC, Chen SJ, Chen CL, Lee CC, (Wu SH), Yen Y, Huang HS, Lin JJ  (2016-10)  Oncotarget  7(42), 67986-68001  "Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation."
  18. Hsu CR, Liao CH, Lin TL, Yang HR, Yang FL, Hsieh PF, (Wu SH), Wang JT  (2016-08)  Scientific reports  6, 31946  "Identification of a capsular variant and characterization of capsular acetylation in Klebsiella pneumoniae PLA-associated type K57."
  19. Liao HF, Lee HH, Chang YS, Lin CL, Liu TY, Chen YC, Yen JC, Lee YT, Lin CY, (Wu SH), Ko YC, Chang JG  (2016-06)  Scientific reports  6, 27350  "Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers."
  20. Wu WL, Lai SJ, Yang JT, Chern J, Liang SY, Chou CC, Kuo CH, Lai MC, (Wu SH)  (2016-06)  Scientific reports  6, 29013  "Phosphoproteomic analysis of Methanohalophilus portucalensis FDF1(T) identified the role of protein phosphorylation in methanogenesis and osmoregulation."
  21. Chang YT, Huang CY, Li KT, Li RN, Liaw CC, (Wu SH), Liu JR, Sheu JH, Chang HW  (2016-06)  Archives of oral biology  66, 147-154  "Sinuleptolide inhibits proliferation of oral cancer Ca9-22 cells involving apoptosis, oxidative stress, and DNA damage."
  22. Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, (Wu SH), Chang YC, Lim C, Chang CI  (2016-05)  Structure  24(5), 676-686  "Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease."
  23. Lin CC, Su SC, Su MY, Liang PH, Feng CC, (Wu SH), Chang CI  (2016-05)  Structure  24(5), 667-675  "Structural Insights into the Allosteric Operation of the Lon AAA+ Protease."
  24. Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, (Wu SH)  (2016-04)  Journal of the American Chemical Society  138(14), 4787-4795  "A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3."
  25. Liao JH, Huang YS, Lin YC, Huang FY, (Wu SH), Wu TH  (2016-03)  Journal of agricultural and food chemistry  64(10), 2080-2086  "Anticataractogenesis Mechanisms of Curcumin and a Comparison of Its Degradation Products: An in Vitro Study."
  26. Lai JH, Yang JT, Chern J, Chen TL, Wu WL, Liao JH, Tsai SF, Liang SY, Chou CC, (Wu SH)  (2016-01)  Molecular & cellular proteomics  15(1), 12-25  "Comparative phosphoproteomics reveals the role of AmpC beta-lactamase phosphorylation in the clinical imipenem-resistant strain Acinetobacter baumannii SK17."
  27. Chen YY, Yang FL, (Wu SH), Lin TL, Wang JT  (2016-01)  Frontiers in microbiology  6, 1458  "Mycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward Dictyostelium."
  28. Liao JH, Wu TH, Chen MY, Chen WT, Lu SY, Wang YH, Wang SP, Hsu YM, Huang YS, Huang ZY, Lin YC, Chang CM, Huang FY, (Wu SH)  (2015-12)  Scientific reports  5, 17614  "The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions."
  29. Hsu CH, Chang CF, Liao YD, (Wu SH), Chen C  (2015-10)  Archives of biochemistry and biophysics  584, 70-78  "Solution structure and base specificity of cytotoxic RC-RNase 2 from Rana catesbeiana."
  30. Lin CK, Tseng CK, Chen KH, (Wu SH), Liaw CC, Lee JC  (2015-09)  British journal of pharmacology  172(18), 4481-4492  "Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-kappaB- and MAPK-ERK1/2-mediated COX-2 expression."
  31. Hua KF, Yang FL, Chiu HW, Chou JC, Dong WC, Lin CN, Lin CY, Wang JT, Li LH, Chiu HW, Chiu YC, (Wu SH)  (2015-09)  Infection and immunity  83(9), 3396-3409  "Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1."
  32. Liaw CC, Yang YL, Lin CK, Lee JC, Liao WY, Shen CN, Sheu JH, (Wu SH)  (2015-05)  Organic letters  17(10), 2330-2333  "New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression."
  33. Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, (Wu SH), Chiu HW, Wong WT, Wang YF, Tsai CL, Ho CL, Lin CH  (2015-04)  Journal of cellular physiology  230(4), 863-874  "Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1beta Production."
  34. Kao TY, Chiu YC, Fang WC, Cheng CW, Kuo CY, Juan HF, (Wu SH), Lee AY  (2015-02)  Cell death & disease  6, e1642  "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex."
  35. Wang DY, Wang DW, Chen HA, Chen TR, Li SS, Yeh YC, Kuo TR, Liao JH, Chang YC, Chen WT, (Wu SH), Hu CC*, Chen CW*, Chen CC*  (2015-02)  Carbon  82, 24-30  "Photoluminescence quenching of graphene oxide by metal ions in aqueous media"
  36. Chang CM, Chern J, Chen MY, Huang KF, Chen CH, Yang YL, (Wu SH)  (2015-01)  Journal of the American Chemical Society  137(1), 267-275  "Avenaciolides: Potential MurA-Targeted Inhibitors Against Peptidoglycan Biosynthesis in Methicillin-Resistant Staphylococcus aureus (MRSA)."
  37. Hsieh PF, Wu MC, Yang FL, Chen CT, Lou TC, Chen YY, (Wu SH), Sheu JC, Wang JT  (2014-11)  Frontiers in Microbiology  5, 608  "D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design."
  38. Chen YD, (Wu SH), Hsu CH  (2014-10)  Biomolecular NMR assignments  8(2), 233-236  "Backbone resonance assignments of the alpha sub-domain of Brevibacillus thermoruber Lon protease."
  39. Si-Peng Li, Wei-Chen Hsiao, Ching-Ching Yu, Wei-Ting Chien, Hong-Jyune Lin, Li-De Huang, Chien-Hung Lin, Wan-Ling Wu, (Shih-Hsiung Wu) and Chun-Cheng Lin  (2014-10)  ADVANCED SYNTHESIS & CATALYSIS  356(14-15), 3199-3213  "Characterization of Meiothermus taiwanensis Galactokinase and its Use in the One-Pot Enzymatic Synthesis of Uridine Diphosphate-Galactose and the Chemoenzymatic Synthesis of the Carbohydrate Antigen Stage Specific Embryonic Antigen-3"
  40. Tu IF, Liao JH, Yang FL, Lin NT, Chan HL, (Wu SH)  (2014-10)  Helicobacter  19(5), 356-366  "Lon protease affects the RdxA nitroreductase activity and metronidazole susceptibility in Helicobacter pylori."
  41. Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, (Wu SH), Wang YF, Tsai CL, Chen A, Ka SM  (2014-08)  Free radical biology & medicine  73, 260-269  "Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kappaB-mediated COX-2 expression and apoptosis."
  42. Liao JH, Lin IL, Huang KF, Kuo PT, (Wu SH), Wu TH  (2014-06)  Journal of agricultural and food chemistry  62(25), 5932-5938  "Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation."
  43. Tai CH, Lu CP, (Wu SH), Lo LC  (2014-05)  Chemical communications  50(46), 6116-6119  "Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells."
  44. Chu YH, Chen CJ, (Wu SH), Hsieh JF  (2014-04)  Journal of agricultural and food chemistry  62(17), 3742-3749  "Inhibition of Xanthine Oxidase by Rhodiola crenulata Extracts and Their Phytochemicals."
  45. Lou YC, Wang I, Rajasekaran M, Kao YF, Ho MR, Hsu ST, Chou SH, (Wu SH), Chen C  (2014-04)  Nucleic acids research  42(6), 4080-4093  "Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae."
  46. Yung-Hung Chu, (Shih-Hsiung Wu), Jung-Feng Hsieh  (2014-03)  Food Research International  57, 8-14  "Isolation and characterization of α-glucosidase inhibitory constituents from Rhodiola crenulata"
  47. A. Y.-L. Lee, Y.-D. Chen, Y.-Y. Chang, Y.-C. Lin, C.-F. Chang, S.-J. Huang, (S.-H. Wu) and C.-H. Hsu  (2014-02)  Acta Crystallographica Section D-Biological Crystallography  D70(2), 218-230  "Structural basis for DNA-mediated allosteric regulation facilitated by the AAA+ module of Lon protease"
  48. Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, (Wu SH)  (2013-10)  Molecular & Cellular Proteomics  12(10), 2701-2713  "Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27."
  49. Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, (Wu SH)  (2013-10)  PloS one  8(10), e76754  "Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation."
  50. Li, J.-K., Liao, J.-H., Li, H., Kuo, C.-I, Huang, K.-F., Yang, L.-W., (Wu, S.-H.), and Chang, C.-I  (2013-09)  Acta Crystallographica Section D Biological Crystallography  D69(9), 1789-1797  "The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones"
  51. Chen YD, Chang YY, (Wu SH), Hsu CH  (2013-08)  Acta Crystallographica Section F-Structural Biology and Crystallization Communications  69(Pt 8), 899-901  "Crystallization and preliminary X-ray diffraction analysis of the alpha subdomain of Lon protease from Brevibacillus thermoruber."
  52. Liao, J.-H., Ihara, K., Kuo, C.-I, Huang, K.-F., Wakatsuki, S., (Wu, S.-H.), and Chang, C.-I  (2013-08)  Acta Crystallographica Section D Biological Crystallography  D69(8), 1395-1402  "Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors"
  53. Jiahn-Haur Liao, Yu-Huan Sun, Chun-Hua Hsu, Yu-Ching Lin, (Shih-Hsiung Wu),Chao-Jen Kuo, Chun-Hao Huang, Shyh-Horng Chiou   (2013-03)  Biochimie  95(6), 1136-1145  "Up-regulation of neutrophil activating protein in Helicobacter pylori under high-salt stress: Structural and phylogenetic comparison with bacterial iron-binding ferritins"
  54. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, (Wu SH), Yang SS, Lin SH, Chang JM, Chen A  (2013)  Free radical biology & medicine  61C, 285-297  "Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome."
  55. Hua KF, Liao PC, Fang Z, Yang FL, Yang YL, Chen YL, Chiu YC, Liu ML, Lam Y, (Wu SH)  (2013)  PloS one  8(6), e67603  "Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells."
  56. Lin HJ, Adak AK, Reddy LV, (Wu SH), Lin CC  (2013)  CHEMISTRY-A EUROPEAN JOURNAL  19(24), 7989-7898  "Total synthesis of an immunomodulatory phosphoglycolipid from thermophilic bacteria."
  57. Liao JH, Kuo CI, Huang YY, Lin YC, Lin YC, Yang CY, Wu WL, Chang WH, Liaw YC, Lin LH, Chang CI, (Wu SH)  (2012)  PloS one  7(7), e40226  "A Lon-Like Protease with No ATP-Powered Unfolding Activity."
  58. Lin TL, Yang FL, Yang AS, Peng HP, Li TL, Tsai MD, (Wu SH), Wang JT  (2012)  PloS one  7(10), e46783  "Amino Acid Substitutions of MagA in Klebsiella pneumoniae Affect the Biosynthesis of the Capsular Polysaccharide."
  59. Chen HW, Yang TS, Chen MJ, Chang YC, Lin CY, Wang EI, Ho CL, Huang KM, Yu CC, Yang FL, (Wu SH), Lu YC, Chao LK  (2012)  Bioresource technology  120, 256-263  "Application of power plant flue gas in a photobioreactor to grow Spirulina algae, and a bioactivity analysis of the algal water-soluble polysaccharides."
  60. Liao WY, Shen CN, Lin LH, Yang YL, Han HY, Chen JW, Kuo SC, (Wu SH), Liaw CC  (2012)  Journal of natural products  75(4), 630-635  "Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus."
  61. Chen CS, Yu YP, Hsu CH, Zou W, Fang JM, (Wu SH)  (2012)  Carbohydrate research  354, 87-93  "Evaluation of the regioselective delactonization of tri-sialic acid lactone by in-solution molecular dynamics simulation."
  62. Hsieh PF, Lin TL, Yang FL, Wu MC, Pan YJ, (Wu SH), Wang JT  (2012)  PloS one  7(3), e33155  "Lipopolysaccharide O1 antigen contributes to the virulence in Klebsiella pneumoniae causing pyogenic liver abscess."
  63. Tsai CC, Yang FL, Huang ZY, Chen CS, Yang YL, Hua KF, Li J, Chen ST, (Wu SH)  (2012)  Journal of agricultural and food chemistry  60(11), 2830-2837  "Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells."
  64. Hu CW, Lin MH, Huang HC, Ku WC, Yi TH, Tsai CF, Chen YJ, Sugiyama N, Ishihama Y, Juan HF, (Wu SH)  (2012)  Journal of proteome research  11(11), 5362-5375  "Phosphoproteomic Analysis of Rhodopseudomonas palustris Reveals the Role of Pyruvate Phosphate Dikinase Phosphorylation in Lipid Production."
  65. Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, (Wu SH)  (2011-01)  Inorganic chemistry  50(1), 365-377  "Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis."
  66. Timothy Eckert, Chun-Ping Lu, Chien-Sheng Chen, (Shih-Hsiung Wu), Jacquelyn Gervay-Hague  (2011-01)  Tetrahedron Letters  52, 2250-2253  "NMR studies of the reversible and regioselective lactonization of α-2,8-linked trisialic acid in aqueous acid."
  67. Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, (Wu SH)  (2011)  Journal of Biological Chemistry  286(20), 17736-17745  "A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2."
  68. Liao JH, Wu TH, Hsu FL, Huang YS, Chiang PH, Huang ZY, Huang CH, (Wu SH), Lin MH  (2011)  International journal of molecular sciences  12(10), 7059-7076  "Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent."
  69. P-F. Su1, C-J. Li, C-C. Hsu, S. Benson, S-Y. Wang, K. Aravindaram1, S. I. Chan, (S-H. Wu), F-L. Yang, W-C. Huang, L-F. Shyur, N-S. Yang  (2011)  EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE  2011, 731308  "Dioscorea Phytocompounds Enhance Murine Splenocyte Proliferation Ex Vivo and Improve Regeneration of Bone Marrow Cells In Vivo."
  70. Chu KC, Ren CT, Lu CP, Hsu CH, Sun TH, Han JL, Pal B, Chao TA, Lin YF, (Wu SH), Wong CH, Wu CY  (2011)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  50(40), 9391-9395  "Efficient and stereoselective synthesis of alpha(2-->9) oligosialic acids: from monomers to dodecamers."
  71. Ho JY, Lin TL, Li CY, Lee A, Cheng AN, Chen MC, (Wu SH), Wang JT, Li TL, Tsai MD  (2011)  PloS one  6(7), e21664  "Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044."
  72. Lu CP, Lin CT, Chang CM, (Wu SH), Lo LC  (2011)  Journal of agricultural and food chemistry  59(21), 11403-11406  "Nitrophenylboronic acids as highly chemoselective probes to detect hydrogen peroxide in foods and agricultural products."
  73. Lu TL, Chuang JY, Yang JS, Chiu ST, Hsiao NW, Wu MC, (Wu SH), Hsu CH  (2011)  Evidence-based Complementary and Alternative Medicine  2011, 283747  "Production of Active Nonglycosylated Recombinant B-Chain of Type-2 Ribosome-Inactivating Protein from Viscum articulatum and Its Biological Effects on Peripheral Blood Mononuclear Cells."
  74. Yang FL, Hassanbhai AM, Chen HY, Huang ZY, Lin TL, (Wu SH), Ho B  (2011)  Helicobacter  16(2), 89-98  "Proteomannans in biofilm of Helicobacter pylori ATCC 43504."
  75. Hu CC, Liao JH, Hsu KY, Lin IL, Tsai MH, Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, (Wu SH), Wu TH  (2011)  Molecular vision  17, 1862-1870  "Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo."
  76. Yang FL, Yang YL, (Wu SH)  (2011)  Advances in experimental medicine and biology  705, 367-380  "Structure and function of glycolipids in thermophilic bacteria."
  77. Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, (Wu SH)  (2011)  Journal of Biological Chemistry  286(24), 21041-21051  "Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4."
  78. Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, (Wu SH)  (2011)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  50(34), 7885-7891  "The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins."
  79. Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, (Wu SH)  (2010-11)  Journal of medicinal chemistry  53(22), 7967-7978  "Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis."
  80. Yang YL, Yang FL, Huang ZY, Tsai YH, Zou W, (Wu SH)  (2010-10)  Organic & biomolecular chemistry  8(19), 4252-4254  "Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures."
  81. J-H. Liao,Y-C. Lin,C-W. Hsu,Alan Y-L. Lee,T-A. Chen,C-H. Hsu,J-L. Chir,K-F. Hua,T-H. Wu,L-J. Hong,P-W. Yen,A. Chiou,(S-H. Wu*)  (2010-06)  Biophys. J.  98(1), 129-137  "Binding and cleavage of E. coli HUbeta by the E. coli Lon protease"
  82. Hsu CH, Pan YR, Liao YD, (Wu SH), Chen C  (2010-04)  Journal of biochemistry  148(2), 209-215  "NMR and biophysical elucidation of structural effects on extra N-terminal methionine residue of recombinant amphibian RNases from Rana catesbeiana."
  83. C-H. Huang1,I-L. Lee,I-J. Yeh,J-H. Liao, C-L. Ni, (S-H. Wu) and S-H. Chiou  (2010-04)  J. Biochem.  147(4), 535-543  "Upregulation of a non-heme iron-containing ferritin with dual ferroxidase and DNA-binding activities in Helicobacter pylori under acid stress"
  84. Y-C. Huang,T-L. Hwang, Y-L. Yang,(S-H. Wu), M-H. Hsu, J-P. Wang, S-C. Chen, L-J. Huang, C-C.Liaw  (2010-03)  PLANTA MEDICA  76(5), 447-53  "Acetogenin and Prenylated Flavonoids from Helminthostachy zeylanica with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils"
  85. Yu CC, Chen HW, Chen MJ, Chang YC, Chien SC, Kuo YH, Yang FL, (Wu SH), Chen J, Yu HH, Chao LK  (2010)  Natural product communications  5(12), 1941-1944  "Chemical composition and bioactivities of the marine alga Isochrysis galbana from Taiwan."
  86. Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.  (2009-12)  Mol Cell Proteomics  8(12), 2613-23  "Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence"
  87. Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and (S-H. Wu*)  (2009-11)  CHEMISTRY-A EUROPEAN JOURNAL  15(43), 11573-80  "Discovery of New Natural Products by Intact-cell Mass Spectrometry and LC-SPE-NMR--Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea"
  88. Liao JH, Chen CS, Maher TJ, Liu CY, Lin MH, Wu TH, "Wu SH*"  (2009)  Chemical research in toxicology  22 (3), 518–525  "Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis."
  89. Liao JH, Lee JS, "Wu SH", Chiou SH  (2009)  Molecular vision  15, 1429-1444  "COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine alphaB-crystallin."
  90. Lin YC, Lee HC, Wang I, Hsu CH, Liao JH, Lee AY, Chen C, "Wu SH*"  (2009)  Biochemical and biophysical research communications  388(1), 62-66  "DNA-binding specificity of the Lon protease alpha-domain from Brevibacillus thermoruber WR-249."
  91. Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, "Wu SH", Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL  (2009)  Infection and immunity  77(2), 615-621  "Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling."
  92. Y-P. Yu, A-T. Wu, W. Zou, C-S. Chen and (S-H. Wu*)  (2009)  Tetrahedron Lett.  50, 6130-6132  "Recognition between a Divalent Sialyl Molecule and Wheat Germ Agglutinin"
  93. Chir JL, Liao JH, Lin YC, "Wu SH*"  (2009)  Biochemical and biophysical research communications  382(4), 762-765  "The N-terminal sequence after residue 247 plays an important role in structure and function of Lon protease from Brevibacillus thermoruber WR-249."
  94. Chen CS, Yu YP, Lin BC, Jacquelyn GH, Fan JM, Hsu CP, (Wu SH*)   (2009)  European Journal of Organic Chemistry  2009(20), 3351-3356  "The Observation of the C-H···Osp3 Hydrogen Bond in Trisialic Acid Lactone and Its Implications for Cooperative Lactonization"
  95. P-H. Chuang,P-W. Hsieh,Y-L. Yang,K-F. Hua,F-R. Chang,Jentaie Shiea, (S-H Wu),Y-C. Wu  (2008)  J. Nat. Prod.  71, 1365-1370  "Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana"
  96. Liaw CC, Yang YL, Chen M, Chang FR, Chen SL, (Wu SH), Wu YC  (2008)  Journal of natural products  71(5), 764-771  "Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators."
  97. Yang YL, Hua KF, Chuang PH, (Wu SH), Wu KY, Chang FR, Wu YC  (2008)  Journal of agricultural and food chemistry  56(2), 386-392  "New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities."
  98. Liu JY, Yang FL, Lu CP, Yang YL, Wen CL, Hua KF, (Wu SH)*  (2008)  Journal of agricultural and food chemistry  56(21), 9892-9898  "Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways."
  99. Sandbhor M, Bhasin M, Williams DT, Hsieh M, (Wu SH), Zou W  (2008)  Carbohydrate research  343, 2878-2886  "Synthesis of iminoalditol analogues of galactofuranosides and their activities against glycosidases."
  100. Chen SH, Suzuki CK, (Wu SH)*  (2008)  Nucleic acids research  36(4), 1273-1287  "Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA."
  101. Yang FL, Hua KF, Yang YL, Zou W, Chen YP, Liang SM, Hsu HY, (Wu SH)*  (2008)  Glycoconjugate journal  25(5), 427-439  "TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria."
  102. Wang I, Lou YC, Lin YC, Lo SC, Lee AY, (Wu SH)*, Chen C  (2007)  Biomolecular NMR assignments  1(2), 201-203  "(1)H, (13)C and (15)N resonance assignments of alpha-domain for Bacillus subtilis Lon protease."
  103. Huang HC, Tsai WJ, Liaw CC, (Wu SH), Wu YC, Kuo YH  (2007)  Chemical & pharmaceutical bulletin  55(9), 1412-1415  "Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi."
  104. C-S. Chen, Y-P. Yu, C-H. Hsu, Y-T. Wu, W. Zou, J-M. Fang, and (S-H. Wu)*  (2007)  Eur. J. Org. Chem.  3648-3654  "Conformation of trisialic acid lactone : NMR spectroscopic analysis and molecular dynamics simulation"
  105. Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and (S. H. Wu)*  (2007)  CHEMISTRY-A EUROPEAN JOURNAL  13(24), 6985-6991  "Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora Thermophila: Elucidation of the Relationship between Cytotoxicity and Stereoconfiguration"
  106. Lu CP, Ren CT, (Wu SH)*, Chu CY, Lo LC  (2007)  CHEMBIOCHEM  8(18), 2187-2190  "Development of an activity-based probe for steroid sulfatases."
  107. Zou W, Wu AT, Bhasin M, Sandbhor M, (Wu SH)  (2007)  The Journal of organic chemistry  72(7), 2686-2689  "Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation."
  108. C. S. Chen, (S. H. Wu), Y. Y. Wu, J. M. Fang and T. H. Wu  (2007)  Org. Lett.  9(16), 2985-2988  "Properties of Astaxanthin/Ca(2+) Complex Formation in the Deceleration of Cis/Trans Isomerization"
  109. C. T. Ren, Y. H. Tsai, Y. L. Yang, W. Zou and (S. H. Wu)*  (2007)  J. Org. Chem.  72(14), 5427-5430  "Synthesis of a Tetrasaccharide Glycosyl Glycerol. Precursor to Glycolipids of Meiothermus taiwanensis ATCC BAA-400"
  110. Huang YC, Lin YM, Chang TW, Wu SJ, Lee YS, Chang MD, Chen C, (Wu SH), Liao YD  (2007)  J. Biol. Chem.  282(7), 4626-4633  "The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity."
  111. J. F. Hsieh, (S. H. Wu), Y. L. Yang, K. F. Choong and S. T. Chen  (2007)  BIOORGANIC & MEDICINAL CHEMISTRY  15(10), 3450-3456  "The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors"
  112. H. Shao, D. T. Williams, S. H. Wu and W. Zou  (2006)  Carbohydrate Research  341(14), 2434-2438  "C-Branched pyrrolidines from 2-C-acetylmethyl-glycosylazides. Reduction of imines formed by monosaccharide ring opening"
  113. Y. P. Yu, M. C. Cheng and S. H. Wu  (2006)  Electrophoresis  27(22), 4487-4499  "High-performance CE: An effective method to study lactonization of alpha2,8-linked oligosialic acid"
  114. A. T. Wu, T. Yi, H. Shao, "S. H. Wu*:, W. Zou*  (2006)  Can. J. Chem.  84(4): 597-602  "Stereoselective synthesis of dioxabicycles from 1-C-allyl-2-O-benzyl-glycosides — An intramolecular cyclization between 2-O-benzyl oxygen and the allyl double bond"
  115. Y. L. Yang, F. L. Yang, S. C. Jao, M. Y. Chen, S. S. Tsay, W. Zou and S. H. Wu  (2006)  J. Lipid Res.  47(8), 1823-1832  "Structural elucidation of phosphoglycolipids from strains of the bacterial thermophiles thermus and meiothermus"
  116. Huawu Shao, Sanchai Ekthawatchai, Chien-Sheng Chen, Shih-Hsiung Wu and Wei Zou  (2005)  J. Org. Chem.  70(12), 4726-4734  "1,2-Migration of 2'-Oxoalkyl Group and Concomitant Synthesis of 2-C-Branched O-, S-Glycosides and Glycosyl Azides via 1,2-Cyclopropanated Sugars"
  117. Y. Tian, A-T. Wu, "S-H Wu*", W. Zou*  (2005)  Tetrahedron  61: 11716-11722  "1-C-(2’-Oxoalkyl) glycosides as latentα,β-unsaturated conjugates."
  118. A. T. Wu, Y. P. Yu, C. T. Ren, W. Zou and S. H. Wu  (2005)  CARBOHYDRATE RESEARCH  340(6), 1219-1223  "9-O-Sulfation on alpha-NeuAc-(2-->8)-NeuAc and inter-residue lactonization"
  119. C. P. Lu, C. T. Ren, Y. N. Lai, S. H. Wu, W. M. Wang, J. Y. Chen and L. C. Lo  (2005)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  44(42), 6888-6892  "Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses"
  120. Iren Wang, Yuan-Chao Lou, Kuen-Phon Wu, Shih-Hsiung Wu, Wen-Chang Chang and Chinpan Chen  (2005)  Journal of Molecular Biology  346(4), 1071-1082  "Novel Solution Structure of Porcine β-Microseminoprotein"
  121. C. H. Hsu, C. Chen, M. L. Jou, A.Y.L. Lee, Y. C. Lin, Y. P. Yu, W. T. Huang and S. H. Wu  (2005)  Nucleic Acids Res.  33, 4053-4064  "Structural and DNA-binding studies on the bovine antimicrobial peptide, indolicidin: evidence for multiple conformations involved in binding to membranes and DNA"
  122. Tian Yi, Shih-Hsiung Wu and Wei Zou  (2005)  CARBOHYDRATE RESEARCH  340(2), 235-244  "Synthesis of C-5-thioglycopyranosides and their sulfonium derivatives from 1-C-(2′-oxoalkyl)-5-S-acetylglycofuranosides"
  123. Zou W, Shao H, "Wu SH*"  (2004-10)  CARBOHYDRATE RESEARCH  339(15), 2475-85.  "Intramolecular aldol cyclization of C-4-ulopyranosyl-2'-oxoalkanes controlled by steric effects. Asymmetric synthesis of substituted 8-oxabicyclo[3.2.1]octanones and -octenones and cyclopentenones"
  124. H. Shao, S. Ekthawatchai, S. H. Wu and W. Zou  (2004)  Org. Lett.  6(20), 3497-3499  "2-C-Branched Glycosides from 2'-Carbonylalkyl 2-O-Ms(Ts)-C-Glycosides. A Tandem S(N)2-S(N)2 Reaction via 1,2-Cyclopropanated Sugars"
  125. Chen HP, Hsui FC, Lin LY, Ren CT, Wu SH  (2004)  EUROPEAN JOURNAL OF BIOCHEMISTRY  271(21), 4293-4297  "Coexpression, purification and characterization of the E and S subunits of coenzyme B(12) and B(6) dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli."
  126. A.Y. Lee, C. H. Hsu and S. H. Wu  (2004)  J. Biol. Chem.  279, 34903-34912  "Functional domains of Brevibacillus thermoruber lon protease for oligomerization and DNA binding: role of N-terminal and sensor and substrate discrimination domains."
  127. M. C. Cheng, C. H. Lin, H. J. Lin, Y. P. Yu and S. H. Wu  (2004)  Glycobiology  14, 147-155  "Hydrolysis, lactonization, and identification of alpha(2 --> 8)/alpha(2 --> 9) alternatively linked tri-, tetra-, and polysialic acids"
  128. A. Y. Lee, S. S. Tsay, M. Y. Chen and S. H. Wu  (2004)  Eur. J. Biochem.  271, 834-844  "Identification of a gene encoding Lon protease from Brevibacillus thermoruber WR-249 and biochemical characterization of its thermostable recombinant enzyme"
  129. M. Y. Chen, S. H. Wu, G. H. Lin, C. P. Lu, Y. T. Lin, W. C. Chang and S. S. Tsay  (2004)  INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY  54(Pt 5), 1849-1855  "Rubrobacter taiwanensis sp. nov., a novel thermophilic, radiation-resistant species isolated from hot springs"
  130. Yang FL, Lu CP, Chen CS, Chen MY, Hsiao HL, Su Y, Tsay SS, Zou W, Wu SH.  (2004)  EUROPEAN JOURNAL OF BIOCHEMISTRY  271(22), 4545-4551  "Structural determination of the polar glycoglycerolipids from thermophilic bacteria Meiothermus taiwanensis"
  131. T. L. Lu, C. S. Chen, F. L. Yang, J. M. Fung, M. Y. Chen, S. S. Tsay, J. Li, W. Zou and S. H. Wu SH.  (2004)  CARBOHYDRATE RESEARCH  339(15), 2593-2598  "Structure of a major glycolipid from Thermus oshimai NTU-063"
  132. H. P. Chen, F. D. Lung, C. C. Yeh, H. L. Chen and S. H. Wu  (2004)  BIOORGANIC & MEDICINAL CHEMISTRY  12, 577-582  "The role of the conserved histidine-aspartate pair in the 'base-off' binding of cobalamins"
  133. Wang I, Yu TA, Wu SH, Chang WC, Chen C  (2003)  FEBS letters  541(1-3), 80-84  "Disulfide pairings and secondary structure of porcine beta-microseminoprotein."
  134. Z. Wang, H. Shao, E. Lacroix, S. H. Wu, H. J. Jennings and W. Zou  (2003)  J. Org. Chem.  68, 8097-8105  "Epimerization of 2'-carbonylalkyl-C-glycosides via enolation, beta-elimination and intramolecular cycloaddition"
  135. Hsu CH, Liao YD, Pan YR, Chen LW, "Wu SH", Leu YJ, Chen C  (2003)  Journal of molecular biology  326(4), 1189-1201  "Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana."
  136. C. T. Ren, C. S. Chen, Y. P. Yu, Y. F. Tsai, P. Y. Lin, Y. J. Chen, W. Zou and S. H. Wu  (2003)  CHEMISTRY-A EUROPEAN JOURNAL  9, 1085-1095  "Synthesis of alpha-(2-->5)Neu5Gc oligomers"
  137. W. Zou, E. Lacroix, Z. Wang, "S. H. Wu*"  (2003)  Tetrahedron Lett.  44: 4431-4433.  "Synthesis of thio-C-glycosides from 2’-carbonylalkyl C-glycosides by a tandemβ-elimination and intramolecular hetero-Michael addition"
  138. H. Shao, Z. Wang, E. Lacroix, "S. H. Wu", H. J. Jenning, W. Zou  (2002)  J. Am. Chem. Soc.  124: 2130-2131  "Novel zinc (II)-mediated epimerization of 2'-carbonylalkyl-α-C-glycopyranosides to their β-anomers"
  139. Wang I, "Wu SH*", Chang HK, Shieh RC, Yu HM, Chen C  (2002)  PROTEIN SCIENCE  11(2), 390-400  "Solution structure of a K(+)-channel blocker from the scorpion Tityus cambridgei."
  140. Hsu CH, "Wu SH*", Chang DK, Chen C  (2002)  The Journal of biological chemistry  277(25), 22725-22733  "Structural characterizations of fusion peptide analogs of influenza virus hemagglutinin. Implication of the necessity of a helix-hinge-helix motif in fusion activity."
  141. C. T. Ren, C. S. Chen and S. H. Wu  (2002)  J. Org. Chem.  67, 1376-1379  "Synthesis of a sialic acid dimer derivative, 2'alpha-O-benzyl Neu5Ac-alph-(2-->5)Neu5Gc"
  142. C. Chen, C. H. Hsu, N. Y. Su, Y. C. Lin, S. H. Chiou and S. H. Wu  (2001)  J. Biol. Chem.  276, 45079-45087  "Solution structure of a Kunitz-type chymotrypsin inhibitor isolated from the elapid snake Bungarus fasciatus"
  143. M. C. Cheng, C. H. Lin, H. Y. Wang, H. R. Lin and S. H. Wu  (2000)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  39, 772-776  "Regioselective Lactonization of Tetrasialic Acid"
  144. T. P. Ko, M. K. Safo, F. N. Musayev, M. L. Di Salvo, C. Wang, S. H. Wu and D. J. Abraham  (2000)  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY  56, 241-245  "Structure of human erythrocyte catalase"
  145. M. C. Cheng, K. T. Wang, S. Inoue, Y. Inoue, K. H. Khoo and S. H. Wu  (1999)  Anal. Biochem.  267, 287-293  "Controlled acid hydrolysis of colominic acid under microwave irradiation"
  146. C. C. Chuang, S. H. Wu, S. H. Chiou and G. G. Chang  (1999)  Biophys J  76, 679-690  "Homology modeling of cephalopod lens S-crystallin: a natural mutant of sigma-class glutathione transferase with diminished endogenous activity"
  147. M. C. Cheng, C. H. Lin, K. H. Khoo and S. H. Wu  (1999)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  38, 686-689  "Regioselective Lactonization of α-(2→8)-Trisialic Acid"
  148. C. Y. Wu, H. J. Lee, S. H. Wu, S. T. Chen, S. H. Chiou and G. G. Chang  (1998)  Biochem J  333, 327-334  "Chemical mechanism of the endogenous argininosuccinate lyase activity of duck lens delta2-crystallin"
  149. M. C. Cheng, S. L. Lin, S. H. Wu, S. Inoue and Y. Inoue  (1998)  Anal. Biochem.  260, 154-159  "High-performance capillary electrophoretic characterization of different types of oligo- and polysialic acid chains"
  150. S. Inoue, S. L. Lin, T. Chang, S. H. Wu, C. W. Yao, T. Y. Chu, F. A. Troy 2nd and Y. Inoue  (1998)  J Biol Chem  273, 27199-27204  "Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells"
  151. L. C. Chuang, H. M. Yu, C. Chen, T. H. Huang, S. H. Wu and K. T. Wang  (1996)  Biochim Biophys Acta  1292, 145-155  "Determination of three-dimensional solution structure of waglerin I, a toxin from Trimeresurus wagleri, using 2D-NMR and molecular dynamics simulation"
  152. Y. M. Hsiao, C. C. Chuang, L. C. Chuang, H. M. Yu, K. T. Wang, S. H. Chiou and S. H. Wu  (1996)  Biochem Biophys Res Commun  227, 59-63  "Protein engineering of venom toxins by synthetic approach and NMR dynamic simulation: status of basic amino acid residues in waglerin I"
  153. L. C. Chuang, P. Y. Chen, C. Chen, T. H. Huang, K. T. Wang, S. H. Chiou and S. H. Wu  (1996)  Biochem Biophys Res Commun  220, 246-254  "Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin gamma with three disulfide bonds by 2D-NMR and computer graphics"
  154. S. Y. Liao, G. T. Ong, K. T. Wang and S. H. Wu  (1995)  Biochim Biophys Acta  1252, 312-320  "Conformation of polymyxin B analogs in DMSO from NMR spectra and molecular modeling"
  155. P. Y. Chen, S. H. Wu and K. T. Wang  (1994)  Protein Eng  7, 941-944  "Chemical synthesis of gamma-echistatin analogues: elucidation of status of C-terminal (45-49)"
  156. G. T. Ong, K. Y. Chang, S. H. Wu and K. T. Wang  (1994)  CARBOHYDRATE RESEARCH  265, 311-318  "Preparation of 2,3,6,2',3',4',6'-hepta-O-acetyl-maltose/cellobiose by enzymatic hydrolysis of maltose/cellobiose octaacetate"
  157. G. T. Ong, K. Y. Chang, S. H. Wu and K. T. Wang  (1993)  CARBOHYDRATE RESEARCH  241, 327-333  "Selective deacylation on the glucosyl moiety of octa-O-acetylsucrose by enzymic hydrolysis: formation of 2,1',3',4',6'-penta-O-acetylsucrose"
  158. K. Y. Chang, S. H. Wu and K. T. Wang  (1991)  CARBOHYDRATE RESEARCH  222, 121-129  "Regioselective enzymic deacetylation of octa-O-acetylsucrose: preparation of hepta-O-acetylsucroses"
  159. S. T. Chen, L. C. Lo, S. H. Wu and K. T. Wang  (1990)  Int J Pept Protein Res  35, 52-54  "Side reaction in peptide synthesis. Formation of oxazolidone derivatives"
  160. C. J. Sih, S. H. Wu  (1989)  Topics in Stereochemistry  19, 63-125  "Resolution of enantiomers via biocatalysis"